Influence of gene action across different time scales on behavior   总被引：2，自引：0，他引：2  

Ben-Shahar Y  Robichon A  Sokolowski MB  Robinson GE 《Science (New York, N.Y.)》2002,296(5568):741-744

Genes can affect natural behavioral variation in different ways. Allelic variation causes alternative behavioral phenotypes, whereas changes in gene expression can influence the initiation of behavior at different ages. We show that the age-related transition by honey bees from hive work to foraging is associated with an increase in the expression of the foraging (for) gene, which encodes a guanosine 3',5'-monophosphate (cGMP)-dependent protein kinase (PKG). cGMP treatment elevated PKG activity and caused foraging behavior. Previous research showed that allelic differences in PKG expression result in two Drosophila foraging variants. The same gene can thus exert different types of influence on a behavior.  相似文献   

Niobium-germanium: becoming a practical superconductor     

Robinson AL 《Science (New York, N.Y.)》1974,185(4154):846-848

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Energy storage (I): using electricity more efficiently     

Robinson AL 《Science (New York, N.Y.)》1974,184(4138):785-787

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How to Do EXAFS in Your Own Laboratory     

Robinson AL 《Science (New York, N.Y.)》1979,205(4413):1367

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Laser light in the extreme ultraviolet     

Robinson AL 《Science (New York, N.Y.)》1983,220(4603):1259-1261

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Quantum mechanics passes another test     

Robinson AL 《Science (New York, N.Y.)》1982,217(4558):435-436

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Smart instruments: microprocessors not the whole story     

Robinson AL 《Science (New York, N.Y.)》1977,195(4284):1315-1367

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Bright Synchrotron Sources Evolve: While funding is not yet assured for all the third-generation synchrotron sources, accelerator scientists are struggling to design a machine that can provide ultrahigh-brightness light     

Robinson AL 《Science (New York, N.Y.)》1987,235(4791):841-842

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Transducin activation by rhodopsin without a covalent bond to the 11-cis-retinal chromophore   总被引：3，自引：0，他引：3  

E A Zhukovsky  P R Robinson  D D Oprian 《Science (New York, N.Y.)》1991,251(4993):558-560

Rhodopsin and the visual pigments are a distinct group within the family of G-protein-linked receptors in that they have a covalently bound ligand, the 11-cis-retinal chromophore, whereas all of the other receptors bind their agonists through noncovalent interactions. The retinal chromophore in rhodopsin is bound by means of a protonated Schiff base linkage to the epsilon-amino group of Lys-296. Two rhodopsin mutants have been constructed, K296G and K296A, in which the covalent linkage to the chromophore is removed. Both mutants form a pigment with an absorption spectrum close to that of the wild type when reconstituted with the Schiff base of an n-alkylamine and 11-cis-retinal. In addition, the pigment formed from K296G and the n-propylamine Schiff base of 11-cis-retinal was found to activate transducin in a light-dependent manner, with 30 to 40% of the specific activity measured for the wild-type protein. It appears that the covalent bond is not essential for binding of the chromophore or for catalytic activation of transducin.  相似文献   

Acquisition by innervated cardiac myocytes of a pertussis toxin-specific regulatory protein linked to the alpha 1-receptor   总被引：4，自引：0，他引：4  

S F Steinberg  E D Drugge  J P Bilezikian  R B Robinson 《Science (New York, N.Y.)》1985,230(4722):186-188

During development, the chronotropic response of rat ventricular myocardium to alpha 1-adrenergic stimulation changes from positive to negative. The alpha 1-agonist phenylephrine increases the rate of contraction of neonatal rat myocytes cultured alone but decreases the rate of contraction when the myocytes are cultured with functional sympathetic neurons. The developmental induction of the inhibitory myocardial response to alpha 1-adrenergic stimulation in intact ventricle and in cultured myocytes was shown to coincide with the functional acquisition of a substrate for pertussis toxin. A 41-kilodalton protein from myocytes cultured with sympathetic neurons and from adult rat myocardium showed, respectively, 2.2- and 16-fold increases in pertussis toxin-associated ADP-ribosylation (ADP, adenosine diphosphate) as compared to controls. In nerve-muscle cultures, inhibition of the actions of this protein by pertussis toxin-specific ADP-ribosylation reversed the mature inhibitory alpha 1-adrenergic response to an immature stimulatory pattern. The results suggest that innervation is associated with the appearance of a functional pertussis toxin substrate by which the alpha 1-adrenergic response becomes linked to a decrease in automaticity.  相似文献