Angiostroneylosis in Cornwall: Clinical presentations of eight cases     

M. W. S. Martin  G. Ashton  V. R. Simpson  C. Neal 《The Journal of small animal practice》1993,34(1):20-25

Clinical signs in eight dogs with Angiostrongylus vasorum infection included chronic cough, dyspnoea, lumbar pain, hindleg paresis/paralysis, abdominal pain, weakness and collapse; two of the dogs were asymptomatic. Thrombocytopenia was present in two dogs and a mild anaemia in one. Thoracic radiographs showed mild right heart enlargement in two out of three dogs and a pneumothorax in one. At post mortem examination in three dogs, the lungs were swollen with a mottled appearance and there was dilatation of the right ventricle. Adult A vasorum were found in the right heart, the pulmonary artery and its branches. Adult worms were also found in the systemic vasculature in one dog, associated with thromboembolism. Treatment with ivermectin in two dogs and fenbendazole in three dogs resulted in the resolution of clinical signs and no demonstrable larvae in the faeces one to two weeks later.  相似文献   

Evaluation of canine small intestinal permeability using the lactulose/rhamnose urinary excretion test     

J. Quigg  G. Brydon  A. Ferguson  J. Simpson 《Research in veterinary science》1993,55(3):156

The use of the lactulose and rhamnose urinary excretion test was evaluated in dogs with gastrointestinal disease. Lactulose and rhamnose rinary excretion was measured in three groups of dogs: clinically healthy dogs and dogs with gastrointestinal disease with and without coexistent panhypoproteinaemia. A significant increase in both the percentage of lactulose: percentage of rhamnose urinary excretion ratio and the percentage of lactulose excretion was demonstrated in dogs with hypoproteinaemia when compared to the other two groups. The results suggest that the lactulose/rhamnose urinary excretion test may prove a useful adjunct to currently available tests for assessing small intestinal function, but lacks sensitivity in detecting small intestinal mucosal damage in the absence of villus atrophy.  相似文献   

Ante mortem diagnosis of pancreatitis in four cats   总被引：1，自引：0，他引：1  

K. W. Simpson  J. T. Shiroma  D. S. Biller  J. Wicks  S. E. Johnson  D. Dimski  D. Chew 《The Journal of small animal practice》1994,35(2):93-99

The ante mortem detection of pancreatitis in four cats is reported. Clinical findings included vomiting, lethargy and constipation in all the cats, diabetes mellitus in two cats and severe jaundice and a vitamin K responsive coagulopathy in one cat. Serum amylase was normal in all the cats and serum lipase was elevated in one azotaemic cat. Ultrasonography revealed predominantly hypoechoic masses in the right cranial quandrant of the abdomen of each cat. The anatomical location of these masses was consistent with the pancreas. Gross examination supported these ultrasonographic observations. The pancreatic lesions were characterised histologically as acute necrotising pancreatitis, acute necrotising pancreatitis with abscessation, chronic active pancreatitis with cystic dilatation of the pancreatic duct causing bile duct obstruction and chronic active pancreatitis with nodular hyperplasia. This report indicates that pancreatitis is a clinically significant disease in cats that may be diagnosed ante mortem.  相似文献   

Right Ventricular Cardiomyopathy in a Dog   总被引：1，自引：0，他引：1  

Kenneth W. Simpson  John D. Bonagura  Kathryn A. Eaton 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》1994,8(4):306-309

  相似文献   

Stabilization of atlantoaxial subluxation secondary to atlantooccipital malformation in a Devon calf     

D J McCoy  R M Simpson  B M Olcott  B Aldridge  E C Hodgin 《The Cornell veterinarian》1986,76(3):277-286

Atlantoaxial subluxation secondary to atlantooccipital malformation in a 14-day-old female Devon calf was corrected by alignment and stabilization of the atlantoaxial joint. Stabilization was achieved by the ventral placement of pins and screws, and the dorsal placement of a figure 8 tension band wire. At 2 and 14 days post operatively, adequate alignment of the atlantoaxial joint was confirmed radiographically. Following surgery the calf improved clinically, but was terminated 14 days following the surgery due to a pneumonia. At necropsy the fixation was stable and spinal cord decompression had been achieved. It was concluded that this technique could be utilized to allow decompression, anatomical alignment, and stabilization of an atlantoaxial subluxation secondary to atlantooccipital malformation in a calf. At necropsy, there was gross and histologic evidence of congenital fusion of the basioccipital bone to the malformed atlas.  相似文献   

Effects of protein concentration on responses to dietary lysine by chicks   总被引：2，自引：0，他引：2  

T R Morris  K Al-Azzawi  R M Gous  G L Simpson 《British poultry science》1987,28(2):185-195

Chicks were fed on diets varying in crude protein (CP) content (140 to 280 g/kg diet) in either 8 steps, experiment 1, or 6 steps, experiment 2. Protein composition was held constant in each experiment. At each protein concentration, 5 (experiment 1) or 6 (experiment 2) concentrations of lysine were tested, ranging from 40 to 60 g/kg CP. Growth rate and efficiency of food utilisation to 21 d of age responded to increasing dietary protein contents up to about 230 g CP/kg. An estimate of lysine requirement at each protein concentration was obtained by fitting a quadratic curve to the response data and calculating the dose of lysine (g/kg CP) needed to maximise either growth rate or gain/food ratio. Although no growth response to dietary protein was obtained between 240 and 280 g CP/kg, the amount of lysine needed to maximise growth and gain/food ratio over this range increased systematically when expressed as g/kg diet, but remained constant if expressed as g/kg CP. The regression of lysine required (g/kg diet) for maximum performance (growth or food efficiency) on CP (g/kg diet) was strictly linear for both responses in both experiments throughout the entire range studied (140 g CP/kg to 280 g CP/kg). The estimated lysine requirement was 0.053 of the CP in experiment 1 and 0.055 of the CP in experiment 2. It is concluded that a fixed ratio of lysine to protein should be specified in practical diet formulation, rather than a minimum dietary concentration of lysine. This would ensure that, if the dietary protein content rises above a prescribed minimum value in least-cost formulation, an appropriate adjustment will automatically be made to the lysine content of the solution.  相似文献   

Comparative pharmacokinetics of paracetamol (acetaminophen) and its sulphate and glucuronide metabolites in desert camels and goats   总被引：1，自引：0，他引：1  

B. H. ALI  Z. CHENG†  G. EL HADRAMI‡  A. K. BASHIR  Q. A. MCKELLAR† 《Journal of veterinary pharmacology and therapeutics》1996,19(3):238-244

Paracetamol was administered at dosages of 5 mg/kg to camels and 10 mg/kg to goats by the intravenous and intramuscular routes. Parent paracetamol had a significantly slower clearance (21.9 ± 1.4 mL/min.kg vs. 52.8 ± 7.3 mL/min.kg) (P < 0.01) in camels than in goats. In camels the predominant metabolite in plasma was the sulphate, although the ratios of glucuronide:paracetamol and sulphate:paracetamol were similar (5.20 ± 0.50 vs. 6.59 ± 0.51) following intravenous administration. In goats the glucuronide metabolite was the predominant moiety in plasma, and the area under the curve (AUC) of the sulphate was only 3.89% of that of the glucuronide conjugate. The apparent AUC for paracetamol in the camel following intramuscular administration was larger than that following intravenous administration, however, when the bioavailability (F) was determined, with correction for altered half-life, within the animal and between study phases it was 71 ± 17% in goats and 105 ± 26% in camels.  相似文献   

Deficiency of bile salts causing steatorrhoea and weight loss in two dogs     

J. W. Simpson  A. van den  Broek 《The Journal of small animal practice》1989,30(10):567-569

Two dogs were presented with chronic diarrhoea, weight loss and skin problems. In each case investigation revealed persistent steatorrhoea due to a failure in fat digestion and absorption which was associated with a bile salt deficiency. Replacement therapy resulted in a significant improvement in the condition of each dog.  相似文献   

Hexachlorophene-pHisohex toxicity in pups     

G T Edds  C F Simpson 《American journal of veterinary research》1974,35(7):1005-1007

  相似文献   

Protection of cattle against heartwater in Botswana: comparative efficacy of different methods against natural and blood-derived challenges     

B C Simpson  M S Lindsay  J R Morris  F S Muirhead  A Pollock  S G Prichard  H G Stanley  G R Thirlwell  A G Hunter  J Bradley 《The Veterinary record》1987,120(6):135-138

Five groups of Tswana-cross castrated male cattle between 20 and 30 months of age (a total of 158 animals) were transported from a ranch in a heartwater-free area of south Botswana to a feedlot near Gaborone in the east of Botswana where heartwater is endemic. On arrival, one group was vaccinated intravenously with the Onderstepoort sheep blood heartwater vaccine, one group was vaccinated intravenously with the new Onderstepoort tick-derived heartwater vaccine and a third group was vaccinated subcutaneously with this tick-derived vaccine. Vaccine reactions were blocked with long acting oxytetracycline on the first day of fever. A fourth group had a series of injections of long acting oxytetracycline on days 0, 7, 14 and 21 after arrival, and a fifth served as untreated controls. The animals remained at the feedlot for 65 days during which time they faced a low level of challenge by Amblyomma hebraeum ticks. None contracted heartwater and so they were then challenged, together with a further group of control cattle, with a dose of the sheep blood vaccine. Some animals in all groups had severe heartwater reactions and died despite therapy, but 76.7 per cent, 64.5 per cent and 74.3 per cent of the cattle in the blood vaccine, intravenous tick vaccine and long acting oxytetracycline groups respectively were resistant to challenge, compared with 48.3 per cent of the subcutaneous tick vaccine group and 36.4 per cent of the controls. It was concluded that intravenous vaccination of susceptible adult cattle with either the blood or the tick-derived vaccine needs careful monitoring in the month after vaccination and does not necessarily result in immune animals.(ABSTRACT TRUNCATED AT 250 WORDS)  相似文献