盐酸苯噁唑在鹿体内的药代动力学研究     

尹柏双  哈达  王洪斌  高利 《畜牧兽医学报》2011,42(1)

本研究的主要目的是建立鹿血浆盐酸苯嗯唑浓度反相高效液相色谱紫外检测法,探讨盐酸苯噁唑在鹿血浆中的药代动力学.6只临床健康的梅花鹿,同一环境下饲养后肌内注射盐酸苯恶唑(0.44 mg·kg-1),颈静脉采血8 mL后分离血浆,通过建立的高效液相色谱检测法,测定各采血时间的血浆药物浓度.结果表明,盐酸苯噁唑单剂量肌内注射给药后,药代动力学符合吸收一室模型,药代动力学参数吸收半衰期(t1/2Ka)、消除半衰期(t1/2Ke)分别为(2.09±0.34)、(13.18±0.24)min,血浆药时曲线下面积(AUC0→∞)为(70±3.50)(μg·mL-1)·min,最大血药浓度(Cmax)为(4.70±0.50)μg·mL-1,血药达峰时间(Tpeak)为(12.46±0.12)min.试验结果提示,盐酸苯噁唑在鹿体内吸收快,消除迅速,4 h后血浆中无药物残留.  相似文献   

A comparison of the pathogenicity of two strains of hog cholera virus: 2. Virological studies     

S. KAMOLSIRIPRICHAIPORN  CJ MORRISSY  HA WESTBURY 《Australian veterinary journal》1992,69(10):245-248

Quantitative and qualitative differences were demonstrated in the amount of virus in a range of tissues from pigs infected with either the Weybridge or New South Wales (NSW) strains of hog cholera (HC) virus. The titre of the Weybridge strain in samples, as assessed by either virus titration in cell culture or by the density of specific fluorescing cells in tissue sections, was higher than that for the NSW strain. This correlated with the greater severity of the clinico-pathological syndrome induced by the Weybridge strain. The implications of the differences in the virus content of tissues in the diagnosis of HC is discussed as is the use of monoclonal antibodies to differentiate HC and bovine virus diarrhoea viruses.  相似文献   

Uterine Responses to Exogenous Oxytocin Before and After Pre-partum Luteolysis in the Cow     

MAM Taverne  NCM de Schwartz  M Kankofer  MM Bevers  HA van Oord  D Schams  St Gutjahr  & GC van der Weijden 《Reproduction in domestic animals》2001,36(5):267-272

The aim of this study was to test the functional status of uterine oxytocin receptors in cows in vivo around parturition. The animals received consecutive, intra‐arterial injections of 800, 1600 and 3200 mU of oxytocin at three different stages: during late gestation (days 260–274), at 12 h and at 24 h after intramuscular injection of a prostaglandin F_2α analogue at day 275 to induce parturition. Cows (n=6) had been provided with myometrial electrodes and a catheter had been installed in the aorta and in a branch of the uterine vein (UV). Regular blood samples were obtained from the UV from 5 min before until 45 min after each oxytocin injection to measure plasma levels of prostaglandin F_2α (PGF_2α) and oxytocin. Uterine electromyographic (EMG) activity was registered continuously during each experiment. The increase of oxytocin levels in UV plasma after intra‐arterial injections was dose dependent (p < 0.02). Pre‐ and post treatment oxytocin levels at 24 h after induction of parturition were significantly increased (p=0.0313). Both during late pregnancy and at 12 h after induction of parturition, oxytocin caused a significant increase in EMG activity (p=0.022). After the 3200 mU dose the increase was significantly higher than with the other 2 doses (p=0.004). After each dose, EMG activity returned to baseline levels within some 15 min. At 24 h after induction of parturition, the pre‐treatment level of EMG activity had increased. Doses of 800 mU and 1600 mU of oxytocin produced a significant (p=0.022) increment of EMG activity, which was of the same magnitude as during the preceding stages; after 3200 mU of oxytocin the response was significantly higher than before (p=0.008). No significant increases of PGF_2α levels in UV plasma could be measured after oxytocin injections at any of the three stages. It is concluded that the myometrium of the pregnant cow responds in vivo to physiological doses of oxytocin. At 24 h after induction of parturition, when luteolysis has occurred and a parturient pattern of parturient myometrial activity has already started to develop, the response is enhanced. Physiological doses of oxytocin did not evoke a spurt release of PGF_2α in uterine venous blood during the peripartal period.  相似文献   

计算机辅助仪器分析教学     

哈玲津  王金娥 《天津农学院学报》2004,11(Z1):122-125

将计算机引入仪器分析教学中,可以激发学生学习的积极性和兴趣,提高教学质量;利用分析仪器的计算机仿真技术,学生可以获得与实际操作仪器一样的经验.  相似文献   

Modeling the Exchanges of Energy, Water, and Carbon Between Continents and the Atmosphere   总被引：19，自引：0，他引：19  

PJ Sellers  RE Dickinson  DA Randall  AK Betts  FG Hall  JA Berry  GJ Collatz  AS Denning  HA Mooney  CA Nobre  N Sato  CB Field  A Henderson-Sellers 《Science (New York, N.Y.)》1997,275(5299):502-509

Atmospheric general circulation models used for climate simulation and weather forecasting require the fluxes of radiation, heat, water vapor, and momentum across the land-atmosphere interface to be specified. These fluxes are calculated by submodels called land surface parameterizations. Over the last 20 years, these parameterizations have evolved from simple, unrealistic schemes into credible representations of the global soil-vegetation-atmosphere transfer system as advances in plant physiological and hydrological research, advances in satellite data interpretation, and the results of large-scale field experiments have been exploited. Some modern schemes incorporate biogeochemical and ecological knowledge and, when coupled with advanced climate and ocean models, will be capable of modeling the biological and physical responses of the Earth system to global change, for example, increasing atmospheric carbon dioxide.  相似文献   

ESR法在五种植物类辐照食品检测中应用     

汪昌保  赵永富  哈益明  李俐俐  石岩 《核农学报》2013,27(5):613-618

本文以辣椒粉、干蘑菇、干红枣、核桃和螺旋藻等5种植物类食品为对象,研究了γ辐照诱导产生的ESR波谱特征,以此作为辐照产品鉴别的检测依据,并用此方法对南京辐照中心日常辐照产品进行了3年跟踪检测。结果表明:利用辐照前后ESR波谱的差异可以检测产品辐照与否。常规辐照剂量下,辣椒粉、干蘑菇、红枣辐照的正判率为100%,核桃粉和螺旋藻粉的正判率分别为80%～88%和85%～92%。ESR法在辐照产品快速鉴别和质量控制中有广泛的应用前景。  相似文献   

A major QTL for gluten strength in durum wheat (Triticum turgidum L. var. durum)     

Ajay Kumar  Elias M. Elias  Farhad Ghavami  Xin Xu  Shalu Jain  Frank A. Manthey  Mohamed Mergoum  Mohammed S. Alamri  Penny M.A. Kianian  Shahryar F. Kianian 《Journal of Cereal Science》2013

Gluten strength is an important characteristic, determining the end product quality of durum wheat semolina. To identify the genetic basis of gluten strength in North Dakota durum cultivars, a doubled haploid population was developed from the cross of a weak gluten cultivar ‘Rugby’ and a strong gluten cultivar ‘Maier’. A framework linkage map consisting of 228 markers was constructed and used with phenotypic data on gluten strength (measured by sedimentation volume) to conduct single- and two-locus QTL analyses. Only one consistent QTL (QGs.ndsu-1B) contributing up to 90% of the phenotypic or 93% of the genotypic variation was detected on 1BS. No QTL × QTL or QTL × environment interactions were observed. The QGs.ndsu-1B was flanked by two DArT markers which were converted to STS markers and used along with SSR and EST-SSRs to develop a map of 1BS. QTL analysis delineated QGs.ndsu-1B in a 7.3 cM region flanked by an STS marker (STS-wPt2395) and a SSR marker (wmc85). The adapted background of this material and availability of PCR-based markers closely associated with this locus represent invaluable resources for marker-assisted introgression of gluten strength into other durum wheat varieties. A single QTL segregating in this population also makes it an ideal target for map-based cloning.  相似文献   

促进区域经济发展深化图书馆信息服务     

海军  乔林红 《农业图书情报学刊》2013,(11):154-156

以哈尔滨市图书馆为例,通过图书馆为企业用户提供信息服务的实践,分析了图书馆为区域经济服务的现状,以及为区域经济服务过程中公共图书馆所起到的作用;提出今后图书馆促进区域经济发展、深化信息服务工作的几点举措。  相似文献   

内蒙古马铃薯疮痂病发生与防治途径   总被引：1，自引：0，他引：1  

张建平  尹玉和  闫任沛  哈斯  林团荣  程玉臣  胡冰 《中国马铃薯》2013,(1):56-59

2011～2012年对内蒙古自治区18个种薯生产单位和11个马铃薯县(旗、市)进行了马铃薯疮痂病(Streptomyces spp.)实地访问和调查。结果被调查的18个种薯生产单位有疮痂病率83.0%,病薯率0.0%～100.0%,11个县(旗、市)商品薯有疮痂病率100.0%,病薯率0.1%～38.0%。重复使用蛭石生产种薯、商品薯生产田轮作少、发病重。种薯较商品薯疮痂病问题更为严重。品种感病、条件适宜、重复使用蛭石、轮作少和缺乏有效杀菌剂是病害严重的主要因素。分析认为,使用效果显著的蛭石消毒剂或种薯处理剂是内蒙古马铃薯疮痂病防治的最佳途径。  相似文献   

Measurement of respiratory system compliance and respiratory system resistance in healthy dogs undergoing general anaesthesia for elective orthopaedic procedures     

Carl A Bradbrook  Louise Clark  Alexandra HA Dugdale  John Burford  Martina Mosing 《Veterinary anaesthesia and analgesia》2013,40(4):382-389

Objective The aim of this study was to investigate normal values for the dynamic compliance of the respiratory system (Crs) and respiratory system resistance (Rrs) in mechanically ventilated anaesthetized dogs.Study design Prospective clinical study.Animals Forty healthy dogs undergoing elective orthopaedic surgery. Body weight was (mean ± SD) 26.8 ± 10.7 kg (range: 1.9–45.0 kg), age 4.7 ± 2.9 years (range: 0.1–10.6 years).Methods Dogs were premedicated with acepromazine and methadone administered intramuscularly and anaesthesia induced with propofol intravenously. After endotracheal intubation the dog's lungs were connected to an appropriate breathing system depending on body weight and isoflurane in oxygen administered for maintenance of anaesthesia. The lungs were ventilated mechanically with variables set to maintain normocapnia (end‐tidal carbon dioxide concentration 4.7–6.0 kPa). Peak inspiratory pressure, Crs, Rrs, tidal volume, respiratory rate and positive end‐expiratory pressure were recorded at 5, 30, 60, 90 and 120 minutes after start of mechanical ventilation. Cardiovascular variables were recorded at time of collection of respiratory data.Results General additive modeling revealed the following relationships: Crs = [0.895 × body weight (kg)] + 8.845 and Rrs = [?0.0966 × body weight (kg)] + 6.965. Body weight and endotracheal tube diameter were associated with Crs (p <0.001 and p =0.002 respectively) and Rrs (p = 0.017 and p =0.002 respectively), body weight being linearly related to Crs and inversely to Rrs.Conclusion and clinical relevance Body weight was linearly related to Crs while Rrs has an inverse linear relationship with body weight in mechanically ventilated dogs. The derived values of Crs and Rrs may be used for monitoring of lung function and ventilation in healthy dogs under anaesthesia.  相似文献