Pharmacokinetics and dosage regimen of cephalexin in buffalo calves (Bubalus bubalis) following single intravenous and intramuscular administration     

Satish K. Garg  R. K. Chaudhary  A. K. Srivastava  B. D. Garg 《Veterinary research communications》1990,14(1):59-62

  相似文献   

Control of Ascaridia galli--the large intestinal roundworm of poultry     

H D Srivastava  H C Malviya 《The Indian veterinary journal》1966,43(4):303-309

  相似文献   

Intramuscular Kinetics and Dosage Regimens for Pralidoxime in Buffalo Calves (Bubalus bubalis)     

Srivastava  A.K.  Malik  J.K. 《Veterinary research communications》2001,25(4):301-309

The plasma levels, disposition kinetics and a dosage regimen for pralidoxime (2-PAM) were investigated in male buffalo calves following single intramuscular administration (15 or 30 mg/kg). The effects of 2-PAM on various blood enzymes were also determined. The absorption half-life, elimination half-life, apparent volume of distribution and total body clearance of 2-PAM were 1.08±0.19 h, 3.14–3.19 h, 0.83–1.01 L/kg and 184.9–252.1 ml/(kg h), respectively. At doses of 15 and 30 mg/kg body weight, a plasma concentration 4 g/ml was maintained for up to 4 and 6 h, respectively. Pralidoxime significantly lowered the serum level of transferases, phosphatases and lactate dehydrogenase but did not influence the acetylcholinesterase and carboxylesterase enzymes. The most appropriate dosage regimen for 2-PAM in the treatment of organophosphate toxicity in buffaloes would be 25 mg/kg followed by 22 mg/kg at 8 h intervals.  相似文献   

PCR assay for rapid detection of Pasteurella multocida serogroup A in morbid tissue materials from chickens with fowl cholera     

Shivachandra SB  Kumar AA  Gautam R  Singh VP  Chaudhuri P  Srivastava SK 《Veterinary journal (London, England : 1997)》2004,168(3):349-352

  相似文献   

Disposition Kinetics and Urinary Excretion of Pefloxacin after Intravenous Injection in Crossbred Calves     

Srivastava AK  Dumka VK  Deol SS 《Veterinary research communications》2000,24(3):189-196

The disposition kinetics and urinary excretion of pefloxacin after a single intravenous administration of 5 mg/kg were investigated in crossbred calves and an appropriate dosage regimen was calculated. At 1 min after injection, the concentration of pefloxacin in the plasma was 18.95±0.892 g/ml, which declined to 0.13±0.02 g/ml at 10 h. The pefloxacin was rapidly distributed from the blood to the tissue compartment as shown by the high values for the initial distribution coefficient, (12.1±1.21 h^–1) and the constant for the rate of transfer of drug from the central to the peripheral compartment, K ₁₂ (8.49±0.99 h^–1). The elimination half-life and volume of distribution were 2.21±0.111 h and 1.44±0.084 L/kg, respectively. The total body clearance (Cl_B) and the ratio of the drug present in the peripheral to that in the central compartment (P/C ratio) were 0.454±0.026 L/kg h) and 5.52±0.519, respectively. On the basis of the pharmacokinetic parameters obtained in the present study, an appropriate intravenous dosage regimen for pefloxacin in cattle for most of the bacteria sensitive to it would be 6.4 mg/kg repeated at 12 h intervals.  相似文献   

Seed mucilage from Ipomoea dasysperma     

Singh V  Pandey M  Srivastava A  Srivastava V 《Fitoterapia》2007,78(3):268-270

A non-ionic water-soluble galactomannan, having galactose and mannose in 1:6 molar ratio, was isolated from endosperm of the seeds of Ipomoea dasysperma. The seed mucilage was found to have a structure having a linear chain of beta (1-->4) linked mannopyranosyl units with D-galactose side chains attached through alpha (1-->6) linkage to the main chain. I. dasysperma seed gum possesses non-ionic characteristics of commercial seed gums and has potential to be used in food and pharmaceutical industries.  相似文献   

Fibrinous pericarditis and pericardial effusion in three neonatal foals     

SK Armstrong  SL Raidal  KJ Hughes 《Australian veterinary journal》2014,92(10):392-399

  相似文献   

Qualitative risk assessment of transmission pathways of highly pathogenic avian influenza (HPAI) virus at live poultry markets in Dhaka city,Bangladesh     

SK Shaheenur Islam  Holy Akwar  Md. Mehedi Hossain  Md. Abu Sufian  Md. Zakiul Hasan  Shovon Chakma  Tongkorn Meeyam  Warangkhana Chaisowwong  Veerasak Punyapornwithaya  Nitish C. Debnath  Eric Brum  Duangporn Pichpol 《Zoonoses and public health》2020,67(6):658-672

Analysis of environmental samples obtained from the Live Poultry Markets (LPMs) of Dhaka City, Bangladesh, has revealed that the highest degree of prevalence of highly pathogenic avian influenza A (HPAI, H5N1), besides other subtypes of the LPAI virus, poses the plausible risk of transmission of these viruses between human and poultry species. The present study was conducted using the OIE risk analysis framework to assess the risk level of each pathway successively. The estimated risk parameters were integrated towards to obtain the overall risk level for each specific HPAI transmission pathway using the matrix adapted by Cristobel Zepeda accompanying other expert consultations. The relevant data obtained from published and unpublished sources, together with survey data of field observations, were used to formulate and confirm the risk pathways and their associated risks. The results revealed that the risk of the release of the HPAI virus was medium when exposure was high. Additionally, the consequence would be considered very high with a medium degree of uncertainty for all parameters. Ultimately, the overall risk for transmission was estimated as medium with a medium degree of uncertainty. The findings of this study reveal that there is a significant threat that HPAI virus transmission could occur among poultry and humans and effectively sustain within the environment of the LPMs. Our findings are primarily focused on public health considerations, the hygienic slaughter of poultry and the relevant cleaning and sanitation practices conducted in the LPMs to support evidence‐based decision‐making processes. The findings of the study have the potential to be used to formulate effective risk reduction measures and can be further adapted in low‐resource settings without major infrastructural changes required of the LPMs. All of which would reduce the risk of HPAI virus release and further lessen the degree of exposure and transmission in established LPMs.  相似文献   

Megabase-scale mapping of the HLA gene complex by pulsed field gel electrophoresis   总被引：18，自引：0，他引：18  

S K Lawrance  C L Smith  R Srivastava  C R Cantor  S M Weissman 《Science (New York, N.Y.)》1987,235(4794):1387-1390

In the study of the genetic structure of mammalian chromosomes, there exists a "resolution gap" between molecular cloning experiments and meiotic linkage analyses. This gap has discouraged attempts to construct full-scale genetic maps of mammalian chromosomes. The organization of the human major histocompatibility complex was examined within this range by pulsed field gel electrophoresis. The data obtained indicate that the complex spans over 3000 kilobases and enable the construction of a megabase-scale molecular map. These results indicate that the techniques employed in DNA extraction, enzymatic digestion, electrophoresis, and hybridization are suitable for the efficient analysis of megabase regions of mammalian chromosomes and effectively bridge the resolution gap between molecular cloning and classical genetics.  相似文献   

Regulation of NF-kappaB activation in T cells via association of the adapter proteins ADAP and CARMA1     

Medeiros RB  Burbach BJ  Mueller KL  Srivastava R  Moon JJ  Highfill S  Peterson EJ  Shimizu Y 《Science (New York, N.Y.)》2007,316(5825):754-758

  相似文献