Sudden cardiac death in a dog during Holter recording—R on T phenomenon     

T. Gunasekaran  R.A. Sanders 《Journal of Veterinary Cardiology》2017,19(5):455-461

A 6-year-old castrated male Golden Retriever was diagnosed with severe subaortic stenosis with severe left atrial enlargement and high heart rate due to atrial fibrillation. Treatment with digoxin and diltiazem to control ventricular response rate was initiated. Ambulatory electrocardiographic monitoring (Holter monitoring) was performed at the beginning of treatment and was repeated to evaluate the patient's response to drug therapy. Drug dose adjustments were made based on response to therapy as assessed by Holter monitoring. The dog experienced sudden death at home 19 days after beginning treatment while wearing the Holter monitor. Analysis of the Holter recording revealed marked increase in number and complexity of ventricular arrhythmias. A ventricular premature complex occurring on a T wave (R on T) was noted preceding the polymorphic ventricular tachycardia. This arrhythmia immediately degenerated into ventricular fibrillation followed by asystole. This case report describes the arrhythmia that preceded cardiac arrest and reviews the risk factors that could have potentiated the fatal arrhythmia in this dog.  相似文献   

The present and future of withdrawal period calculations for milk in the European Union: dealing with data below the limit of quantification          下载免费PDF全文

J. Henri  A.‐M. Jacques  P. Sanders  A. Chevance  M. Laurentie 《Journal of veterinary pharmacology and therapeutics》2017,40(2):116-122

The assessment of withdrawal periods for milk is affected by the occurrence of data below the lower analytical quantification limit (BLQ data) and the resulting uncertainty. The current regulatory approach for dealing with BLQ residues is simple and easy: BLQ data (and missing data) are arbitrarily reassigned a value of one‐half the LOQ before any calculation on the data with one of the three currently applicable methods. Here, we reconsider the determination of the withdrawal period of milk with data below the limit of quantification. Theoretical background on analytical limits and pharmacometric considerations will be established. Then, we analyze the uncertainty problems caused by the current approach and propose a calculation solution (maximum‐likelihood estimation handling left‐censored data) included in nonlinear mixed‐effects modeling. Finally, we illustrate this issue using a case example.  相似文献   

Juniper Invasions in Grasslands: Research Needs and Intervention Strategies     

Sherry A. Leis  Carol E. Blocksome  Dirac Twidwell  Sam D. Fuhlendorf  John M. Briggs  Larry D. Sanders 《Herpetological Monographs》2017,39(2):64-72

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Metabolic adaptations to heat stress in growing cattle   总被引：1，自引：0，他引：1  

M.D. O’Brien  R.P. RhoadsS.R. Sanders  G.C. DuffL.H. Baumgard 《Domestic animal endocrinology》2010

To differentiate between the effects of heat stress (HS) and decreased dry matter intake (DMI) on physiological and metabolic variables in growing beef cattle, we conducted an experiment in which a thermoneutral (TN) control group (n = 6) was pair fed (PF) to match nutrient intake with heat-stressed Holstein bull calves (n = 6). Bulls (4 to 5 mo old, 135 kg body weight [BW]) housed in climate-controlled chambers were subjected to 2 experimental periods (P): (1) TN (18 °C to 20 °C) and ad libitum intake for 9 d, and (2) HS (cyclical daily temperatures ranging from 29.4 °C to 40.0 °C) and ad libitum intake or PF (in TN conditions) for 9 d. During each period, blood was collected daily and all calves were subjected to an intravenous insulin tolerance test (ITT) on day 7 and a glucose tolerance test (GTT) on day 8. Heat stress reduced (12%) DMI and by design, PF calves had similar nutrient intake reductions. During P1, BW gain was similar between environments and averaged 1.25 kg/d, and both HS and PF reduced (P < 0.01) average daily gain (-0.09 kg/d) during P2. Compared to PF, HS decreased (P < 0.05) basal circulating glucose concentrations (7%) and tended (P < 0.07) to increase (30%) plasma insulin concentrations, but neither HS nor PF altered plasma nonesterified fatty acid concentrations. Although there were no treatment differences in P2, both HS and PF increased (P < 0.05) plasma urea nitrogen concentrations (75%) compared with P1. In contrast to P1, both HS and PF had increased (16%) glucose disposal, but compared with PF, HS calves had a greater (67%; P < 0.05) insulin response to the GTT. Neither period nor environment acutely affected insulin action, but during P2, calves in both environments tended (P = 0.11) to have a blunted overall glucose response to the ITT. Independent of reduced nutrient intake, HS alters post-absorptive carbohydrate (basal and stimulated) metabolism, characterized primarily by increased basal insulin concentrations and insulin response to a GTT. However, HS-induced reduction in feed intake appears to fully explain decreased average daily gain in Holstein bull calves.  相似文献   

Estimation of transmission parameters of a fluoroquinolone-resistant Escherichia coli strain between pigs in experimental conditions     

Andraud M  Rose N  Laurentie M  Sanders P  Le Roux A  Cariolet R  Chauvin C  Jouy E 《Veterinary research》2011,42(1):44

Antimicrobial resistance is of primary importance regarding public and animal health issues. Persistence and spread of resistant strains within a population contribute to the maintenance of a reservoir and lead to treatment failure. An experimental trial was carried out to study the horizontal transmission of a fluoroquinolone-resistant Escherichia coli strain from inoculated to naïve pigs. All naïve contact pigs had positive counts of fluoroquinolone-resistant E. coli after only two days of contact. Moreover, re-infections of inoculated pigs caused by newly contaminated animals were suspected. A maximum likelihood method, based on a susceptible-infectious-susceptible (SIS) model, was used to determine the transmission parameters. Two transmission levels were identified depending on the quantity of bacteria shed by infected individuals: (i) low-shedders with bacterial counts of resistant E. coli in the faeces between 5*10³ and 10⁶ CFU/g (β_L = 0.41 [0.27; 0.62]), (ii) high shedders with bacterial counts above 10⁶ CFU/g (β_H = 0.98 [0.59; 1.62]). Hence, transmission between animals could be pivotal in explaining the persistence of resistant bacteria within pig herds.  相似文献   

High occurrence of various Clostridium difficile PCR ribotypes in pigs arriving at the slaughterhouse     

Hopman NE  Oorburg D  Sanders I  Kuijper EJ  Lipman LJ 《The Veterinary quarterly》2011,31(4):179-181

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Effects of benomyl on vesicular‐arbuscular mycorrhizal infection of red clover (Trifolium pratense L.) and consequences for phosphorus inflow.     

Kerry A. Hale  F. E. Sanders 《Journal of plant nutrition》2013,36(12):1355-1367

The roots of red clover plants inoculated with the vesicular‐arbuscular mycorrhizal fungus Glomus clarus Nicolson & Schenck were treated with a drench of benomyl at a time when mycorrhizal infection was already well established. Benomyl halted further infection and reduced phosphorus inflow by one order of magnitude compared to untreated controls. The fungicide also decreased the rate of plant growth probably as a consequence of reduced phosphorus inflow.  相似文献   

The influence of mist irrigation on the potato IV. Tuber quality factors     

D. C. Sanders  R. E. Nylund  E. C. Quisumbing  K. V. P. Shetty 《American Journal of Potato Research》1972,49(7):243-254

The influence of irrigation method on tuber quality factors was assessed during three seasons. Low volume “mist” irrigation (M), furrow irrigation (F), mist plus furrow (MF) and no irrigation (NI) were compared. Tubers from misted treatments (M and MF) tended to be lower in dry matter, had a high incidence of secondary growth and hollowheart, yielded darker chips, required more time to condition, were less mature, and contained more reducing sugars than those from NI treatments. Further the tubers from misted treatments tended to contain more P, Mg, Ca, Fe, Al, B and Mn, than those from NI plots at various times during the latter part of the season.  相似文献   

Methodology for recovery and identification of enteropathogenic Escherichia coli     

I J Mehlman  A C Sanders  N T Simon  J C Olson 《Journal of the Association of Official Analytical Chemists》1974,57(1):101-110

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New England potato outlook slightly below average     

V. A. Sanders 《American Journal of Potato Research》1924,1(11):241-243

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