Suppression of testicular function using two dose rates of a reversible water soluble gonadotrophin releasing hormone (GnRH) vaccine in colts     

KF DOWSETT  LM KNOTT  U. TSHEWANG  AE JACKSON  DAY BODERO  TE TRIGG 《Australian veterinary journal》1996,74(3):228-235

Objective: To investigate the effect of two dose rates (200 and 400 ng) of a gonadotrophin releasing hormone (GnRH) vaccine on testicular function. Design: A vaccination dose rate experiment. Procedure: Two injections were administered 4 weeks apart to six colts in each treatment group. To maintain immunosuppression until the end of the breeding season, a third injection was given if antibody titres fell below 1000. Results: Effective antibody titres were present for 12 to 27 weeks. Testosterone concentrations decreased from 2.22 to 0.31 nmol/L 6 weeks after primary vaccination. Androstenedione concentrations decreased from 1.78 to 0.28 nmol/L 5 weeks after vaccination. Testosterone and androstenedione concentrations above 0.69 and 0.87 nmol/L were attained 31 to 43 weeks after vaccination. Mean scrotal widths and lengths decreased over 29 weeks from 9.2 cm and 9.7 cm to 6.7 cm and 7.6 cm. At surgical castration these dimensions were 10.1 cm and 11.0 cm. Mean semen characteristics before vaccination and after recovery were: gel-free volume 16.5 and 13.5 mL, sperm concentration 295.5 times 10⁶ 315.6 times 10⁶/mL, total sperm per ejaculate 4041 times 10⁶ 4657 times 10⁶ live normal spermatozoa 32% and 60%. Histologically, the testes showed active spermatogenesis. The mean testicular parenchyma weights for the 200 and 400 mg groups were 129.0 g and 109.8 g. Daily sperm production per testis and per gram of testis for the 200 and 400 mg groups were 3.7 times 10⁸ 2.8 times 10⁶ 2.3 times 10⁸ 2.0 times 10⁶. Conclusions: Both dose rates suppressed testicular function. Data showed that the vaccine effects were reversible. Individual immune response was less varied in the 200 mg group. Further work is necessary to achieve a less variable response in the immunosuppression of testicular function.  相似文献   

In this issue – January/February 2018          下载免费PDF全文

AE Jackson 《Australian veterinary journal》2018,96(1-2):1-2

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In this issue – March 2018          下载免费PDF全文

AE Jackson 《Australian veterinary journal》2018,96(3):55-56

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In this issue – December 2014     

AE Jackson  L Cabral 《Australian veterinary journal》2014,92(12):459-460

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Erratum     

AE Jackson 《Australian veterinary journal》2014,92(11):432-432

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Type of kindergarten and other potential determinants of overweight in pre-school children   总被引：3，自引：0，他引：3  

Rapp K  Schick KH  Bode H  Weiland SK 《Public health nutrition》2005,8(6):642-649

OBJECTIVE: The study aimed to assess the relationship of various types of kindergarten differing in length of care and food availability with the development of overweight in pre-school children. DESIGN, SETTING AND SUBJECTS: A cross-sectional study was carried out in 2002 in Stuttgart, Germany, as part of the school entrance examination. Height and weight of 2140 children (participation 70.2%) were measured and information on type of kindergarten and other potential determinants of overweight was collected by a parental questionnaire. Change in relative body mass index (BMI) position between the ages of 4 and 6 years was assessed using medical records. RESULTS: The prevalence of overweight or change in relative BMI position did not differ according to the type of kindergarten. For the prevalence of overweight in German children, adjusted odds ratios (OR) comparing institutions that open only in the morning with those opening in the morning and afternoon or for the full day were 0.86 (95% confidence interval (CI) 0.40, 1.83) and 0.63 (95% CI 0.25, 1.58), respectively. Parental BMI and duration of television watching were positively associated, and maternal educational status and duration of breast-feeding were negatively associated, with overweight and/or change in relative BMI position. The prevalence of overweight was substantially higher among non-German than among German children (adjusted OR 2.17 (95% CI 1.53, 3.07)). CONCLUSIONS: These data show no association between different types of kindergarten and the development of overweight in early childhood. Duration of television watching and breast-feeding, as well as the relatively high prevalence of overweight in ethnic minorities, deserve further attention.  相似文献   

Possibility of leaching of organic nitrogen in a field under heavy application of organic matter-model experiment using soil columns     

Nobuyuki MIURA  Noriharu AE 《Soil Science and Plant Nutrition》2006,52(1):134-135

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The crystal structure of [Fe]-hydrogenase reveals the geometry of the active site     

Shima S  Pilak O  Vogt S  Schick M  Stagni MS  Meyer-Klaucke W  Warkentin E  Thauer RK  Ermler U 《Science (New York, N.Y.)》2008,321(5888):572-575

Biological formation and consumption of molecular hydrogen (H2) are catalyzed by hydrogenases, of which three phylogenetically unrelated types are known: [NiFe]-hydrogenases, [FeFe]-hydrogenases, and [Fe]-hydrogenase. We present a crystal structure of [Fe]-hydrogenase at 1.75 angstrom resolution, showing a mononuclear iron coordinated by the sulfur of cysteine 176, two carbon monoxide (CO) molecules, and the sp2-hybridized nitrogen of a 2-pyridinol compound with back-bonding properties similar to those of cyanide. The three-dimensional arrangement of the ligands is similar to that of thiolate, CO, and cyanide ligated to the low-spin iron in binuclear [NiFe]- and [FeFe]-hydrogenases, although the enzymes have evolved independently and the CO and cyanide ligands are not found in any other metalloenzyme. The related iron ligation pattern of hydrogenases exemplifies convergent evolution and presumably plays an essential role in H2 activation. This finding may stimulate the ongoing synthesis of catalysts that could substitute for platinum in applications such as fuel cells.  相似文献   

New perspective to control of tenacibaculosis in sea bass Dicentrarchus labrax L          下载免费PDF全文

Riad H Khalil  Amany M Diab  Medhat S Shakweer  Hanan A Ghetas  Mohammed M Khallaf  Amira AE‐D Omar 《Aquaculture Research》2018,49(7):2357-2365

This work was carried out to investigate the effects of injection of Tenacibaculum maritimum formalin‐killed cells (FKC), extracellular products (ECPs) and crude lipopolysaccharide (LPS) as well as 1% feed supplements of oil extracts of Echinacea purpurea and Origanum vulgare on sea bass immunity improvement to the favour of T. maritimum experimental infection control after 4 weeks of the experiment. Tenacibaculum maritimum isolated from naturally infected sea bass showed brown to yellowish‐brown lesions (sores) on gills, skin and/or fins and identified by different biochemical methods and polymerase chain reaction technique. Immune parameters namely, total protein, globulin and lysozyme activity, as well as the relative level of protection were improved by T. maritimum (FKC), (LPS), (ECPs), O. vulgare and E. purpurea, respectively compared with control. Histopathological examination of T. maritimum naturally infected sea bass indicated many pathological changes in gill, skin and musculatures. Present study could be concluded that application of T. maritimum (FKC), (LPS), (ECPs), O. vulgare or E. purpurea improved sea bass immunity to the favour of disease resistance against T. maritimum. Further investigations on the combination between the previous control methods and the vaccine application methods will be needed.  相似文献   

Prevalence of exon 11 internal tandem duplications in the C‐KIT proto‐oncogene in Australian canine mast cell tumours          下载免费PDF全文

VS Tamlin  AE Kessell  RJ Mccoy  EC Dobson  TS Smith  M Hebart  L Brown  D Mitrovic  AE Peaston 《Australian veterinary journal》2017,95(10):386-391

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