Pathogenic characteristics of highly virulent avian reovirus, strain 58-132, isolated from a chicken with tenosynovitis   总被引：1，自引：0，他引：1  

K Takase  H Nishikawa  F Nonaka  S Yamada 《Nippon juigaku zasshi. The Japanese journal of veterinary science》1985,47(4):567-574

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Correction to: Precocious maturation in male tiger pufferfish Takifugu rubripes: genetics and endocrinology     

Yoshikawa  Sota  Chuda  Hisashi  Hamasaki  Masaomi  Kadomura  Kazushi  Yamada  Toshiyuki  Kikuchi  Kiyoshi  Hosoya  Sho 《Fisheries Science》2021,87(3):431-431

Fisheries Science - A correction to this paper has been published: https://doi.org/10.1007/s12562-021-01505-w  相似文献   

A critical role for the innate immune signaling molecule IRAK-4 in T cell activation     

Suzuki N  Suzuki S  Millar DG  Unno M  Hara H  Calzascia T  Yamasaki S  Yokosuka T  Chen NJ  Elford AR  Suzuki J  Takeuchi A  Mirtsos C  Bouchard D  Ohashi PS  Yeh WC  Saito T 《Science (New York, N.Y.)》2006,311(5769):1927-1932

IRAK-4 is a protein kinase that is pivotal in mediating signals for innate immune responses. Here, we report that IRAK-4 signaling is also essential for eliciting adaptive immune responses. Thus, in the absence of IRAK-4, in vivo T cell responses were significantly impaired. Upon T cell receptor stimulation, IRAK-4 is recruited to T cell lipid rafts, where it induces downstream signals, including protein kinase C activation through the association with Zap70. This signaling pathway was found to be required for optimal activation of nuclear factor kappaB. Our findings suggest that T cells use this critical regulator of innate immunity for the development of acquired immunity, suggesting that IRAK-4 may be involved in direct signal cross talk between the two systems.  相似文献   

Rhabdomyosarcoma in the abdominal cavity of a 12-month-old female donryu rat     

Inoue K  Yoshida M  Takahashi M  Cho YM  Takami S  Nishikawa A 《Journal of toxicologic pathology》2009,22(3):195-198

Neoplasms of skeletal muscle origin are very rare in the rat. Recently, we experienced a case of rhabdomyosarcoma as a white mass involving the junction of the esophagus and stomach in the abdominal cavity of a 12-month-old female Donryu rat. Histopathologically, the neoplastic cells composing the mass invasively spreaded from the lamina propia to the tunica serosa in the stomach as well as the esophagus. Although the neoplastic cells varied in appearance, pleomorphic atypical cells with abundant eosinophilic cytoplasm were prominent. Some tumor cells were stained blue with phosphotungstic acid hematoxylin. The nuclei of spindle-shaped neoplastic cells were arranged longitudinally like beads. Multinucleate giant cells and mitotic figures were also frequently observed. Immunohistochemically, these neoplastic cells were positive for desmin and myoglobin, whereas they were negative for alpha-smooth muscle actin. Taken together these findings, this tumor was diagnosed as a pleomorphic rhabdomyosarcoma, probably derived from the muscle layer of the lower part of the esophagus. This is the first report of rhabdomyosarcoma in a Donryu rat.  相似文献   

Subtype analysis of stx1, stx2 and eae genes in Shiga toxin-producing Escherichia coli (STEC) and typical and atypical enteropathogenic E. coli (EPEC) from lambs in India     

Wani SA  Hussain I  Fayaz I  Mir MA  Nishikawa Y 《Veterinary journal (London, England : 1997)》2009,182(3):489-490

Seventy-five Escherichia coli isolates with at least one targeted virulence gene were recovered from 338 lambs with (n=230) and without (n=108) diarrhoea. The isolates belonged to 36 different serogroups. Shiga toxin-producing E. coli (STEC) was isolated from 9.6% of lambs with and 24.1% of lambs without diarrhoea. Enteropathogenic E. coli (EPEC) was isolated from 6.1% of lambs with and 11.1% of lambs without diarrhoea. Of 26 EPEC isolates, seven were typical (positive for bfpA), and, of 34 stx(1) positive isolates, 25 were subtyped as stx(1c). Five of 29 stx(2) positive isolates were subtyped as stx(2d) and two as stx(2c). Seven of 45 eae positive isolates were subtyped as eae subtype zeta (eaezeta). This appears to be the first report of the isolation of typical EPEC from sheep in India.  相似文献   

Determination and Evaluation of Sampling Velocity in a Simple Passive Sampling Method to Monitor HNO3(g) in Ambient Air     

Masahide Aikawa  Yoshinori Nishikawa  Makiko Yamagami  Takatoshi Hiraki  Kentaro Murano  Hitoshi Mukai 《Water, air, and soil pollution》2010,208(1-4):183-191

We evaluated the applicability of a simple passive sampling method to quantify HNO₃(g) in ambient air. The method has the advantages of not only ease of operation but also low cost. A sampling velocity of 214 m day^?1 was determined based on the concentration of HNO₃(g) measured by the four-stage filter-pack method at nine sites located within a 250?×?250-km area in Japan. This sampling velocity was applied at sites located outside of area to verify the applicability and accuracy of the simple passive sampling method. The variation in the results for the application of the sampling velocity ranged from 0.39 to 0.95. The simple passive sampling method should be applied to sites with different meteorological conditions, and the obtained data should be used to obtain more significant information and/or to indicate the need for further developments in the methodology.  相似文献   

A comparison of the phenotype of dendritic cells derived from discrete Peyer's patch macrophages of non-infected and Toxoplasma gondii infected mice   总被引：2，自引：0，他引：2  

Makala LH  Reyes JC  Nishikawa Y  Tsushima Y  Xuan X  Huang X  Nagasawa H 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2003,65(5):591-597

A comparison of the expression of surface membrane antigens between dendritic cells (DC) derived from Peyer's patch macrophages (DPP-DC) of non-infected and Toxoplasma gondii (T. gondii) infected mice was performed. C57BL/6J mice aged 6-8 weeks of both sexes were infected orally with a 0.5 ml suspension containing 2 x 10(4) bradyzoites of the Beverley strain of T. gondii, sacrificed on day 8 and DC generated using discrete Peyer's patch macrophages (DPP-M?) as progenitor cells. When a comparison of the expression of surface membrane antigens between the antigen presenting cells (APC) obtained from discrete Peyer's patches of non-infected and T. gondii infected mice was carried out, no significant differences were observed in the macrophage progenitor and DC populations expression of F4/80, DEC-205, CD11c, CD80 (B7-1) and CD34. However, a significant decrease in MHC class II antigen levels and a down regulation of the co-stimulatory molecule CD86 (B7-2) were noted. B7-1 appeared to be the dominant co-stimulatory ligand, whereas B7-2, which was down regulated during T. gondii infection, had a weak expression. Taken together, these results may help clarify the role of DC in the complex network regulating surface membrane antigens, as well as, their capacity for antigen uptake, processing and presentation during toxoplasmosis.  相似文献   

Phenotype and function of murine peritoneal cavity macrophage derived-dendritic cells   总被引：4，自引：0，他引：4  

Makala LH  Nishikawa Y  Mishima M  Inoue N  Xuan X  Suzuki H  Fujisaki K  Mikami T  Nagasawa H 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2002,64(9):813-820

The accessory activity was reported in murine peritoneal cavity macrophage derived dendritic cells (PEC-DC) in a mixed lymphocyte reaction (MLR). Here we continue the characterization of the generated PEC-DC using the criteria of morphology, phenotype and other accessory function. We have demonstrated that murine peritoneal cavity macrophages can be induced to differentiate in vitro into cells exhibiting typical dendritic cell (DC) morphology, phenotype and function. The proliferative capacity of the progenitors was amplified in the first step of the culture (day 0-7) using a combination of early cytokines: interleukin 4 and granulocyte-macrophage colony-stimulating factor. The second step of the culture started at day 7 with the removal of early growth factors to allow differentiation and final maturation of DC during 2 days of culture with interferon gamma plus either Toxoplasma lysate antigen (TLA) or lipopolysaccharide (LPS), a bacterial agent as a DC maturing agent. The resulting DC population exhibited typical DC morphology and expressed higher levels of MHC class II and the co-stimulatory molecules CD80 and CD86 compared to the untreated peritoneal cells. The generated DC cells efficiently presented soluble protein antigen to CD3(+) spleen T cells.  相似文献   

Gene silencing of ribosomal protein P0 is lethal to the tick Haemaphysalis longicornis     

Gong H  Liao M  Zhou J  Hatta T  Huang P  Zhang G  Kanuka H  Nishikawa Y  Xuan X  Fujisaki K 《Veterinary parasitology》2008,151(2-4):268-278

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Isolation and identification of DPPH radical scavenging compounds in Kurosu (Japanese unpolished rice vinegar)   总被引：7，自引：0，他引：7  

Shimoji Y  Tamura Y  Nakamura Y  Nanda K  Nishidai S  Nishikawa Y  Ishihara N  Uenakai K  Ohigashi H 《Journal of agricultural and food chemistry》2002,50(22):6501-6503

Dihydroferulic acid (DFA) and dihydrosinapic acid (DSA) were isolated from Kurosu (unpolished rice vinegar) as the major constituents responsible for Kurosu's radical scavenging activity. The levels of antioxidative activity of DFA and DSA in DPPH radical scavenging were higher than those of their respective structurally related compounds, ferulic acid and sinapic acid. The concentrations of DFA and DSA were low in common rice vinegar (polished rice vinegar), suggesting that Kurosu is more advantageous than rice vinegars as an antioxidative food item. As the concentrations of DFA and DSA were low in unpolished rice, too, these acids are thought to be produced in Kurosu through the process of the fermentation from ferulic acid and sinapic acid, respectively.  相似文献