Use of force plate analysis to assess the analgesic effects of etodolac in horses with navicular syndrome     

Symonds KD  MacAllister CG  Erkert RS  Payton ME 《American journal of veterinary research》2006,67(4):557-561

OBJECTIVE: To evaluate the musculoskeletal analgesic effect of etodolac administered PO every 12 or 24 hours in chronically lame horses by use of force plate analysis. ANIMALS: 22 horses with navicular syndrome. PROCEDURE: Horses received etodolac (23 mg/kg, PO, q 12 h; n = 7), etodolac (23 mg/kg, PO, q 24 h; 8), or corn syrup (20 mL, PO, q 24 h; control treatment; 7) for 3 days. Combined forelimb peak vertical ground reaction force (PVF) was measured via force plate analysis before the first treatment (baseline) and at 6, 12, 24, and 36 hours after the last treatment. Differences in mean PVF (mPVF) between baseline and subsequent measurements were analyzed (repeated-measures ANOVA) and evaluated for treatment and time effects and treatment-time interaction. RESULTS: Once- or twice-daily administration of etodolac resulted in significant increases in mPVF from baseline at 6, 12, and 24 hours after the last treatment, compared with the control treatment. There were no significant differences in mPVF between the etodolac treatment groups at any time point. In both etodolac treatment groups, there was a significant increase in mPVF from baseline at 6, 12, and 24 hours, compared with that at 36 hours. Etodolac-associated adverse effects were not detected. CONCLUSIONS AND CLINICAL RELEVANCE: In horses with navicular syndrome, once-daily oral administration of 23 mg of etodolac/kg appears to provide effective analgesia for as long as 24 hours. Twice-daily administration of etodolac at this same dose does not appear to provide any additional analgesic efficacy or duration of effect.  相似文献   

Gait abnormalities caused by selective anesthesia of the suprascapular nerve in horses     

Devine DV  Jann HW  Payton ME 《American journal of veterinary research》2006,67(5):834-836

OBJECTIVE: To assess gait abnormalities associated with selective anesthesia of the suprascapular nerve (SSN) achieved by use of perineural catheterization and thereby determine the function of that nerve as it relates to gait in horses. ANIMALS: 3 adult horses with no preexisting clinically apparent lameness at a walk. PROCEDURE: Each horse was anesthetized; the right SSN was exposed surgically for placement of a perineural catheter to permit delivery of 1 mL of 2% mepivacaine hydrochloride. Six hours after recovery from anesthesia, each horse was videotaped while walking (50-step data acquisition period) before and after administration of mepivacaine. Videotapes were reviewed and the proportion of abnormal steps before and after selective SSN anesthesia was assessed. A step was considered abnormal if a marked amount of scapulohumeral joint instability (ie, lateral luxation of the proximal portion of the humerus) was observed during the weight-bearing phase of the stride. RESULTS: Clinically apparent gait dysfunction was detected in all 3 horses following perineural administration of the local anesthetic agent. Anesthesia of the SSN resulted in scapulohumeral joint instability as evidenced by consistent lateral excursion of the shoulder region during the weight-bearing phase of gait at a walk. The proportion of abnormal steps before and after SSN anesthesia was significantly different in all 3 horses. CONCLUSIONS AND CLINICAL RELEVANCE: These data support the role of the SSN in shoulder joint stability in horses and define SSN dysfunction as 1 mechanism by which the syndrome and gait dysfunction clinically referred to as sweeny may develop.  相似文献   

Physical Quality and Carotene Content of Solar-Dried Green Leafy and Yellow Succulent Vegetables     

Mdziniso P  Hinds MJ  Bellmer DD  Brown B  Payton ME 《Plant foods for human nutrition (Dordrecht, Netherlands)》2006,61(1):12-20

The effects of vegetable type, vegetable dimensions, and solar drier load on dehydration rate; and texture, color, water activity, and carotene content of solar-dried carrots, sweet potatoes, and collard greens were studied. Mean dehydration rates (moisture loss,%/hr) for solar dried loads of 430 g/m² and 715 g/m² were 3.3 ± 0.30% and 3.8 ± 0.20% for carrots and sweet potatoes, respectively. Loads of 360 g/m² and 465 g/m² of collard greens had dehydration rates of 6.3 ± 0.10% moisture loss per hr. The results showed that vegetable type accounted for significant differences (p < 0.01) in dehydration rate, and beta-carotene content. Vegetable dimensions affected (p < 0.05) water activity. Solar drier load affected water activity (p < 0.01), and hue angle (p < 0.05). Beta-carotene contents (dry basis) of dehydrated carrot, sweet potato, and collard treatments were 10.9–17.4%, 7.6–9.8%, and 11.9–21.5%, respectively. Among the carrot treatments, the 5-mm thick slices packed at a load of 715 g/m² contained the highest beta-carotene (17.4%, dry basis) and vitamin A activity (362 IU/g, dry basis), and good physical properties. For collard greens, the 2-cm and 3-cm wide strips packed at 360 g/m² loads had the best combinations of high beta-carotene (21.5% and 17.2%, dry basis, respectively), vitamin A activity (357.2 and 293.1 IU/g, dry basis, respectively), and optimal color, texture, and water activity. Beta-carotene losses due to solar dehydration were 48.9–67.5%, 4.0–5.8%, and 1.9–19.8% (dry basis) in carrots, sweet potato and collard greens, respectively.  相似文献   

Analgesic effect of pre-operative etodolac and butorphanol administration in dogs undergoing ovariohysterectomy     

T  Inoue  JCH Ko  RE Mandsager  ME Payton  DS Galloway  DN Lange 《Veterinary anaesthesia and analgesia》2003,30(2):109-110

The analgesic, bleeding, and renal effects of dogs pre‐medicated with etodolac with and without butorphanol were evaluated. Twenty‐four 1‐year‐old healthy dogs, weighing 19 ± 3 kg (mean ± SD) were randomly assigned to four treatment groups (n = 6): control (C), etodolac (E), butorphanol (B), and etodolac with butorphanol (EB). Etodolac (12–14 mg kg^?1 PO) was given 1 hour before propofol induction and isoflurane maintenance anesthesia. Butorphanol (0.4 mg kg^?1 IV) was given immediately following endotracheal intubation. Control dogs received only propofol (8 mg kg^?1 to effect) and isoflurane anesthesia. All dogs were mechanically ventilated to maintain Pe ′CO₂ between 35 and 45 mm Hg (4.7–6.0 kPa). Lactated Ringer's solution was given at 10 mL kg^?1 hour^?1 during anesthesia. Plasma cortisol concentrations were assessed 1 day prior to surgery (baseline), immediately prior to anesthesia induction, and every 30 minutes until 5 hours following extubation, and 1 day after surgery. Total duration of anesthesia was 50 minutes and total surgery duration was 30 minutes. Isoflurane concentration area under the curve (AUC) over time during the anesthesia was compared among treatment groups. Buccal mucosal bleeding time (BMBT) was assessed 1 day before E administration and during surgery. Urine GGT to urine creatinine ratio, BUN, and plasma creatinine were taken daily from 1 day before to 3 days after surgery. Behavioral pain scores (numerical rating scale) were assessed by two observers blinded to the treatment during the 5‐hour recovery period at 30 minute intervals until 3 hours, and again at 5 hours after extubation. All data were analyzed using anova . Multiple comparisons were performed if the anova was significant. Alpha value was set at 0.05. Plasma cortisol concentrations significantly increased from time of extubation in all the treatment groups. They did not return to the baseline until 5, 2.5, 1.5, and 1.5 hours after extubation in the C, B, E, and EB groups, respectively. Isoflurane AUC was not significantly different among treatment groups. Dogs treated with EB had significantly less behavioral pain than all other groups throughout the 5‐hour recovery period. No significant difference was found between treatment groups or within treatment groups over time in BMBT, or any renal variables. This study demonstrated that (i) pre‐operative administration of E provides profound analgesia during the post‐operative period without renal or bleeding side‐effects in dogs undergoing OHE; and (ii) a combination of butorphanol–etodolac provides the best analgesic effect during the post‐operative period based on the behavioral pain score.  相似文献   

The effects of protein level on cytokines and chemokines in the uterine environment of beef heifers during development     

Taylor B Ault-Seay  Taylor D Harrison  Kiernan J Brandt  Rebecca R Payton  Liesel G Schneider  Phillip R Myer  Justin D Rhinehart  Louisa A Rispoli  Kyle J McLean 《Journal of animal science》2021,99(6)

The development of replacement heifers is crucial for breeding success and herd efficiency. Nutritional management can affect not only reproductive development but also the inflammatory status of the uterine environment, which may impact reproductive functions such as pregnancy establishment and development. The study herein evaluated the concentration of cytokines and chemokines in the uterus of heifers supplemented with different levels of protein. Angus heifers (n = 60) were blocked by body weight (BW) and randomly assigned to 1 of 3 treatments based on protein supplementation level: control of 10% crude protein (CON), 20% crude protein (P20), or 40% crude protein (P40). BW, body condition score, and blood samples were taken every 2 wk for 140 d to monitor development. Uterine flushes were performed monthly and concentrations of cytokines (IL-1α, IL-1β, TNF-α, IFN-γ, IL-10, VEGF-α, IL-17A, and IL-36RA) and chemokines (IL-8, MCP-1, MIP-1α, and MIP-1β) were quantified via ELISA multiplex. To test if there were mean differences in cytokines between the treatment groups or over time, PROC GLIMMIX (SAS v 9.4) was utilized. Concentrations of all cytokines and chemokines, except IL-1α, changed throughout heifer development (P < 0.05). Heifers in the P40 treatment group displayed reduced concentrations of MCP-1 (P = 0.007) and tended to have decreased concentrations of IFN-γ (P = 0.06). Cytokine IL-36RA tended (P = 0.06) to be affected by protein level, with the lowest concentrations observed in CON heifers. Most cytokines and chemokines increased following the initial month of supplementation (P < 0.05). The increase in concentrations after 1 mo may indicate an adaptive response in the uterus to diet change. Cytokines and chemokines fluctuated due to physiological changes occurring during development. Further research is needed to determine the influence of nutrition on uterine inflammation and long-term impacts on reproductive function.  相似文献   

Outcomes of dogs undergoing immediate or delayed surgical treatment for gastrointestinal foreign body obstruction: A retrospective study by the Society of Veterinary Soft Tissue Surgery     

Elizabeth A. Maxwell  Danielle R. Dugat  Michelle Waltenburg  David Upchurch  Pedro Soto‐Elias  Daniel J. Duffy  Daniel Spector  Brian Petrovsky  Mark Payton 《Veterinary surgery : VS》2021,50(1):177-185

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日本血吸虫非叉型尾蚴感染动物试验   总被引：2，自引：1，他引：1  

谢银杰  吴定宇  杨建发  孙绍美  孙秀涛  段纲  邹丰才 《中国畜牧兽医》2011,38(3):226-227

试验采集云南巍山地区自然条件下的钉螺,压碎钉螺、检获尾蚴,发现为非叉型尾蚴。将非叉型尾蚴400~850条/只经皮肤感染家兔,同时,用云南洱源的叉型尾蚴作对照试验。感染后50～55 d解剖兔子,试验组检获到日本血吸虫,荷虫量为10～15条/只。试验结果表明,云南巍山非叉型尾蚴能感染动物,该试验结果为丰富日本血吸虫的生活史提供了极有价值的补充。  相似文献   

生态型农业观光园规划设计   总被引：1，自引：0，他引：1  

赵志刚  谢小立  陈安磊  王凯荣 《北方园艺》2011,(11):199-202

通过阐述园区规划设计原则及理论根据,结合实例分析了生态型农业观光园的设计内容,有利于更好的研究与开发农业观光园项目。  相似文献   

乌冈栎地理分布与水热环境因子的关系     

谢春平  方彦  方炎明 《水土保持研究》2011,18(1):125-131

在广泛收集乌冈栎地理分布资料的基础上,利用目前常用的植被与气候相互关系的研究方法,结合温暖指数(WI)、寒冷指数(CI)、干燥度指数(K)、水热综合指数(S)、年均生物温度(BT)、可蒸散量(PET)和年均可能蒸发量率(PER),以及单一的气象因子一月均温(TM-Jan)、七月均温(TM-Jul)、最高温(TMax)、最低温(TMin)、年均温(TM-A)、年均降水量(PM)等,对乌冈栎在东亚地区的地理分布及其与气候的关系进行了研究。结果表明:乌冈栎在中国地理分布在23°-34°N、100°-120°E,日本分布在26°-37°N、128°-140°E,均属于亚热带分布。气候环境指数研究的结果表明乌冈栎各项指数平均值均较低,与亚热带分布的青冈的指数接近,因此其性质为亚热带耐寒树种。通过热量曲线的比较,反映了中日两国乌冈栎分布范围的差异。结合主成分分析可知,影响乌冈栎分布的最主要因素是温度,并将其分布区划分为5类,包括:日本区(A)、中国华东区(B)中国西南部区(C)、中国西北部区(D)和中国南部区(E)。最后建立了乌冈栎生物地理模型,对预测该物种的分布提供了科学参考依据。  相似文献   

The effect of extension and loading of the carpus on radial rotation     

Erez Bitton DVM  Rotem Joseph DVM  Diplomate ECVS  Lena Portman BSc  Gilad Segev DVM  Diplomate ECVIM‐CA  Yaron Meiner BSc ME  Anna Shipov DVM  Diplomate ECVS  Joshua Milgram BVSc  Diplomate ECVS 《Veterinary surgery : VS》2013,42(8):909-917

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