Thoracic neoplasia in equids: 35 cases (1967-1987)     

C R Sweeney  D M Gillette 《Journal of the American Veterinary Medical Association》1989,195(3):374-377

Thirty-two horses and 3 ponies had neoplasia involving the thoracic cavity. Lymphosarcoma of the thorax was found in 19 (54.2%) of the equids. The other 16 equids had metastatic adenocarcinoma (7 horses; 20%), metastatic squamous cell carcinoma (5 equids; 14.3%), metastatic hemangiosarcoma (3 equids; 8.6%) or undifferentiated sarcoma (1 horse; 2.9%). Thoracic neoplasia was diagnosed before death in 15 equids (42.9%).  相似文献   

Exercised-induced pulmonary hemorrhage in polo and racing horses     

B T Voynick  C R Sweeney 《Journal of the American Veterinary Medical Association》1986,188(3):301-302

Philippine polo and racing horses were examined for exercise-induced pulmonary hemorrhage after their competitive exercise. Exercise-induced pulmonary hemorrhage occurred in 11.1% of the polo horses and 64% of the racing horses. None of the horses had blood at the nostrils.  相似文献   

Mycotic omasitis and rumenitis as sequelae to sepsis in dairy cattle: six cases (1979-1986)     

R W Sweeney  T J Divers  D M Gillette  R H Whitlock 《Journal of the American Veterinary Medical Association》1989,194(4):552-553

Medical records of 6 cows with mycotic rumenitis or omasitis, but no history of grain engorgement, were reviewed. A diagnosis was made at necropsy in all cows, although the condition was suspected before euthanasia in 3 cows. Common clinical findings included inappetence, rumen stasis, fluid rumen contents, and scant, pasty, or loose feces. Postmortem findings included severe ulcerative rumenitis or omasitis, with thrombosis of blood vessels in the submucosa, and branching, septate fungal hyphae abundant in inflamed tissues. In these cows, mycotic omasitis and rumenitis were thought to be sequelae of sepsis, with reflux of abomasal fluid into the forestomach and broad spectrum antimicrobial therapy as possible predisposing factors for mycotic infections.  相似文献   

Intracranial lymphosarcoma in a Holstein bull     

R W Sweeney  T J Divers  E Ziemer  C A Lichtensteiger 《Journal of the American Veterinary Medical Association》1986,189(5):555-556

A 2-year-old Holstein bull was examined because of decreased appetite. Clinical signs included head tilt, circling, head pressing, ptosis, hypesthesia of the face, and dysfunction of the parasympathetic component of cranial nerve III. Necropsy revealed intracranial lymphosarcoma.  相似文献   

Mycobacterium paratuberculosis isolated from fetuses of infected cows not manifesting signs of the disease.     

R W Sweeney  R H Whitlock  A E Rosenberger 《American journal of veterinary research》1992,53(4):477-480

Fetuses were obtained from 58 cows that were fecal culture-positive for Mycobacterium paratuberculosis, but were not manifesting signs of paratuberculosis. Fetal tissues from 5 of 58 cows were culture-positive for M paratuberculosis. All 5 culture-positive fetuses were from cows that were classified as heavy fecal shedders (5/28; 17.8%). Difference in prevalence of fetal infection between light (less than 70 colonies/tube) and heavy fecal shedders was significant (Fisher's exact test, P less than 0.05). Association was not evident between serologic status of the dam and prevalence of fetal infection. In infected cows without signs of paratuberculosis, fetal infection develops with lower frequency than previously reported for cows with clinical signs of the disease. In this study, fetal infection was found only in cows that were heavy fecal shedders.  相似文献   

Pharmacokinetics of metronidazole given to horses by intravenous and oral routes     

R W Sweeney  C R Sweeney  L R Soma  C B Woodward  C A Charlton 《American journal of veterinary research》1986,47(8):1726-1729

Serum and peritoneal fluid concentrations of metronidazole were determined in 6 healthy adult horses given the drug (25 mg/kg) by IV or oral routes. The disposition of metronidazole in horses given the drug by the IV route conformed to a 2-compartment model with a distribution half-life of 0.16 hours, an elimination half-life of 2.9 hours, and a body clearance of 0.40 +/- 0.05 L/kg/hr. The oral absorption half-life was 0.40 hours, and the bioavailability, 85.0 +/- 18.6%. Peritoneal fluid concentrations were approximately equal to serum concentrations at all times, regardless of the route of administration. On the basis of reported minimal inhibitory concentrations for anaerobic bacteria, a dosage of 15 to 25 mg/kg given orally 4 times daily was recommended.  相似文献   

Clostridium botulinum type B toxicosis in a herd of cattle and a group of mules   总被引：2，自引：0，他引：2  

T J Divers  R C Bartholomew  J B Messick  R H Whitlock  R W Sweeney 《Journal of the American Veterinary Medical Association》1986,188(4):382-386

Clostridium botulinum type B toxicosis was diagnosed as the cause of generalized weakness and death in a group of cows and mules fed from the same batch of rye silage. One severely affected cow was treated and recovered, as did other less severely affected cows. All affected mules died. The remaining cattle in the herd were then vaccinated before continued feeding of the silage.  相似文献   

Sudden death attributable to exercise-induced pulmonary hemorrhage in racehorses: nine cases (1981-1983)     

D E Gunson  C R Sweeney  L R Soma 《Journal of the American Veterinary Medical Association》1988,193(1):102-106

Pathologic changes are described in 11 horses that died during racing or training; 9 died of acute pulmonary hemorrhage (exercise-induced pulmonary hemorrhage), 1 died of exsanguination, and 1 died of CNS trauma. Cardiac lesions were not found in any horse. Severe engorgement of pulmonary vessels, with hemorrhage into alveoli, airways, interstitium, and subpleural tissues, was observed in all 9 horses that died of exercise-induced pulmonary hemorrhage. Infiltration of eosinophils and/or lymphocytes around vessels and airways was seen in 6 horses. Focally extensive fibrosis was observed in the pleura and interstitium of 6 horses, and collections of siderophages were seen in the fibrous tissue and in the airways. Focal occlusion of bronchioles with inspissated mucus, such as that associated with small airway disease, was found in 4 horses. Underlying respiratory tract lesions, particularly those associated with small airway disease or bronchiolitis, may have a role in fatal pulmonary hemorrhage.  相似文献   

Gastrointestinal nematode infection in sheep--a review of the alternatives to anthelmintics in parasite control     

Sayers G  Sweeney T 《Animal health research reviews / Conference of Research Workers in Animal Diseases》2005,6(2):159-171

Efforts to curb production losses caused by nematode parasitism in sheep have led to the development of a number of control methods to complement or replace anthelmintics. The need for alternative control measures stems from the emergence of anthelmintic-resistant parasitic nematodes with reports of multi-class resistance to these drugs now emerging. A number of these control methods such as predacious microfungi, protein supplementation, plant extracts in feed and vaccines have demonstrated potential to control infection but require development and examination under natural conditions. Breeding for natural resistance to nematode infection has already shown success in controlling the disease under natural conditions. Selection for resistance is currently based on fecal egg count measurements but identification of genetic indicators of resistance will provide a more efficient method of selection. Current quantitative trait loci for nematode resistance include the MHC genes, interferon gamma gene, IgE gene and microsatellites on chromosome 1, 5 and 6. This paper reviews the current alternatives to anthelmintics to control infection, with an emphasis on breeding for host resistance and identification of genetic indicators of resistance.  相似文献   

Idiopathic pericarditis and cardiac tamponade in two cows     

Jesty SA  Sweeney RW  Dolente BA  Reef VB 《Journal of the American Veterinary Medical Association》2005,226(9):1555-8, 1502

Idiopathic pericarditis is an uncommon diagnosis in cattle with cardiac tamponade. Two cows were examined for clinical signs of right-sided congestive heart failure, including tachycardia, venous distention, and peripheral edema. Muffled heart sounds were detected in one of the cows. Echocardiography in both cows revealed voluminous anechoic pericardial effusion and compression of the right atrium and right ventricle. Cytologic analysis of the pericardial fluid revealed hemorrhagic inflammation but no evidence of a septic or neoplastic condition such as traumatic reticulopericarditis or lymphoma, respectively. Pericardial drainage and lavage accompanied by treatment with anti-inflammatory drugs were curative in both cows. It is important to differentiate cows with idiopathic pericarditis from cows with more common septic pericarditis because the prognosis for the former disease appears to be good with appropriate treatment.  相似文献