Effect of tryptophana as dietary supplement on dogs with abnormal-repetitive behaviors     

Patricia Kaulfuss  Sara Hintze  Hanno Würbel 《Journal of Veterinary Behavior: Clinical Applications and Research》2009,4(2):97

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Cider proteins and foam characteristics: a contribution to their characterization     

Blanco-Gomis D  Mangas-Alonso JJ  Junco-Corujedo S  Gutiérrez-Alvarez MD 《Journal of agricultural and food chemistry》2007,55(7):2526-2531

A capillary sieving electrophoretic method for protein analysis and molecular weight determination was used to characterize ciders from Asturias, northern Spain. The total protein content (Bradford method) and the foam parameters (Bikerman method) were also analyzed to complete this characterization. The polypeptide profile, based on the molecular weight, together with exploratory and classification techniques, that is, principal component analysis (PCA) or linear discriminant analysis (LDA), allowed ciders to be differentiated on the basis of their foam assessment and the apple juice extraction technology used in the cidermaking process. In addition, the application of correlation analysis, that is, canonical correlations (CCA) or partial least-squares (PLS), revealed that the proteins with higher molecular weight were more relevant with respect to cider foamability. PLS analysis also provided a mathematical equation that is able to predict the stabilization time of foam from the polypeptide profile of the cider, because this is the foam parameter most influenced by these compounds.  相似文献   

Standardization of canine meningioma grading: Validation of new guidelines for reproducible histopathologic criteria     

Sara Belluco  Giuseppe Marano  Thibaut Lurier  Giancarlo Avallone  Chiara Brachelente  Stefano Di Palma  Roberta Rasotto  Kerstin Baiker  Andreas Beineke  Anna Oevermann  Frauke Seehusen  Fabiano José Ferreira de Sant'Ana  Patrizia Boracchi  Martí Pumarola  Maria Teresa Mandara 《Veterinary and comparative oncology》2023,21(4):685-699

Canine meningiomas are currently graded using the human grading system. Recently published guidelines have adapted the human grading system for use in dogs. The goal of this study was to validate the new guidelines for canine meningiomas. To evaluate the inter-observer agreement, 5 veterinary surgical pathologists graded 158 canine meningiomas following the human grading system alone or with the new guidelines. The inter-observer agreement for histologic grade and each of the grading criteria (mitotic grade, invasion, spontaneous necrosis, macronucleoli, small cells, hypercellularity, pattern loss and anaplasia) was evaluated using the Fleiss kappa index. The diagnostic accuracy (sensitivity and specificity) was assessed by comparing the diagnoses obtained with the 2 grading systems with a consensus grade (considered the reference classification). The consensus histologic grade was obtained by agreement between 4 experienced veterinary neuropathologists following the guidelines. Compared with the human grading alone, the canine-specific guidelines increased the inter-observer agreement for: histologic grade (κ = 0.52); invasion (κ = 0.67); necrosis (κ = 0.62); small cells (κ = 0.36); pattern loss (κ = 0.49) and anaplasia (κ = 0.55). Mitotic grade agreement remained substantial (κ = 0.63). The guidelines improved the sensitivity in identifying grade 1 (95.6%) and the specificity in identifying grade 2 (96.2%) meningiomas. In conclusion, the new grading guidelines for canine meningiomas are associated with an overall improvement in the inter-observer agreement and higher diagnostic accuracy in diagnosing grade 1 and grade 2 meningiomas.  相似文献