Comparison of Two Doses of the GnRH Antagonist, Acyline, for Pregnancy Termination in Bitches     

C Valiente  Y Corrada  PE de la Sota  PG Blanco  D Arias  C Gobello 《Reproduction in domestic animals》2009,44(S2):156-159

Gonadotropin-releasing hormone (GnRH) antagonists are particularly useful when a rapid inhibitory effect on the gonadal axis is required. The aim of this study was to test the efficacy and clinical safety of a low and high dose of the third generation GnRH antagonist, acyline, on pregnancy termination in female dogs. The effect of the antagonist on the progesterone (P₄) serum concentration was also described. Twenty-one mid-pregnant bitches were randomly assigned to a single subcutaneous (SC) dose of a placebo (PLACE; n = 7), a low (ACY-L; 110 μg/kg; n = 6) or high (ACY-H; 330 μg/kg; n = 8) dose of acyline. The animals were followed up for 15 days. All ACY treated but no placebo-treated animals terminated their pregnancy by abortion (p < 0.01). The ACY-L and ACY-H groups interrupted their pregnancy 7 ± 1.9 and 6.4 ± 1.3   days after treatment, respectively (p = 0.7). A significant interaction between treatment and day was found (p < 0.01) for P₄ serum concentrations when PLACE was compared with both ACY groups. No difference was found for this hormone between both ACY groups (p > 0.05) where P₄ diminished throughout the study. The decreasing rate varied among animals and was closely related to the time of abortion when P₄ reached basal concentrations. In PLACE animals, gestation progressed normally and P₄ did not change throughout the study (p > 0.05). None of the bitches presented side effects. It was concluded that acyline safely terminated mid-pregnancy by permanently decreasing P₄ serum concentrations.  相似文献   

Randomized controlled trial of the efficacy of cyclosporine in the treatment of atopic dermatitis in dogs     

Olivry T  Steffan J  Fisch RD  Prélaud P  Guaguère E  Fontaine J  Carlotti DN;European Veterinary Dermatology Cyclosporine Group 《Journal of the American Veterinary Medical Association》2002,221(3):370-377

OBJECTIVE: To evaluate efficacy of cyclosporine A, administered at either of 2 dosages, in dogs with atopic dermatitis (AD). DESIGN: Multicenter randomized controlled trial. ANIMALS: 91 dogs with AD. PROCEDURE: Dogs were assigned to receive placebo (30 dogs), cyclosporine at a low dosage (2.5 mg/kg [1.1 mg/lb], PO, q 24 h for 6 weeks; 30 dogs), or cyclosporine at a high dosage (5.0 mg/kg [2.3 mg/lb], PO, q 24 h for 6 weeks; 31 dogs). RESULTS: After 6 weeks, mean percentage reductions, compared with baseline scores, in scores of lesion severity were 34, 41, and 67% for dogs treated with the placebo, cyclosporine at the low dosage, and cyclosporine at the high dosage, respectively. Similarly, mean percentage reductions in pruritus scores were 15, 31, and 45%, respectively. Percentage reductions in skin lesion and pruritus scores were significantly higher for dogs given cyclosporine at the high dosage than for dogs given the placebo. Treatment efficacy was significantly associated with whether dogs had a history of seasonal AD. Percentage reductions in skin lesion and pruritus scores were high for dogs treated with cyclosporine at the highest dosage that had a history of nonseasonal AD. Dogs in all groups with seasonal AD improved during the study period. CONCLUSIONS AND CLINICAL RELEVANCE: Results suggest that oral administration of cyclosporine at a dosage of 5.0 mg/kg once daily is effective in reducing severity of pruritus and skin lesions in dogs with AD, especially those with nonseasonal disease.  相似文献   

Changes in Glucocorticoid Receptor Levels of Bovine Lymphocyte and Neutrophil during Estrous Cycle     

PE Martínez  MTP Lopes  MS Martins  AP Marques Jr  CE Salas 《Reproduction in domestic animals》1998,33(2):61-66

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美国控制土壤侵蚀的经验     

John.W.Peterson PE 《中国水土保持》2002,(7)

对美国土壤侵蚀的历史及其后果的研究十分有意义。自美国殖民时期和 1 8世纪建国开始 ,有许多文献表明 ,最早期的殖民者已明了由于人们耕种土地产生的土壤侵蚀所引发的问题 ,也有意做点什么来减少土壤侵蚀。 1 86 1年各州之间发生战争 ,有记录表明 ,河流被来自管理不善的农田的泥沙淤塞。由于认为土地资源取之不尽 ,当时的农民常常是当农地变得无法耕种时 ,就打起行装向西部新的土地转移。然而很快当全国从东海岸到西海岸都居住有人后 ,这种做法就行不通了。2 0世纪 30年代的大平原“沙尘暴”及随之而来的美国经济大萧条 ,为罗斯福政府创造…  相似文献   

Minutes of the 69th Annual General Meeting of the Australian Veterinary Association     

PE Greenwood 《Australian veterinary journal》1992,69(9):234-235

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The application of 3‐dimensional printing for preoperative planning in oral and maxillofacial surgery in dogs and cats          下载免费PDF全文

Jenna N. Winer DVM  Derek D. Cissell VMD  PhD  DACVR  Steven Lucero BS  Kyriacos A. Athanasiou PhD  PE  Boaz Arzi DVM  DAVDC  DEVDC 《Veterinary surgery : VS》2017,46(7):942-951

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Discriminating power of microsatellites in cranberry organelles for taxonomic studies in <Emphasis Type="Italic">Vaccinium</Emphasis> and Ericaceae     

Brandon Schlautman  Giovanny Covarrubias-Pazaran  Diego Fajardo  Shawn Steffan  Juan Zalapa 《Genetic Resources and Crop Evolution》2017,64(3):451-466

Simple sequence repeats (SSRs) in chloroplast and mitochondrial DNA, which have not been previously developed in the Ericaceae or, more specifically, in the genus Vaccinium, can be powerful tools for determining evolutionary relationships among taxa. In this study, 30 chloroplast, 23 mitochondrial, and 1 mitochondrion-like SSRs were identified in cranberry (V. macrocarpon), and primer-pairs were developed and tested for each locus. Although no polymorphisms were detected for any of the 54 SSR loci in nine diverse cranberry genotypes, all primers were cross-transferable to some extent to a panel of 12 additional Vaccinium taxa and four non-Vaccinium Ericaceae species. A Neighbor-Joining tree of the estimated average squared distances resolved the species by genus and by section within Vaccinium. Similar topologies with increased branch support were observed in Bayesian inference trees constructed from the DNA sequences of six plastid and two mitochondrial SSR loci. Two multiplexing/poolplexing panels of M13 fluorescently labeled primers, which amplify 24 of the 54 markers, were developed and can serve as an efficient, cost-effective means for characterizing the basic molecular phylogeny of Vaccinium. Increased understanding of evolutionary relationships among Vaccinium species should facilitate interspecific hybridization and introgression efforts to improve economically important traits of commercial berry crops.  相似文献   

A survey of public attitudes towards barking dogs in New Zealand     

EL Flint  EO Minot  PE Perry 《New Zealand veterinary journal》2013,61(6):321-327

AIMS: To investigate public attitudes towards barking dogs in New Zealand in order to quantify the extent to which people perceive barking dogs to be a problem, to compare tolerance of barking with that of other common suburban noises, to assess the level of public understanding about the function of barking, to determine risk factors for intolerance of barking and to assess knowledge of possible strategies for the investigation and management of problem barking.

METHODS: A 12-page questionnaire was sent to 2,000 people throughout New Zealand randomly selected from the electoral roll. Risk factors for being bothered by barking were examined using logistic regression analysis.

RESULTS: A total of 1,750 questionnaires were successfully delivered; of these, 727 (42%) were returned. Among respondents, 356/727 (49.0%) indicated that frequent barking during the day would bother them while 545/727 (75.0%) would be bothered by barking at night. Barking and howling were ranked above other suburban noises as a cause of annoyance. Risk factors for being bothered by daytime barking were not being home during the day, not owning a dog, and considering a dog bite to be a serious health risk. Risk factors for being bothered by night-time barking were not being home during the day, marital status, considering dog bites to pose a serious health risk, and having been frightened by a dog. Overall, 510/699 (73%) respondents understood that barking was a form of communication.

Action likely to be taken by 666 respondents hearing frequent barking included notifying and offering to help the owner (119; 17.8%), complaining to the owner (127; 19.1%) or the authorities (121; 18.2%), or doing nothing (299; 48%). Possible responses by 211 dog owners if they had a barking dog included seeking help from dog trainers (59; 28%) or behaviourists (54; 26%), buying an anti-barking device (33; 15%) or getting rid of the dog (20; 10%).

CONCLUSIONS: Barking was considered to be potentially disturbing by respondents to this survey. Attitudes towards barking were most influenced by age, dog ownership, past experience with dogs and attitude towards dog bites. Public understanding of the possible reasons for barking and appropriate methods of managing the behaviour when it becomes a problem could be improved by better education and the provision of information through veterinary clinics and social media.  相似文献   

Minutes of the 70th Annual General Meeting of the Australian Veterinary Association     

PE Greenwood 《Australian veterinary journal》1993,70(10):383-385

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Carbohydrate malabsorption in dogs assessed using bioluminescence assays to measure simple sugars     

PH BIRD  PE HARTMANN  SE KELLY  WT CLARK 《Australian veterinary journal》1990,67(9):341-342

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