Frame-shift deletions in patients with Duchenne and Becker muscular dystrophy   总被引：33，自引：0，他引：33  

S B Malhotra  K A Hart  H J Klamut  N S Thomas  S E Bodrug  A H Burghes  M Bobrow  P S Harper  M W Thompson  P N Ray 《Science (New York, N.Y.)》1988,242(4879):755-759

Duchenne muscular dystrophy (DMD) and its less severe form Becker muscular dystrophy (BMD) are allelic disorders. It has been suggested that in the mutations involving BMD, the translational reading frame of messenger RNA is maintained and a smaller, though partially functional, protein is produced. In order to test this, the exon-intron boundaries of the first ten exons of the DMD gene were determined, and 29 patients were analyzed. In a number of BMD patients (mild and severe BMD), the reading frame of messenger RNA was not maintained. On the basis of these findings, a model for reinitiation from an internal start codon is suggested.  相似文献   

SOUTHERNMOST GLACIATED PEAK IN THE UNITED STATES     

Smith HT  Ray LL 《Science (New York, N.Y.)》1941,93(2409):209-210

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Amplification and molecular cloning of HTLV-I sequences from DNA of multiple sclerosis patients   总被引：15，自引：0，他引：15  

E P Reddy  M Sandberg-Wollheim  R V Mettus  P E Ray  E DeFreitas  H Koprowski 《Science (New York, N.Y.)》1989,243(4890):529-533

Techniques of gene amplification, molecular cloning, and sequence analysis were used to test for the presence of sequences related to human T-lymphotropic virus type I (HTLV-I) in peripheral blood mononuclear cells of six patients with multiple sclerosis (MS) and 20 normal individuals. HTLV-I sequences were detected in all six MS patients and in one individual from the control group by DNA blot analysis and molecular cloning of amplified DNAs. The viral sequence in MS patients were associated with adherent cell populations consisting predominantly of monocytes and macrophages. Molecular cloning and nucleotide sequence analysis indicated that these amplified viral sequences were related to the HTLV-I proviral genome.  相似文献   

Thunderstorms: an important mechanism in the transport of air pollutants   总被引：3，自引：0，他引：3  

Dickerson RR  Huffman GJ  Luke WT  Nunnermacker LJ  Pickering KE  Leslie AC  Lindsey CG  Slinn WG  Kelly TJ  Daum PH  Delany AC  Greenberg JP  Zimmerman PR  Boatman JF  Ray JD  Stedman DH 《Science (New York, N.Y.)》1987,235(4787):460-465

Acid deposition and photochemical smog are urban air pollution problems, and they remain localized as long as the sulfur, nitrogen, and hydrocarbon pollutants are confined to the lower troposphere (below about 1-kilometer altitude) where they are short-lived. If, however, the contaminants are rapidly transported to the upper troposphere, then their atmospheric residence times grow and their range of influence expands dramatically. Although this vertical transport ameliorates some of the effects of acid rain by diluting atmospheric acids, it exacerbates global tropospheric ozone production by redistributing the necessary nitrogen catalysts. Results of recent computer simulations suggest that thunderstorms are one means of rapid vertical transport. To test this hypothesis, several research aircraft near a midwestern thunderstrom measured carbon monoxide, hydrocarbons, ozone, and reactive nitrogen compounds. Their concentrations were much greater in the outflow region of the storm, up to 11 kilometers in altitude, than in surrounding air. Trace gas measurements can thus be used to track the motion of air in and around a cloud. Thunderstorms may transform local air pollution problems into regional or global atmospheric chemistry problems.  相似文献   

Enrichment of heavy metals and organic compounds in the surface microlayer of Narragansett Bay, Rhode Island   总被引：2，自引：0，他引：2  

R A Duce  J G Quinn  C E Olney  S R Piotrowicz  B J Ray  T L Wade 《Science (New York, N.Y.)》1972,176(31):161-163

Concentrations of lead, iron, nickel, copper, fatty acids, hydrocarbons, and chlorinated hydrocarbons are enriched from 1.5 to 50 times in the top 100 to 150 micrometers of Narragansett Bay water relative to the bulk water 20 centimeters below the surface. Trace metal enrichment was observed in the particulate and organic fractions but not in the inorganic fraction. If these substances are concentrated in films only a few molecular layers thick on the water surface, the actual enrichment factor in the films may be well over 10(4), resulting in extremely high localized pollutant concentrations in the surface microlayer.  相似文献   

Peroxidase-mediated virucidal systems   总被引：23，自引：0，他引：23  

M E Belding  S J Klebanoff  C G Ray 《Science (New York, N.Y.)》1970,167(915):195-196

Peroxidase (myeloperoxidase or lactoperoxidase), hydrogen peroxide, and a halide such as iodide, bromide, or chloride form a potent virucidal system that is effective against polio and vaccinia viruis, particularly at a low pH. The peroxidase-halide-hydrogen peroxide system may contribute to the host defense against certain viral infections.  相似文献   

Radio Tracking of a Fin Whale (Balaenoptera physalus)     

Ray GC  Mitchell ED  Wartzok D  Kozicki VM  Maiefski R 《Science (New York, N.Y.)》1978,202(4367):521-524

A tagged whale of the genus Balaenoptera was intermittently tracked by radio for 27.8 hours over a distance of about 145 kilometers. Data on breathing and movement show that during that time the whale took 58 breaths in 130 minutes and traveled 20 kilometers at more than 9 kilometers per hour. Precise measurements of such parameters and of other features of the life history of great whales, which travel long distances over the high seas, often in groups, are now possible through radio tagging.  相似文献   

Sign Change of Poisson's Ratio for Carbon Nanotube Sheets     

Hall LJ  Coluci VR  Galvão DS  Kozlov ME  Zhang M  Dantas SO  Baughman RH 《Science (New York, N.Y.)》2008,320(5875):504-507

Most materials shrink laterally like a rubber band when stretched, so their Poisson's ratios are positive. Likewise, most materials contract in all directions when hydrostatically compressed and decrease density when stretched, so they have positive linear compressibilities. We found that the in-plane Poisson's ratio of carbon nanotube sheets (buckypaper) can be tuned from positive to negative by mixing single-walled and multiwalled nanotubes. Density-normalized sheet toughness, strength, and modulus were substantially increased by this mixing. A simple model predicts the sign and magnitude of Poisson's ratio for buckypaper from the relative ease of nanofiber bending and stretch, and explains why the Poisson's ratios of ordinary writing paper are positive and much larger. Theory also explains why the negative in-plane Poisson's ratio is associated with a large positive Poisson's ratio for the sheet thickness, and predicts that hydrostatic compression can produce biaxial sheet expansion. This tunability of Poisson's ratio can be exploited in the design of sheet-derived composites, artificial muscles, gaskets, and chemical and mechanical sensors.  相似文献   

Shaping the vertebrate body plan by polarized embryonic cell movements     

Keller R 《Science (New York, N.Y.)》2002,298(5600):1950-1954

Polarized cell movements shape the major features of the vertebrate body plan during development. The head-to-tail body axis of vertebrates is elongated in embryonic stages by "convergent extension" tissue movements. During these movements cells intercalate between one another transverse to the elongating body axis to form a narrower, longer array. Recent discoveries show that these polarized cell movements are controlled by homologs of genes that control the polarity of epithelial cells in the developing wing and eye of the fruit fly, Drosophila.  相似文献   

An Automatic Proportioning Apparatus for Experimental Study of the Effects of Chemical Solutions on Aquatic Animals     

Collier A  Ray SM 《Science (New York, N.Y.)》1948,107(2787):576-577

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