A comparison of the survival times of dogs treated with mitotane or trilostane for pituitary-dependent hyperadrenocorticism     

Barker EN  Campbell S  Tebb AJ  Neiger R  Herrtage ME  Reid SW  Ramsey IK 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2005,19(6):810-815

The survival times of 148 dogs treated for pituitary-dependent hyperadrenocorticism were studied using clinical records from 3 UK veterinary centers between 1998 and 2003. Of these animals, 123 (83.1%) were treated with trilostane, while 25 (16.9%) were treated with mitotane. Treatment groups were compared using t-tests and analysis of variance (or their nonparametric equivalents) and chi-square tests. Survival data were analyzed using Kaplan-Meier survival plots and Cox proportional hazard methods. There was no significant difference between the population attributes from each center or between treatment groups. The median survival time for animals treated with trilostane was 662 days (range 8-1,971) and for mitotane it was 708 days (range 33-1,399). There were no significant differences between the survival times for animals treated with trilostane and those treated with mitotane. In the multivariable model (including drug, center, breed group, weight, diagnostic group, and age at diagnosis), only age at diagnosis and weight were significantly negatively associated with survival. Importantly, there was no significant effect of drug choice on survival.  相似文献   

Application of a scaling model to establish and validate an interval level pain scale for assessment of acute pain in dogs     

Morton CM  Reid J  Scott EM  Holton LL  Nolan AM 《American journal of veterinary research》2005,66(12):2154-2166

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Risk factors for musculoskeletal injuries of the lower limbs in Thoroughbred racehorses in New Zealand     

Perkins NR  Reid SW  Morris RS 《New Zealand veterinary journal》2005,53(3):171-183

AIM: To investigate risk factors for injury to musculoskeletal structures of the lower fore- and hind-limbs of Thoroughbred horses training and racing in New Zealand. METHODS: A case-control study analysed by logistic regression was used to compare explanatory variables for musculoskeletal injuries (MSI) in racehorses. The first dataset, termed the Training dataset, involved 459 first-occurrence cases of lower-limb MSI in horses in training, and the second, the Starting dataset, comprised a subset of those horses that had started in at least one trial or race in the training preparation that ended with MSI (n=294). All training preparations for horses that did not suffer from MSI for which complete data were available were used in the analyses as controls, and provided 2,181 and 1,639 preparations for the Training and Starting datasets, respectively. Multivariate logistic regression was used to evaluate risk factors, and results were reported as odds ratios (OR) and 95% confidence intervals (CI). RESULTS: Horses aged > or =5 years were at higher risk of injury than 2-year-olds. Elevated odds of MSI occurred in horses in the Starting dataset that were training in the 1997-1998 year compared with the 1999-2000 year, and in those horses where trials comprised >20% of all starts in a preparation. Training preparations that ended in winter, and horses in their third or later training preparation, had lower odds of MSI compared with those ending in other seasons or the first preparation, respectively. Reduced odds of MSI were observed in preparations in which starts occurred compared with those that had no starts, and in the Starting dataset, preparations that included more than one start had a reduced likelihood of MSI compared with preparations that had only one start. In the Training dataset, preparations longer than 20 weeks were associated with reduced odds of MSI compared with those shorter than 20 weeks. Cumulative racing distance in the last 30 days of a training preparation was best modelled with linear and quadratic terms. Results indicated that increasing cumulative racing distances were associated with an initial reduction in the odds of MSI that then levelled out and finally appeared to increase again as the explanatory variable continued to increase. The risk of MSI varied significantly between trainers. CONCLUSION: This study identified intrinsic (age) and extrinsic risk factors for MSI in training and racing Thoroughbreds in New Zealand. The risk of MSI initially decreased, then increased, as cumulative racing distance increased. Significant variation between trainers indicated management and training methods influence the risk of MSI.  相似文献   

Effect of plane of nutrition, sex and bodyweight on the chemical composition of yorkshire pigs     

G M Babatunde  W G Pond  L D VanVleck  G H Kroening  J T Reid 《Journal of animal science》1967,26(4):718-726

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Coccidiosis immunity following early and late exposure to Marek's disease   总被引：1，自引：0，他引：1  

J T Rice  W M Reid 《Avian diseases》1973,17(1):66-71

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Studies on ovine fascioliasis. I. Observations on the sequential development of the naturally-acquired disease     

J F Reid  J Armour  G M Urquhart  F W Jennings 《The Veterinary record》1970,86(9):242-249

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Xeroradiographic evaluation of the equine larynx     

P G Orsini  C W Raker  C F Reid  P Mann 《American journal of veterinary research》1989,50(6):845-849

The normal radiographic anatomy of the equine larynx was determine by use of xeroradiography and dissection. The body and laminae of the thyroid cartilage, the muscular process of the arytenoid cartilages, and the dorsal lamina and arch of the cricoid cartilage had radiographic evidence of mineralization (calcification) and/or ossification in clinically normal horses. There was a significant (P less than 0.01) increase in the degree of mineralization of the thyroid and arytenoid cartilages with advancing age. Horses with diagnosis of arytenoid chondrosis (arytenoid chondral dysplasia, arytenoid chondropathy) by use of endoscopy had radiographic changes that included: enlargement with increased density of the arytenoid cartilage region, abnormal patterns of mineralization (dystrophic mineralization or osseous metaplasia), abnormal contour of the corniculate process(es) and laryngeal masses, sometimes obliterating part or all of the lateral laryngeal ventricles.  相似文献   

Effect of body size on gastric emptying using the 13C-octanoic acid breath test     

Yam PS  McLellan J  Wyse C  Reid SW  Cooper J  Preston T 《The Journal of small animal practice》2004,45(8):386-389

The 13C-octanoic acid breath test (OABT) may be a useful non-invasive method for assessing the rate of gastric emptying in dogs. The aim of this study was to determine whether an association exists between body size and rate of gastric emptying in dogs. Fifty-five dogs ranging from 6 to 39 kg were recruited and rate of gastric emptying was assessed using the OABT. The time to peak 13CO2 excretion (tmax) and half-dose recovery time (t1/2) were calculated. The OABT was simple to perform and well tolerated by the dogs. Mean (sd) tmax was 2.67 hours (0.6) and mean t1/2 was 3.38 hours (0.79). Inter-individual variation in the rate of gastric emptying was 23.3 per cent for t1/2 and 22.5 per cent for tmax. No association was detected between the rate of gastric emptying and body surface area, mass, age, sex or test operator. The OABT may be a useful non-invasive and non-radioactive test for assessment of the rate of gastric emptying in dogs in clinical practice.  相似文献   

Putative role of pith cell wall phenylpropanoids in Sesamia nonagrioides (Lepidoptera: Noctuidae) resistance     

Santiago R  Butron A  Arnason JT  Reid LM  Souto XC  Malvar RA 《Journal of agricultural and food chemistry》2006,54(6):2274-2279

The stem borer Sesamia nonagrioides (Lefèbvre) is the most important insect pest that attacks maize, Zea mays L., in northwestern Spain. Host plant resistance to this borer was investigated in relation to the cell wall phenylpropanoids content in the pith. Eight inbred lines that differ in resistance were analyzed. Three major simple phenolic acids, p-coumaric, trans-ferulic, and cis-ferulic acids, and three isomers of diferulic acid, 8-5', 8-O-4', and 8-5'b (benzofuran form), were identified. The amount of all these compounds was correlated with the resistance level in the genotypes, with the resistant inbreds having the highest concentrations. The role of these compounds in cell wall fortification and lignification is well-documented, suggesting their possible intervention in S. nonagrioides resistance. Future studies that focus on these compounds could be useful to enhance S. nonagroides resistance.  相似文献   

Foot-and-mouth disease virus: a first inter-laboratory comparison trial to evaluate virus isolation and RT-PCR detection methods     

Ferris NP  King DP  Reid SM  Hutchings GH  Shaw AE  Paton DJ  Goris N  Haas B  Hoffmann B  Brocchi E  Bugnetti M  Dekker A  De Clercq K 《Veterinary microbiology》2006,117(2-4):130-140

Five European reference laboratories participated in an exercise to evaluate the sensitivity and specificity of their routinely employed RT-PCR tests and cell cultures for the detection and isolation of foot-and-mouth disease (FMD) virus. Five identical sets of 20 coded samples were prepared from 10 vesicular epithelia, which were derived from submissions from suspect cases of FMD or swine vesicular disease (SVD). Sixteen samples were derived from six FMD virus positive epithelia representing four different serotypes (two each of types O and A and one each of types Asia 1 and SAT 2), two from samples which had been found to be negative by antigen ELISA and virus isolation (VI) in cell culture and two from SVD virus positive epithelia. Some of the FMD virus positive samples were prepared from 10-fold serial dilutions of three of the initial suspensions. Each laboratory tested the samples by one or more of its available RT-PCR procedures and inoculated cell cultures that it routinely uses for FMD diagnosis in attempts to isolate virus, the specificity of which was confirmed by antigen ELISA. The best of the RT-PCR assays used in each laboratory gave comparable results while the sensitivity of cell cultures was variable from high in one laboratory, moderate in two and low in two others. This prototype panel of samples would appear suitable for external quality assurance of these tests but would benefit from the inclusion of more negative samples and an extension in the serial dilution range of one or more of the FMD positive sample titration series.  相似文献