Spongiform encephalopathy in sheep scrapie: electron microscopic observations     

S Sasaki  S Mizoi  A Akashima  M Shinagawa  H Goto 《Nippon juigaku zasshi. The Japanese journal of veterinary science》1986,48(4):791-796

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Detection of uremic peaks in dogs by anion exchange high performance liquid chromatography.     

M Kawamura  F Ohashi  F Murakami  N Takai  R Nishimura  N Sasaki  A Takeuchi 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》1992,54(5):951-955

Sera of dogs with gentamicin-induced uremia were analyzed by high performance liquid chromatography system with strongly basic macroreticular anion exchange resin. Satisfactory separation of peaks was achieved with good reproducibility after deproteinization of sera with trichloroacetic acid at a final concentration of 3%, confirming that the system was suitable for qualitative analysis of uremic serum. The chromatograms showed that the number of peaks and the peak area had relation to concentrations of serum urea nitrogen or creatinine and severity of uremia. Four peaks were selected as suspected canine uremic peaks with high correlation to serum creatinine concentrations which were hardly influenced by extrarenal factors. The results suggested that these four fractions might contain uremic toxins.  相似文献   

Tumourigenesis by partial body X-irradiation in mice     

F Sato  S Sasaki  F Chino  D Endoh 《Nippon juigaku zasshi. The Japanese journal of veterinary science》1988,50(6):1161-1168

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Antibody-dependent adherence of guinea pig eosinophils to the third-stage larvae of Metastrongylus apri     

O Sasaki  M Katsuno 《Nippon juigaku zasshi. The Japanese journal of veterinary science》1986,48(3):623-627

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Inhibitory effects of human interferons on the syncytium formation by bovine leukemia virus (BLV) and the proliferation of BLV     

H Ike  O Sasaki  A Yamada  J Imanishi 《Nippon juigaku zasshi. The Japanese journal of veterinary science》1989,51(4):801-803

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Serum creatine kinase activities in dogs with dirofilariasis.     

H Kitagawa  M Kano  Y Sasaki  Y Hirano 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》1991,53(4):569-575

Total serum creatine kinase (CK) and its isozyme activities were determined in dogs with dirofilariasis. Before heartworm removal, total CK and isozyme activities in dogs of the mild group were not different from those in dogs of the heartworm-free group. BB activity was higher in dogs of the hemoptysis group. Dogs of the ascites group displayed a mild increase in MM activity. In dogs of the caval syndrome (CS) group, total CK and MM activities were highest among the heartworm-free and heartworm-infected dogs, and MM isozyme accounted for most (75%) of total CK activity. MB and BB activities were also higher. However, there were no significant differences in CK activities between the surviving and non-surviving cases. In dogs with pulmonary heartworm disease (mild and ascites groups), MM activity correlated significantly with the number of heartworms (r = 0.45), hematocrit value (Ht, r = -0.40), serum alanine aminotransferase (ALT, r = 0.42) and lactate dehydrogenase (LDH, r = 0.46) activities, mean pulmonary arterial pressure (r = 0.64) and total pulmonary resistance (r = 0.50). In dogs with CS, MM activity did not correlate with any parameter, but BB activity correlated with the number of heartworms at the right atrium (r = 0.61), Ht (r = -0.53), ALT (r = 0.80), LDH (r = 0.73) and serum urea nitrogen (r = 0.47). At 1 week after heartworm removal, BB and MM activity decreased in dogs of the hemoptysis and ascites groups, respectively. In dogs of the CS group, total CK and MM isozyme activities decreased markedly (P less than 0.01) regardless of their prognosis.  相似文献   

Cardiopulmonary values in dogs with artificial model of caval syndrome in heartworm disease.     

Y Kuwahara  H Kitagawa  Y Sasaki  K Ishihara 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》1991,53(1):59-64

Cardiopulmonary values were determined in dogs with an artificial model of heartworm caval syndrome, which was produced by insertion of heartworm-like silicone tubes into the tricuspid valve orifice and right atrium. Fifteen to 25 tubes with some knots were inserted in 6 dogs (knot group), and 7 to 11 tubes (small-number group) or 29 to 37 tubes (large-number group) without a knot in 3 dogs, respectively. After tube insertion, angiographic contrast medium infused into the right ventricle regurgitated to the right atrium in all cases, and the regurgitation was the most severe in the large-number group. On electrocardiographic findings, the atrial and/or ventricular premature beat developed. The height of a- and v-wave of right atrial pressure curves elevated in all groups. The elevation in v-wave was obvious in the large-number group. The pulmonary arterial pressure tended to fall or to elevate slightly, and total pulmonary resistance increased in all groups. The right cardiac output decreased significantly in all cases. The right heart hemodynamics of the model might resemble those in spontaneous cases without disturbed pulmonary circulation.  相似文献   

Alterations in acetyl coenzyme A carboxylase activities in voles and mice treated with monosodium aspartate.     

T Arai  M Sasaki  M Shiomi  T Nonaka  K Ochiai  Y Oki 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》1992,54(1):131-135

Changes of body weights and hepatic acetyl-CoA carboxylase activities were measured in voles and mice treated with monosodium-L-aspartate (MSA). MSA was administrated subcutaneously to neonates at 4 mg/g. The MSA-treated mice showed remarkable obesity, associated with the increase in the plasma insulin concentrations and acetyl-CoA carboxylase activities. The activity of acetyl-CoA carboxylase of control voles was very low; under half that of mice. In the MSA-treated voles, although the plasma insulin concentrations also increased, acetyl-CoA carboxylase activities were not elevated and signs of obesity were not observed.  相似文献   

The half-life of erythrocytes in dogs with pulmonary heartworm disease.     

H Kitagawa  Y Sasaki  A Matsui 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》1992,54(1):161-162

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Clinical studies on canine dirofilarial hemoglobinuria: changes in right heart hemodynamics inducing heartworm migration from pulmonary artery     

H Kitagawa  Y Sasaki  T Sukigara  K Ishihara 《Nippon juigaku zasshi. The Japanese journal of veterinary science》1987,49(3):485-489

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