Field trials of a formulation containing moxidectin and 6 in 1 vaccines for sheep     

CL SCHWARTZKOFF  RM COBB 《Australian veterinary journal》1996,74(3):225-227

Objective: To assess the efficacy and safety of a formulation containing moxidectin and 6 in 1 vaccine in sheep under field conditions.
Design: Efficacy and safety study.
Animals: Two hundred and five crossbred Merino lambs and two hundred and eight Merino ewes were used in the studies.
Procedure: A formulation was made for the simultaneous treatment of sheep with moxidectin and immunisation against clostridial diseases and caseous lymphadenitis. The efficacy against nematodes, vaccine response and safety were assessed.
Results: Effective control of nematodes and responses to antigens were achieved following subcutaneous administration. The formulation was safe to administer; occasional minor tissue reactions were evident, but no other adverse effects of treatment were observed in either pregnant ewes or lambs, using either the recommended dose, or an overdose of the formulation.
Conclusion: Administration of a formulation containing moxidectin, five clostridial antigens and caseous lymphadenitis antigen proved safe and efficacious under field conditions.  相似文献   

Patterns of Follicular Growth in Superovulated Sheep and Influence on Endocrine and Ovarian Response     

A Gonzalez-Bulnes  RM Garcia-Garcia  CJH Souza  J Santiago-Moreno  A Lopez-Sebastian  MJ Cocero  DT Baird 《Reproduction in domestic animals》2002,37(6):357-361

Objectives of this study were to characterize patterns of follicular development in sheep superovulated with purified follicle stimulating hormone (FSH) (OVAGEN^TM, ICP, Auckland, New Zealand) and to determine its influence on preovulatory events (onset of the oestrus behaviour and timing of the preovulatory luteinizing hormone surge) and ovarian response (ovulation rate and embryo yield). Number and size of all ≥ 23 mm follicles from the first FSH injection to withdrawal of progestagen sponges was determined by transrectal ultrasonography just prior to every FSH injection in nine Manchega ewes superovulated with eight decreasing doses (ml) (1.5 × 3, 1.25 × 2 and 1 × 3) of OVAGEN injected twice daily from 60 h before to 24 h after the withdrawal of 40 mg fluorogestone acetate sponges. Oestrous detection and jugular blood sampling for LH radioimmunoassay were performed every 3 h from 14 to 53 h after sponge removal and ovulation rate and number of embryos were determined 4 days after progestagen withdrawal. Administration of OVAGEN induced a significant rise (p < 0.0005) in the number of follicles ≥ 4 mm in size because of an increased growth in size of follicles from the first FSH injection to sponge removal, an increase in the number of newly detected follicles from 12 to 36 h of the first FSH dose (p < 0.005) and a decrease in regression rate from 24 h (p < 0.001). The number of follicles 2–3 mm in size at first FSH dose (10.4 ± 1.5) was positively correlated with the number of ≥ 4 mm follicles at 0 h (19.0 ± 2.7, p < 0.01). A higher number of ≥ 4 mm follicles at 0 h was related with an earlier appearance of oestrus (31.5 ± 1.5 h, p = 0.08) and LH surge (45.0 ± 2.3 h, p < 0.005), and a higher ovulation rate (18.2 ± 3.8, p < 0.005). On the other hand, the rate of embryo recovery was decreased in ewes with earlier preovulatory LH peaks (p < 0.005), with a shorter interval between oestrus and LH peak (p < 0.05).  相似文献   

The 1872 outbreak of foot-and-mouth disease in Australia why didnt it become established?     

CM BUNN  MG GARNER  RM CANNON 《Australian veterinary journal》1998,76(4):262-269

  相似文献   

Influence of Gonadotrophin‐Induced First Oestrus on Gilt Fertility     

DM Hidalgo  RM Friendship  L Greiner  R Manjarín  MR Amezcua  JC Domínguez  RN Kirkwood 《Reproduction in domestic animals》2014,49(6):899-902

The aim of this study was to determine the association between the oestrous response of pre‐pubertal gilts to gonadotrophin injection or boar exposure and their subsequent farrowing rate and litter size. At 154 days of age, randomly selected pre‐pubertal gilts received an intramuscular injection of 400 IU equine chorionic gonadotrophin plus 200 IU human chorionic gonadotrophin (PG600^®; Merck Animal Health; n = 181). From the remaining pool of animals not treated with hormones, the first gilts showing signs of oestrus were selected to act as controls (n = 201). Boar exposure began at 155 days of age for both groups, and gilts were bred at a weight of approximately 130 kg. Comparisons were made between PG600^®‐treated gilts exhibiting oestrus or not within 7 days post‐injection (early and late responders, respectively) and control gilts exhibiting oestrus or not within 30 days after beginning of boar exposure (select and non‐select control gilts, respectively). By 162 days, oestrus was detected in 67.5% of PG600^®‐treated gilts compared with 5.7% of control gilts (p < 0.0001). The proportion of animals observed in oestrus at least three times before breeding was greater for select control gilts compared with early and late responder PG600^®‐treated gilts (p ≤ 0.001). There were no significant differences in farrowing rate and litter size between the four treatment groups. These data indicate that PG600^® is an effective tool to induce an earlier oestrus in gilts, that subsequent farrowing rate and born alive litter size compare favourably to that of select gilts and that gilts failing to respond promptly to hormonal stimulation do not exhibit compromised fertility.  相似文献   

Effect of eCG or eCG Plus hCG on Oestrus Expression and Ovulation in Prepubertal Gilts     

R Manjarin  G Cassar  DJ Sprecher  RM Friendship  JC Dominguez  RN Kirkwood 《Reproduction in domestic animals》2009,44(3):411-413

To meet weekly breeding targets, it is occasionally necessary to inject exogenous gonadotrophins to induce oestrus in prepubertal gilts. However, the gilt oestrus response to equine chorionic gonadotrophin (eCG) either alone or in combination with human chorionic gonadotrophin (hCG) can be unpredictable. The objective of the present study was to examine possible reasons for this unpredictability. Prepubertal gilts (90 kg and 153 days of age, n = 109) received an injection of either 600 IU eCG or a combination of 400 IU eCG and 200 IU hCG (PG600), or were non-injected controls, and were then exposed to a mature boar for 15 min daily for 7 days for oestrus detection. At the time of injection, real-time ultrasound revealed that the gilt ovaries had primarily 1–2 mm follicles. Blood samples were obtained at time of hormone injection (day 0) and at days 3, 7 and 10 for assay of serum progesterone concentrations. The oestrus responses by 7 days were15.5%, 73.3% and 0%, for eCG, PG600, and control gilts, respectively (p < 0.001). The oestrus response improved (p < 0.05) with increasing body weight. Based on circulating progesterone levels, all oestrous gilts ovulated except for four of the PG600 gilts. Failure to express oestrus in PG600 gilts was not associated with a premature rise in progesterone.  相似文献   

Activity-dependent regulation of MEF2 transcription factors suppresses excitatory synapse number     

Flavell SW  Cowan CW  Kim TK  Greer PL  Lin Y  Paradis S  Griffith EC  Hu LS  Chen C  Greenberg ME 《Science (New York, N.Y.)》2006,311(5763):1008-1012

  相似文献   

Prediction of oriented strand board properties from mat formation and compression operating conditions. Part 1. Horizontal density distribution and vertical density profile     

Greer Painter  Hector Budman  Mark Pritzker 《Wood Science and Technology》2006,40(2):139-158

A model is presented to determine the horizontal density distribution (HDD) and vertical density profile (VDP) of oriented strand board (OSB) panels produced by batch pressing. The HDD is simulated using input distributions of flake dimensions and orientation from plant measurements. Many previous HDD models rely on assumed distributions, which may not accurately characterize current manufacturing processes. The model predicts the VDP based on the compression behaviour of cellular materials in combination with temperature and moisture profiles calculated using a previously published heat and mass transport model. A novel empirical approach is applied rather than the time–temperature–moisture superposition method commonly used. The model predictions compare favourably with plant data and exhibit trends similar to previously reported experimental results. This work is the first of a two-part publication. The second part is concerned with stiffness property prediction and an optimization of the OSB manufacturing process. This work is novel in that no comprehensive model including HDD, VDP, stiffness property prediction and optimization has been reported in the literature.  相似文献   

Multi-drug resistant Escherichia coli with extended-spectrum β -lactamase activity and fluoroquinolone resistance isolated from clinical infections in dogs     

AL WARREN  KM TOWNSEND  T KING  S MOSS  D O''BOYLE  RM YATES  DJ TROTT 《Australian veterinary journal》2001,79(9):621-623

  相似文献   

Risk factors for duration of equine rhinitis A virus respiratory disease     

T. M. Rossi  A. Moore  T. L. O’Sullivan  A. L. Greer 《Equine veterinary journal》2020,52(3):369-373

  相似文献   

Identifying the environmental drivers of Campylobacter infection risk in southern Ontario,Canada using a One Health approachs     

Melanie Cousins  Jan M. Sargeant  David N. Fisman  Amy L. Greer 《Zoonoses and public health》2020,67(5):516-524

  相似文献