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91.
92.
Wilhelm Tischendorf 《Forstwissenschaftliches Centralblatt》1928,50(12):404-409
Ohne ZusammenfassungErschienen in Annales pro experimentis Foresticis, II. Ig., Zagreb 1927. 50 S. stark, mit 18 graphischen Datstellungen und zahlreichen Tabellen (in deutscher Sprache). 相似文献
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A microbiological assay to estimate the antimicrobial activity of parenteral tildipirosin against foodborne pathogens and commensals in the colon of beef cattle and pigs 下载免费PDF全文
M. Rose A. Pridmore A. Shaw C. Wilhelm M. Menge S. Kilp R. Röpke M. Nürnberger 《Journal of veterinary pharmacology and therapeutics》2016,39(3):277-286
Tildipirosin (TIP) is a novel 16‐membered‐ring macrolide authorized for the treatment of bovine and swine respiratory disease. The pH dependency of macrolide antimicrobial activity is well known. Considering that the pH in the colon contents of growing beef cattle and pigs is usually below pH 7.0, the minimum inhibitory concentrations (MIC) of TIP against foodborne bacterial pathogens such as Campylobacter (C.) coli, C. jejuni and Salmonella enterica and commensal species including Enterococcus (E.) faecalis, E. faecium and Escherichia coli were determined under standard (pH 7.3 ± 1) or neutral as well as slightly acidic conditions. A decrease in pH from 7.3 to 6.7 resulted in an increase in MICs of TIP. Except for the MICs > 256 μg/mL observed in the resistant subpopulation of the C. coli and the Enterococcus species, the MIC ranges increased from 2–8 μg/mL to 64–> 256 μg/mL for Salmonella enterica and E. coli, from 8–16 μg/mL to 32–128 μg/mL for the two Campylobacter species, and from 4–32 μg/mL to 128–> 256 μg/mL for both Enterococcus species. To estimate the antimicrobial activity of TIP in the colon contents of livestock during recommended usage of the parenterally administered TIP (Zuprevo®), and to compare this with the increased MICs at the slightly acidic colonic pH, we developed and validated a microbiological assay for TIP and used this to test incurred faecal samples collected from cattle and pigs. Microbiological activity of luminal TIP was determined in aqueous supernatants from diluted faeces, using standard curves produced from TIP‐spiked faecal supernatants. The limit of quantification (LOQ) for TIP was 1 μg/mL (ppm). In a cattle study (n = 14), 3 of 28 faecal samples collected 24 and 48 h post‐treatment were found to contain TIP above the LOQ (concentrations of 1.3–1.8 ppm). In another cattle study (n = 12) with faecal samples collected at 8, 24 and 48 h post‐treatment, TIP concentrations were above the LOQ in 4 of the 8 h samples (1.2–2.6 ppm) and one of the 24‐h samples (1.3 ppm). In a pig study (n = 12) with faecal samples collected 24, 48 and 72 h post‐treatment, only one sample contained TIP above the LOQ (concentration 1.5 ppm). In another pig study (n = 12), with samples collected at 8, 24 48 and 96 h post‐treatment, TIP concentrations were above the LOQ in one 8‐h sample (1.1 ppm) and two 24‐h samples (2.3 and 2.5 ppm). None of the 48‐h and 96‐h samples from these 4 studies contained measurable TIP concentrations. Thus, in cattle and pigs, only a small fraction of faecal samples collected up to 24 h postdosing contained measurable microbiologically active TIP, with its maximum limited to 2.6 μg/mL. This is several log2 dilution steps below the MICs of TIP against foodborne pathogens and commensals collected under acidic conditions comparable with those in the colonic contents and may explain a lack of intestinal dysbacteriosis with parenteral tildipirosin in livestock. 相似文献
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96.
Marcin Przybyo Marcus Clauss Sylvia Ortmann Zygmunt M. Kowalski Pawe Grka 《Journal of animal physiology and animal nutrition》2019,103(6):1684-1693
The aim of the study was to determine the effect of fructose supplementation in the diet on feed intake, nutrient digestibility and digesta retention time in Reeves's muntjac (Muntiacus reevesi), a browsing cervid. In Experiment 1, six adult males of Reeves's muntjac were used in a replicated 3 × 3 Latin square design and fed a diet consisting of dehydrated chopped lucerne (ad libitum), high‐fibre pellet (120 g/day) and wheat bran (30 g/day) without (F0) or with addition of 12 and 24 g fructose/day (F12 and F24, respectively). In Experiment 2, the same six adult muntjacs were used in crossover design and fed F0 or F12. Doses of supplemental fructose were set to increase intake of water‐soluble carbohydrates (WSC; ≈40 g/day; ≈8% of WSC in consumed dry matter [DM]) by 25 and 50% relative to F0. Feed intake was controlled daily (Experiment 1 and 2) and total tract digestibility and digesta retention time were determined (Experiment 2). In Experiment 1, DM intake of chopped dehydrated lucerne decreased with fructose supplementation (F0 vs. F12 and F24; p = .01) but was not different between F12 and F24 (p = .76). Total DM intake was also not different between treatments (p ≥ .13). In Experiment 2, DM intake of lucerne, total DM intake and nutrient digestibility was not affected by fructose supplementation (p ≥ .17), but mean retention time of long particles in the whole GIT tended to be longer for F12 compared to F0 (p = .09). Under conditions of the current study, additional fructose intake (resulting in a range of WSC content in consumed DM from 8.6% to 13%) had only minor impact on feed intake and investigated functions of the gastrointestinal tract of Reeves's muntjac. 相似文献
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Heinrich Wilhelm Weber 《Forstwissenschaftliches Centralblatt》1923,45(10):361-368
Ohne Zusammenfassung 相似文献
99.
Wilhelm Tischendorf 《Forstwissenschaftliches Centralblatt》1926,48(8):578-589
Ohne Zusammenfassung 相似文献
100.