The role of beta 2-microglobulin in peptide binding by class I molecules   总被引：8，自引：0，他引：8  

A Vitiello  T A Potter  L A Sherman 《Science (New York, N.Y.)》1990,250(4986):1423-1426

Efficient transport of class I major histocompatibility complex molecules to the cell surface requires association of the class I heavy chain with endogenous peptide and the class I light chain, beta 2-microglobulin (beta 2M). A mutant cell line deficient in beta 2M transports low amounts of nonpeptide-associated heavy chains to the cell surface that can associate with exogenously provided beta 2M and synthetic peptide antigens. Normal beta 2M-sufficient cells grown in serum-free media devoid of beta 2M also require an exogenous source of beta 2M to efficiently bind synthetic peptide. Thus, class I molecules on normal cells do not spontaneously bind or exchange peptides.  相似文献   

Two different cis-active elements transfer the transcriptional effects of both EGF and phorbol esters   总被引：27，自引：0，他引：27  

H P Elsholtz  H J Mangalam  E Potter  V R Albert  S Supowit  R M Evans  M G Rosenfeld 《Science (New York, N.Y.)》1986,234(4783):1552-1557

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Polymorphism of heavy-chain genes in immunoglobulins of wild mice   总被引：3，自引：0，他引：3  

R Lieberman  M Potter 《Science (New York, N.Y.)》1966,154(748):535-537

The serums of 123 wild mice from six different geographic locations in the United States contain five of the six known heavy-chain antigenic determinants that have been identified in immunoglobulin of inbred laboratory strains of mice. On the basis of the distribution of determinants in inbred strains,44 of the mice were judged to be heterozygotes of various combinations and two had combinations of determinants that were unusual and could only have occurred in laboratory inbred mice by recombination.  相似文献   

Nuclei from rat liver: isolation method that combines purity with high yield   总被引：170，自引：0，他引：170  

G Blobel  V R Potter 《Science (New York, N.Y.)》1966,154(757):1662-1665

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DNA rearrangement and altered RNA expression of the c-myb oncogene in mouse plasmacytoid lymphosarcomas   总被引：51，自引：0，他引：51  

J F Mushinski  M Potter  S R Bauer  E P Reddy 《Science (New York, N.Y.)》1983,220(4599):795-798

Three types of tumors termed plasmacytomas (ABPC's), lymphosarcomas (ABLS's), and plasmacytoid lymphosarcomas (ABPL's) arise in BALB/c mice treated with pristane and Abelson murine leukemia virus (A-MuLV). While most ABPC's and BLS's contain integrated A-MuLV proviral genome and synthesize the v-abl RNA, most ABPL's do not. The ABPL tumors were examined for the expression of other oncogenes that may be associated with their transformed state, in the absence of transforming virus. These tumors expressed abundant c-myb RNA of unusually large size and showed DNA rearrangements of the c-myb locus.  相似文献   

Evidence for magnetospheric effects on the sodium atmosphere of mercury     

Potter AE  Morgan TH 《Science (New York, N.Y.)》1990,248(4957):835-838

Monochromatic images of Mercury at the sodium D(2) emission line showed excess sodium emission in localized regions at high northern and southern latitudes and day-to-day global variations in the distribution of sodium emission. These phenomena support the suggestion that magnetospheric effects could be the cause. Sputtering of surface minerals could produce sodium vapor in polar regions during magnetic substorms, when magnetospheric ions directly impact the surface. Another important process may be the transport of sodium ions along magnetic field lines toward polar regions, where they impact directly on the surface of Mercury and are neutralized to regenerate neutral sodium atoms. Day-to-day variations in planetary sodium distributions could result from changing solar activity, which can change the magnetosphere in time scales of a few hours. Observations of the sodium exosphere may provide a tool for remote monitoring of the magnetosphere of Mercury.  相似文献   

2-chain immunoglobulin A molecules: abnormal or normal intermediates in synthesis   总被引：4，自引：0，他引：4  

R Lieberman  J F Mushinski  M Potter 《Science (New York, N.Y.)》1968,159(821):1355-1357

Immunoglobulin A (gammaA) myeloma proteins secreted by plasma-cell tumors of mice are of two types, a common four-chain molecule and a rare two-chain (3.9S) molecule. The close similarity between two-chain gammaA molecules and four-chain gammaA molecules and their polymers is demonstrated in tryptic peptide maps of isolated polypeptide chains and by precipitin reactions with rabbit antiserums to gammaA immzunoglobulins. However, a difference between these two types is distinguishable with homologous antiserums. Homologous antiserums to two-chain gammaA immunoglobulins are specific and do not cross-react with four-chain gammaA immutnoglobulins.  相似文献   

Taiwan's family planning program. Large-scale family planning programs may be more effective than is sometimes believed     

R G Potter  R Freedman  L P Chow 《Science (New York, N.Y.)》1968,160(830):848-853

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AWARDS OF THE ELLA SACHS PLOTZ FOUNDATION     

Franke KW  Potter VR 《Science (New York, N.Y.)》1936,83(2153):330-332

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Activation of the c-myb locus by viral insertional mutagenesis in plasmacytoid lymphosarcomas   总被引：32，自引：0，他引：32  

G L Shen-Ong  M Potter  J F Mushinski  S Lavu  E P Reddy 《Science (New York, N.Y.)》1984,226(4678):1077-1080

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