ARBOVIRUS INFECTIONS OF DOMESTIC ANIMALS IN AUSTRALIA   总被引：1，自引：0，他引：1  

P. B. Spradbrow  B.V.Sc.  Ph.D. 《Australian veterinary journal》1972,48(4):181-185

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THE ISOLATION OF A BOVINE ENTEROVIRUS IN AUSTRALIA     

P. B. Spradbrow  B.V.SC  Ph.D. 《Australian veterinary journal》1963,39(10):398-399

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The Functional Role of Oxytocin in the Induction of Oocyte Meiotic Resumption in Cattle     

K Gutierrez  L Siqueira  ML Rigo  WG Glanzner  JF Oliveira  PB Gonçalves 《Reproduction in domestic animals》2013,48(5):844-849

The aim of the present study was to examine the role of oxytocin (OT) in the progesterone (P4) and prostaglandins (PGs) pathway to induce oocyte meiotic resumption. Cumulus–oocyte complexes were co‐cultured with follicular hemisections for 15 h to determine the effects of different doses of OT or atosiban (ATO; oxytocin receptor antagonist) on oocyte meiotic resumption. In another experiment, we examined the effect of the interaction between P4, OT and PGs on the regulatory cascade of the oocyte meiotic resumption. Oxytocin at 1 μm was effective in inducing meiotic resumption in oocytes co‐cultured with follicular cells (84.0%), not differing from the positive control group (74.4%). Atosiban inhibited in a dose‐dependent manner the positive effect of OT on the meiotic resumption (27.6% metaphase I with 10 μm of ATO, which did not differ from the 25.5% of the negative control group). Furthermore, a third experiment showed that P4 was able to induce oocyte meiotic resumption, which was inhibited by ATO. However, the OT positive effect was not blocked by mifepristone (P4 antagonist), but was inhibited by indomethacin (a non‐selective PTGS2 inhibitor). Collectively, these data suggest a sequential role of P4, OT and PGs in the induction of oocyte meiotic resumption.  相似文献   

THE ISOLATION OF PICORNAVIRUSES FROM CATS WITH RESPIRATORY DISEASE     

P. B. Spradbrow  B.V.Sc.  Ph.D.  T. J. Bagust  B.V.Sc.  G. Burges  B. Portas 《Australian veterinary journal》1970,46(3):105-108

One hundred and sixty samples including nasal swabs, conjunctival swabs, lung tissue, swabs of tonsil and an oral swab were taken from 59 cats suffering from respiratory disease. Thirty-nine of the specimens (from 23 cats) contained agents that produced a rapid cytopathic effect in cultures of feline kidney cells. Two of the isolates were studied in detail, and they were found to be resistant to lipid solvents, stable at pH 5 but not at pH 3, able to pass through a 50 mμ filter and not stabilized to inactivation at 50°C in the presence of molar concentrations of MgCl₂. Electron microscopy of negatively stained preparations revealed particles about 45 mμ in diameter that lacked an outer envelope. These properties indicate that the agents are feline picornaviruses.
Antibodies to one of the isolates were present in 14 of 56 cat serums. Four kittens inoculated with picornaviruses developed upper respiratory tract disease, but 3 died with signs of enteritis possibly caused by concurrent infection with pan-leucopenia virus. Picornaviruses were isolated from nasal swabs from 3 of these kittens, and from lung and spleen of the other.  相似文献   

STUDIES ON VACCINES AGAINST BOVINE EPHEMERAL FEVER     

S. Tzipory  B.V.Sc. P. B. Spradbrow  B.V.Sc.  Ph.D. 《Australian veterinary journal》1973,49(4):183-187

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Adenoviral infection of Arab foals with respiratory tract disease.     

A R Moorthy  P B Spradbrow 《Zentralblatt für Veterin?rmedizin. Reihe B. Journal of veterinary medicine. Series B》1978,25(6):469-477

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Transmission of virus from serosal fluids and demonstration of antigen in neutrophils and mesothelial cells of cattle infected with bovine ephemeral fever virus     

P L Young  P B Spradbrow 《Veterinary microbiology》1985,10(3):199-207

Following intravenous injection of bovine ephemeral fever (BEF) virus 6 cattle were autopsied after clinical disease became evident. Fluid from serosal cavities with serofibrinous inflammatory changes showed large increases in neutrophil numbers. BEF virus was detected for the first time in pericardial, thoracic and abdominal fluids. Virus was also detected in synovial fluids, confirming an earlier report of transmission with a synovial fluid sample. Using a direct fluorescent antibody technique, BEF virus antigen was identified for the first time in synovial, pericardial, thoracic and abdominal fluids, in synovial membranes and epicardium. In synovial membranes and epicardium, specific fluorescence was observed in two cell types, mesothelial cells and neutrophils. In the fluids, fluorescence was restricted to neutrophils, the predominant cell type. Specific fluorescence was observed in blood smears from only one animal although blood samples collected at autopsy from all animals contained infective virus.  相似文献   

Selective oral vaccination against newcastle disease by creep feeding young chicks in an open-range poultry flock     

J. L. Samuel  P. B. Spradbrow 《Preventive veterinary medicine》1991,10(4):273-282

Oral Newcastle disease vaccine, strain V4, was administered to an open-range multi-age chicken flock. Adult birds in this flock had low levels of haemagglutination inhibition antibody as a result of vaccination of the flock with strain V4 more than 3 years previously and apparent persistence of the vaccine virus. Eight clutches of chicks were hatched over a period of 3 months. Vaccine, given at fortnightly intervals, was restricted to young chicks by creep feeding. Chicks in all the clutches produced antibody in response to vaccination, and levels of antibody in the adult flock increased as the first clutches were responding to vaccination. When oral vaccine is used in the field, restriction of vaccination to chicks could conserve without reducing the efficacy of vaccination.  相似文献   

Behavioral and cardiopulmonary effects of dexmedetomidine alone and in combination with butorphanol,methadone, morphine or tramadol in conscious sheep          下载免费PDF全文

Luisa PB Borges  Lilian T Nishimura  Leonardo L Carvalho  Sofia A Cerejo  Adam Auckburally  Ewaldo Mattos‐Junior 《Veterinary anaesthesia and analgesia》2016,43(5):549-560

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Total intravenous anesthesia with propofol and S(+)‐ketamine in rabbits     

Fernando SF Cruz  Adriano B Carregaro  Alceu G Raiser  Marina Zimmerman  Rafael Lukarsewski  Renata PB Steffen 《Veterinary anaesthesia and analgesia》2010,37(2):116-122

ObjectiveTo evaluate total intravenous anesthesia with propofol alone or in combination with S(+)-ketamine in rabbits undergoing surgery.Study designProspective, randomized, blinded trial.AnimalsNine 6-month-old New Zealand white rabbits, weighing 2.5–3 kg.MethodsAnimals received acepromazine (0.1 mg kg^?1) and buprenorphine (20 μg kg^?1) IM, and anesthesia was induced with propofol (2 mg kg^?1) and S(+)-ketamine (1 mg kg^?1) IV. Rabbits received two of three treatments: propofol (0.8 mg kg^?1 minute^?1) (control treatment, P), propofol (0.8 mg kg^?1 minute^?1) + S(+)-ketamine (100 μg kg^?1 minute^?1) (PK100) or propofol (0.8 mg kg^?1 minute^?1) + S(+)-ketamine (200 μg kg^?1 minute^?1) (PK200). All animals received 100% O₂ during anesthesia. Heart rate, mean arterial pressure, hemoglobin oxygen saturation and respiratory rate were measured every 5 minutes for 60 minutes. Blood-gas parameters were measured at zero time and 60 minutes. Additional propofol injections, if necessary, and recovery time were recorded.ResultsAn increase in heart rate was observed in P and PK200 up to 10 minutes after induction of anesthesia. Blood pressure decreased from baseline values during the first 10 minutes in P and PK200, and during the first 15 minutes and between 45 and 55 minutes in PK100. A reduction in respiratory rate was observed after 5 minutes in all treatments. Respiratory acidosis was observed in all treatments. Six (2.8) [median (interquartile range)] further propofol injections were necessary in P, which differed statistically from PK100 [1 (0.2)] and PK200 [2 (0.6)]. Recovery time was shorter in P compared with PK100 and PK200, being [7.5 minutes (4.11)], [17.5 minutes (10.30)], and [12 minutes (10.30)], respectively.Conclusions and clinical relevanceS(+)-ketamine potentiates propofol-induced anesthesia in rabbits, providing better maintenance of heart rate. All of these techniques were accompanied by clinically significant respiratory depression.  相似文献