Treatment of bovine trichornoniasis with ipronidazole     

SZ SKIRROW  RH BONDURANT 《Australian veterinary journal》1988,65(5):156-156

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Introduction to Environmental Physiology          下载免费PDF全文

R. H. Dunlop 《The Canadian veterinary journal. La revue veterinaire canadienne》1969,10(3):88

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Clinical report, "Hepatic necrosis following halothane anesthesia in goats," viewed as unacceptable     

W V Lumb  J L Grandy  R B Heath  C I Dunlop  D S Hodgson 《Journal of the American Veterinary Medical Association》1987,190(9):1076-1077

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Antiproliferative activity of Saponaria vaccaria constituents and related compounds     

Balsevich JJ  Ramirez-Erosa I  Hickie RA  Dunlop DM  Bishop GG  Deibert LK 《Fitoterapia》2012,83(1):170-181

Total methanolic extracts of Saponaria vaccaria seed derived from several varieties, as well as various purified components obtained through successive chromatographic separations of total extracts were evaluated for their growth inhibitory activity in WiDr (colon), MDA-MB-231 (breast), NCI-417 (lung) and PC-3 (prostate) human cancer cells as well as the non-tumorigenic fibroblast BJ (CRL-2522) cell line using MTT colorimetric assay. Purified bisdesmosidic saponins segetoside H and I were further examined using microscopy and apoptosis assays. Bisdesmosidic saponins exhibited dose-dependent growth inhibitory and selective apoptosis-inducing activity. Growth inhibitory effects were particularly strong in a breast (MDA-MB-231) and a prostate (PC-3) cancer cell line. Total extracts exhibited a different preference being most active against a colon cancer cell line (WiDr). In a comparison of varieties, all of the total seed extracts exhibited similar dose-dependent activities, but with some variation in potency. Monodesmosidic saponins vaccarosides A and B, phenolic vaccarin, and cyclopeptide segetalin A, co-occurring seed substituents, did not exhibit activity. The non-tumorigenic fibroblast cell line BJ (CRL 2522) was growth inhibited but did not undergo apoptosis when treated with bisdesmosidic saponins at low micromolar concentrations. Saponin-rich extracts from Kochia scoparia seed and Chenopodium quinoa were also evaluated alongside Saponaria saponins but did not exhibit activity. Closely related Quillaja saponins exhibited activity but were less potent.  相似文献   

Testing the efficacy of kitasamycin for use in the control and treatment of swine dysentery in experimentally infected pigs     

T La  ND Phillips  H Dunlop  K Lugsomya  F Coiacetto  DJ Hampson 《Australian veterinary journal》2019,97(11):452-464

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Susceptibility of eliteAcacia mearnsii families to Ceratocystis wilt in south Africa     

Jolanda Roux  Rob Dunlop  Michael J. Wingfield 《Journal of Forest Research》1999,4(2):187-190

Ceratocystis albofundus is a recently described pathogen infectingAcacia mearnsii in South Africa, and it causes a disease known as Ceratocystis wilt. Symptoms of the disease include die-back, gummosis and wilting of infected trees. In order to select trees tolerant to this fungus, susceptibility tests were conducted on trees representing fourteen families ofA. mearnsii. A virulent isolate ofC. albofundus was selected and inoculated into the stems of twelve-month-old plants in a plantation. Lesion lengths, in the bark, and disease development were assessed after 6 weeks. All fourteen families ofA. mearnsii were susceptible to infection byC. albofundus. Considerable variation was, however, noticed between individual trees within the same family and the incorporation of disease tolerant trees into breeding programmes is proposed.  相似文献   

Direct observations of structural phase transitions in planar crystallized ion plasmas     

TB Mitchell  JJ Bollinger  DHE Dubin  X Huang  WM Itano  RH Baughman 《Science (New York, N.Y.)》1998,282(5392):1290-1293

Laser-cooled 9Be+ ions confined in two-dimensionally extended lattice planes were directly observed, and the images were used to characterize the structural phases of the ions. Five different stable crystalline phases were observed, and the energetically favored structure could be sensitively tuned by changing the areal density of the confined ions. The experimental results are in good agreement with theoretical predictions for the planar (infinite in two dimensions) one-component plasma. Qualitatively similar structural phase transitions occur, or are predicted to occur, in other experimentally realizable planar systems.  相似文献   

Regulation of integrin adhesions by varying the density of substrate-bound epidermal growth factor     

Shahal T  Geiger B  Dunlop IE  Spatz JP 《Biointerphases》2012,7(1-4):23

Substrates coated with specific bioactive ligands are important for tissue engineering, enabling the local presentation of extracellular stimulants at controlled positions and densities. In this study, we examined the cross-talk between integrin and epidermal growth factor (EGF) receptors following their interaction with surface-immobilized Arg-Gly-Asp (RGD) and EGF ligands, respectively. Surfaces of glass coverslips, modified with biotinylated silane-polyethylene glycol, were functionalized by either biotinylated RGD or EGF (or both) via the biotin-NeutrAvidin interaction. Fluorescent labeling of the adhering A431 epidermoid carcinoma cells for zyxin or actin indicated that EGF had a dual effect on focal adhesions (FA) and stress fibers: at low concentrations (0.1; 1 ng/ml), it stimulated their growth; whereas at higher concentrations, on surfaces with low to intermediate RGD densities, it induced their disassembly, leading to cell detachment. The EGF-dependent dissociation of FAs was, however, attenuated on higher RGD density surfaces. Simultaneous stimulation by both immobilized RGD and EGF suggest a strong synergy between integrin and EGFR signaling, in FA induction and cell spreading. A critical threshold level of EGF was required to induce significant variation in cell adhesion; beyond this critical density, the immobilized molecule had a considerably stronger effect on cell adhesion than did soluble EGF. The mechanisms underlying this synergy between the adhesion ligand and EGF are discussed.  相似文献   

Superovulatory Response of Zebu Cows Treated with pFSH in a Single Subcutaneous Injection Followed by an Additional Intramuscular Sub‐Dose 48 h Later     

RH Alvarez  AC Martinez  RML Pires 《Reproduction in domestic animals》2010,45(3):421-424

The aim of this study was to evaluate whether an additional intramuscular (im) injection of pFSH would increase the embryo production in zebu cows superovulated with a single subcutaneous (sc) pFSH injection. Twenty‐one Nelore cows were treated with a progesterone vaginal implant (Controlled Internal Drug Relased – CIDR B^®) and injected im with 2.5 mg estradiol benzoate. Four days later, cows were assigned randomly into three groups and superovulated with pFSH. Groups A and B received single sc injections of 400 and 320 IU, respectively; Group C received multiple im injections of 400 IU in decreasing doses at 12‐h intervals over 4 days. In the morning (07:00 am) of day 3 after starting superovulation, cows received im 150 mcg cloprostenol and Group B was additionally injected im with 80 IU of pFSH. CIDR‐B was withdrawn in the afternoon (07:00 pm). Cows were inseminated 48 and 62 h after the cloprostenol injection. Embryo collection and corpora lutea (CL) estimation were done 7 days after insemination. Alternation of treatments (crossover design) occurred at a 60‐day interval. There was no significant difference (p > 0.05) of CL counts among treatments. The total (transferable and no transferable) number of recovered embryos from Group A (6.9 ± 1.5) was not different from Group C (9.8 ± 1.2), whereas Group B (5.7 ± 1.5) was lower than Group C (p < 0.05). The number of transferable embryos from Groups A (2.4 ± 0.7) and B (1.7 ± 0.6) was lower (p < 0.05) than Group C (4.6 ± 1.2). Lesser (p < 0.05) embryo production from Group B was related to lower recovery rate (46.4%), compared with Groups A (65.1%) and C (81.7%). It was concluded that an additional im subdose of pFSH, injected 48 h after a single subcutaneous (sc) dose of pFSH, does not improve the embryo production in zebu cows.  相似文献   

Suspected tick-borne flavivirus meningoencephalomyelitis in dogs from the UK: six cases (2021)     

V. Gonzalo-Nadal  A. Kohl  M. Rocchi  B. Brennan  J. Hughes  J. Nichols  A. Da Silva Filipe  J. I. Dunlop  M. Fares  J. J. Clark  R. Tandavanitj  A. H. Patel  A. Cloquell-Miro  J. Bongers  J. Deacon  A. Kaczmarska  C. Stalin  T. Liatis  J. Irving  R. Gutierrez-Quintana 《The Journal of small animal practice》2024,65(2):132-143

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