Hyperglycaemia but not hyperlipidaemia decreases serum amylase and increases neutrophils in the exocrine pancreas of cats     

Eric Zini  Melania Osto  Marco Franchini  Hans Lutz  Aurel Perren  Mathias Ackermann  Claudia E. Reusch 《Research in veterinary science》2010,89(1):20-26

The goal of the study was to determine whether hyperglycaemia or hyperlipidaemia causes pancreatitis in cats and to assess the effect of excess serum glucose and lipids on amylase and lipase activity. Ten-day hyperglycaemic and hyperlipidaemic clamps were carried out in five and six healthy cats, respectively. Ten healthy cats received saline and served as controls. The activity of amylase was below the normal range in 4 of 5 hyperglycaemic cats by day 10. The activity of lipase did not vary in any of the cats. Samples of exocrine pancreas were normal on histological examination, but the number of tissue neutrophils was increased in hyperglycaemic cats (P < 0.05). In a retrospective study 14 of 40 (35%) cats with naturally occurring diabetes mellitus had amylase activities below the reference range at the time of admission. Amylase activities normalised within 1 week of insulin therapy and subsequent glycaemic control. Lipase activity was increased in 26 of 40 (65%) diabetic cats and remained elevated despite glycaemic control. In conclusion, hyperglycaemia, but not hyperlipidaemia, increases pancreatic neutrophils in cats. However, because the histological morphology of the exocrine pancreas was normal, hyperglycaemia may play only a minor role in the pathogenesis of pancreatitis. Low amylase activities in diabetic cats may reflect an imbalance in glucose metabolism rather than pancreatitis.  相似文献   

Predictors of Clinical Remission in Cats with Diabetes Mellitus     

E. Zini  M. Hafner  M. Osto  M. Franchini  M. Ackermann  T.A. Lutz  C.E. Reusch 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2010,24(6):1314-1321

Background: Clinical remission is frequent in cats with well‐controlled diabetes mellitus, but few studies explored predictors of this phenomenon. Hypothesis: Data retrieved from medical records at admission might be valuable to identify likelihood of remission and its duration in diabetic cats. Animals: Ninety cats with newly diagnosed diabetes, followed‐up until death or remission. Methods: Retrospective cohort study. Data were collected from records at admission, including history, signalment, physical examination, haematology, and biochemical profile, and the occurrence and duration of remission, defined as normoglycemia without insulin for ≥4 weeks. Predictors of remission were studied with univariate and multivariate logistic regression. Factors associated with remission duration were analyzed with Kaplan‐Meier and Cox proportional hazard models. Results: Forty‐five (50%) cats achieved remission, after a median time of 48 days (range: 8–216). By study end, median remission duration was 114 days (range: 30–3,370) in cats that died and 151 days (range: 28–1,180) in alive cats. Remission was more likely with higher age (OR: 1.23, 95% CI: 1.04–1.46; P= .01) and less likely with increased serum cholesterol (OR: 0.36, 95% CI: 0.11–0.87; P= .04). Remission was longer with higher body weight (HR: 0.65, 95% CI: 0.42–0.99; P= .04) and shorter with higher blood glucose (HR: 1.01, 95% CI: 1.00–1.02; P= .02). Conclusions and Clinical Importance: Age, body weight, cholesterol, and glucose levels are suggested for prediction of remission or its duration in diabetic cats. Older cats developing diabetes may have a better outcome, possibly suggesting a slower disease progression.  相似文献   

Morpho‐physical Recording of Bovine Conceptus (Bos indicus) and Placenta from Days 20 to 70 of Pregnancy     

AC Assis Neto  FTV Pereira  TC Santos  CE Ambrosio  R Leiser  MA Miglino 《Reproduction in domestic animals》2010,45(5):760-772

The study is based on 141 pregnant Bos indicus cows, from days 20 to 70 post‐insemination. First, special attention was given to the macroscopically observable phenomena of attachment of the conceptus to the uterus, i.e. the implantation, from about days 20 to 30 post‐insemination up to day 70, and placentome development by growth, vascularization and increase in the number of cotyledons opposite to the endometrial caruncles. Secondly, as for the conceptuses, semiquantitative, statistical analyses were performed of the lengths of chorio‐allantois, amnion and yolk sac; and the different parts of the centre and two extremes of the yolk sacs were also analysed. Thirdly, the embryos/foetuses corresponding to their membranes were measured by their greatest length and by weight, and described by the appearance of external developmental phenomena during the investigated period like neurulation, somites, branchial arcs, brain vesicles, limb buds, C‐form, pigmented eye and facial grooves. In conclusion, all the data collected in this study from days 20 to 70 of bovine pregnancy were compared extensively with corresponding data of the literature. This resulted in an ‘embryo/foetal age‐scale’, which has extended the data in the literature by covering the first 8 to 70 days of pregnancy. This age‐scale of early bovine intrauterine development provides model for studies, even when using slaughtered cows without distinct knowledge of insemination or fertilization time, through macroscopic techniques. This distinctly facilitates research into the cow, which is now being widely used as ‘an experimental animal’ for testing new techniques of reproduction like in vitro fertilization, embryo transfer and cloning.  相似文献   

The dipeptidyl peptidase IV inhibitor NVP-DPP728 reduces plasma glucagon concentration in cats     

Daniela Furrer  Karin Kaufmann  Flurin Tschuor  Claudia E. Reusch  Thomas A. Lutz 《Veterinary journal (London, England : 1997)》2010,183(3):355-357

Glucagon-like peptide-1 (GLP-1) analogues and inhibitors of its degrading enzyme, dipeptidyl peptidase IV (DPPIV), are interesting therapy options in human diabetics because they increase insulin secretion and reduce postprandial glucagon secretion. Given the similar pathophysiology of human type 2 and feline diabetes mellitus, this study investigated whether the DPPIV inhibitor NVP-DPP728 reduces plasma glucagon levels in cats. Intravenous glucose tolerance tests (ivGTT; 0.5 g/kg glucose after 12 h fasting) and a meal response test (test meal of 50% of average daily food intake, offered after 24 h fasting) were performed in healthy experimental cats. NVP-DPP728 (0.5–2.5 mg/kg IV or SC) significantly reduced glucagon output in all tests and increased insulin output in the ivGTT. Follow-up studies will investigate the potential usefulness as therapy in diabetic cats.  相似文献   

Effect of twice-daily oral administration of hydrocortisone on the bile acids composition of gallbladder bile in dogs     

Kook PH  Schellenberg S  Rentsch KM  Reusch CE  Glaus TM 《American journal of veterinary research》2011,72(12):1607-1612

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Severe gastrointestinal bleeding secondary to lornoxicam in the dog     

Kook PH  Reusch CE 《Schweizer Archiv für Tierheilkunde》2011,153(5):223-229

Six dogs with lornoxicam induced severe gastrointestinal bleeding are described. The ingested dose ranged between 0.5 - 5.1?mg/kg BW (median 0.63?mg/kg BW). The severity of the bloodloss anemia was moderate to severe with PCV values ranging between 12 - 27 % (median 16 %) and serum albumin concentrations between 12 - 22 g/l (median 16 g/l). One dog had evidence of chronic thrombocytopathia over 13 days and clinicopathologic findings of gastrointestinal bleeding over 55 days. None of the dogs developed kidney injuries. The clinical condition required transfusion of blood products in 5 of 6 cases. One dog with a perforated duodenal ulcer and septic peritonitis survived until discharge but had to be euthanized later on due to recrudescent clinical signs (hematemesis, melena). The median length of hospitalisation was 12 days (5 - 14). No correlation was seen between the ingested dose and severity of clinical signs. Lornoxicam ingestion leads to severe and longlasting gastrointestinal bleeding in the dog and requires immediate intensive therapy.  相似文献   

Glycemic variability in newly diagnosed diabetic cats treated with the glucagon-like peptide-1 analogue exenatide extended release     

Anna L. Krämer  Angelina Riederer  Federico Fracassi  Felicitas S. Boretti  Nadja S. Sieber-Ruckstuhl  Thomas A. Lutz  Barbara Contiero  Eric Zini  Claudia E. Reusch 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2020,34(6):2287-2295

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Tumors of the exocrine pancreas in the cat     

M Münster  C Reusch 《Tier?rztliche Praxis》1988,16(3):317-320

Five cases of carcinoma and one case of lymphosarcoma of the pancreas in cats are reported. Duration of clinical signs ranged between three days and ten weeks, the mean age was 10.2 years. Anorexia, depression, and cachexia were the mean symptoms, in four animals a palpable mass in the cranial abdomen was noted. Laboratory evaluation was unspecific, in all cases diagnosis was performed by necropsy. Further diagnostical and therapeutical possibilities are discussed critically.  相似文献   

Glucose concentrations after insulin‐induced hypoglycemia and glycemic variability in healthy and diabetic cats          下载免费PDF全文

Eric Zini  Elena Salesov  Perrine Dupont  Laura Moretto  Barbara Contiero  Thomas A. Lutz  Claudia E. Reusch 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2018,32(3):978-985

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Evaluation of a low‐dose desoxycorticosterone pivalate treatment protocol for long‐term management of dogs with primary hypoadrenocorticism     

Nadia S. Sieber‐Ruckstuhl  Claudia E. Reusch  Nathalie Hofer‐Inteeworn  Claudia Kuemmerle‐Fraune  Claudia Müller  Regina Hofmann‐Lehmann  Felicitas S. Boretti 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2019,33(3):1266-1271

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