USE OF COMPUTED TOMOGRAPHY IN THE DIAGNOSIS OF A CEREBRAL ABSCESS IN A GOAT     

Terry C.  Gerros  DVM  MS  John S.  Mattoon  DVM  Stanley P.  Snyder  DVM  PHD 《Veterinary radiology & ultrasound》1998,39(4):322-324

A 7-month-old La Mancha doe was presented with a right head tilt and ventral strabismus while circling to the left. History and physical examination led to a tentative diagnosis of a cerebral abscess. Computed tomography revealed a large, complex mass with ring enhancement in the left cerebral hemisphere, supporting the diagnosis. Postmortem examination confirmed the cerebral abscess. Bacterial cultures yielded heavy growth of Actinomyces pyogenes.  相似文献   

Results of grid keratotomy, superficial keratectomy and debridement for the management of persistent corneal erosions in 92 dogs   总被引：2，自引：0，他引：2  

Stanley RG  Hardman C  Johnson BW 《Veterinary ophthalmology》1998,1(4):233-238

Ninety-two cases of persistent corneal erosions in dogs were analyzed for breed, gender, age and which eye was affected. The results of the treatment of 92 persistent corneal erosions in dogs by superficial keratectomy (SK), grid keratotomy (GK), or debridement with a sterile dry cotton swab are presented. These techniques gave better rates of healing than have been previously reported. All cases of persistent corneal erosions healed in this study. However, it must be noted that three cases treated with debridement only failed to heal after several treatments and were eventually treated with SK. After one procedure 80 out of 92 (87%) had healed. After one procedure, 63% of cases treated with debridement healed, 100% of cases treated with SK healed, and 85% of cases treated with GK healed. At the first postoperative visit, 88% (21/24 cases) of ulcers treated by SK had healed, and 75% (39/52 cases) of ulcers treated by GK had healed. Only 25% of the persistent corneal erosions had healed at the first visit after debridement. All 24 cases of persistent corneal erosions treated with SK healed after one treatment in a mean +/- SD of 9.3 +/- 3.9 days (median of 7 days). Fifty-two cases were managed with GK; 44 (83%) of these healed with one procedure and eight cases required a second GK procedure to resolve. A mean +/- SD of 13.4 +/- 5.1 days (median of 11.5 days) following GK was required for the persistent corneal erosions to heal. Nineteen cases were initially managed by debridement with a dry cotton swab under local anesthesia. Sixteen out of these 19 debridement cases healed (giving an overall healing rate of 84%) in a mean +/- SD time of 23.4 +/- 11.1 days (median 21.5). There were three cases that did not heal with debridement. These cases were debrided at 10-20 day intervals for 30-60 days, and were then treated with SK. Two of these cases healed within 7 days, the other case required 18 days to heal. Sixty-three per cent of persistent corneal erosions treated with debridement healed after one procedure; however, only four out of 19 cases (21%) were healed at the first revisit. Complications were rare: corneal edema occurred in two cases following multiple GK, and excessive granulation tissue in one case was managed with a SK. There was the occurrence of an ulcer adjacent to the surgery site in four cases, two cases following GK and two cases following SK.  相似文献   

RADIOGRAPHY OF THE CANINE HEAD     

Stanley P.  Kus  DVM  MS  Joe P.  Morgan  DVM  Vet med dr 《Veterinary radiology & ultrasound》1985,26(6):196-202

Through the use of a purebred dog skull collection, specific positioning recommendations were established for radiography for the three skull types. It is suggested that the central ray of the beam be maintained at the following mean angles relative to the hard palate for the rostrodorsal-to-caudoventral oblique projection of the foramen magnum: dolicocephalic, 30° mesaticephalic, 20° and brachycephalic, 10°. It is recommended that the head be axially rotated as follows to radiographically separate the roots of the superior canine teeth: dolicocephalic, 48° mesaticephalic, 43° and brachycephalic, 35°. If only the cheek teeth require evaluation, the head should be rotated as follows: dolicocephalic, 37° mesaticephalic, 34° and brachycephalic, 25°. For evaluation of the inferior cheek teeth, it is recommended that the head be rotated as follows: dolicocephalic, 46° mesaticephalic, 44° and brachycephalic, 28°. It is recommended that radiographs of the temporo-mandibular joint be made with the skull axially rotated 10° and longitudinally obliqued as follows: dolicocephalic, 10° mesaticephalic, 14° and brachycephalic, 27°. Suggestions for open-mouth projections for evaluation of the tympanic bullae are that the central ray maintain the following angles relative to the hard palate: dolicocephalic, 4° mesaticephalic, 9° and brachycephalic, 21°. It is recommended that a caudoventral-rostrodorsal oblique projection of the nasal cavity made at 30° to the hard palate replace the open-mouth ventrodorsal in brachycephalic breeds.  相似文献   

Pharmacokinetic and pharmacodynamic analysis comparing diverse effects of detomidine,medetomidine, and dexmedetomidine in the horse: a population analysis          下载免费PDF全文

K. N. Grimsrud  S. Ait‐Oudhia  B. P. Durbin‐Johnson  D. M. Rocke  K. R. Mama  M. L. Rezende  S. D. Stanley  W. J. Jusko 《Journal of veterinary pharmacology and therapeutics》2015,38(1):24-34

The present study characterizes the pharmacokinetic (PK) and pharmacodynamic (PD) relationships of the α₂‐adrenergic receptor agonists detomidine (DET), medetomidine (MED) and dexmedetomidine (DEX) in parallel groups of horses from in vivo data after single bolus doses. Head height (HH), heart rate (HR), and blood glucose concentrations were measured over 6 h. Compartmental PK and minimal physiologically based PK (mPBPK) models were applied and incorporated into basic and extended indirect response models (IRM). Population PK/PD analysis was conducted using the Monolix software implementing the stochastic approximation expectation maximization algorithm. Marked reductions in HH and HR were found. The drug concentrations required to obtain inhibition at half‐maximal effect (IC₅₀) were approximately four times larger for DET than MED and DEX for both HH and HR. These effects were not gender dependent. Medetomidine had a greater influence on the increase in glucose concentration than DEX. The developed models demonstrate the use of mechanistic and mPBPK/PD models for the analysis of clinically obtainable in vivo data.  相似文献   

Versatility of the Angularis Oris Axial Pattern Flap for Facial Reconstruction          下载免费PDF全文

Sara L. Losinski  Bryden J. Stanley  Sandra P. Schallberger  Laura L. Nelson  Heather A.M. Towle Millard 《Veterinary surgery : VS》2015,44(8):930-938

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Perception of Teaching and Assessing Technical Proficiency in American College of Veterinary Surgeons Small Animal Surgery Residency Programs          下载免费PDF全文

Stanley E. Kim BVSc  MS  DACVS  J. Brad Case DVM  MS  DACVS  Daniel D. Lewis DVM  DACVS  Gary W. Ellison DVM  MS  DACVS 《Veterinary surgery : VS》2015,44(6):790-797

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Pharmacokinetics of buprenorphine following intravenous and buccal administration in cats,and effects on thermal threshold     

A. R. Hedges  B. H. Pypendop  Y. Shilo‐Benjamini  S. D. Stanley  J. E. Ilkiw 《Journal of veterinary pharmacology and therapeutics》2014,37(3):252-259

This study reports the pharmacokinetics of buprenorphine, following i.v. and buccal administration, and the relationship between buprenorphine concentration and its effect on thermal threshold. Buprenorphine (20 μg/kg) was administered intravenously or buccally to six cats. Thermal threshold was determined, and arterial blood sampled prior to, and at various times up to 24 h following drug administration. Plasma buprenorphine concentration was determined using liquid chromatography/mass spectrometry. Compartment models were fitted to the time–concentration data. Pharmacokinetic/pharmacodynamic models were fitted to the concentration‐thermal threshold data. Thermal threshold was significantly higher than baseline 44 min after buccal administration, and 7, 24, and 104 min after i.v. administration. A two‐ and three‐compartment model best fitted the data following buccal and i.v. administration, respectively. Following i.v. administration, mean ± SD volume of distribution at steady‐state (L/kg), clearance (mL·min/kg), and terminal half‐life (h) were 11.6 ± 8.5, 23.8 ± 3.5, and 9.8 ± 3.5. Following buccal administration, absorption half‐life was 23.7 ± 9.1 min, and terminal half‐life was 8.9 ± 4.9 h. An effect‐compartment model with a simple effect maximum model best predicted the time‐course of the effect of buprenorphine on thermal threshold. Median (range) k_e0 and EC50 were 0.003 (0.002–0.018)/min and 0.599 (0.073–1.628) ng/mL (i.v.), and 0.017 (0.002–0.023)/min and 0.429 (0.144–0.556) ng/mL (buccal).  相似文献   

Aquaculture pond temperature modeling     

Stanley L. Klemetson  Gary L. Rogers 《Aquacultural Engineering》1985,4(3):191-208

The prediction of aquaculture pond temperatures throughout the year is essential to the design and evaluation of potential aquaculture sites. A site may obtain the necessary heat inputs from the sun, geothermal wells or industrial and power plant waste heat. The amount of heat addition necessary is dependent upon climatic and environmental factors at the site.The MAPT (Maintenance of Aquaculture Pond Temperatures) model was developed to determine the potential for warm water aquaculture at any site in the world. Hot water sources and solar radiation provided the heat inputs to the model while the heats of evaporation, convection and radiation were responsible for the heat losses.The model was used to consider a variety of heat loss reduction methods, heat transfer methods and projected the pond temperatures and animal production rates. It has been applied to several sites around the world and provides an inexpensive means for evaluation of production potential without extensive site data collection.  相似文献   

Growth of American oysters increased by polyploidy induced by blocking meiosis I but not meiosis II     

Jon G. Stanley  Herbert Hidu  Standish K. Allen 《Aquaculture (Amsterdam, Netherlands)》1984,37(2):147-155

Triploidy in American oysters (Crassostrea virginica) was induced by blocking polar body formation with cytochalasin B. Triploid oysters created by treatment during meiosis I grew faster during the first 3 years of life than did diploid siblings. Triploid oysters created during meiosis II grew at the same rate as their controls. Because heterozygosity was higher in oysters created during meiosis I than in other groups, the increased growth must be due to heterozygosity rather than to triploidy per se.  相似文献   

Ammonia removal in selected aquaculture water reuse biofilters     

Gary L. Rogers  Stanley L. Klemetson 《Aquacultural Engineering》1985,4(2):135-154

Four fixed-film biological filters (rotating biological contactor, biodrum, trickling filter, and a submerged anaerobic filter) were tested for the removal of ammonia using a simulated warmwater fish and invertebrate culture water supply. Filter design may be determined based on the results of ammonia removal efficiency over a wide range of hydraulic loads. The rotating biological contactor (RBC) provided the best ammonia removal (over 90%) up to about 0·06 m³ m^?2 day^?1 (1·2 gpd ft^?2). The biodrum removed over 80% of the ammonia to a hydraulic load of 0·05 m³ m^?2 day^?1 (0·9 gpd ft^?2). The trickling filter removed 50% of the ammonia at a hydraulic loading of 0·012 m³ m^?2 day^?1 (0·3 gpd ft^?2).  相似文献