Surgical approach for tentorial meningiomas in cats: a review of six cases     

Forterre F  Fritsch G  Kaiser S  Matiasek K  Brunnberg L 《Journal of Feline Medicine and Surgery》2006,8(4):227-233

The surgical technique for removal of tentorial meningiomas is described on six cats using a unilateral temporal supracerebellar transtentorial approach. Complete gross tumour resection was achieved in four of six cats. In one cat, only subtotal resection was achieved. One cat died shortly after surgery because of extensive cerebral haemorrhage. The surgical approach, combined with cisternal or ventricular cerebrospinal fluid puncture and an open-window technique (tumour fenestration and enucleation) provided sufficient visibility and tumour accessibility without excessive manipulation of the brain parenchyma. In all patients, a postoperative transient worsening of the clinical signs was observed. The neurological signs resolved with time with the exception of blindness in two cats. All five surviving cats were monitored for a mean follow-up time of 19 months (median 20 months; range 6-30 months). All patients died or were euthanased because of tumour regrowth within the follow-up period. Although challenging, surgical treatment is a useful therapeutic measure in the treatment of cats presenting with tentorial meningiomas.  相似文献   

Efficacy and safety of firocoxib in the management of canine osteoarthritis under field conditions     

Hanson PD  Brooks KC  Case J  Conzemius M  Gordon W  Schuessler J  Shelley B  Sifferman R  Drag M  Alva R  Bell L  Romano D  Fleishman C 《Veterinary therapeutics : research in applied veterinary medicine》2006,7(2):127-140

A total of 249 client-owned dogs with osteoarthritis were treated with firocoxib (5 mg/kg/day) or a positive control, etodolac (10-15 mg/kg/day), for 30 days. Veterinary examinations were performed on approximately days 0 (visit 1), 14 (visit 2), and 29 (visit 3). Based on defined noninferiority criteria, firocoxib and etodolac were comparable. Based on the magnitude of the change from baseline, improvement with firocoxib was significantly greater than with etodolac for lameness at a trot (visits 2 and 3) and for lameness at a walk, pain on manipulation, and range of motion (visit 3) (P < .05). In weekly owner evaluations, firocoxib provided significantly greater improvement than etodolac (P < .05) at each scoring.  相似文献   

The Women's Health Initiative. What is on trial: nutrition and chronic disease? Or misinterpreted science, media havoc and the sound of silence from peers?     

Yngve A  Hambraeus L  Lissner L  Serra Majem L  Vaz de Almeida MD  Berg C  Hughes R  Cannon G  Thorsdottir I  Kearney J  Gustafsson JA  Rafter J  Elmadfa I  Kennedy N 《Public health nutrition》2006,9(2):269-272

The first results of the Women's Health Initiative dietary intervention trial were published in the USA in February. This is a colossal intervention designed to see if diets lower in fat and higher in fruits, vegetables and grains than is usual in high-income countries reduce the incidence of breast cancer, colorectal cancer, heart disease and other chronic diseases, in women aged 50-79 years. As interpreted by US government media releases, the results were unimpressive. As interpreted by a global media blitz, the results indicate that food and nutrition has little or nothing to do with health and disease. But the trial was in key respects not reaching its aims, was methodologically controversial, and in any case has not produced the reported null results. What should the public health nutrition profession do about such messes?  相似文献   

Expression of neural markers on bone marrow-derived canine mesenchymal stem cells   总被引：5，自引：0，他引：5  

Kamishina H  Deng J  Oji T  Cheeseman JA  Clemmons RM 《American journal of veterinary research》2006,67(11):1921-1928

OBJECTIVE: To evaluate cell surface markers of bone marrow-derived canine mesenchymal stem cells (MSCs) by use of flow cytometric analysis and determine whether canine MSCs express proteins specific to neuronal and glial cells. SAMPLE POPULATION: Bone marrow aspirates collected from iliac crests of 5 cadavers of young adult dogs. PROCEDURES: Flow cytometric analysis was performed to evaluate cell surface markers and homogeneity of third-passage MSCs. Neural differentiation of canine MSCs was induced by use of dibutyryl cAMP and methyl-isobutylxanthine. Expressions of neuronal (beta III-tubulin) and glial (glial fibrillary acidic protein [GFAP] and myelin basic protein) proteins were evaluated by use of immunocytochemical and western blot analyses before and after neural differentiation. RESULTS: Third-passage canine MSCs appeared morphologically homogeneous and shared phenotypic characteristics with human and rodent MSCs. Immunocytochemical and western blot analyses revealed that canine MSCs constitutively expressed beta III-tubulin and GFAP. After induction of neural differentiation, increased expression of GFAP was found in all samples, whereas such change was inconsistent in beta III-tubulin expression. Myelin basic protein remained undetectable on canine MSCs for these culture conditions. CONCLUSIONS AND CLINICAL RELEVANCE: Canine bone marrow-derived mononuclear cells yielded an apparently homogeneous population of MSCs after expansion in culture. Expanded canine MSCs constitutively expressed neuron or astrocyte specific proteins. Furthermore, increases of intracellular cAMP concentrations induced increased expression of GFAP on canine MSCs, which suggests that these cells may have the capacity to respond to external signals. Canine MSCs may hold therapeutic potential for treatment of dogs with neurologic disorders.  相似文献   

Alkylresorcinol content and homologue composition in durum wheat (Triticum durum) kernels and pasta products     

Landberg R  Kamal-Eldin A  Andersson R  Aman P 《Journal of agricultural and food chemistry》2006,54(8):3012-3014

The total alkylresorcinol (AR) content and relative homologue composition of 21 durum wheat (Triticum durum) kernel samples, as well as 5 pasta products and the corresponding flour mixtures, were determined. Durum wheat contained on average 455 microg/g ARs, and the average relative homologue composition was C17:0 (0.4%), C19:0 (14%), C21:0 (58%), C23:0 (21%), and C25:0 (6.5%). The homologue composition was found to be relatively consistent among samples, with durum wheat being different from common wheat by having a higher proportion of the longer homologues. No differences in content or homologue composition were observed in pasta products compared to flour ingredients, showing that alkylresorcinols are stable during pasta processing. The ratio of the homologues C17:0 to C21:0 was < or =0.02 for whole grain durum wheat products, which is different from those of common wheat (0.1) and rye (0.9).  相似文献   

Effect of compaction on pore functions of soils in a Saalean moraine landscape in North Germany     

Stephan Gebhardt  Heiner Fleige  Rainer Horn 《植物养料与土壤学杂志》2009,172(5):688-695

Soil compaction and related changes of soil physical parameters are of growing importance in agricultural production. Different stresses (70, 230, 500, and 1000 kPa) were applied to undisturbed soil core samples of eight typical soils of a Saalean moraine landscape in N Germany by means of a confined compression device to determine the effect on (1) total porosity/pore‐size distribution, (2) saturated hydraulic conductivity, and (3) air conductivity to assess the susceptibility towards compaction. Different deformation behaviors after exceeding the mechanical strength particularly resulted from a combination of soil characteristics like texture and initial bulk density. The saturated hydraulic conductivity, as an indicator for pore continuity, was largely affected by the volume of coarse pores (r² = 0.82), whereas there was no relationship between bulk density and saturated hydraulic conductivity. Since coarsely textured soils primarily possess a higher coarse‐pore fraction compared to more finely textured soils, which remains at a high level even after compaction, only minor decreases of saturated hydraulic conductivity were evident. The declines in air conductivity exceeded those in hydraulic conductivity, as gas exchange in soils is, besides the connectivity of coarse pores, a function of water content, which increases after loading in dependence of susceptibility to compaction. A soil‐protection strategy should be focused on more finely textured soils, as stresses of 70 kPa may already lead to a harmful compaction regarding critical values of pore functions such as saturated hydraulic conductivity or air capacity.  相似文献   

Testing In Situ Sulfate Reduction by H2 injection in a Bench-Scale Column Experiment     

Felix Bilek  Stephan Wagner 《Water, air, and soil pollution》2009,203(1-4):109-122

Autotrophic microbial sulfate reduction was tested in a fixed-bed bench-scale column experiment to lower sulfate and iron loads in acid-mine-drainage-influenced groundwater. The microbial process was enhanced by injecting H₂ gas as electron donor into the silicate bed. The experiments were performed at 2.5 atm and 10°C. Complete iron removal (3.8?±?0.3 mM) and partial sulfate removal from 17 to 9 mM were achieved at rates of about 0.004–0.019 mmol SO₄ per liter per hour and at hydraulic retention times of 51.5–19.8 days. The tests showed that most microbial activity took place in immobile zones. These zones create stable environmental conditions for the microorganisms leading to constant reduction rate despite possibly unfavorable conditions prevailing in the mobile phase. Diffusion between mobile and the immobile zones was not found to be the limiting factor for sulfate reduction. Rather, low H_2(aq) concentrations due to low H₂ solubility combined with the inhomogeneous distribution of H₂ gas in the pore space limited sulfate reduction. H_2(aq) concentrations in some parts of the sediment body were insufficient to maintain H_2(aq) concentrations in the immobile zones above the level of substrate limitation. Fe and S precipitated mostly as iron monosulfide and accumulated in regions with high H_2(aq) availability. Calculations showed that the deposition of iron sulfide in the pore space does not affect the pore volume significantly.  相似文献   

Cancer. Cancer and telomeres--an ALTernative to telomerase     

Shay JW  Reddel RR  Wright WE 《Science (New York, N.Y.)》2012,336(6087):1388-1390

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Gravity field and internal structure of Mercury from MESSENGER     

Smith DE  Zuber MT  Phillips RJ  Solomon SC  Hauck SA  Lemoine FG  Mazarico E  Neumann GA  Peale SJ  Margot JL  Johnson CL  Torrence MH  Perry ME  Rowlands DD  Goossens S  Head JW  Taylor AH 《Science (New York, N.Y.)》2012,336(6078):214-217

Radio tracking of the MESSENGER spacecraft has provided a model of Mercury's gravity field. In the northern hemisphere, several large gravity anomalies, including candidate mass concentrations (mascons), exceed 100 milli-Galileos (mgal). Mercury's northern hemisphere crust is thicker at low latitudes and thinner in the polar region and shows evidence for thinning beneath some impact basins. The low-degree gravity field, combined with planetary spin parameters, yields the moment of inertia C/MR(2) = 0.353 ± 0.017, where M and R are Mercury's mass and radius, and a ratio of the moment of inertia of Mercury's solid outer shell to that of the planet of C(m)/C = 0.452 ± 0.035. A model for Mercury's radial density distribution consistent with these results includes a solid silicate crust and mantle overlying a solid iron-sulfide layer and an iron-rich liquid outer core and perhaps a solid inner core.  相似文献   

Effect of overexpressing rsmA from Pseudomonas aeruginosa on virulence of select phytotoxin-producing strains of P. syringae     

Kong HS  Roberts DP  Patterson CD  Kuehne SA  Heeb S  Lakshman DK  Lydon J 《Phytopathology》2012,102(6):575-587

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