Cross-sectional study on acrylamide hemoglobin adducts in subpopulations from the European Prospective Investigation into Cancer and Nutrition (EPIC) Study     

Vesper HW  Slimani N  Hallmans G  Tjønneland A  Agudo A  Benetou V  Bingham S  Boeing H  Boutron-Ruault MC  Bueno-de-Mesquita HB  Chirlaque D  Clavel-Chapelon F  Crowe F  Drogan D  Ferrari P  Johansson I  Kaaks R  Linseisen J  Lund E  Manjer J  Mattiello A  Palli D  Peeters PH  Rinaldi S  Skeie G  Trichopoulou A  Vineis P  Wirfält E  Overvad K  Strömberg U 《Journal of agricultural and food chemistry》2008,56(15):6046-6053

Acrylamide exposure was investigated in subgroups of the EPIC study population (510 subjects from 9 European countries, randomly selected and stratified by age, gender, and smoking status) using hemoglobin adducts of acrylamide (HbAA) and its primary metabolite glycidamide (HbGA). Blood samples were analyzed for HbAA and HbGA by HPLC/MS/MS. Statistical models for HbAA and HbGA were developed including body mass index (BMI), educational level, and physical activity. A large variability in acrylamide exposure and metabolism between individuals and country groups was observed with HbAA and HbGA values ranging between 15-623 and 8-377 pmol/g of Hb, respectively. Both adducts differed significantly by country, sex, and smoking status. HbGA values were significantly lower in high alcohol consumers than in moderate consumers. With increasing BMI, HbGA in nonsmokers and HbAA in smokers decreased significantly. In the assessment of potential health effects related to acrylamide exposure, country of origin, BMI, alcohol consumption, sex, and smoking status should be considered.  相似文献   

Flavonoids of white lupin roots participate in phosphorus mobilization from soil     

Nicola Tomasi  Laure Weisskopf  Giancarlo Renella  Loretta Landi  Roberto Pinton  Zeno Varanini  Paolo Nannipieri  Josè Torrent  Enrico Martinoia  Stefano Cesco 《Soil biology & biochemistry》2008,40(7):1971-1974

The impact of flavonoids released by phosphorus-deficient white lupin roots on inorganic P and soil microorganisms is largely unknown. We report that flavonoids isolated from white lupin roots mobilized inorganic phosphorus and decreased soil microbial respiration, citrate mineralization, and soil phosphohydrolase activities, but did not reduce the soil ATP content. The results suggest that white lupin's release of flavonoids into the rhizosphere plays a significant role in its efficient P-acquisition strategy by solubilizing Fe-bound P and by limiting the microbial mineralization of citrate.  相似文献   

The severity of smouldering peat fires and damage to the forest soil   总被引：1，自引：0，他引：1  

Guillermo Rein  Natalie CleaverClare Ashton  Paolo PironiJosé L. Torero 《CATENA》2008

Smouldering wildfires propagate slowly through surface and subsurface organic layers of the forest ground and severely affect the soil, producing physical, chemical and biological changes. These effects are caused by the prolonged heating and the large loss of soil mass but are poorly documented in the literature. A series of smouldering experiments with boreal peat have been conducted under laboratory conditions to quantify these effects using small-scale samples. Peat samples of 100 mm by 100 mm in cross section and 50 mm in depth of different moisture were exposed to an external ignition source. Thermocouples placed throughout the sample bed measured the temperature evolution and tracked the peat ignition, intensity and spread of the smouldering front. The results show that moisture content controls peat ignition and that moisture below 125 ± 10% (in dry base) are required. The severity of the smouldering peat on the soil has been quantified in terms of temperature vs. residence time curves and mass loss. The measurements show temperatures in excess of 300 °C for residence times of 1 h leading to sterilization of the soil and mass loss in burnt layers above 90%.  相似文献   

Cutaneous sterile pyogranuloma/granuloma syndrome in a dog     

Domenico Santoro  Andrea Spaterna  Luca Mechelli  Paolo Ciaramella 《The Canadian veterinary journal. La revue veterinaire canadienne》2008,49(12):1204-1207

A case of canine cutaneous sterile pyogranuloma/granuloma syndrome (SPGS) with generalized asymmetrical alopecia and plaques is described. Results from histopathologic examination were suggestive of SPGS and failed to demonstrate any etiological agent. A systematic approach on how to definitively rule out infectious skin diseases is discussed.  相似文献   

Cat and dog ownership and management patterns in central Italy     

Slater MR  Di Nardo A  Pediconi O  Villa PD  Candeloro L  Alessandrini B  Del Papa S 《Preventive veterinary medicine》2008,85(3-4):267-294

Three hundred and ninety-seven randomly selected households were interviewed by telephone to determine the numbers and management of owned cats and dogs in the Teramo Province of Italy. The households were selected using stratified random sampling for each municipality; municipalities were combined into coastal, central hills and mountain regions for analysis. The interviews were completed during May and June of 2004 with a response rate of 74% (397/536). Forty-six percent of households (n=181) owned pets; 15% of all households (n=60) owned cats and 33% (n=130) owned dogs. Twenty-seven of these households (7%) owned both cats and dogs. Data were provided on 91 cats evenly divided between males and females. The median age was 3 years (range 0.2-10 years). Forty-one percent of cats (36/87) entered the household as strays. Nearly half lived entirely outside. Seventy percent (62/88) had visited a veterinarian at least once; 43% (39/91) were sterilized. About 1/3 had had a litter and all litters were considered accidental rather than planned. Age, indoor/outdoor status, veterinarian visit and region were all associated with sterilization. Age, confined to a yard, veterinary visit and region were associated with allowing the cat to roam freely. Data were provided on 182 dogs. Sixty-two percent (113/181) were male, with a median age of 4 years (range newborn to 17 years) and 40% (72/181) were purebred. Almost half were acquired as a gift. Sixty-two percent (112/180) were kept entirely outside despite the fact that 82% (147/180) were considered companions rather than working dogs. Almost all of the dogs had been to a veterinarian at least once; only 20% (n=29) were sterilized. Male dogs were significantly less likely to be sterilized than females. Almost half the dogs had had at least one litter. Seventy-six percent (137/180) of dogs knew some basic commands. Sex, source and training to sit/stay/come were significantly associated with whether the dog was sterilized. Dog size, confinement to a yard, trained to leash walk, veterinary visit and region were predictors of roaming freely. Source and trained to leash walk were associated with dog registration. For cats and dogs, education about sterilization seemed to be critically important. For dogs, factors relating to training, which may reflect the strength of the human-animal bond, were also important.  相似文献   

Migration of a Kirschner wire to the heart in a Yorkshire terrier   总被引：1，自引：0，他引：1  

Crosara S  Zabarino S  Morello E  Iussich S  Buracco P  Borgarelli M 《The Journal of small animal practice》2008,49(2):100-102

A 12-year-old, male Yorkshire terrier was presented for acute pulmonary oedema. Thoracic radiographs showed a linear metallic foreign body within the cardiac silhouette. Echocardiogram showed a hyperechoic line extending through the left ventricle, the mitral valve, leading into the left atrium. A 4 cm long Kirschner wire was surgically removed by left fourth thoracotomy. The dog died two days after surgery for acute pulmonary oedema. Necropsy showed thrombi on the mitral leaflets that impeded their movement.  相似文献   

Meloxicam vs robenacoxib for postoperative pain management in dogs undergoing combined laparoscopic ovariectomy and laparoscopic‐assisted gastropexy     

Cristiano Bendinelli  Roberto Properzi  Paolo Boschi  Carla Bresciani  Erica Rocca  Alberto Sabbioni  Fabio Leonardi 《Veterinary surgery : VS》2019,48(4):578-583

  相似文献   

MicroRNA expression in the cerebrospinal fluid of dogs with and without cervical spondylomyelopathy     

Daniella P. Vansteenkiste  Joelle M. Fenger  Paolo Fadda  Paula Martin‐Vaquero  Ronaldo C. da Costa 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2019,33(6):2685-2692

  相似文献   

A sonographic investigation for the development of ultrasound-guided paravertebral brachial plexus block in dogs: cadaveric study     

Paolo Monticelli  Ella Fitzgerald  Jaime Viscasillas 《Veterinary anaesthesia and analgesia》2018,45(2):195-202

  相似文献   

The effects of starter microbiota and the early life feeding of medium chain triglycerides on the gastric transcriptome profile of 2-or 3-week-old cesarean delivered piglets     

Paolo Trevisi  Davide Priori  Vincenzo Motta  Diana Luise  Alfons J.M.Jansman  Sietse-Jan Koopmans  Paolo Bosi 《畜牧与生物技术杂志(英文版)》2018,(1)

Background: The stomach is an underestimated key interface between the ingesta and the digestive system, affecting the digestion and playing an important role in several endocrine functions. The quality of starter microbiota and the early life feeding of medium chain triglycerides may affect porcine gastric maturation. Two trials(T1, T2) were carried out on 12 and 24 cesarean-delivered piglets(birth, d0), divided over two microbiota treatments, but slaughtered and sampled at two or three weeks of age, respectively. All piglets were fed orally: sow serum(T1) or pasteurized sow colostrum(T2) on d0; simple starter microbiota(Lactobacillus amylovorus, Clostridium glycolicum and Parabacteroides spp.)(d1-d3); complex microbiota inoculum(sow diluted feces, CA) or a placebo(simple association, SA)(d3-d4) and milk replacer ad libitum(d0-d4). The The T1 piglets and half of the T2 piglets were then fed a moist diet(CTRL); the remaining half of the T2 piglets were fed the CTRL diet fortified with medium chain triglycerides and 7% coconut oil(MCT). Total m RNA from the oxyntic mucosa was analyzed using Affymetrix?Porcine Gene array strips. Exploratory functional analysis of the resulting values was carried out using Gene Set Enrichment Analysis.Results: Complex microbiota upregulated 11 gene sets in piglets of each age group vs. SA. Of these sets, 6 were upregulated at both ages, including the set of gene markers of oxyntic mucosa. In comparison with the piglets receiving SA, the CA enriched the genes in the sets related to interferon response when the CTRL diet was given while the same sets were impoverished by CA with the MCT diet.Conclusions: Early colonization with a complex starter microbiota promoted the functional maturation of the oxyntic mucosa in an age-dependent manner. The dietary fatty acid source may have affected the recruitment and the maturation of the immune cells, particularly when the piglets were early associated with a simplified starter microbiota.  相似文献