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51.
Antioxidative activity of green tea polyphenol in cholesterol-fed rats 总被引：17，自引：0，他引：17
This study investigated the effects of green tea polyphenol on the serum antioxidative activity and cholesterol levels of cholesterol-fed rats and compared them with those of probucol, an antioxidant hypocholesterolemic agent. To evaluate the antioxidative activity, the susceptibility to oxidative modification of low-density lipoprotein (LDL) isolated from the serum of cholesterol-fed rats was measured, as was the serum antioxidative activity using the spontaneous autoxidation system of brain homogenate. Administration of green tea polyphenol effectively inhibited LDL oxidation and elevated serum antioxidative activity to the same degree as probucol. However, higher amounts of polyphenol than probucol needed to be administered to reduce the total, free, and LDL cholesterol levels. Furthermore, green tea polyphenol increased the levels of high-density lipoprotein (HDL) cholesterol, leading to dose-dependent improvement of the atherogenic index, an effect that was not seen with probucol. Thus, green tea polyphenol may exert an antiatherosclerotic action by virtue of its antioxidant properties and by increasing HDL cholesterol levels. 相似文献
52.
Rathanon KHEMGAEW Mari OMACHI Tomoe TAKESADA Torrung VETCHAPITAK Hiroyuki SATO Takako TANIGUCHI Naoaki MISAWA 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2021,83(6):889
Papillomatous digital dermatitis (PDD) is a polymicrobial infection causing lameness in dairy cattle. Culture-independent analysis has shown that Treponema phagedenis is present consistently and predominantly in the lesions. However, the pathogenesis of PDD, especially the tissue penetration pathway, has not been examined. In the present study, we investigated whether T. phagedenis strains isolated from PDD produce proteolytic enzyme (s) for disruption of the epithelial cell barrier and have the ability to translocate in polarized normal human epidermal keratinocytes (NHEK) in vitro. Ten strains of T. phagedenis isolated from lesions did not show proteolytic activity on modified skim milk agar, although a human strain of T. denticola used as a control showed such activity. The integrity of tight junctions was monitored by measurement of transepithelial electrical resistance (TER). The TER values after inoculation of the T. phagedenis strains examined did not change during the experimental period; however, apical to basolateral translocation of T. phagedenis was confirmed after 24 hr by microscopy and Treponema-specific PCR. We further confirmed that translocation of T. phagedenis was accelerated by co-inoculation with live T. denticola, but not with heat-killed organisms. Furthermore, tight junction ZO-1 protein was not lost intensity after inoculation with T. phagedenis and the organism was observed in NHEK cells using a florescence microscope. These results suggest that T. phagedenis strains may translocate via a transcellular route in vitro and that the invasion is accelerated by other bacteria, such as T. denticola, producing proteolytic activity. 相似文献
53.
Abstract The presence of 4-MeGln in the tulip plant was discovered by ZACHARIUS et al. (1954), and it was found that this amide generally occurred in the leaves of almost all the species of genus Tulipa (FOWDEN and STEWARD 1957a). The 4-MeGln compound has been detected in every part of the tulip plant, i.e., bulb scales, roots, basal plate, young shoots, leaves, stern, and flower (FOWDEN and STEWARD 1957a, b; OHYAMA 1986; OHYAMA et al. 1985, 1988a, b; ZACHARIUS et al. 1954, 1957). Especially 4-MeGln was found to be a major soluble N constituent in the leaves and stem of tulip of the flowering stage (OHYAMA et al. 1985; OHYAMA 1986). 相似文献
54.
Sakata Nanami Aoyagi Taketo Ishiga Takako Ishiga Yasuhiro 《Journal of General Plant Pathology》2021,87(6):387-393
Journal of General Plant Pathology - Bacterial brown stripe caused by Acidovorax avenae subsp. avenae (Aaa) causes serious damage on creeping bentgrass on golf course greens. However, there are few... 相似文献
55.
Masukuni Mori Takako Fujimoto Machiko Murakami Mitsuo Matsudaira 《Fibers and Polymers》2013,14(12):2202-2211
The purpose of this research is in solution of two important subjects mutually related; (1) creation of fabrics of various handlings by finish processing and (2) mechanism of generation of itchy feeling acting as the hindrance of a comfortable clothing life and establishment of its objective evaluation method. For the purpose of solution of these two subjects, the same fabrics were used and they were changed by 18 kinds of different physicochemical procedures, which come out 18 levels of fabric handlings ranging from very soft to very stiff. As for handlings of 18 kinds of fabrics, the items of Hand Value were calculated based on all of KES basic properties in terms of KES procedures. Solution of these subjects is also connected with a high level of fabric finishing technology. On the other hand, one of the authors is an expert in fabric finish processing, and has been sure of itchy feeling of fabrics being closely connected with the hardness of fabrics from many years of experience. The degrees of itchy feeling for 18 kinds of fabric were judged by 50 evaluators of different ages and occupations, in terms of five ranks of evaluation method beforehand. As a result, itchy feeling had a high correlation with shear properties and Koshi, and had a negative high correlation with Numeri. It was confirmed that that itchy feeling could be evaluated by objective data of KES properties in terms of KES procedure. 相似文献
56.
Shuzo Fujita Takako Kumagai Mashimi Yanagimachi Suguru Sakuraba Ryuichi Sanpei Mika Yamoto Haruka Tohara 《Journal of Cereal Science》2012
Waxy wheat (Triticum aestivum L.), a type of wheat that was first developed in Japan, produces grain amylopectin. I carried out three researches. Firstly, using Japanese adults, we carried out sensory evaluation of three types of mochi (a dumpling-like cake made of steamed and pounded grains) prepared from waxy wheat, normal wheat and waxy rice, and demonstrated that waxy wheat mochi had low adhesiveness and had the greatest ease of swallowing among the samples tested. Secondly, using the members of the JSDR (the Japanese Society of Dysphagia Rehabilitation) who attended the annual meeting, we performed another texture evaluations between waxy wheat and waxy rice mochi. The respondents reported waxy wheat mochi was less sticky and thus easier to chew and swallow than waxy rice mochi. 相似文献
57.
Yasuharu Watanabe Yin-Hsuan Chang Osamu Nakamura Takako Naganuma Tomohisa Ogawa Koji Muramoto 《Fisheries Science》2013,79(3):513-519
Rhamnose-binding lectins (RBLs) have been isolated and characterized from various kinds of fish. RBLs recognize the structures of lipopolysaccharides and lipoteichoic acid on microbes, and have an opsonic effect, suggesting that RBLs play an important role as pattern recognition proteins in innate immunity. However, the function of RBLs in the removal of pathogens from the body has not yet been elucidated. In this study, we investigated the effect of three RBLs—named CSL1, 2, and 3—that were isolated from chum salmon Oncorhynchus keta eggs on the respiratory burst activity in a macrophage cell line. The CSLs induced reactive oxygen species in the peritoneal macrophage cell line from rainbow trout Oncorhynchus mykiss (RTM5). However, this activity was not affected by l-rhamnose or dl-threo-1-phenyl-2-palmitoylamino-3-morpholino-1-propanol, an inhibitor for glucosylceramide synthesis, indicating that the interaction between CSLs and Gb3 on cell surfaces was not involved in the induction of respiratory burst activity. 相似文献
58.
Junichiro Enya Kentaro Ikeda Taeko Takeuchi Norio Horikoshi Takahiko Higashi Takako Sakai Yuichiro Iida Kazufumi Nishi Masaharu Kubota 《Journal of General Plant Pathology》2009,75(1):76-79
Tomato leaf mold caused by Passalora fulva was found on two tomato varieties carrying the Cf-9 gene in Japan, in 2007. The isolates obtained from Chiba and Fukushima were identified as race 4.9.11, and those from Gunma
were races 4.9 or 4.9.11. This is the first report in Japan of tomato leaf mold caused by P. fulva strains that can overcome the Cf-9 gene. 相似文献
59.
The protective effect of proanthocyanidins from persimmon peel, using both oligomers and polymers, was investigated in a db/db type 2 diabetes model. Male db/db mice were divided into three groups: control (vehicle), polymer-, or oligomer- (10 mg/(kg body weight x day x p.o.)) administered mice. Age-matched nondiabetic m/m mice were used as a normal group. The administration of proanthocyanidins reduced hyperglycemia in db/db mice through a decline in the serum level of glucose and glycosylated protein. In addition, it had a strong effect on hyperlipidemia through lowering levels of triglyceride, total cholesterol, and nonesterified fatty acids. The protective effect against hyperglycemia and hyperlipidemia was greater in the groups administered the oligomeric rather than polymeric form. The increased oxidative stress in db/db mice was attenuated by the administration of oligomers through inhibiting the generation of reactive oxygen species and lipid peroxidation and elevating the reduced glutathione/oxidized glutathione ratio. On the other hand, polymers did not show such an effect. Moreover, expressions in the liver of sterol regulatory element binding protein (SREBP)-1 and SREBP-2 were downregulated by the administration of proanthocyanidins, especially the oligomeric form. Oligomers caused a slight elevation in the expression of peroxisome proliferator-activated receptors alpha. Furthermore, oligomeric proanthocyanidin regulated the expression of nuclear factor kappaB in db/db type 2 diabetes via the activation of inhibitor protein kappaB-alpha. It also attenuated the protein expressions of cyclooxygenase-2 and inducible nitric oxide synthase. This suggests that oligomers would act as a regulator in inflammatory reactions associated with oxidative stress in type 2 diabetes. The present study results suggest that proanthocyanidin administration, especially the oligomeric form, may improve oxidative stress via the regulation of hyperlipidemia than hyperglycemia in type 2 diabetes. 相似文献
60.