Neurologic conditions causing lameness in companion animals.     

J J McDonnell  S R Platt  L A Clayton 《Veterinary Clinics of North America: Small Animal Practice》2001,31(1):17-38

Animals presented with non-weight-bearing lameness are a diagnostic challenge for the veterinarian. It is extremely important to distinguish between orthopedic and neurologic causes of lameness, because the diagnostic and therapeutic plans can be quite different. Myopathies can be confused with orthopedic disease because of gait abnormalities and associated muscle pain. Common myopathies seen in companion animal medicine include polymyositis, muscular dystrophy, endocrine and infectious myopathies, and myasthenia gravis. Lameness caused by disease of the nerve root or nerve is confused with orthopedic disease because of the disturbances of a nerve's sensory distribution (nerve-root signature) or disruption of the motor innervation. The diseases of the nerve root or nerve discussed are lateralized intervertebral disk disease, spinal cord neoplasia, malignant peripheral nerve sheath tumors, and traumatic neuropathies. The diagnosis of these diseases requires careful attention to the signalment, a complete history, and a thorough physical examination focusing on the neurologic and orthopedic components. Ancillary testing should be selected based on these results and a minimum database. Electrodiagnostic testing, radiography, and advanced imaging may help to localize the lesion more precisely and sometimes to confirm the diagnosis. Surgical exploration and histopathology often provide the definitive diagnosis. These cases of non-weight-bearing lameness are a diagnostic challenge, but when successful resolution can be reached, it is gratifying to the clinician, client, and patient.  相似文献   

Septicaemia in the foal. A review of 61 cases   总被引：2，自引：0，他引：2  

H Platt 《The British veterinary journal》1973,129(3):221-229

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Genetic stability of the thermal,trypsin, rabbit and mouse markers of Aujeszky's disease (pseudorabies) virus in the pig     

K.B. Platt 《Veterinary microbiology》1981,6(3):225-232

The heat, trypsin, rabbit and mouse markers of three wild and one vaccine strain of Aujeszky's disease virus were evaluated for genetic stability in the pig. A cloned population of each virus was serially passaged in nasal cavities of five to nine pigs. At the end of serial passage, virus was re-isolated and produced in cell culture. The individual markers of the cloned pre-passaged and the non-cloned post-passaged populations of each virus were then evaluated for change. No significant changes occured and the markers were considered to be genetically stable.  相似文献   

Comparison of in vitro replication and cytopathology caused by strains of canine distemper virus of vaccine and field origin     

M B Evans  T O Bunn  H T Hill  K B Platt 《Journal of veterinary diagnostic investigation》1991,3(2):127-132

Three biological properties of canine distemper virus were examined to determine if any would consistently differentiate field from vaccine strains of the virus. The properties were the ability to (1) infect macrophages and epithelial cells, (2) produce distinct cytopathologic effect in alveolar and peritoneal macrophages and Vero cells, and (3) produce pocks on the chorioallantoic membrane of embryonated chicken eggs. Four vaccine strains and 5 field isolates were used in the study. The 5 field isolates were obtained directly from canine tissues. Of the 3 properties studied, only the comparison of the ability of the viruses to infect macrophages and epithelial cells was a consistent marker of virus origin. Virulent field isolates would only infect macrophage cultures, whereas the vaccine strains infected both types of cells. One avirulent field isolate from a case of old dog encephalitis reacted more like a vaccine strain by infecting both cell types.  相似文献   

1966 nobel laureate in chemistry: robert s. Mulliken     

Platt JR 《Science (New York, N.Y.)》1966,154(3750):745-747

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On the Nature and Color of the Moon's Surface     

Platt JR 《Science (New York, N.Y.)》1958,127(3313):1502-1503

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Diversity     

Platt JR 《Science (New York, N.Y.)》1966,154(3753):1132-1139

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Broadening the participation of the colleges     

Platt JR 《Science (New York, N.Y.)》1968,162(3853):517

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Comparison of plasma benzodiazepine concentrations following intranasal and intravenous administration of diazepam to dogs     

Platt SR  Randell SC  Scott KC  Chrisman CL  Hill RC  Gronwall RR 《American journal of veterinary research》2000,61(6):651-654

OBJECTIVE: To determine whether plasma concentrations of benzodiazepines (BDZ) in dogs following intranasal (IN) administration of diazepam are comparable to concentrations following IV administration. ANIMALS: 6 (4 male, 2 female) healthy adult Greyhounds. PROCEDURE: Dogs were randomly assigned to 2 groups of 3 dogs in a crossover design. Diazepam (0.5 mg/kg of body weight) was administered intravenously to dogs in group 1 and intranasally to dogs in group 2. Blood was collected from the jugular vein of each dog into tubes containing lithium heparin before and 3, 6, 9, 12, 15, 20, 30, 60, 120, 240, and 480 minutes following diazepam administration. After a 4-day washout period, dogs in group 1 received diazepam intranasally, dogs in group 2 received diazepam intravenously, and blood was again collected. Plasma concentration of BDZ was determined by use of a fluorescence polarization immunoassay. RESULTS: Mean (+/- SD) peak plasma concentration of BDZ following IV administration (1,316 +/- 216 microg/L) was greater than that following IN administration (448 +/- 41 microg/L). Time to peak concentration was < or = 3 minutes following IV administration and 4.5 +/- 1.5 minutes following IN administration. Mean bioavailability of BDZ following IN administration was 80 +/- 9%. CONCLUSIONS AND CLINICAL RELEVANCE: Diazepam is rapidly and efficiently absorbed following IN administration of the parenteral formulation. Plasma concentrations match or exceed the suggested therapeutic concentration (300 microg/L). Intranasal administration of diazepam may be useful for treatment of seizures in dogs by owners or when intravenous access is not readily available.  相似文献   

What is your diagnosis? Axial osteosarcoma     

Radaelli ST  Platt SR  McDonnell JJ 《The Journal of small animal practice》2000,41(2):51, 84-51, 86

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