Comparison of effects of dexamethasone and the leukotriene D4 receptor antagonist L-708,738 on lung function and airway cytologic findings in horses with recurrent airway obstruction     

Lavoie JP  Léguillette R  Pasloske K  Charette L  Sawyer N  Guay D  Murphy T  Hickey GJ 《American journal of veterinary research》2002,63(4):579-585

OBJECTIVE: To evaluate whether the leukotriene (LT) D4 receptor antagonist L-708,738 is therapeutically beneficial in treating horses with recurrent airway obstruction (heaves). ANIMALS: 12 adult horses with heaves and healthy lung lobes from 20 slaughtered horses. PROCEDURE: Lung lobes were used for smooth muscle tension and radioligand binding studies. Horses with heaves were given a placebo for 14 days and administered L-708,738 (n = 6; 2.5 mg/kg PO, q 12 h) or dexamethasone (6; 0.04 mg/kg, IV, q 24 h) from days 14 to 28. Pulmonary function was measured weekly for 36 days, and bronchoalveolar cells were collected on days 0,14, and 29 for cytologic examination. RESULTS: Nanomolar concentrations of L-708,738 were effective at antagonizing LTD4-induced bronchoconstriction and LTD4-receptor binding in lung lobes. Mean peak and trough L708,738 plasma concentrations during the treatment period were 1.54 and 0.28 microM, respectively. On days 21 and 29, lung mechanics were significantly improved in the dexamethasone-treated horses but not in the L-708,738-treated horses. Neither dexamethasone nor L-708,738 had a significant effect on cytologic findings. CONCLUSIONS AND CLINICAL RELEVANCE: L-708,738 was bioavailable after oral administration and sustained concentrations in plasma during the dosing period that exceeded in vitro efficacy values. However, airway function did not improve, suggesting that either drug concentrations in the lungs were subtherapeutic or that cysteinyl LT may not be important mediators of airway inflammation in heaves. Results provide the first evidence of cysteinyl LT1 receptors in airways of horses.  相似文献   

THE TELEPHONE AMONG THE INDIANS     

Sawyer EF 《Science (New York, N.Y.)》1880,1(16):191-192

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Freezing complete polymerase chain reaction master mix reagents for routine molecular diagnostics.     

Donna Marie West  Jason Sawyer 《Journal of veterinary diagnostic investigation》2006,18(6):580-582

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Border disease-like syndrome in lambs: antibodies to hog cholera and bovine viral diarrhea viruses   总被引：3，自引：0，他引：3  

B I Osburn  G L Clarke  W C Stewart  M Sawyer 《Journal of the American Veterinary Medical Association》1973,163(10):1165-1167

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Nicotine blocks the suckling-induced rise in circulating prolactin in lactating rats   总被引：2，自引：0，他引：2  

C A Blake  C H Sawyer 《Science (New York, N.Y.)》1972,177(49):619-621

In lactating rats the rapid suckling-induced release of pituitary prolactin into circulating blood is inhibited by a subcutaneous injection of nicotine. This treatment does not block the lesser "stress-induced" rise in prolactin in response to either. Although nicotine may impair milk production by its effect on prolactin release, it does not appear to block milk ejection from the lactating mammary gland.  相似文献   

Passive transfer of colostral immunoglobulins from ewe to lamb and its influence on neonatal lamb mortality   总被引：3，自引：0，他引：3  

M Sawyer  C H Willadsen  B I Osburn  T C McGuire 《Journal of the American Veterinary Medical Association》1977,171(12):1255-1259

The transfer of immunoglobulin G (IgG) and immunoglobulin M (IgM) from ewe to lamb was quantitated to determine the occurrence of failure in passive transfer. Concentrations of IgG and IgM in ewe serum did not correlate with those in the colostrum. Colostrum from all ewes contained abundant amounts of immunoglobulins when compared with serum values, with IgG being selectively concentrated over IgM. Absorption through the intestinal tract of the lamb appeared to be a nonselective process, lacking predilection for IgG and IgM. All lambs tested 24 hours after birth absorbed colostral immunoglobulins to some extent; however, 13 (14%) of 91 clinically normal lambs demonstrated some failure of passive transfer. In contrast, failure of passive transfer was found in 27 (46%) of 59 lambs dying of natural causes between 24 hours and 5 weeks of age. Evidence presented emphasizes the importance of absorption of adequate amounts of immunoglobulins to enable the newborn lamb to survive the first few weeks of life.  相似文献   

Yield variability among Katahdin seed sources     

R. L. Sawyer  R. C. Cetas 《American Journal of Potato Research》1962,39(3):116-121

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Anhydrous ammonia vs. ammonium nitrate as sources of nitrogen for rye cover crops on the potato soils of long Island1     

S. L. Dallyn  R. L. Sawyer 《American Journal of Potato Research》1964,41(7):201-207

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Some considerations on processing plant location     

Richard L. Sawyer 《American Journal of Potato Research》1960,37(12):424-427

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Call for papers     

Richard L. Sawyer 《American Journal of Potato Research》1963,40(2):62-62

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