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排序方式: 共有2167条查询结果,搜索用时 218 毫秒
921.
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924.
Alonso Pardo-Vargas Ingrid de Barcelos Oliveira Paulo Roberto Soares Stephens Claudio Cesar Cirne-Santos Izabel Christina Nunes de Palmer Paix?o Freddy Alejandro Ramos Carlos Jiménez Jaime Rodríguez Jackson Antonio Lamounier Camargos Resende Valeria Laneuville Teixeira Leonardo Castellanos 《Marine drugs》2014,12(7):4247-4259
925.
T. Tiecher L. B. Oliveira D. S. Rheinheimer F. L. F. Quadros L. C. Gatiboni G. Brunetto J. Kaminski 《Grass and Forage Science》2014,69(4):567-579
Studies of responses of native and introduced grassland species to lime and phosphorus (P) applications could contribute to improved understanding of the potential production of South American natural grasslands. To determine the effect of applying lime and different P sources on forage production, diversity and floristic composition, and on soil chemical properties, a small‐plot experiment was conducted over 12 years in natural grassland oversown with Lolium multiflorum and Trifolium vesiculosum in the Campos of southern Brazil. In treatments with soluble phosphate application, dry‐matter (DM) yield in November 2008, after 164 d of winter and early spring growth, increased from 2·3 to 3·2 t ha?1. Differences in DM yield in March 2009, after 111 d of growth during late spring and early summer, were not significant. The DM yield in April 2010, after 419 d of growth, increased from 7·7 to 9·2 t ha?1 in the treatments with P, regardless of the P source. Increased forage yield during the slow growth period in winter was only possible with the introduction of winter‐growing species (L. multiflorum and T. vesiculosum) and soluble phosphate application. Assessment of annual forage yield showed that the effectiveness of Gafsa rock phosphate was equivalent to that of soluble phosphates in the long term. Soluble phosphates and liming modified the botanical composition of natural Campos grassland in the long term, but floristic diversity was not altered. 相似文献
926.
Costa LS Telles CB Oliveira RM Nobre LT Dantas-Santos N Camara RB Costa MS Almeida-Lima J Melo-Silveira RF Albuquerque IR Leite EL Rocha HA 《Marine drugs》2011,9(4):603-614
Fucan is a term used to denominate a family of sulfated polysaccharides rich in sulfated l-fucose. Heterofucan SF-1.5v was extracted from the brown seaweed Sargassum filipendula by proteolytic digestion followed by sequential acetone precipitation. This fucan showed antiproliferative activity on Hela cells and induced apoptosis. However, SF-1.5v was not able to activate caspases. Moreover, SF-1.5v induced glycogen synthase kinase (GSK) activation, but this protein is not involved in the heterofucan SF-1.5v induced apoptosis mechanism. In addition, ERK, p38, p53, pAKT and NFκB were not affected by the presence of SF-1.5v. We determined that SF-1.5v induces apoptosis in HeLa mainly by mitochondrial release of apoptosis-inducing factor (AIF) into cytosol. In addition, SF-1.5v decreases the expression of anti-apoptotic protein Bcl-2 and increased expression of apoptogenic protein Bax. These results are significant in that they provide a mechanistic framework for further exploring the use of SF-1.5v as a novel chemotherapeutics against human cervical cancer. 相似文献
927.
da Matta CB de Souza ET de Queiroz AC de Lira DP de Araújo MV Cavalcante-Silva LH de Miranda GE de Araújo-Júnior JX Barbosa-Filho JM de Oliveira Santos BV Alexandre-Moreira MS 《Marine drugs》2011,9(3):307-318
Marine natural products have been the focus of discovery for new products of chemical and pharmacological interest. The aim of this study was to evaluate the antinociceptive activity of the methanolic (ME), acetate (AE), hexanic (HE) and chloroform (CE) extracts obtained from Caulerpa mexicana, and ME, CE and HE obtained from Caulerpa sertularioides. These marine algae are found all over the world, mainly in tropical regions. Models such as the writhing test, the hot plate test and formalin-induced nociception test were used to evaluate antinociceptive activity in laboratory mice. In the writhing test, all the extracts were administered orally at a concentration of 100 mg/kg, and induced high peripheral antinociceptive activity, with a reduction in the nociception induced by acetic acid above 65%. In the hot plate test, treatment with extracts from C. sertularioides (100 mg/kg, p.o.) did not significantly increase the latency of response, although the ME, AE and HE from C. mexicana showed activity in this model. This result suggests that these extracts exhibit antinociceptive activity. In the formalin test, it was observed that ME, AE and HE obtained from C. mexicana reduced the effects of formalin in both phases. On the other hand only CE from C. sertularioides induced significant inhibition of the nociceptive response in the first phase. To better assess the potential anti-inflammatory activity of the extracts, the carrageenan-induced peritonitis test was used to test Caulerpa spp. extracts on cell migration into the peritoneal cavity. In this assay, all extracts evaluated were able to significantly inhibit leukocyte migration into the peritoneal cavity in comparison with carrageenan. These data demonstrate that extracts from Caulerpa species elicit pronounced antinociceptive and anti-inflamatory activity against several nociception models. However, pharmacological and chemical studies are continuing in order to characterize the mechanism(s) responsible for the antinociceptive action and also to identify the active principles present in the Caulerpa species. 相似文献
928.
de Andrade Moura L Ortiz-Ramirez F Cavalcanti DN Ribeiro SM Muricy G Teixeira VL Fuly AL 《Marine drugs》2011,9(8):1346-1358
The ischemic disorders, in which platelet aggregation and blood coagulation are involved, represent a major cause of disability and death worldwide. The antithrombotic therapy has unsatisfactory performance and may produce side effects. So, there is a need to seek molecules with antithrombotic properties. Marine organisms produce substances with different well defined ecological functions. Moreover, some of these molecules also exhibit pharmacological properties such as antiviral, anticancer, antiophidic and anticoagulant properties. The aim of this study was to evaluate, through in vitro tests, the effect of two extracts of brown algae and ten marine sponges from Brazil on platelet aggregation and blood coagulation. Our results revealed that most of the extracts were capable of inhibiting platelet aggregation and clotting measured by plasma recalcification tests, prothrombin time, activated partial thromboplastin time, and fibrinogenolytic activity. On the other hand, five of ten species of sponges induced platelet aggregation. Thus, the marine organisms studied here may have molecules with antithrombotic properties, presenting biotechnological potential to antithrombotic therapy. Further chemical investigation should be conducted on the active species to discover useful molecules for the development of new drugs to treat clotting disorders. 相似文献
929.
Souza Shenia O. Oliveira Luciana C. Cavagis Alexandre D. M. Botero Wander G. 《Water, air, and soil pollution》2014,225(12):1-13
Treated and untreated rice straw extensively exists in the soil. In order to elucidate its possible effect on the fate of organic pollutants, sorption of pyrene by rice straw and its main constituents (lignin, cellulose, and hemi-cellulose) were studied, as single solute and in the presence of other co-existing organic pollutants, phenanthrene (Phen), benzo[a]pyrene (BaP), phenol, and pentachlorophenol (PCP). Pyrene showed the greatest sorption on lignin with greater aromaticity and smaller polarity, and the sorption coefficient was almost two orders of magnitude greater than those on cellulose and hemi-cellulose. Bi-solute sorption results showed that Phen, BaP and PCP exhibited apparent competitive sorption with pyrene on the four sorbents; while the existence of phenol promoted the sorption of pyrene on rice straw and lignin but inhibited the sorption on cellulose and hemi-cellulose. For the two polycyclic aromatic hydrocarbon (PAH) co-solutes and PCP, hydrophobicity and molecular size played important roles in competition, suggesting the direct competition for hydrophobic sorption sites and pore blockage mechanisms. In contrast, the polar co-solute, phenol showed different effects on pyrene sorption onto the four sorbents, suggesting that multiple interactions between polar organic compounds and sorbents are involved in the sorption. 相似文献
930.
Canassa Vinícius Fernandes Baldin Edson Luiz Lopes Sacilotto Matheus Gerage Lourenção André Luiz Fanela Thiago Luis Martins 《Phytoparasitica》2021,49(4):633-644
Phytoparasitica - Severe attacks of Brevicoryne brassicae (Hemiptera: Aphididae) on brassica crops may lead to a significant decrease in yield and can cause plant death. Host plant... 相似文献