Complex cardiac congenital defects in an adult dog: An ultrasonographic and magnetic resonance imaging study     

M. Belén García-Rodríguez  M. Angeles Ríos Granja  C. César Pérez García  Jose M. Gonzalo Orden  Maria J. Cano Rábano  Inmaculada Diez Prieto 《The Canadian veterinary journal. La revue veterinaire canadienne》2009,50(9):933-935

This article describes a complex and not previously reported combination of congenital cardiac defects. Echocardiography showed dilation of right and left chambers, accompanied with patent ductus arteriosus, persistence of the left cranial vena cava, atrial septal defect (ASD), subaortic stenosis, and tricuspid dysplasia. The interatrial wall was examined and the diameter of the ASD was measured by magnetic resonance imaging (MRI).  相似文献   

Obstetric and fetal outcomes in dystocic and eutocic sows to an injection of exogenous oxytocin during farrowing     

Miguel González-Lozano  Daniel Mota-Rojas  E. Yadira Velázquez-Armenta  Alejandro A. Nava-Ocampo  Rafael Hernández-González  Marcelino Becerril-Herrera  María E. Trujillo-Ortega  María Alonso-Spilsbury 《The Canadian veterinary journal. La revue veterinaire canadienne》2009,50(12):1273-1277

Sixty hybrid Yorkshire-Landrace penned sows, 30 with eutocic farrowing and 30 experiencing a dystocic parturition, were studied to evaluate the obstetric and neonatal outcomes to low doses of oxytocin administered at advanced stages of parturition. Animals in each group were randomly subdivided into 2 subgroups: 15 eutocic and 15 dystocic sows received oxytocin 0.083 IU/kg (equivalent to 1 IU/12 kg body weight), administered intramuscularly after the delivery of the 5th piglet; the other 15 eutocic and 15 dystocic sows received saline solution intramuscularly at the same time. Oxytocin decreased the number of intrapartum deaths by approximately 50% (P = 0.002). No piglet was born dead from the saline- and oxytocin-treated eutocic sows. The highest viability score was observed among piglets born to eutocic sows treated with oxytocin. In summary, this dose schedule would help to decrease the number of stillbirths in both eutocic and dystocic farrowing sows.  相似文献   

Micro-environmental conditions modulate protein secretion and infectivity of the Trichinella spiralis L1 larva     

Francisco Bolas-Fernández  María Auxiliadora Dea-Ayuela  Bernadette Connolly  Mark W. Robinson 《Veterinary parasitology》2009,159(3-4):236-239

After digestion of infected meat the free L1 of Trichinella spp. penetrate the intestinal mucosa where they moult to the mature adult stage. We have used proteomics to identify changes in protein secretion during in vitro culture of free T. spiralis muscle larvae under different environmental conditions, and to correlate these changes with their infectivity in mice. Muscle larvae were cultured in different media (RPMI-1640, C-199 and HBSS) under conditions of anaerobiosis, microaerobiosis and in 5% CO₂ at 37 °C. Following incubation the larval excretory/secretory proteins were analysed by two-dimensional gel electrophoresis and the larvae were used to orally infect naïve CD1 mice. For all culture media tested, infectivity of the L1 was preserved following incubation in anaerobic conditions. In contrast, the infectivity of worms cultured in nutrient-rich media was almost completely abolished in both microaerobiosis and in the presence of 5% CO₂. Some infectivity was retained in poor or reduced culture media. Comparative analysis of larval infectivity and protein secretion showed that loss of infectivity correlated with the appearance of non-tyvelosylated proteins that in turn may be related to the onset of moulting.  相似文献   

The expression pattern of TIR8 is conserved among vertebrates   总被引：1，自引：0，他引：1  

Federica Riva  Nadia Polentarutti  Giulia Tribbioli  Alberto Mantovani  Cecilia Garlanda  Lauretta Turin 《Veterinary immunology and immunopathology》2009,131(1-2):44-49

IL-1R/TLRs play an important role in the inflammatory responses. Their signaling pathway is tightly regulated to keep inflammation under control. The regulation involves both extracellular and intracellular mechanisms. TIR8, also known as SIGIRR (Single Immunoglobulin IL-1R-Related molecule), is an orphan receptor belonging to the IL-1R/TLRs super-family. Recent studies suggest its role in modulating the inflammatory response in the gastrointestinal tract in mice, acting as an IL-1 receptor family antagonist. We identified the sequence and analyzed the expression of TIR8 in a wide panel of organs and tissues in different animals. There was high homology of the cDNA sequence among human, mouse and the domestic species (74–85%). The pattern of expression of this receptor was similar in all the species examined (high levels in kidney and gastrointestinal tract) and similar to the human. These results demonstrate that TIR8 is conserved, in evolutionary terms, both with regard to sequence and pattern of expression, a finding consistent with a key function of this molecule in modulating inflammation in the gastrointestinal tract.  相似文献   

Effect of paratuberculosis on the diagnosis of bovine tuberculosis in a cattle herd with a mixed infection using interferon-gamma detection assay     

Alvarez J  de Juan L  Bezos J  Romero B  Sáez JL  Marqués S  Domínguez C  Mínguez O  Fernández-Mardomingo B  Mateos A  Domínguez L  Aranaz A 《Veterinary microbiology》2009,135(3-4):389-393

Interferon-gamma (IFN-gamma) detection assay is being applied as an ancillary test to tuberculin tests in the diagnosis of bovine tuberculosis to detect the maximum number of infected animals. Among possible factors influencing the performance of tuberculosis-diagnostic tests, paratuberculosis, a widespread disease in Spain and other European countries, has been pointed out as a cause of false positive reactions. Still, its effect on the sensitivity of these tests in cattle has yet to be fully characterized. The impact of paratuberculosis in the apparent sensitivity of IFN-gamma assay was studied in a bullfighting cattle herd with a mixed tuberculosis-paratuberculosis infection, using culture of Mycobacterium bovis and Mycobacterium avium paratuberculosis as the gold standard to determine the infection status of every animal. A total of 218 animals were slaughtered and sampled for bacteriology after blood sampling. IFN-gamma assay showed a lower apparent sensitivity in animals with a mixed infection (50%) compared to all animals suffering tuberculosis (78.3%). This finding indicates that the presence of paratuberculosis in tuberculosis-infected herds could imply a serious impairment in the sensitivity of IFN-gamma detection test.  相似文献   

Multiple abscesses caused by <Emphasis Type="Italic">Salmonella enterica</Emphasis> and <Emphasis Type="Italic">Corynebacterium pseudotuberculosis</Emphasis> in a dromedary camel     

Tejedor-Junco MT  Lupiola P  Caballero MJ  Corbera JA  Gutierrez C 《Tropical animal health and production》2009,41(5):711-714

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Genetic immunization with the immunodominant antigen P48 of Mycoplasma agalactiae stimulates a mixed adaptive immune response in BALBc mice     

Bernardo Chessa  Marco Pittau  Maria Puricelli  Rosanna Zobba  Elisabetta Coradduzza  Paola Dall&#x;Ara  Sergio Rosati  Giorgio Poli  Alberto Alberti 《Research in veterinary science》2009,86(3):414-420

A DNA vaccine against contagious agalactia was developed for the first time, encoding the P48 of Mycoplasma agalactiae. Specific immune responses elicited in BALB/c mice were evaluated. Both total IgG and IgG1 were detected in mice vaccinated with pVAX1/P48. Proliferation of mononuclear cells of the spleen, levels of gamma interferon, interleukin-12, and interleukin-2 mRNAs were enhanced in immunized animals. Results indicate that pVAX1/P48 vaccination induced both T_h1 and T_h2 immune responses. Nucleic acid immunization could be a new strategy against M. agalactiae infections and may be potentially used to develop vaccines for other Mycoplasma diseases.  相似文献   

A recombinant-based ELISA evaluating the efficacy of netobimin and albendazole in ruminants with naturally acquired fascioliasis     

María Sol Arias  Jos Luis Surez  G.V. Hillyer  Ivn Francisco  Enrique Calvo  Rita Snchez-Andrade  Pablo Díaz  Rubn Francisco  Pablo Díez-Baos  Patrocinio Morrondo  Adolfo Paz-Silva 《Veterinary journal (London, England : 1997)》2009,182(1):73-78

The therapeutic efficacy of albendazole and netobimin in ruminants with naturally occurring fascioliasis was investigated using a recombinant-based ELISA. The variation in the IgG response against a 2.9-kDa recombinant protein (FhrAPS), termed efficacy index (EI) 1, and the egg-output changes, termed EI 2, were used to evaluate drug efficacy.The values of EI 1 ranged between 0% and 50% in sheep, and between 0% and 30% in cattle after treatment with albendazole and netobimin. Similar EI 2 values were observed in sheep receiving albendazole or netobimin, but the highest values were found in cattle treated with netobimin. The significant reduction in the IgG response to FhrAPS found in this study shows promise in terms of developing alternative methods for evaluating the efficacy of chemotherapy against Fasciola hepatica in grazing ruminants.  相似文献   

Intensive, extensive, expensive. Management of distal limb shearing injuries in cats     

Sandra Corr BVMS CertSAS DipECVS FHEA PhD MRCVS   《Journal of Feline Medicine and Surgery》2009,11(9):747-757

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The pharmacokinetics and metabolism of ivermectin in domestic animal species     

González Canga A  Sahagún Prieto AM  José Diez Liébana M  Martínez NF  Vega MS  Vieitez JJ 《Veterinary journal (London, England : 1997)》2009,179(1):25-37

The pharmacokinetic properties of drugs are closely related to their pharmacological efficacy. The kinetics of ivermectin are characterised, in general terms, by a slow absorption process, a broad distribution in the organism, low metabolism, and slow excretion. The kinetics vary according to the route of administration, formulation, animal species, body condition, age, and physiological status, all of which contribute to differences in drug efficacy. Characterisation of ivermectin kinetics can be used to predict and optimise the value of the parasiticide effects and to design programmes for parasite control. This article reviews the pharmacokinetics of ivermectin in several domestic animal species.  相似文献