Influence of isoprinosine on bovine herpesvirus type-1 infection in cattle   总被引：1，自引：0，他引：1  

F Blecha  G A Anderson  F Osorio  S K Chapes  P E Baker 《Veterinary immunology and immunopathology》1987,15(3):253-265

A study was conducted to determine the in vivo efficacy of isoprinosine (ISO) in calves infected with bovine herpesvirus type-1 (BHV-1). Calves were infected with BHV-1 on day 0 and received ISO daily for 14 days. Clinical signs of disease, shedding of BHV-1, lymphocyte proliferative responses to mitogens, interleukin-2 production, and alveolar macrophage bactericidal activity were monitored during the study. Rectal temperatures were increased (P less than 0.05) in BHV-1 and ISO-BHV-1 calves at days 3 to 7 postinfection (PI). Isoprinosine did not influence BHV-1 shedding in calves. Lymphocyte proliferative responses to phytohemagglutinin (PHA) were lower (P less than 0.01) in BHV-1 calves when compared to control or ISO calves at day 4 PI, but ISO did not ameliorate this effect. Interleukin-2 activity was greater (P less than 0.05) in ISO-BHV-1 calves on days 4 and 8 PI in PHA-stimulated lymphocytes and on day 8 PI in concanavalin A-stimulated lymphocytes when compared to control, ISO or BHV-1 calves. Isoprinosine treatment of BHV-1-infected calves tended to decrease alveolar macrophage bactericidal activity. These data suggest that ISO does not reverse BHV-1 suppression of lymphocyte proliferation, but may enhance IL-2 production in BHV-1 infected calves.  相似文献   

Influence of vaccination route on the efficacy of Aujeszky's disease deletion-mutant vaccine.     

H Hasebe  F A Osorio  A Hogg  H Liauw  M J Bartkoski  M Sugiyama 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》1992,54(4):693-698

In order to compare the effect of the route of immunization on the efficacy of a modified live Aujeszky's disease (AD) vaccine, which had deletions in both thymidine kinase (TK-) and glycoprotein gIII genes (gpIII-), 20 six-week-old pigs were vaccinated by either the intramuscular (IM) (n = 10) or subcutaneous (SC) (n = 10) route. All the animals, including five non-vaccinated control animals, were challenged with virulent AD virus 22 days after vaccination. Four of five non-vaccinated animals died within 12 days after challenge. Although none of vaccinated animals died, three of animals in the SC group exhibited clinical signs, and average daily gains in the SC group were depressed. The animals in the IM group were not found to shed challenge virus, but those in the SC group shed the virus up to 9 days. Virus neutralizing antibody titers in the vaccinated animals were low or non-detectable by 21 days after vaccination. A glycoprotein gII (gpII) screening ELISA detected gpII antibody in all animals in the IM group. While, only 30% of animals in the SC group were positive by the same test. The results of this study indicate that TK-, gpIII modified live AD virus vaccine is effective against challenge with virulent AD virus; however, vaccination by the SC route reduced vaccine efficacy in comparison with IM route.  相似文献   

HOW DOES YOUR PRACTICE MEASURE UP?: Looking at the CVMA National Benchmarking Program (3 in a Series)          下载免费PDF全文

Suzanne Lavictoire 《The Canadian veterinary journal. La revue veterinaire canadienne》2003,44(6):461

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Research in progress: Case studies of family adaptation to changing resources and environments     

M. Suzanne Sontag  Margaret W. Bubolz 《Agriculture and Human Values》1985,2(1):48-51

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NATIONAL SURVEY ON EXTRA-LABEL VETERINARY DRUG USE:          下载免费PDF全文

Suzanne Lavictoire 《The Canadian veterinary journal. La revue veterinaire canadienne》2003,44(2):115

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Growth in three Karoo shrub species under various grazing treatments: the tracking of marked individuals over 25 years     

Helga van der Merwe  Suzanne J Milton 《African Journal of Range and Forage Science》2019,36(1):61-66

Growth studies of long-lived shrubs are uncommon. In semi-arid rangelands, livestock and wildlife grazing influence growth processes and may interact with changing climate. Tierberg-LTER, excluded from livestock since 1987, and two adjacent ranches allowed for a comparative growth study of three shrub species (Osteospermum sinuatum – palatable, Pteronia empetrifolia – moderately palatable, and P. pallens – unpalatable) across contrasting present ungulate herbivory (none in exclosures, wildlife only, or livestock and wildlife combined) and past livestock herbivory (moderate and overgrazed). Marked individuals were measured at irregular intervals over 25 years. Stem basal diameter (mm), height (m) and two canopy diameters (m) were measured at the onset of the study and in 2014. Mean basal diameter growth (mm y^?1) varied between species and treatments. Change in mean attribute values was influenced by interactions with grazing history and treatments. Some historical and grazing treatments had a negative effect on the palatable O. sinuatum and no significant effect on moderately palatable P. empetrifolia or unpalatable P. pallens. The age of the originally marked individuals are unknown but >70% of these individuals survived over the 25-year period. Our results support previous findings that dwarf shrubs in deserts are slow growing and long lived, and that grazing regime affects plant growth.  相似文献   

Comparison of the performance of the IDEXX SediVue Dx® with manual microscopy for the detection of cells and 2 crystal types in canine and feline urine     

Annalisa M. Hernandez  Graham E. A. Bilbrough  Dennis B. DeNicola  Celine Myrick  Suzanne Edwards  Jeremy M. Hammond  Alex N. Myers  Johanna C. Heseltine  Karen Russell  Marco Giraldi  Mary B. Nabity 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2019,33(1):167-177

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Comparison of a computed tomographic pulmonary trunk to aorta diameter ratio with echocardiographic indices of pulmonary hypertension in dogs          下载免费PDF全文

James Sutherland‐Smith  Elyshia J. Hankin  Suzanne M. Cunningham  Amy F. Sato  Bruce A. Barton 《Veterinary radiology & ultrasound》2018,59(1):18-26

There are limited criteria for the detection of pulmonary hypertension in dogs undergoing computed tomography (CT) for pulmonary disease. This retrospective analytical exploratory study compared a CT pulmonary trunk to aorta ratio with echocardiographic estimates of pulmonary hypertension. Dogs having both a contrast thoracic CT and echocardiogram were selected and maximal pulmonary trunk and descending aorta diameters were measured by two observers on a single transverse CT image. Computed tomographic diameter ratios were compared with the echocardiographic parameters of tricuspid regurgitation gradient, right ventricular acceleration time‐to‐ejection time ratio, pulmonary insufficiency gradient, and pulmonary artery to aorta diameter. A total of 78 dogs were sampled, with 44 dogs having one or more finding suggestive of pulmonary hypertension. A moderate positive correlation was shown between tricuspid regurgitation gradient and CT pulmonary trunk to aorta ratio (r = 0.61, P‐value < 0.0001). Mean CT pulmonary trunk to aorta ratio of dogs with moderate (P = 0.0132) and severe (P < 0.0003) pulmonary hypertension were significantly higher than normal dogs. There was no significant difference in mean CT pulmonary trunk to aorta ratio between normal and mild pulmonary hypertension dogs (P = 0.4244). The intraclass correlation coefficient (0.72) showed good reproducibility of the ratio. Findings indicated that CT pulmonary trunk to aorta ratio is a reproducible and potentially useful method to predict moderate and severe pulmonary hypertension in dogs, but not mild pulmonary hypertension. In dogs undergoing thoracic CT for pulmonary disease, an increased ratio should prompt follow up echocardiography.  相似文献   

Correction to: Vulnerability of coffee (Coffea spp.) genetic resources in the United States     

Krishnan  Sarada  Matsumoto  Tracie  Nagai  Chifumi  Falconer  James  Shriner  Suzanne  Long  Jennifer  Medrano  Juan F.  Vega  Fernando E. 《Genetic Resources and Crop Evolution》2021,68(7):2711-2711

Genetic Resources and Crop Evolution - The correct article title is provided here, Vulnerability of coffee (Coffea spp.) genetic resources in the United States.  相似文献   

Cucurbita-5,23-diene-3beta,25-diol from Sicana odorifera     

Nakano S  Fujimoto Y  Takaishi Y  Osorio C  Duque C 《Fitoterapia》2004,75(6):609-611

The spectral data of a new triterpene, cucurbita-5,23-diene-3beta,25-diol, isolated from the seeds of Sicana odorifera, are reported.  相似文献