Evaluation of surface plasmon resonance biosensors for detection of tetrodotoxin in food matrices and comparison to analytical methods     

Yakes BJ  Deeds J  White K  Degrasse SL 《Journal of agricultural and food chemistry》2011,59(3):839-846

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Investigation and response to an outbreak of leptospirosis among raspberry workers in Australia, 2018     

Anthea L. Katelaris  Keira Glasgow  Kerryn Lawrence  Paul Corben  Anthony Zheng  Suhasini Sumithra  John Turahui  Janet Terry  Debra van den Berg  Daneeta Hennessy  Stacey Kane  Scott B. Craig  Ellena Heading  Mary‐Anne Burns  Hanisah L. Corner  Vicky Sheppeard  Jeremy McAnulty 《Zoonoses and public health》2020,67(1):35-43

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Non-traditional vectors for paralytic shellfish poisoning   总被引：2，自引：0，他引：2       下载免费PDF全文

Deeds JR  Landsberg JH  Etheridge SM  Pitcher GC  Longan SW 《Marine drugs》2008,6(2):308-348

Paralytic shellfish poisoning (PSP), due to saxitoxin and related compounds, typically results from the consumption of filter-feeding molluscan shellfish that concentrate toxins from marine dinoflagellates. In addition to these microalgal sources, saxitoxin and related compounds, referred to in this review as STXs, are also produced in freshwater cyanobacteria and have been associated with calcareous red macroalgae. STXs are transferred and bioaccumulate throughout aquatic food webs, and can be vectored to terrestrial biota, including humans. Fisheries closures and human intoxications due to STXs have been documented in several non-traditional (i.e. non-filter-feeding) vectors. These include, but are not limited to, marine gastropods, both carnivorous and grazing, crustacea, and fish that acquire STXs through toxin transfer. Often due to spatial, temporal, or a species disconnection from the primary source of STXs (bloom forming dinoflagellates), monitoring and management of such non-traditional PSP vectors has been challenging. A brief literature review is provided for filter feeding (traditional) and non-filter feeding (non-traditional) vectors of STXs with specific reference to human effects. We include several case studies pertaining to management actions to prevent PSP, as well as food poisoning incidents from STX(s) accumulation in non-traditional PSP vectors.  相似文献   

Ultrasound characteristics of feline urinary bladder transitional cell carcinoma are similar to canine urinary bladder transitional cell carcinoma     

Alessandra N. Hamlin  Laura E. Chadwick  Stacey A. Fox‐Alvarez  Eric T. Hostnik 《Veterinary radiology & ultrasound》2019,60(5):552-559

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Dexamethasone, melphalan, actinomycin D, cytosine arabinoside (DMAC) protocol for dogs with relapsed lymphoma     

Alvarez FJ  Kisseberth WC  Gallant SL  Couto CG 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2006,20(5):1178-1183

BACKGROUND: In general, treatment of relapsed lymphoma is associated with a lower probability of response and shorter duration of remission. The purpose of this study was to evaluate the efficacy of the combination chemotherapy protocol DMAC (dexamethasone, melphalan, actinomycin D, and cytosine arabinoside) for reinduction of remission in dogs with relapsed lymphoma. HYPOTHESIS: That DMAC would be an effective reinduction protocol for dogs with relapsed lymphoma. ANIMALS: Fifty-four dogs. RESULTS: Seventy-two percent of the dogs achieved remission (44% complete remission [CR] and 28% partial remission [PR]), 11% had stable disease (SD), and 17% had progressive disease (PD). The median remission duration was 61 days (range, 2-467+ days). The median remission durations for dogs with CR, PR, and SD were 112, 44, and 27 days, respectively. Factors that affected the response rate were previous treatment with doxorubicin and an inability to achieve remission with the previous protocol. Thrombocytopenia occurred in 56% of the dogs (grade 1 in 3 dogs, grade 2 in 6 dogs, grade 3 in 7 dogs, and grade 4 in 7 dogs) and neutropenia in 17% of the dogs (grade 2 in 1 dog, grade 3 in 2 dogs, and grade 4 in 4 dogs). Gastrointestinal toxicosis occurred in 22% of the dogs (grades 1 in 5 dogs, grade 2 in 3 dogs, and grade 3 in 1 dog). CONCLUSIONS AND CLINICAL IMPORTANCE: The DMAC protocol is an effective rescue protocol for dogs with relapsed multicentric lymphoma. Although thrombocytopenia is a common manifestation of toxicity, in general, the protocol is well tolerated.  相似文献   

Evolution and functional impact of rare coding variation from deep sequencing of human exomes     

Tennessen JA  Bigham AW  O'Connor TD  Fu W  Kenny EE  Gravel S  McGee S  Do R  Liu X  Jun G  Kang HM  Jordan D  Leal SM  Gabriel S  Rieder MJ  Abecasis G  Altshuler D  Nickerson DA  Boerwinkle E  Sunyaev S  Bustamante CD  Bamshad MJ  Akey JM;Broad GO;Seattle GO;NHLBI Exome Sequencing Project 《Science (New York, N.Y.)》2012,337(6090):64-69

As a first step toward understanding how rare variants contribute to risk for complex diseases, we sequenced 15,585 human protein-coding genes to an average median depth of 111× in 2440 individuals of European (n = 1351) and African (n = 1088) ancestry. We identified over 500,000 single-nucleotide variants (SNVs), the majority of which were rare (86% with a minor allele frequency less than 0.5%), previously unknown (82%), and population-specific (82%). On average, 2.3% of the 13,595 SNVs each person carried were predicted to affect protein function of ~313 genes per genome, and ~95.7% of SNVs predicted to be functionally important were rare. This excess of rare functional variants is due to the combined effects of explosive, recent accelerated population growth and weak purifying selection. Furthermore, we show that large sample sizes will be required to associate rare variants with complex traits.  相似文献   

Effects of stem girdling on cone yield and endogenous phytohormones and metabolites in developing long shoots of Douglas-fir (Pseudotsuga menziesii)     

Lisheng Kong  Patrick von Aderkas  Stacey J. Owen  Barry Jaquish  Jack Woods  Suzanne R. Abrams 《New Forests》2012,43(4):491-503

Stem-girdling treatments were applied in early spring to stimulate cone formation in two genotypes of interior Douglas-fir (Pseudotsuga menziesii var. glauca (Beissn.) Franco). After girdling treatments, male cone yield increased significantly in the next growing season. The increase was 14-fold in genotype 9137. In genotype 9550, more than 8,700 male cones were induced from each tree whereas no male cones were found in controls. Female cone yield was zero in controls and low for girdled trees in both genotypes. Multiple phytohormone-related compounds, including gibberellins (GAs), cytokinins, indole-3-acetic acid (IAA), abscisic acid (ABA) and their selected metabolites, were analyzed in developing long shoots after girdling treatments by high performance liquid chromatography-electrospray ionization tandem mass spectrometry (HPLC?CESI?CMS/MS) in multiple reaction monitoring mode. Concentrations of GA₄ were slightly higher at week 2 following girdling treatment, whereas at week 8 lower GA₄ concentrations were found in girdled samples. Stem girdling did not affect concentrations of IAA and major cytokinins, such as zeatin riboside and isopentenyl adenosine. Concentrations of ABA differed two-fold between the genotypes. Although girdling treatment did not cause differences in ABA concentrations, it generally resulted in higher concentrations of ABA glucose ester. Concentration increase of 7??-hydroxy ABA by girdling was only found in genotype 9550 at week 8. Girdling caused little change in concentrations of phaseic acid in both genotypes.  相似文献   

Chemical Control of Sand Sagebrush: Implications for Lesser Prairie-Chicken Habitat     

Eric T. Thacker  Robert L. Gillen  Stacey A. Gunter  Tim L. Springer 《Strength and Conditioning Journal》2012,65(5):516-522

Traditional management of sand sagebrush (Artemisia filifolia) rangelands has emphasized sagebrush control to increase forage for livestock. Since the 1950s shrub removal has been primarily achieved with herbicides. Concerns over declining lesser prairie-chicken (Tympanuchus pallidicinctus; LPC) populations have led to increased scrutiny over the use of herbicides to control shrubs. The objective of our research was to describe changes to LPC habitat qualities following chemical control of sand sagebrush in northwest Oklahoma. Study pastures ranged in size from 10 to 21 ha. Five pastures were sprayed with 2,4-dichlorophenoxyacetic acid (2,4-D) in 2003 (RECENT), five were sprayed with 2,4-D in 1984 (OLD), and four received no treatment (SAGE). We measured habitat structure (sagebrush cover, sagebrush density, visual obstruction [VO], and basal grass cover), and dietary resources (forb density, forb richness, and grasshopper density) in all pastures from 2003 to 2006. OLD and RECENT pastures had less sagebrush (cover and density) and VO than SAGE pastures. OLD pastures produced more annual forbs than either SAGE or RECENT pastures. SAGE pastures had more perennial forbs than RECENT pastures. Herbicide application reduced protective cover while providing no increase in forb abundance in RECENT pastures. Our results indicated that it may take several years to realize increases in annual forbs following application of 2,4-D. However, loss of protective cover may persist for multiple years (20+ yr), and removal of sagebrush did not increase forb richness or grasshopper abundance. Thus, 2,4-D may have limited use as a habitat management tool because it takes numerous years to reap the benefit of increased forb abundance while reducing habitat structure in the long term.  相似文献   

Comparison of endotracheal intubation techniques in llamas     

Stacey R. Byers  Julie A. Cary  Kelly D. Farnsworth 《The Canadian veterinary journal. La revue veterinaire canadienne》2009,50(7):745-749

This study evaluated a retrograde orotracheal intubation technique and compared it to the traditional normograde intubation technique used in llamas. Oral anatomical features, which can impair visualization of the epiglottis and laryngeal structures, and the production of excessive salivary secretions make it difficult to establish an airway under emergency conditions. Normograde intubation involves placing a stylet through the mouth into the trachea and advancing the endotracheal tube over the stylet into the trachea. For retrograde intubation, a nested trochar with cannula is placed into the cervical trachea and a stylet is advanced through the cannula and out the mouth. The endotracheal tube is advanced over the stylet back into the trachea. Our evaluation of both techniques found no statistical difference in time to place the stylet or endotracheal tube; however, fewer attempts were needed to place the tube using the retrograde technique. We found the retrograde technique to be a viable option for intubating llamas.  相似文献   

Bovine intelectins: cDNA sequencing and expression in the bovine intestine     

Blease SC  French AT  Knight PA  Gally DL  Pemberton AD 《Research in veterinary science》2009,86(2):254-256

Intelectins (Itlns) are lectins with potential roles in innate immunity, capable of binding bacteria via galactofuranose residues. Itlns also function as intestinal receptors for the antimicrobial glycoprotein lactoferrin (Lf). Since Lf binds strongly to enterohemorrhagic Escherichia coli O157:H7 (EHEC), we aimed to determine the expression of Lf receptor in terminal rectum, the site of predilection of EHEC in cattle. We sequenced two bovine intelectins (Itln1 and Itln2) and showed that both were expressed in abomasum and rectum, but expression appeared minimal in the jejunum. There was significantly higher expression of Itln2 in terminal rather than proximal rectum. Lactoferrin was expressed in all samples examined. Thus, we have demonstrated two novel bovine Itlns and shown that they are expressed along with Lf in the gastrointestinal tract, where they may interact with microbial pathogens.  相似文献