CARL LUDWIG     

Lee FS 《Science (New York, N.Y.)》1895,1(23):630-632

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PHYSICAL EXERCISE FROM THE STAND-POINT OF PHYSIOLOGY     

Lee FS 《Science (New York, N.Y.)》1909,29(744):521-527

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SECTION F--ZOOLOGY THE AMERICAN SOCIETY OF ZOOLOGISTS II     

Lee TG 《Science (New York, N.Y.)》1908,27(703):940-954

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Discovery of a Jupiter/Saturn analog with gravitational microlensing     

Gaudi BS  Bennett DP  Udalski A  Gould A  Christie GW  Maoz D  Dong S  McCormick J  Szymanski MK  Tristram PJ  Nikolaev S  Paczynski B  Kubiak M  Pietrzynski G  Soszynski I  Szewczyk O  Ulaczyk K  Wyrzykowski L;OGLE Collaboration  Depoy DL  Han C  Kaspi S  Lee CU  Mallia F  Natusch T  Pogge RW  Park BG;MuFUN Collaboration  Abe F  Bond IA  Botzler CS  Fukui A  Hearnshaw JB  Itow Y  Kamiya K  Korpela AV  Kilmartin PM  Lin W  Masuda K  Matsubara Y  Motomura M  Muraki Y  Nakamura S  Okumura T  Ohnishi K  Rattenbury NJ  Sako T  Saito T  Sato S 《Science (New York, N.Y.)》2008,319(5865):927-930

Searches for extrasolar planets have uncovered an astonishing diversity of planetary systems, yet the frequency of solar system analogs remains unknown. The gravitational microlensing planet search method is potentially sensitive to multiple-planet systems containing analogs of all the solar system planets except Mercury. We report the detection of a multiple-planet system with microlensing. We identify two planets with masses of approximately 0.71 and approximately 0.27 times the mass of Jupiter and orbital separations of approximately 2.3 and approximately 4.6 astronomical units orbiting a primary star of mass approximately 0.50 solar mass at a distance of approximately 1.5 kiloparsecs. This system resembles a scaled version of our solar system in that the mass ratio, separation ratio, and equilibrium temperatures of the planets are similar to those of Jupiter and Saturn. These planets could not have been detected with other techniques; their discovery from only six confirmed microlensing planet detections suggests that solar system analogs may be common.  相似文献   

Apolipoprotein B-48 is the product of a messenger RNA with an organ-specific in-frame stop codon   总被引：63，自引：0，他引：63  

S H Chen  G Habib  C Y Yang  Z W Gu  B R Lee  S A Weng  S R Silberman  S J Cai  J P Deslypere  M Rosseneu 《Science (New York, N.Y.)》1987,238(4825):363-366

The primary structure of human apolipoprotein (apo) B-48 has been deduced and shown by a combination of DNA excess hybridization, sequencing of tryptic peptides, cloned complementary DNAs, and intestinal messenger RNAs (mRNAs) to be the product of an intestinal mRNA with an in-frame UAA stop codon resulting from a C to U change in the codon CAA encoding Gln2153 in apoB-100 mRNA. The carboxyl-terminal Ile2152 of apoB-48 purified from chylous ascites fluid has apparently been cleaved from the initial translation product, leaving Met2151 as the new carboxyl-terminus. These data indicate that approximately 85% of the intestinal mRNAs terminate within approximately 0.1 to 1.0 kilobase downstream from the stop codon. The other approximately 15% have lengths similar to hepatic apoB-100 mRNA even though they have the same in-frame stop codon. The organ-specific introduction of a stop codon to a mRNA appears unprecedented and might have implications for cryptic polyadenylation signal recognition and RNA processing.  相似文献   

Against the neoliberal steamroller? The Biosafety Protocol and the social regulation of agricultural biotechnologies   总被引：1，自引：0，他引：1  

Daniel Lee Kleinman  Abby J. Kinchy 《Agriculture and Human Values》2007,24(2):195-206

Through a discursive and organizational analysis we seek to understand the Biosafety Protocol and the place of socioeconomic regulation of agricultural biotechnology in it. The literature on the Protocol has been fairly extensive, but little of it has explored debates over socioeconomic regulation during the negotiation process or the regulatory requirements specified in the final document. This case is especially important at a time when the spread of neoliberalism is increasingly associated with deregulation, because it sheds light on the conditions under which circumvention of the market is deemed legitimate and socio-economic regulation of agricultural technology is possible. Daniel Lee Kleinman is a professor in the Department of Rural Sociology at the University of Wisconsin, Madison, where he is also affiliated with the Holtz Center for Science and Technology Studies and the Integrated Liberal Studies Program. He is the author and editor of a number of books, including Impure Cultures: University Biology and the World of Commerce (2003). Abby J. Kinchy is a PhD candidate in the Departments of Sociology and Rural Sociology at the University of Wisconsin, Madison. Her current research examines the controversies surrounding the genetic “contamination” of Mexican maize and Canadian canola.  相似文献   

The chemical genomic portrait of yeast: uncovering a phenotype for all genes     

Hillenmeyer ME  Fung E  Wildenhain J  Pierce SE  Hoon S  Lee W  Proctor M  St Onge RP  Tyers M  Koller D  Altman RB  Davis RW  Nislow C  Giaever G 《Science (New York, N.Y.)》2008,320(5874):362-365

Genetics aims to understand the relation between genotype and phenotype. However, because complete deletion of most yeast genes ( approximately 80%) has no obvious phenotypic consequence in rich medium, it is difficult to study their functions. To uncover phenotypes for this nonessential fraction of the genome, we performed 1144 chemical genomic assays on the yeast whole-genome heterozygous and homozygous deletion collections and quantified the growth fitness of each deletion strain in the presence of chemical or environmental stress conditions. We found that 97% of gene deletions exhibited a measurable growth phenotype, suggesting that nearly all genes are essential for optimal growth in at least one condition.  相似文献   

The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolase   总被引：42，自引：0，他引：42  

K D Wilkinson  K M Lee  S Deshpande  P Duerksen-Hughes  J M Boss  J Pohl 《Science (New York, N.Y.)》1989,246(4930):670-673

A complementary DNA (cDNA) for ubiquitin carboxyl-terminal hydrolase isozyme L3 was cloned from human B cells. The cDNA encodes a protein of 230 amino acids with a molecular mass of 26.182 daltons. The human protein is very similar to the bovine homolog, with only three amino acids differing in over 100 residues compared. The amino acid sequence deduced from the cDNA was 54% identical to that of the neuron-specific protein PGP 9.5. Purification of bovine PGP 9.5 confirmed that it is also a ubiquitin carboxyl-terminal hydrolase. These results suggest that a family of such related proteins exists and that their expression is tissue-specific.  相似文献   

Late Glacial and Postglacial Hudson Bay Sea Episode     

Lee HA 《Science (New York, N.Y.)》1960,131(3413):1609-1611

Geological investigations, archeological studies, and radiocarbon dates indicate a similarity of events around Hudson Bay, commencing at the time Hudson Bay Basin was freed of glacier ice. The sea that then spread around Hudson Bay 7000 to 8000 years ago is here named "Tyrrell Sea." The subsequent rate of land emergence decreased exponentially.  相似文献   

Small-diameter silicon nanowire surfaces     

Ma DD  Lee CS  Au FC  Tong SY  Lee ST 《Science (New York, N.Y.)》2003,299(5614):1874-1877

Small-diameter (1 to 7 nanometers) silicon nanowires (SiNWs) were prepared, and their surfaces were removed of oxide and terminated with hydrogen by a hydrofluoric acid dip. Scanning tunneling microscopy (STM) of these SiNWs, performed both in air and in ultrahigh vacuum, revealed atomically resolved images that can be interpreted as hydrogen-terminated Si (111)-(1 x 1) and Si (001)-(1 x 1) surfaces corresponding to SiH3 on Si (111) and SiH2 on Si (001), respectively. These hydrogen-terminated SiNW surfaces seem to be more oxidation-resistant than regular silicon wafer surfaces, because atomically resolved STM images of SiNWs were obtained in air after several days' exposure to the ambient environment. Scanning tunneling spectroscopy measurements were performed on the oxide-removed SiNWs and were used to evaluate the electronic energy gaps. The energy gaps were found to increase with decreasing SiNW diameter from 1.1 electron volts for 7 nanometers to 3.5 electron volts for 1.3 nanometers, in agreement with previous theoretical predictions.  相似文献