Antitumor effect of adriamycin entrapped in liposomes conjugated with anti-bovine tumor antigen monoclonal antibody in leukemic cows     

M Onuma  Y Yasutomi  M Yamamoto  S Watarai  T Yasuda  Y Kawakami 《Zentralblatt für Veterin?rmedizin. Reihe B. Journal of veterinary medicine. Series B》1989,36(2):139-147

Monoclonal antibody c143 against tumor-associated antigen (TAA) expressed on bovine leukemia cells was conjugated to liposomes containing adriamycin (ADM), and therapeutic effects of conjugates were examined in leukemic or preleukemic cows to prevent the progression of the disease. Five cows with TAA-positive in their peripheral blood lymphocytes were divided into two groups. Each group of cows received 4 injections of ADM alone (0.4 mg/kg) or c143-conjugated liposomes containing the same dose of ADM (L-AMD-c143) through the jugular vein at about 4 day intervals. In three animals treated with L-ADM-c143, the TAA-positive cells gradually decreased with treatment and finally two animals became TAA-negative during a 6 week period and a 14 week period after treatment, respectively. In the control, two animals treated with ADM alone showed only a slight decrease of TAA-positive cells.  相似文献   

Impact of postovulatory food deprivation on the ova transport, hormonal profiles and metabolic changes in sows.     

P Razdan  A M Mwanza  H Kindahl  F Hultén  S Einarsson 《Acta veterinaria Scandinavica》2001,42(1):45-55

The effect of food deprivation on ova transport, hormonal profiles and metabolic changes was studied in 20 crossbred multiparous sows during their second oestrus after weaning. To determine the time of ovulation, transrectal ultrasonographic examination was performed. The sows were divided into 2 groups, one control group (C-group), which was fed according to Swedish standards, and one experimental group (E-group). The E-group sows were deprived of food from the first morning meal after ovulation until slaughter. Blood samples were collected every second hour from about 12 h before expected ovulation in the second oestrus after weaning until slaughter and were analysed for progesterone, prostaglandin F2 alpha-metabolite, insulin, glucose, free fatty acids and triglycerides. All sows were slaughtered approximately 48 h after ovulation and the genital tract was recovered. The isthmic part of the oviduct was divided into 3 equally long segments and flushed separately with phosphate buffered saline (PBS). Uterine horns were also flushed with PBS. A significantly greater number of ova were found in the first and second part of the isthmus in the E-group (p = 0.05) while in the C-group most of the ova were found in the third part of the isthmus or the uterus (p = 0.01). The level of prostaglandin F2 alpha-metabolite was significantly higher in the E-group compared with the C-group. The concentration of progesterone increased in both groups after ovulation but there were no significant differences between the groups. The other blood parameters showed that the food-deprived sows were in a catabolic state. The 48 h period of fasting results, directly or indirectly in an delayed ova transport, which may be due to a delayed relaxation in the smooth circular muscle layer of the isthmus.  相似文献   

Plasma digoxin concentration in dogs with mitral regurgitation.     

Y Nagashima  H Hirao  S Furukawa  K Hoshi  M Akahane  R Tanaka  Y Yamane 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2001,63(11):1199-1202

Fifteen and eight mature beagles, without (normal group) and with experimental mitral regurgitation (MR group), respectively, were given 0.02 mg/kg/day digoxin powder for 10 days orally. The optimum time for sample collection after administration of digoxin was observed to be 8-18 hr and 10-22 hr in the normal and MR groups, respectively. In both groups, a stable concentration was reached after 3-5 days of treatment. No differences in plasma level were observed between sexes. The optimum concentration of digoxin was attained at an earlier stage than has been previously reported for both dogs and humans.  相似文献   

Seasonal changes in serum total thyroxine, free thyroxine, and canine thyroid-stimulating hormone in clinically healthy beagles in Hokkaido.     

E Oohashi  K Yagi  Y Uzuka  S Tanabe  T Sarashina  T Ishida 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2001,63(11):1241-1243

The purpose of this study was to evaluate seasonal influences on thyroid hormone levels of healthy outdoor dogs in Hokkaido. We surveyed serum basal total thyroxine (tT4), free thyroxine (fT4), and canine thyroid-stimulating hormone (cTSH) levels, and tT4 levels after administration of TSH for a year. Basal tT4 levels decreased in January, and increased in August and September. fT4 levels increased in January and November. No significant seasonal variation was found in cTSH. tT4 levels after administration of TSH in August and November increased. These results suggested that the thyroid gland may have been activated in November. We should take seasonal variation into consideration when thyroid function is tested.  相似文献   

Fisheries for non-native species in England and Wales: angling or the environment?   总被引：3，自引：0，他引：3  

P. Hickley  & S. Chare 《Fisheries Management and Ecology》2004,11(3-4):203-212

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Prevalence and clinical implications of anthelmintic resistance in cyathostomes of horses.     

J L Tarigo-Martinie  A R Wyatt  R M Kaplan 《Journal of the American Veterinary Medical Association》2001,218(12):1957-1960

OBJECTIVE: To determine the prevalence and clinical implications of anthelmintic resistance in cyathostomes of horses. DESIGN: Prospective study. ANIMALS: 80 horses on 10 farms in a 5-county region of northeast Georgia. PROCEDURE: On each farm, horses were stratified in descending order according to pretreatment fecal egg count (FEC), blocked into groups of 4, and then randomly assigned to 1 of 4 treatment groups: no treatment (controls), and treatment with pyrantel pamoate, fenbendazole, or ivermectin. Fecal samples were collected 24 hours prior to treatment and 2, 4, and 6 weeks after treatment for determination of FEC. Mean percentage of reduction in FEC was then calculated for each treatment group. For horses from each farm, the efficacy of each anthelmintic was categorized on the basis of mean percentage of reduction in FEC at 2 weeks after treatment (< 80% reduction = ineffective; 80 to 90% reduction = equivocal; and > 90% reduction = effective). RESULTS: Pyrantel pamoate was effective at reducing FEC in horses from 7 farms, ineffective in horses from 2 farms, and equivocal in horses from 1 farm. Fenbendazole was ineffective at reducing FEC in horses from 9 farms and equivocal in horses from 1 farm. Ivermectin was effective at reducing FEC in horses from all 10 farms. CONCLUSIONS AND CLINICAL RELEVANCE: Results suggest that cyathostome resistance to fenbendazole is highly prevalent, and resistance to pyrantel pamoate is high enough to warrant concern. Resistance to ivermectin was not detected. On the basis of these data, it appears that ivermectin continues to be fully effective in horses. However, too few farms were used in this study to determine the prevalence of cyathostome resistance to ivermectin. Therefore, the efficacy of ivermectin should continue to be monitored closely.  相似文献   

微量元素相对生物学利用率的研究方法     

S.Durosoy 《中国饲料》2004,(23):18-19

有机微量元素具有多种优点,本文阐述了有关外源微量元素生物学利用率,回顾了微量元素不同添加方法的研究成果并进行比较。1影响动物对微量元素吸收的因素微量元素的吸收水平直接影响动物机体对微量元素的利用。如果饲喂量超过机体的代谢量,微量元素的吸收下降;如果饲喂量不足,机体则会提高对微量元素的吸收,这就说明机体自我平衡作用可以调节营养素的吸收。日粮总体消化率及各营养素间的相互作用均会影响矿物质吸收,这种相互作用包括协同作用(如铁和维生素C)和拮抗作用(如钙和锌,铜和钼、硫)。动物种类、品种、年龄、性别等也会影响微量元…  相似文献   

Maladies de l'eucalyptus1     

L. LANIER 《EPPO Bulletin》1986,16(2):255-263

Les eucalyptus constituent—au moins au meme titre que les genres Pinus et Populus—l'un des genres d'arbres forestiers les plus importants à l'échelle mondiale, et en particulier par l'extension considérable des reboisements (plus de 4 millions d'ha) en régions tropicales, sahéliennes et tempérées chaudes. L'article tente de faire le point sur les problèmes posés par les maladies pouvant gener cet effort de reboisement, notamment en région méditerranéenne, et souligne l'importance et l'avenir des eucalyptus dans cette région. Il est procédéà un inventaire général, à l'échelle mondiale, des maladies des eucalyptus et de l'importance des parasites en cause. Un certain nombre d'entre eux sont étudiés plus en détail, selon qu'ils sont présents dans le pays d'origine des eucalyptus ou dans les zones où ils ont été introduits. Une section est réservée à la région méditerranéenne, où certaines maladies s'en prenant aux racines, aux rameaux, aux feuilles ou au bois ont été identifiées; pour l'instant, la plupart d'entre elles ne sont pas trop graves. Enfin, des propositions et des règles de protection phytosanitaire, visant à restreindre les risques d'introduction des parasites les plus dangereux ou d'extension de ceux existant actuellement, sont citées, en insistant sur les risques de transport de maladies d'une région à une autre par l'intermédiaire des échanges de matériel végétal autres que les graines.  相似文献   

Milking the golden cow--her comfort.     

S L Berry 《Journal of the American Veterinary Medical Association》2001,219(10):1382-1387

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No effect of turkey herpesvirus infections on the outcome of avian pneumovirus infections in turkeys.     

S Van de Zande  H Nauwynck  M Pensaert 《Avian diseases》2001,45(2):517-521

To determine whether turkey herpesvirus (HVT) impairs the aspecific and specific defense against an avian pneumovirus (APV) infection, specific-pathogen-free turkeys were inoculated at 7 days of age with HVT and 1, 5, or 7 wk later with APV. Clinical signs, APV replication, and development of antibodies against APV were evaluated. No differences were found between the birds that received both HVT and APV and those that received only APV.  相似文献