Clinical-pathological correlation of an equine cardiac arrhythmia     

E W Fisher  H M Pirie  H Andrew 《The Veterinary record》1970,86(17):499-502

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Insulin-like growth factors and recurrent hypoglycemia associated with renal cell carcinoma in a horse     

Swain JM  Pirie RS  Hudson NP  Else RW  Evans H  McGorum BC 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2005,19(4):613-616

The case was examined at the Easter Bush Veterinary Hospital, The University of Edinburgh. A 520 kg, 6-year-old Thoroughbred gelding was referred for evaluation of acute onset profound depression, head pressing, and lack of response to external stimuli. The horse had a history of moderate weight loss over several months despite adequate nutrition and a good appetite. Previous episodes of weakness had been observed following administration of anthelmintics, namely, alternate doses of pyrantel and ivermectin, administered every 8 weeks. In an attempt to eliminate a possible parasitic cause of weight loss, over the 7 days prior to presentation, the referring veterinary surgeon treated the horse with a 5-day course of fenbendazole^a (7.5 mg/kg PO q24h) and moxidectin^b (0.4 mg/kg PO), 2 days later. A 5-day course of prednisolone^c (1 mg/kg PO q24h) was initiated on the same day as the fenbendazole. This dose was then tapered to 0.5 mg/kg PO q24h, and was still being administered at the time of presentation.  相似文献   

Cytokine profiles of peripheral blood and airway CD4 and CD8 T lymphocytes in horses with recurrent airway obstruction     

Kleiber C  McGorum BC  Horohov DW  Pirie RS  Zurbriggen A  Straub R 《Veterinary immunology and immunopathology》2005,104(1-2):91-97

Equine recurrent airway obstruction (RAO) is thought to result from an aberrant immune response to inhaled antigens, modulated by T lymphocytes via the secretion of pro-inflammatory cytokines. However data relating to the phenotypes of the T lymphocytes present in peripheral blood and bronchoalveolar lavage fluid of RAO horses and their cytokine profiles are contradictory. The aim of this study was to further investigate the cytokine (IL-4, IL-5, IL-13 and INF-gamma) mRNA expression profile in peripheral blood lymphocytes and bronchoalveolar lavage lymphocytes from RAO and control horses, before and at 48 h after horses were exposed to hay/straw. In contrast to previous studies, cytokine expression was quantified in populations of CD4 and CD8 T lymphocytes which were purified using magnetic bead antibody cell separation. Hay/straw exposure induced clinical airway obstruction, airway neutrophilia and airway lymphocytosis in RAO horses, and, induced a mild, but significant, airway neutrophilia in controls. However, hay/straw exposure had no significant effect on peripheral blood lymphocyte or bronchoalveolar lavage lymphocyte cytokine expression in either group. In conclusion, RAO was not associated with alterations in lymphocyte cytokine expression that are consistent with Th1 or Th2 responses, but rather with a general down-regulation in expression of the measured cytokines in peripheral blood lymphocytes and bronchoalveolar lavage lymphocytes.  相似文献   

Fog fever in cattle: pathology   总被引：2，自引：0，他引：2  

H M Pirie  R G Breeze  I E Selman  A Wiseman 《The Veterinary record》1974,95(21):479-483

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Reactive histiocytosis of the orbit and posterior segment in a dog     

Pumphrey SA  Pizzirani S  Pirie CG  Sato AF  Buckley FI 《Veterinary ophthalmology》2013,16(3):229-233

We present a case of reactive histiocytic disease involving the orbit, optic nerve, retina, and choroid in a Border Collie dog initially presenting for vision loss. Long-term partial return of vision has been achieved with systemic immunosuppression. Anterior segment and ocular surface manifestations of reactive histiocytic disease in dogs are relatively common. Posterior segment and orbital involvement, however, are minimally documented in the existing literature. To the authors' knowledge, this is the first report of disease confined to the orbit and posterior segment as well as the first report of vision loss as a presenting complaint for reactive histiocytic disease. Clinical, magnetic resonance imaging, cytologic, and histopathologic findings are reviewed.  相似文献   

The equine alveolar macrophage: Functional and phenotypic comparisons with peritoneal macrophages     

Anna E. Karagianni  Ronan Kapetanovic  Bruce C. McGorumDavid A. Hume  Scott R. Pirie 《Veterinary immunology and immunopathology》2013

Alveolar macrophages (AMs) constitute the first line of defence in the lung of all species, playing a crucial role in the regulation of immune responses to inhaled pathogens. A detailed understanding of the function and phenotype of AMs is a necessary pre-requisite to both elucidating their role in preventing opportunistic bacterial colonisation of the lower respiratory tract and developing appropriate preventative strategies. The purpose of the study was to characterise this important innate immune cell at the tissue level by making functional and phenotypic comparisons with peritoneal macrophages (PMs). We hypothesised that the tissue of origin determines a unique phenotype of AMs, which may constitute an appropriate therapeutic target for certain equine respiratory diseases. Macrophages isolated from the lung and the peritoneal cavity of 9 horses were stimulated with various toll like receptor (TLR) ligands and the production of nitrite, tumour necrosis factor alpha (TNFα), interleukin (IL) 10 and indoleamine 2,3-dioxygenase (IDO) were measured by the Griess reaction and enzyme linked immunosorbent assay (ELISA) and/or quantitative polymerase chain reaction, respectively. Cells were also compared on the basis of phagocytic-capacity and the expression of several cell surface markers. AMs, but not PMs, demonstrated increased TNFα release following stimulation with LPS, polyinosinic polycytidylic acid (Poly IC) and heat-killed Salmonella typhinurium and increased TNFα and IDO mRNA expression when stimulated with LPS. AMs showed high expression of the specific macrophage markers cluster of differentiation (CD) 14, CD163 and TLR4, whereas PMs showed high expression of TLR4 only. AMs, but not PMs, demonstrated efficient phagocytic activity. Our results demonstrate that AMs are more active than PMs when stimulated with various pro-inflammatory ligands, thus supporting the importance of the local microenvironment in the activation status of the macrophage. This information provides a valuable knowledge base on which to improve our understanding of the role of macrophages and their microenvironment in equine innate immunity.  相似文献   

Isolations of avian paramyxovirus type 2 from domestic fowl in Scotland in 2002 and 2006     

Wood AM  Dagless MD  Pirie JO  Garcia-Rueda MC  Manvell RJ  Cox WJ  Ceeraz V  Pearson DB  Law WA  Alexander DJ  Brown IH 《The Veterinary record》2008,162(24):788-789

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Compartment syndrome of the muscles of mastication in a working dog following a traumatic training incident     

Amy L. Brida  Therese E. O&#x; Toole  James Sutherland‐Smith  Christopher Pirie  Michael P. Kowaleski 《Journal of Veterinary Emergency and Critical Care》2019,29(3):321-325

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Corneal epithelial inclusion cyst in a Llama     

Pirie CG  Pizzirani S  Parry NM 《Veterinary ophthalmology》2008,11(2):111-113

A 13-year-old, female Llama presented for evaluation of a limbal based corneal mass involving the OD of 4 months duration. The mass was excised en bloc by a nonpenetrating keratectomy, followed by placement of a conjunctival advancement flap covering the keratectomy site. The mass was submitted for histological evaluation. Histopathology identified the mass to be a corneal epithelial inclusion cyst filled with necrotic squamous and neutrophilic debris. Surgical excision was complete and considered curative with no signs of recurrence 3 months postoperatively. There was no known prior ocular trauma; however, a previously performed corneal biopsy for evaluation of recurrent epithelial erosions may have been an initiating cause.  相似文献   

Pseudo truncus arteriosus in a dog--a case report     

E W Fisher  R Lee  H M Pirie  K G Evans 《The Journal of small animal practice》1974,15(10):627-635

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