Liquorice and canine Addison's disease     

RH Jarrett  EJ Norman  RA Squires 《New Zealand veterinary journal》2013,61(3)

Abstract

Extract

Hypoadrenocorticism, or Addison's disease, is an uncommon en-docrinopathy of dogs (Feldman and Nelson 2004 Feldman, EC and Nelson, RW. 2004. “Hypoadrenocorticism (Addison's disease)”. In Canine and Feline Endocrinology and Reproduction, 3rd, 394–439. Philadelphia, , USA: WB Saunders.  [Google Scholar]). Long-term management of affected dogs in New Zealand involves treatment with oral fludrocortisone acetate (Florinef tablets; Bristol-Myers Squibb (NZ) Ltd, Auckland, NZ), which is a relatively expensive synthetic adrenocortical steroid. Table salt may be added to the food, in an attempt to reduce the amount of fludrocortisone required. Despite fludrocortisone therapy, many Addisonian dogs remain hyponatraemic and hyperkalaemic and the required dose of fludrocortisone may need to be increased during the first year of treatment. Increasing the dose of fludrocortisone is not only expensive, but may also have undesirable effects through its potent glucocorticoid action.  相似文献   

The effect of some cryoprotectants on dromedary camel frozen‐thawed semen          下载免费PDF全文

DA El‐Badry  RH Mohamed  HA EL‐Metwally  TR Abo Al‐Naga 《Reproduction in domestic animals》2017,52(3):522-525

The cryopreserved camel semen is often associated with poor quality and fertility. This study aimed to improve the dromedary frozen semen quality by comparing the efficiency of four cryoprotectant agents (CPAs) on sperm freezability. Semen samples were collected from seven male Maghrabi camels, diluted with Shotor diluent supplemented with glycerol (Sh‐G), dimethyl formamide (DMF, Sh‐DF), dimethyl sulfoxide (DMSO, Sh‐DS) or ethylene glycol (EG, Sh‐EG), all at 6% final concentration, and the samples were subjected to cryopreservation. The results revealed the superiority of Sh‐DF over Sh‐G and Sh‐DS in terms of post‐thaw motility (55.83 ± 2.20 vs. 47.50 ± 4.33 and 45.00 ± 2.89%, respectively), sperm membrane (49.00 ± 0.58, 39.33 ± 3.33 and 42.67 ± 1.45%, respectively) and acrosomal integrities (53.00 ± 0.58, 57.33 ± 0.88 and 52.33 ± 1.45%, respectively). Sh‐EG group showed the lowest post‐thaw motility, plasma membrane and acrosome integrities (12.50 ± 1.44, 22.67 ± 1.45 and 30.67 ± 1.45, respectively). In conclusion, the protocols of dromedary camel semen cryopreservation could be enhanced using 6% DMF as a cryoprotectant agent.  相似文献   

Pathophysiology of the periparturient egg rise in sheep: a possible role for IgA.     

I A Jeffcoate  H Wedrychowicz  G Fishwick  E M Dunlop  J L Duncan  P H Holmes 《Research in veterinary science》1992,53(2):212-218

The relationship between anti-parasite IgA antibody levels in plasma and the periparturient egg rise in sheep was investigated. Ostertagia circumcincta larvae (5000 third stage larvae three times weekly) were administered to three groups of seven adult immune ewes from 12 weeks before until three weeks after lambing (group 1) or from six (group 2) or 14 (group 3) weeks before until three weeks before lambing. Seven additional ewes were not challenged (group 4 controls). Ewes in groups 1, 2 and 4 received anthelmintics 14 weeks before lambing. Challenge of the pregnant ewes with O circumcincta larvae resulted in substantial increases in faecal egg counts only during the periparturient period regardless of the larval dosing regimen. Furthermore, the periparturient rise in faecal egg counts was closely associated with a significant increase in anti-parasite IgA antibody levels in plasma. This rise in IgA antibody levels occurred at a time when IgA is transported from the gut to milk during early lactation. It is postulated that this may lead to a temporary reduction in abomasal antibody levels of ewes and hence permit the establishment of larvae and, or, the emergence and development of inhibited larvae and thereby lead to the periparturient rise in faecal egg count.  相似文献   

INDUCED THIAMIN DEFICIENCY IN LAMBS     

E. J. Thornber  R. H. Dunlop  J. M. Gawthorne  C. R. Huxtable 《Australian veterinary journal》1981,57(1):21-26

By following a feeding regimen which consistently induced polio-encephalomalacia in pre-ruminant lambs it was possible to study certain characteristics just before the terminal stage in poliocencephalomalacia.
There was always a marked deficit in erythrocyte precursors in bone marrow and this preceded any pathological changes in the brain. Erythrocyte transketolase activity decreased in control lambs, and decreased to an even greater extent in thiamin-deficient lambs. Glucose was the only substrate of those measured which was used by the brain, and its rate of use was not affected by thiamin deficiency. After a single intravenous injection of ³⁵S-thiamin, the decrease of ³⁵S in the plasma was consistent with its dispersal into two pools: the half-time of disappearance of ³⁵S into the slowly equilibrating pool was less in thiamin-deficient lambs than in their controls. Characteristics which were not altered in thiamin deficiency were concentrations of calcium and magnesium in various regions of brain and concentrations of calcium, magnesium, sodium and potassium in plasma.  相似文献   

Mammalian Cell Water–Physiologic and Clinical Aspects          下载免费PDF全文

R. H. Dunlop 《The Canadian veterinary journal. La revue veterinaire canadienne》1967,8(8):185

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Chloramphenicol residue in eggs.          下载免费PDF全文

C S Sisodia  R H Dunlop 《The Canadian veterinary journal. La revue veterinaire canadienne》1972,13(12):279-282

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Editorial          下载免费PDF全文

Dunlop RH 《The Canadian veterinary journal. La revue veterinaire canadienne》1969,10(2):31-32

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Cardiovascular and respiratory measurements in awake and isoflurane-anesthetized horses   总被引：1，自引：0，他引：1  

E P Steffey  C I Dunlop  T B Farver  M J Woliner  L J Schultz 《American journal of veterinary research》1987,48(1):7-12

Circulatory and respiratory function was monitored in nonmedicated, spontaneously breathing horses (n = 7) immediately before, during, and 1 hour after 85 +/- 4.1 (X +/- SEM) minutes of constant 1.57% isoflurane in O2 anesthesia. Comparison of values during anesthesia with those obtained while horses were awake revealed a significant (P less than 0.05) decrease in arterial blood pressure that was related to a slight, but insignificant, decrease in cardiac output and peripheral vascular resistance. Although isoflurane anesthesia and recumbency resulted in a significant (P less than 0.05) decrease in stroke volume, cardiac output did not decrease significantly because heart rate tended to increase. Isoflurane and recumbency also significantly (P less than 0.05) increased PaCO2, peak expiratory gas flow, total expiratory time, and PCV and significantly decreased PaO2, minute expired ventilation, and the ratio of peak inspired to expired gas flow. Differences imposed by isoflurane anesthesia were reversed by 1.5 hour after anesthesia.  相似文献   

AN INSEMINATION CRATE FOR SHEEP     

A. A. Dunlop  M.Agr.Sc  Ph.D. 《Australian veterinary journal》1959,35(5):256-258

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Damping loss in wood at mid kilohertz frequencies     

J. I. Dunlop 《Wood Science and Technology》1978,12(1):49-62

Summary The dynamic moduli and logarithmic decrement of Rimu (Dacrydium cupressinum) were measured along the grain and perpendicular to it in the frequency range 45–85 kHz using a Marx regenerative oscillator system. The moduli and decrement were observed to exhibit strong dispersions between-20°C and-80°C, the actual temperature being dependent on measurement frequency and moisture content of the sample. The activation enthalpy of the dispersion mechanism varied from 3.9 kcal/mole at moisture contents in excess of 7 % to 6 kcal/mole at lower (1%) moisture content. Impregnation of the wood with solvents produced dispersion effects different from those associated with water impregnation. It is postulated that this mechanical dispersion observed in moisture-bearing wood results from the motion of the adsorbed water molecules.The author wishes to thank the Head of the Princes Risborough Laboratory, Building Research Establishment, for the hospitality and facilities provided during his year's residence, and also the Council of the University of New South Wales for their generous allowance of sabbatical leave.  相似文献