Acute echocardiographic effects of sotalol on ventricular systolic function in dogs with ventricular arrhythmias          下载免费PDF全文

Lance C. Visser  Joanna L. Kaplan  Satoko Nishimura  Catherine T. Gunther‐Harrington  Catherine Bélanger  Maureen S. Oldach  Joshua A. Stern  Mikaela S. Mueller 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2018,32(4):1299-1307

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High-pressure balloon valvuloplasty for severe pulmonary valve stenosis: a prospective observational pilot study in 25 dogs     

Catherine Belanger  Catherine T. Gunther-Harrington  Satoko Nishimura  Maureen S. Oldach  Samantha L. Fousse  Lance C. Visser  Joshua A. Stern 《Journal of Veterinary Cardiology》2018,20(2):115-122

Objectives

We aimed to evaluate safety and efficacy of high-pressure balloon valvuloplasty (HPBVP) for treatment of canine severe pulmonary valve stenosis (PS). A secondary aim was to provide pre-procedure predictors of success.

Animals

Twenty-five dogs.

Methods

Prospective observational study. Dogs with severe PS (echocardiographically derived trans-pulmonary peak/maximum pressure gradient (EDPG) ≥80 mmHg) were recruited. All dogs underwent echocardiography before and 20–24hrs after HPBVP using a high-pressure balloon with rated burst pressures ranging from 12 to 18 ATM. Procedural success was defined as a post-HPBVP EDPG reduction of ≥50% or reduction into at least the moderate category of PS (50–79 mmHg). Optimal result was defined as a post-procedural EDPG ≤30 mmHg.

Results

Initial median (IQR) EDPG for all dogs was 96 (88, 127) mmHg with a post-operative median of 48 (36, 65) mmHg. The median EDPG reduction provided by HPBVP was 63% (39, 68); procedural success rate was 92% (23 dogs). Optimal results were achieved in 56% (14 dogs). There were no significant correlations between EDPG reduction and valve morphology (Type A and Type B) or severity of right ventricular hypertrophy. Pulmonary valve annulus diameter was the only echocardiographic variable that was significantly correlated to EDPG reduction (p = 0.02; r = ?0.46). No dog experienced any anesthetic or surgical complications, and all patients survived the procedure.

Conclusions

In this cohort of 25 dogs with severe PS, HPBVP was safe and effective. The procedural success rate and high number of optimal results achieved with HPBVP suggest future randomized controlled trials comparing HPBVP to conventional valvuloplasty are warranted.  相似文献   

A Single Flashlight Source for Ultracentrifuge Research     

Lipschultz LL  Stern KG 《Science (New York, N.Y.)》1947,105(2728):395-396

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Frequency of vomiting during the postoperative period in hydromorphone-treated dogs undergoing orthopedic surgery     

LC Stern  MP Palmisano 《Journal of the American Veterinary Medical Association》2012,241(3):344-347

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MODE OF COMBINATION OF AN ENZYME WITH AN ADSORBENT AND WITH A SUBSTRATE     

Stern KG 《Science (New York, N.Y.)》1936,83(2147):190-191

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Pedagogy meets neuroscience     

Stern E 《Science (New York, N.Y.)》2005,310(5749):745

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Relationship of messenger RNA reverse transcriptase-polymerase chain reaction signal to Campylobacter spp. viability     

Sung KD  Stern NJ  Hiett KL 《Avian diseases》2004,48(2):254-262

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Influence of Zinc Bacitracin and Bacillus licheniformis on Microbial Intestinal Functions in Weaned Piglets     

Collinder E  Cardona ME  Berge GN  Norin E  Stern S  Midtvedt T 《Veterinary research communications》2003,27(7):513-526

The influence of zinc bacitracin (ZB) and of Bacillus licheniformis on host microbial-related functions in young piglets was investigated by applying the concept of microflora-associated characteristics. Six biochemical parameters were determined before and after weaning in faecal samples from piglets in four litters having access to a diet containing ZB, to a diet containing B. licheniformis, to a diet with both additives, or to a diet with no additives, from 3 weeks of age. Statistically significant differences were found in three of the intestinal functions investigated: formation of short-chain fatty acids (at 7 and 10 weeks of age), degradation of mucin (at 7 and 10 weeks of age) and conversion of bilirubin to urobilins (at 7 weeks of age). We also found age-dependent influences on the formation of short-chain fatty acids, on conversion of cholesterol to coprostanol and on conversion of bilirubin to urobilins. We conclude that a functional approach is appropriate for measuring exogenous influence(s) on the microbial intestinal metabolisms in weaned piglets.  相似文献   

Genotype analyses of Campylobacter isolated from the gastrointestinal tracts and the reproductive tracts of broiler breeder roosters     

Hiett KL  Siragusa GR  Cox NA  Buhr RJ  Musgrove MT  Stern NJ  Wilson JL 《Avian diseases》2003,47(2):406-414

Campylobacter is considered to be the leading bacterial etiologic agent of acute gastroenteritis in humans. Evidence implicates poultry as a major source of the organism for human illness; however, the pathways involved in Campylobacter contamination of poultry flocks, horizontal transmission and/or vertical transmission, remain unclear. Recent evidence implicates breeders as a potential source for Campylobacter contamination of the subsequent broiler offspring. In this investigation, Campylobacter isolated from feces, cloacal swabs, ceca, semen, and vas deferens of 12 breeder broiler roosters were genotyped by both flagellin A short variable region (flaA SVR) DNA sequence analysis and repetitive element (rep)-polymerase chain reaction (PCR). In 9 of 12 roosters, Campylobacter was isolated from multiple sites sampled. Comparison of multiple isolates obtained from individual roosters revealed variable results. In five of the nine roosters, all Campylobacter isolated demonstrated closely related flaA SVR DNA sequences as well as rep-PCR patterns; isolates from these roosters were collected from both the gastrointestinal and the reproductive tracts or from the gastrointestinal tract alone. The remaining four roosters had Campylobacter that were distinct by both typing methods. Isolates from two of these four roosters originated from both the gastrointestinal and the reproductive tracts. Isolates from the remaining two roosters originated from only the reproductive tract. Comparisons of all Campylobacter isolates recovered from a distinct sample type within either the reproductive tract or the gastrointestinal tract (feces, semen, cloaca, vas deferens, or ceca) were quite diverse. No relationship between the genotypes and the sample type could be ascertained. Further investigation is needed to determine the route of contamination and if the presence of Campylobacter within the rooster leads to contamination of the broiler offspring via the fertilized egg.  相似文献   

Direct polymerase chain reaction detection of Campylobacter spp. in poultry hatchery samples     

Hiett KL  Cox NA  Stern NJ 《Avian diseases》2002,46(1):219-223

A rapid, sensitive, and specific polymerase chain reaction (PCR) assay was developed for the direct detection of Campylobacter in environmental samples from hatcheries. PCR, with a set of primers specific for the Campylobacter flaA short variable region (SVR), detected the presence of Campylobacter in both fluff and eggshell samples; however, a determination of whether the organism was living or dead could not be made. Conventional cultural methods detected no Campylobacter from the same samples. An additional benefit of the direct PCR assay is it allows for the production of a product that can be sequenced to provide further epidemiologic information.  相似文献