Toxicology of a PFPE Surfactant     

Johnston KP  Randolph T  Bright F  Howdle S 《Science (New York, N.Y.)》1996,272(5269):1726b

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INCREASE IN VITAMIN A ACTIVITY OF CORN CAUSED BY DOUBLING THE NUMBER OF CHROMOSOMES     

Randolph LF  Hand DB 《Science (New York, N.Y.)》1938,87(2263):442-443

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The role of CCR7 in TH1 and TH2 cell localization and delivery of B cell help in vivo     

Randolph DA  Huang G  Carruthers CJ  Bromley LE  Chaplin DD 《Science (New York, N.Y.)》1999,286(5447):2159-2162

Subsets of murine CD4+ T cells localize to different areas of the spleen after adoptive transfer. Na?ve and T helper 1 (TH1) cells, which express the chemokine receptor CCR7, are home to the periarteriolar lymphoid sheath, whereas activated TH2 cells, which lack CCR7, form rings at the periphery of the T cell zones near B cell follicles. Retroviral transduction of TH2 cells with CCR7 forces them to localize in a TH1-like pattern and inhibits their participation in B cell help in vivo but not in vitro. Thus, differential expression of chemokine receptors results in unique cellular migration patterns that are important for effective immune responses.  相似文献   

Hypersomatotropism and insulin-resistant diabetes mellitus in a cat   总被引：1，自引：0，他引：1  

S A Morrison  J Randolph  C D Lothrop 《Journal of the American Veterinary Medical Association》1989,194(1):91-94

In this report, we described the clinical, radiographic, and echocardiographic findings in a cat with hypersomatotropism and insulin-resistant diabetes mellitus. Growth hormone determinations were made because of persistent hyperglycemia despite insulin requirements exceeding 2.2 U/kg of body weight, and the acromegalic features of the cat. Also, the results of a therapeutic trial in which a long-acting analogue of somatostatin was used are discussed.  相似文献   

X-Chromosomal Monosomy (77, XO) in a Doberman Pinscher With Gonadal Dysgenesis     

F. W. K. Smith Jr  DVM  L. C. Buoen BA    A. F. Weber DVM  PhD    S. D. Johnston DVM  PhD    J. F. Randolph DVM  D. J. Waters DVM 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》1989,3(2):90-95

A 6-month-old stunted female Doberman Pinscher was found to have a 77,X0 chromosomal complement. The ovaries were small, consisting primarily of interstitial-type cells and solid epithelial cords. The dam, sire, and a male littermate had normal karyotypes.  相似文献   

Congenital Fanconi Syndrome Associated With Renal Dysplasia in 2 Border Terriers   总被引：1，自引：0，他引：1  

Ruth A. Darrigrand-Haag DVM    Sharon A. Center  John F. Randolph  Robert M. Lewis  Philip A. Wood 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》1996,10(6):412-419

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Evaluation of prognostic factors, survival rates, and treatment protocols for immune-mediated hemolytic anemia in dogs: 151 cases (1993-2002)   总被引：4，自引：0，他引：4  

Weinkle TK  Center SA  Randolph JF  Warner KL  Barr SC  Erb HN 《Journal of the American Veterinary Medical Association》2005,226(11):1869-1880

OBJECTIVE: To evaluate prognostic factors, survival, and treatment protocols for immune-mediated hemolytic anemia (IMHA) in dogs. DESIGN: Retrospective study. ANIMALS: 151 dogs with IMHA not associated with underlying infectious or neoplastic disease. PROCEDURE: lnformation recorded from review of medical records included signalment at the time of initial evaluation; vaccination history; 30-, 60-, and 365-day follow-up outcomes; laboratory data; results of imaging studies; and necropsy findings. Dogs were grouped according to the presence of spherocytes, autoagglutination, a regenerative erythrocyte response, and treatments received (azathioprine, azathioprine plus ultralow-dose aspirin, azathioprine plus mixed-molecular-weight heparin [mHEP], or azathioprine plus ultralow-dose aspirin plus mHEP) for comparisons. All dogs received glucocorticoids. RESULTS: Cocker Spaniels, Miniature Schnauzers, neutered dogs, and female dogs were overrepresented. Alterations in certain clinicopathologic variables were associated with increased mortality rate. Rates of survival following treatment with azathioprine, azathioprine plus ultralow-dose aspirin, azathioprine plus mHEP, and azathioprine plus ultralow-dose aspirin plus mHEP were 74%, 88%, 23%, and 70%, respectively, at hospital discharge; 57%, 82%, 17%, and 67%, respectively, at 30 days; and 45%, 69%, 17%, and 64%, respectively, at 1 year. In comparison, mean survival rates at discharge and at 30 days and 1 year after evaluation collated from 7 published reviews of canine IMHA were 57%, 58%, and 34%, respectively. CONCLUSIONS AND CLINICAL RELEVANCE: Treatment with a combination of glucocorticoids, azathioprine, and ultralow-dose aspirin significantly improved short- and long-term survival in dogs with IMHA.  相似文献   

Effects of insulation on the temperature within farrowing huts and the weaning weights of piglets reared on a commercial outdoor pig unit     

Randolph CE  O'Gorman AJ  Potter RA  Jones PH  Miller BG 《The Veterinary record》2005,157(25):800-805

The air temperatures inside uninsulated and insulated huts were recorded on an outdoor pig unit in the south of England between September 1997 and September 1998, and the herd's production parameters were also recorded. During the summer the temperatures inside some of the uninsulated huts exceeded 45 degrees C, but the temperatures inside the insulated huts were lower and fluctuated less. Despite the high temperatures, the weaning weight of piglets reared in the uninsulated huts were often higher than those of the piglets reared in the insulated huts, possibly as a result of the higher mortality of small piglets in the uninsulated huts, especially during the winter. The weaning weights of the piglets were higher during the summer.  相似文献   

Hypertrophic osteopathy associated with adenocarcinoma of the esophageal glands in a dog     

J F Randolph  S A Center  J A Flanders  R W Diters 《Journal of the American Veterinary Medical Association》1984,184(1):98-99

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Vacuolar hepatopathy in dogs: 336 cases (1993-2005)     

Sepesy LM  Center SA  Randolph JF  Warner KL  Erb HN 《Journal of the American Veterinary Medical Association》2006,229(2):246-252

OBJECTIVE: To determine disorders associated with vacuolar hepatopathy (VH), morphologic hepatic and clinicopathologic abnormalities, and affiliation with steroidogenic hormone excess in dogs. DESIGN: Retrospective case series. Animals-336 dogs with histologically confirmed moderate or severe VH. PROCEDURES: Information on signalment, results of diagnostic testing, definitive diagnoses, and exposure to glucocorticoids (ie, exogenous glucocorticoid administration or high endogenous concentrations of steroidogenic hormones) was obtained from medical records. Dogs were grouped by underlying disorder, glucocorticoid exposure, acinar zonal distribution of lesions, and histologic severity. RESULTS: 12 disease groups (neoplastic, acquired hepatobiliary, neurologic, immune-mediated, gastrointestinal tract, renal, infectious, cardiac disease, diabetes mellitus, portosystemic vascular anomaly, adrenal gland dysfunction, and miscellaneous disorders) were identified. There were 186 (55%) dogs with and 150 (45%) dogs without evidence of glucocorticoid exposure. Acinar zonal distribution of hepatic vacuolation and clinicopathologic values did not differ between dogs with and without evidence of glucocorticoid exposure. However, a 3-fold increased likelihood of severe VH was associated with steroidogenic hormone exposure. Of 226 dogs with high serum alkaline phosphatase activity, 102 (45%) had no evidence of glucocorticoid exposure. CONCLUSIONS AND CLINICAL RELEVANCE: Results suggest that neoplasia and congenital or acquired hepatobiliary disease are common in dogs with VH and provide support for the suggestion that VH, high alkaline phosphatase activity, and illness-invoked physiologic stress may be associated. Histologic confirmation of VH should initiate a diagnostic search for a primary disease if glucocorticoid treatment and hyperadrenocorticism are ruled out.  相似文献