Infestation in the dog by the paralysis tick, Ixodes holocyclus — 5. Treatment     

JE ILKIW†  DM TURNER 《Australian veterinary journal》1988,65(8):236-238

In this study the value of drugs administered with hyperimmune serum in the treatment of advanced disease produced by Ixodes holocyclus was compared under controlled conditions. All control dogs died rapidly whereas one dog survived and 3 dogs died after receiving hyperimmune serum alone. When promethazine hydrochloride was administered with hyperimmune serum 2 dogs recovered rapidly while the remaining 2 died. Administration of dexamethasone and hyperimmune serum allowed 3 dogs to survive while administration of phenoxybenzamine hydrochloride in conjunction with hyperimmune serum allowed rapid recovery of all 4 dogs. Phenoxybenzamine hydrochloride, an alpha-adrenergic blocking drug, was chosen because of its potential to attenuate the arterial hypertension previously reported (Ilkiw et al 1988). The survival of all dogs together with the rapid return to normality indicated that this drug was beneficial in the treatment of dogs with advanced signs of tick paralysis.  相似文献   

Adverse drug reactions: Report of the Australian Veterinary Association Adverse Drug Reaction Subcommittee, 1994     

JE MADDISON 《Australian veterinary journal》1996,73(4):132-136

Seventy-seven reports of suspected adverse drug reactions (ADRs) were received by the Adverse Drug Reaction Subcommittee (ADRSc) of the Australian Veterinary Association from April 1993 to December 1994 inclusive. The number of reports received/number of animals involved per species were: dogs (32/44), cats (18/31), horses (17/48), and cattle (10/21). Of these, 49 (64%) were classified as definite ADRs and 9 (12%) as probable ADRs. In 11 (14%) reports an ADR could not be substantiated or there was insufficient information available to make a decision. Eight reports were not classified because the manufacturer and the ADRSc disagreed as to the appropriate classification. Sixteen reports involved apparent hypersensitivity reactions, which resulted in death on 6 occasions. Six reports were associated with ‘off label’ use and 1 report with use of an expired product. Of the definite, probable and unclassified reports of suspect ADRs, the most frequent types of drugs involved were antimicrobial drugs (13 reports), anthelmintics (13), insecticides (11), vaccines (10), nonsteroidal anti-inflammatory preparations (5), chondroprotective agents (4), anaesthetic/sedative agents (4) and vitamin preparations (2). Single reports concerning definite, probable or unclassified ADRs to a vasodilator, a corticosteroid, a local anaesthetic and a disinfectant were received.  相似文献   

Associations between hoof shape and the position of the frontal plane ground reaction force vector in walking horses     

GR Colborne  JE Routh  KR Weir  JE McKendry  E Busschers 《New Zealand veterinary journal》2016,64(2):76-81

AIMS: To determine the frontal plane position of the ground reaction force vector at its centre of pressure under the hoof of walking horses, and its projection through the distal limb joints, and to relate this to hoof geometric measurements.

METHODS: Reflective markers were glued to the forelimb hooves and skin of 26 horses, over palpable landmarks representing centres of the coffin, fetlock and carpal joints, and the dorsal toe at its most distal point. A 4-camera kinematic system recorded the position of these markers as the horse walked in hand across a force platform, to generate a frontal plane representation of the ground reaction force vector passing between the markers at the joints. The position of the vector was calculated as the relative distance between the lateral (0%) and medial (100%) markers at each joint. Digital photos were taken of the hoof in frontal and sagittal views to determine hoof geometric measurements. Associations between these and the position of the force vector at each joint were examined using Pearson correlation coefficients.

RESULTS: Mean vector position for both forelimbs at the toe, coffin, fetlock and carpal joint was 50.1 (SD 8.9), 53.0 (SD 9.2), 54.6 (SD 11.4) and 50.5 (SD17.3)%, respectively, of the distance between the lateral and medial sides of the joint in the frontal plane. Across all four joints, the vector position was slightly more medial (2–4%) for the right than left limb (p>0.05). Medial hoof wall angle was correlated (p<0.05) with force vector position at the fetlock (r=?0.402) and carpal (r=?0.317) joints; lateral hoof wall angle with vector position at the toe (r=0.288) and carpal (r=?0.34) joint, and medial hoof wall height with vector position at the fetlock (r=?0.306) and carpal (r=?0.303) joints.

CONCLUSION: The position of the two-dimensional frontal plane ground reaction force vector at the toe, and at the fetlock and carpal joints was associated with hoof shape. Mediolateral hoof balance has been shown in vitro to affect articular forces, which may be a factor in development of joint disease. The effect of hoof shape needs to be evaluated at faster gaits to determine the potential for joint injury in the presence of larger forces.  相似文献   

Concentrations of buparvaquone in milk and tissue of dairy cows     

S McDougall  JE Hillerton  D Pegram 《New Zealand veterinary journal》2016,64(6):318-323

AIM: To determine the concentration of the anti-theilerial drug buparvaquone in the milk and tissue of dairy cattle following treatment with two different formulations, and to assess the effect of clinical theileriosis on the concentration of buparvaquone in milk.

METHODS: Healthy lactating dairy cows (n=25) were injected once (Day 0) I/M with 2.5?mg/kg of one of two formulations of buparvaquone (Butalex; n=12 or Bupaject; n=13). Milk samples were collected from all cows daily until Day 35. Five cows were slaughtered on each of Days 56, 119, 147, 203 and 328, and samples of liver, muscle and injection site tissue collected. Milk samples were also collected from cows (n=14) clinically affected with theileriosis for up to 21 days after treatment with buparvaquone. Milk and tissue samples were analysed by liquid chromatography-mass spectrometry; limits of detection (LOD) were 0.00018?mg/kg for muscle and 0.00023?mg/L for milk. Concentrations of buparvaquone in milk and tissues were log₁₀-transformed for analysis using multivariate models.

RESULTS: In healthy cows, concentrations of buparvaquone in milk declined with time post-treatment (p<0.001), but were above the LOD in 11 of 25 cows at Day 35. Concentration in milk was higher one day after treatment in cows treated with Butalex than in cows treated with Bupaject, but not different thereafter (p=0.007). Concentrations of buparvaquone in muscle were below the LOD for four of five animals at Day 119 and for all animals by Day 147, but were above the LOD at the injection site of one cow, and in the liver of three cows at Day 328. Tissue concentrations did not differ with formulation nor was there a formulation by time interaction (p>0.3).

Concentrations of buparvaquone in the milk of clinically affected animals were not different from those of healthy animals at 1 and 21 days post-treatment (p=0.72). Between 21 and 25 days post-treatment concentrations were below the LOD in 9/14 milk samples from clinically affected cows.

CONCLUSIONS: Detectable concentrations of buparvaquone were found in the milk of some cows for at least 35 days and in the liver and injection site of some cows until at least 328 days after injection. There were no biologically meaningful differences in milk or tissue concentrations between the formulations, or in the milk concentrations for cows that were clinically affected compared with those that were healthy at the time of treatment.  相似文献   

Setting priorities for protected area planning in a conflict zone – Afghanistan’s National Protected Area System Plan     

McKenzie F. Johnson  Nina Kanderian  Christopher C. Shank  Haqiq Rahmani  David Lawson  Peter Smallwood 《Biological conservation》2012,148(1):146-155

Planning for protected area networks is often done on an ad hoc basis, especially in data-poor countries. Afghanistan, a country mired in conflict for the past 30 years, has little of the relevant data to plan a protected area network, and security concerns hinder collection of new data. However, conservation of Afghanistan’s natural resources will be critical to recovery efforts. To assist Afghanistan in planning for its protected area network, we conducted an analysis to identify ecologically important areas for conservation. We overlaid data from ecoregion, floral, and faunal analyses on a grid map of Afghanistan (313 cells each 2500 km²), and used a ranking system to determine those cells containing diverse and/or threatened ecosystems. A color gradation was applied to each cell (white – least diverse to black – most diverse) to produce a map visually depicting ecological diversity across Afghanistan. Those cells with the highest scores were labeled as Priority Zones – defined as areas in which Afghanistan should prioritize conservation activities for protected area designation. Our results formed the basis of the National Protected Area System Plan of Afghanistan, a document setting quantitative protected area targets and outlining a concrete plan of action for the designation of a protected area network. We found the Priority Zone model to be useful in helping Government partners locate areas potentially important for conservation and prioritize activities for protected area designation. This process may be useful for other conflict or post-conflict countries working to establish protected area networks in a data deficient environment.  相似文献   

Molecular epidemiology of clinical isolates of Pseudomonas aeruginosa isolated from horses in Ireland     

Tazumi A  Maeda Y  Buckley T  Millar B  Goldsmith C  Dooley J  Elborn J  Matsuda M  Moore J 《Irish veterinary journal》2009,62(7):456-459

Clinical isolates (n = 63) of Pseudomonas aeruginosa obtained from various sites in 63 horses were compared using ERIC2 RAPD PCR to determine their genetic relatedness. Resulting banding patterns (n = 24 genotypes) showed a high degree of genetic heterogeneity amongst all isolates examined, indicating a relative non-clonal relationship between isolates from these patients, employing this genotyping technique. This study characterised 63 clinical isolates into 24 distinct genotypes, with the largest cluster (genotype E) accounting for 10/63 (15.9%) of the isolates. ERIC2 RAPD PCR proved to be a highly discriminatory molecular typing tool of P. aeruginosa in isolates recovered from horses. With the adoption of several controls to aid reproducibility, this technique may be useful as an alternative to PFGE, particularly in epidemiological investigations of outbreaks where speed may be a significant parameter. This is the first report of clonal heterogeneity amongst P. aeruginosa from horses and demonstrated that ERIC RAPD PCR is a rapid method for the examination of this species in horses, which may be useful in outbreak analysis.  相似文献   

Morphological Changes of the Endometrial Epithelium in the Bitch during Metoestrus and Anoestrus     

G Galabova  M Egerbacher  JE Aurich  M Leitner  I Walter 《Reproduction in domestic animals》2003,38(5):415-420

Although cyclic changes of the endometrium in dogs involving both stromal and glandular compartments have been described, the fate of the surface epithelium after progressive growth and secretion is still unclear. In the present study, uteri of 43 healthy bitches in metoestrus and anoestrus were examined macroscopically and histologically. Tissue biopsies were taken from three different locations (cranial and middle parts of uterine horns and bifurcation). The stage of the oestrous cycle was determined by evaluation of progesterone and oestradiol levels in plasma hormone and was also confirmed clinically. Crypts formed in the luteal phase were covered with a columnar epithelium which gradually underwent fatty degeneration. In addition, the stromal part of the crypts disappeared and finally, in early anoestrus, epithelial sheaths desquamated and shed off into the uterine lumen. The surface epithelium was replaced by new cuboidal cells proliferating and migrating from the glandular openings. These findings were confirmed by oil red O staining and immunohistochemical detection of proliferation with Ki‐67 marker.  相似文献   

ANATOMIC REFERENCE FOR COMPUTED TOMOGRAPHY OF THE HEAD OF THE FOAL     

James E.  Smallwood  DVM  MS  Brett C.  Wood  DVM  MEM  W. Eric Taylor    DVM  Lloyd P.  Tate Jr.  VMD 《Veterinary radiology & ultrasound》2002,43(2):99-117

The purpose of this study was to produce an anatomic reference for computed tomography (CT) of the head of the foal for use by radiologists, clinicians, and veterinary students. The head from each of 2 foals, euthanized for reasons unrelated to head pathology, was removed and prepared for CT scanning. Using a third-generation CT scanner, 5-mm contiguous transverse images were acquired. The heads were then frozen and sectioned using a band saw, with the cuts matched as closely as possible to the CT slices. The anatomic sections were photographed and radiographed. The radiographs and anatomic photographs were digitized and matched with the corresponding CT image. Each CT image was compared with its corresponding radiographic and anatomic section to assist in the accurate identification of specific structures. Clinically relevant structures were identified and labeled in corresponding images (CT, anatomic slice, and radiograph of slice). Only structures identified in the CT image were labeled in 1 of the other 2 images. Sagittal (reference) images of the horse's head were reconstructed from the transverse CT scans, and were used to indicate the level from which each of the transverse images was obtained. Corresponding labeled images were then formatted together with a legend for identification of specific anatomic structures.  相似文献   

The diagnosis and treatment of a thoracic abscess in an alpaca     

JE ADOLF  NL DYKES  S SEMEVOLOS  TJ DIVERS 《Australian veterinary journal》2001,79(10):675-679

A 6-month-old alpaca presented for lethargy, failure to thrive and leucocytosis. Diagnostic procedures, including thoracic ultrasound, radiographs and a computed tomography scan, were used to document a thoracic mass. Based on appearance and ultrasound-guided aspiration of purulent material, the mass was determined to be a large abscess. The abscess was treated with surgical drainage and long-term antibiotic therapy. The origin of this thoracic abscess was felt to be the caudal mediastinum, secondary to bacterial seeding of the caudal mediastinal lymph nodes. Although an aetiological agent was not definitively determined, the most likely was Actinomyces spp or Arcanobacterium pyogenes. The alpaca made a complete recovery following treatment.  相似文献   

THE NORMAL XERORADIOGRAPHIC AND RADIOGRAPHIC ANATOMY OF THE ORANGE-WINGED AMAZON PARROT (AMAZONA AMAZONICA AMAZONICA)     

Bonnie J.  Smith  DVM  PhD  Stephen A.  Smith  MS  DVM  Keven  Flammer  DVM  Kathy A.  Spaulding  DVM  James E.  Smallwood  MS  DVM 《Veterinary radiology & ultrasound》1990,31(3):114-124

The purpose of the study was to provide a reference for xeroradiographic and conventional radio-graphic anatomy of the orange-winged Amazon parrot ( Amazona amazonica amazonica ) as a representative of medium-sized psittacine birds that are commonly kept as pets. The head, body, wing, and pelvic limb of a mature bird were radiographed using xeroradiographic and conventional radiographic techniques. Ten xeroradiographs and ten corresponding radiographs were selected, and the xeroradiographs labeled to illustrate the normal radiographic anatomy of these regions. Also included is a short discussion of unique avian anatomic features which are important to clinical evaluation.  相似文献