Enhanced mechanical properties of silk fibroin-based composite plates for fractured bone healing     

Youngeun Choi  Se Youn Cho  Semi Heo  Hyoung-Joon Jin 《Fibers and Polymers》2013,14(2):266-270

We successfully fabricated bacterial cellulose/silk fibroin (BC/SF) composite plates having similar strength to that of human cortical bone (12.8–17.7 GPa). The mechanical properties of the BC/SF composite plates were investigated at various BC nanofiber contents. The BC nanofibers acted as good reinforcements for the stress transfer produced by the interactions between the BC nanofibers and the SF matrix, as confirmed by the molecular deformation of the BC nanofibers. The BC/SF composite plates have a promising potential as a replacement material for existing metal bone plate.  相似文献   

Enhanced dielectric properties of electrospun titanium dioxide/polyvinylidene fluoride nanofibrous composites     

Hyun Ho Park  Youngeun Choi  Doo Jin Park  Se Youn Cho  Young Soo Yun  Hyoung-Joon Jin 《Fibers and Polymers》2013,14(9):1521-1525

Titanium dioxide/polyvinylidene fluoride (TiO₂/PVDF) composite was prepared by electrospinning process to enhance the dielectric properties for application as a gate insulator in organic thin-film transistors (OTFTs). Scanning electron microscopy, thermogravimetric analysis, and X-ray diffraction were employed to characterize the as-prepared samples, and then their dielectric constants were investigated by impedance analysis. The impedance results show that the dielectric constant of the electrospun TiO₂/PVDF nanofibers is higher than those of other samples, demonstrating that electrospun TiO₂/PVDF composite can be a proper candidate for gate insulators in OTFTs.  相似文献   

Pentacene crystal formation on the surface of silk fibroin films     

Youngeun Choi  Young Soo Yun  Se Youn Cho  Min Eui Lee  Hyoung-Joon Jin 《Fibers and Polymers》2013,14(12):2006-2009

Silk fibroin (SF) has attracted interest as a gate dielectric due to its electrical insulation and high mobility in pentacene based organic thin film transistors (OTFTs). In this research, the surface energy of SF is controlled by water annealing, ethanol, and methanol solution treatments in order to study the effect of pentacene morphology on SF thin films with various treatments. For different crystallization methods, the crystal structures and surface energies of SF were investigated in detail by FT-IR and contact angle. Methanol treated SF thin film has a lower surface energy than the other two thin films. Topologies of pentacene on the SF thin films with various surface energies were obtained by atomic force microscopy (AFM). The AFM results showed that the smallest grain size of pentacene was that on methanol treated SF thin film which demonstrated that methanol treated SF thin film can be a proper candidate for a gate dielectric in OTFTs.  相似文献   

Comparison of two electroretinography systems used in dogs: the HMsERG and the RETIport     

Jeong MB  Son WG  Park YW  Kim SE  Park SA  Seo KM 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2011,73(4):431-438

The purpose of the study was to compare two different electroretinography (ERG) instruments used on the same animal in a laboratory setting. Retinal function in both eyes of 12 healthy miniature schnauzers was evaluated under general anesthesia. Scotopic and photopic ERGs were recorded by the HMsERG and the RETIport using the Dog Standard Protocol recommended by the European College of Veterinary Ophthalmologists (ECVO). The waveforms of the ERGs obtained by the two ERG units were similar to those described in previous studies. The 90% reference ranges using the multiple of medians (MoM) showed that the changes in ERG parameters obtained by the HMsERG unit were very similar to those of the RETIport for most ERG responses, except for a few. The results demonstrate that the two ERG systems are comparable for evaluating retinal function in dogs. Further, the results also show that it is necessary to establish ERG system-specific limits of normality in each laboratory or clinic in order to obtain a correct diagnosis, for example by using a graphical representation of the 90% reference range.  相似文献   

In Vitro and In Silico Characterization of G-Protein Coupled Receptor (GPCR) Targets of Phlorofucofuroeckol-A and Dieckol     

Pradeep Paudel  Su Hui Seong  Se Eun Park  Jong Hoon Ryu  Hyun Ah Jung  Jae Sue Choi 《Marine drugs》2021,19(6)

Phlorotannins are polyphenolic compounds in marine alga, especially the brown algae. Among numerous phlorotannins, dieckol and phlorofucofuroeckol-A (PFF-A) are the major ones and despite a wider biological activity profile, knowledge of the G protein-coupled receptor (GPCR) targets of these phlorotannins is lacking. This study explores prime GPCR targets of the two phlorotannins. In silico proteocheminformatics modeling predicted twenty major protein targets and in vitro functional assays showed a good agonist effect at the α2C adrenergic receptor (α_2CAR) and an antagonist effect at the adenosine 2A receptor (A_2AR), δ-opioid receptor (δ-OPR), glucagon-like peptide-1 receptor (GLP-1R), and 5-hydroxytryptamine 1A receptor (5-TH_1AR) of both phlorotannins. Besides, dieckol showed an antagonist effect at the vasopressin 1A receptor (V_1AR) and PFF-A showed a promising agonist effect at the cannabinoid 1 receptor and an antagonist effect at V_1AR. In silico molecular docking simulation enabled us to investigate and identify distinct binding features of these phlorotannins to the target proteins. The docking results suggested that dieckol and PFF-A bind to the crystal structures of the proteins with good affinity involving key interacting amino acid residues comparable to reference ligands. Overall, the present study suggests α_2CAR, A_2AR, δ-OPR, GLP-1R, 5-TH_1AR, CB₁R, and V_1AR as prime receptor targets of dieckol and PFF-A.  相似文献   

Subcritical water extraction of antioxidant compounds from rosemary plants   总被引：7，自引：0，他引：7  

Ibañez E  Kubátová A  Señoráns FJ  Cavero S  Reglero G  Hawthorne SB 《Journal of agricultural and food chemistry》2003,51(2):375-382

Subcritical water extraction at several temperatures ranging from 25 to 200 degrees C has been studied to selectively extract antioxidant compounds from rosemary leaves. An exhaustive characterization of the fractions obtained using subcritical water at different temperatures has been carried out by LC-MS, and the antioxidant activities of the extracts have been measured by a free radical method (DPPH). Results indicate high selectivity of the subcritical water toward the most active compounds of rosemary such as carnosol, rosmanol, carnosic acid, methyl carnosate, and some flavonoids such as cirsimaritin and genkwanin. The antioxidant activity of the fractions obtained by extraction at different water temperatures was very high, with values around 11.3 microg/mL, comparable to those achieved by SFE of rosemary leaves. A study of the effect of the temperature on the extraction efficiency of the most typical rosemary antioxidant compounds has been performed.  相似文献   

RECENT ADVANCES IN ARTIFICIAL INSEMINATION.     

D. S. Wishart  B.V.Se. 《Australian veterinary journal》1956,32(2):42-46

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PENICILLIN SERUM LEVELC IN THE DOG FOLLOWING ORAL DOSAGE WITH A CALCIUM SALT OF PENICILLIN V     

P. B. English  B.V.Se. 《Australian veterinary journal》1958,34(7):202-206

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THE SYMPTOMS, DIAGNOSIS AND TREATMENT OF SNAKE-BITE IN THE DOG     

R. N. Gordon  B.V.Se. 《Australian veterinary journal》1958,34(7):216-221

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A serological investigation of caseous lymphadenitis in four flocks of sheep     

Malone FE  Fee SA  Kamp EM  King DC  Baird GJ  O'Reilly KM  Murdock FE 《Irish veterinary journal》2006,59(1):19-21

A double antibody sandwich ELISA developed by ID-DLO, Lelystad to detect Corynebacterium pseudotuberculosis infection was used on 329 sheep from four pedigree Suffolk flocks in which clinical cases of caseous lymphadenitis (CLA) had occurred. At subsequent necropsy, typical CLA lesions were seen in 133 sheep, and the diagnosis was confirmed on culture. Lesions were most commonly seen in lungs (n = 46), parotid lymph nodes (n = 44), prescapular lymph nodes (n = 38) and mediastinal lymph nodes (n = 31). The sensitivity of the ELISA test for detecting culture-positive sheep was 0.88, while the specificity of the test was 0.55. The antibody ELISA detected 87.5 per cent of sheep that had CLA lesions restricted to internal organs only. It was concluded that the ELISA test has a valuable role in detecting sheep with both clinical and subclinical CLA.  相似文献