ORTHOVOLTAGE RADIOTHERAPY OF CANINE TRANSMISSIBLE VENEREAL TUMORS     

Donald E.  Thrall  DVM  PhD 《Veterinary radiology & ultrasound》1982,23(5):217-219

Eighteen dogs with transmissible venereal tumors were treated with orthovoltage radiotherapy. Total radiation doses ranged from 10 to 30 Gy, given during periods of one to 34 days. Tumor cure, defined as lack of recurrence within one year after completion of radiotherapy, was observed in all 18 dogs. In seven of eight dogs, tumors were cured with a single dose of 10 Gy. The tumor that recurred after the single 10 Gy dose had been treated with chemotherapy prior to radiotherapy and was subsequently cured with additional radiotherapy. Data presented indicate that transmissible venereal tumors are radiocurable and that a single dose of 10 Gy is sufficient for cure in most dogs.  相似文献   

Mucopolysaccharidosis VII in a cat     

Schultheiss PC  Gardner SA  Owens JM  Wenger DA  Thrall MA 《Veterinary pathology》2000,37(5):502-505

Mucopolysaccharidosis VII was diagnosed in a domestic shorthair cat from California. The cat was small and had multiple abnormalities, including a small body disproportionate to the size of the skull, angular deformities of the ribs, abnormally short forelimbs, luxating patellas, generalized epiphyseal dysplasia involving the vertebrae and long bones, cuboidal vertebrae, pectus excavatum, subluxation of both hips, osteosclerosis of the tentorium cerebelli and left petrous temporal bone, tracheal hypoplasia, and corneal clouding. Beta-glucuronidase activity was markedly decreased in peripheral blood leukocytes. The cat died at 21 months of age, and a complete necropsy was performed. Tissues were examined by light and transmission electron microscopy. Large clear, round vacuoles representing distended lysosomes were present in many epithelial and connective tissue cells, including fibrocytes, chondrocytes, smooth muscle cells, hepatocytes, astrocytes, and macrophages.  相似文献   

Scintigraphic evaluation of pulmonary perfusion in dogs experimentally infected with Dirofilaria immitis     

D E Thrall  R R Badertscher  R E Lewis  J W McCall 《American journal of veterinary research》1979,40(10):1426-1432

Pulmonary arterial perfusion was evaluated by perfusion lung scans in ten dogs experimentally infected with heartworm. After larval inoculation, scans were done once a month for 11 months. In 8 of 10 dogs, pulmonary arterial perfusion deficits were detected. The perfusion deficits involved the left cranial, right cranial, and right caudal lung lobes. Generally, there was a poor correlation between vascular abnormalities detected on the survey thoracic radiographs and the perfusion deficits detected by lung scanning. The perfusion deficits did not produce clinical signs or pulmonary infarction.  相似文献   

Mesothelioma in the Dog: Six Case Reports     

Donald E.  Thrall Michael H.  Goldschmidt 《Veterinary radiology & ultrasound》1978,19(4):107-115

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Canine Lung Scanning1     

Donald E. Thrall  Edward L. Gillette 《Veterinary radiology & ultrasound》1971,12(1):88-95

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Hemolytic anemia,spherocytosis, and thrombocytopenia associated with honey bee envenomation in a dog     

Rajeev Nair  Emily A. Riddle  Mary Anna Thrall 《Veterinary clinical pathology / American Society for Veterinary Clinical Pathology》2019,48(4):620-623

This case report describes a massive honey bee envenomation in a 14‐month‐old male Belgian Malinois dog from St. Kitts, West Indies. Acute and delayed onsets of hemolytic anemia, echinocytosis, spherocytosis, thrombocytopenia, hemoglobinemia, and hemoglobinuria developed following envenomation. The dog recovered after treatment with glucocorticoids and supportive therapy. Spherocytosis, hemolysis, and thrombocytopenia in patients with massive bee envenomation are likely due to the direct toxic effects of the primary components of bee venom, melittin and phospholipase A₂ (PLA₂). Mellitin causes hemolysis by forming large pores in erythrocytes resulting in leakage of hemoglobin and also causes spectrin stiffening and resultant echinocyte and spherocyte formation. Melittin also stimulates PLA₂, a hydrolase that causes echinocytosis and spherocytosis, in vivo and in vitro, and mitochondrial breakdown in platelets. However, delayed manifestations could be attributed to immune‐mediated mechanisms from the generation of antibodies against damaged erythrocytes and platelet membrane proteins.  相似文献   

Trichomonosis in free-ranging Eurasian collared doves (Streptopelia decaocto) and African collared dove hybrids (Streptopelia risoria) in the Caribbean and description of ITS-1 region genotypes     

Stimmelmayr R  Stefani LM  Thrall MA  Landers K  Revan F  Miller A  Beckstead R  Gerhold R 《Avian diseases》2012,56(2):441-445

We report the first documented occurrence of an outbreak of trichomonosis in a free-ranging small flock of Eurasian collared doves (Streptopelia decaocto) and African collared dove hybrids (Streptopelia risoria) in the Caribbean. In total, 18 birds were examined, including six African collared dove x Eurasian collared dove hybrids and 12 Eurasian collared doves. The affected age class consisted of adults. Sex distribution was equal. With a flock population size of 200 birds, mortality rate for the outbreak was estimated at 15-20%. Living birds were weak, showing evidence of mucus-stained beaks and open-mouth breathing. Caseous ulcerative yellow lesions were restricted to the upper gastrointestinal tract, with the exception of one bird, which had lesions in the upper gastrointestinal tract and in the liver. Ninety-four percent (17/18) of the affected birds had multiple extensive lesions. Lesions located on the roof of the oral cavity extended in 33% (6/18) into the orbit and in 11% (2/18) into the braincase. Using wet-mount microscopy, we were able to confirm Trichomonas gallinae in 22% (4/18) of the sampled animals. Fifteen samples submitted for PCR analysis tested positive. Sequence analysis of the internal transcribed spacer 1 (ITS-1) region of the ribosomal RNA (rRNA) revealed two distinct genotypes of Trichomonas. One sequence had 100% identity to the prototype T. gallinae isolate, whereas the other sequences had 98-100% identity to recently described Trichomonas-like parabasalid. On the basis of gross and histologic findings, along with the sequence results from the columbids in this report, it is likely that this Trichomonas-like parabasalid is pathogenic.  相似文献   

Usefulness of a half-fourier acquisition single-shot turbo spin-echo pulse sequence in identifying arachnoid diverticula in dogs     

Seiler GS  Robertson ID  Mai W  Widmer WR  Suran J  Nemanic S  Lamb CR  Lang J  Johnson JL  Thrall DE 《Veterinary radiology & ultrasound》2012,53(2):157-161

Single-shot turbo spin-echo sequences are heavily T2-weighted sequences that are exceptionally well suited to evaluate the subarachnoid space. In the T2-weighted fast spin-echo sequences that are used routinely in spinal magnetic resonance (MR) imaging, the subarachnoid space is not well differentiated from the surrounding epidural fat, which could lead to decreased detection of lesions of the subarachnoid space such as arachnoid diverticula. Our purpose was to determine the added value of a single-shot turbo spin-echo sequence in identifying cystic lesions of the subarachnoid space in dogs. MR images of six dogs with a confirmed arachnoid diverticulum and 24 dogs with other spinal disease were included. Six observers were asked to interpret only T2-weighted images initially, and in a second session, T2-weighted and half-Fourier acquisition single-shot turbo spin-echo (HASTE) sequences. The MR images were anonymized, and no signalment, history, or clinical information was provided. Without the HASTE sequences, 25% of arachnoid diverticula were identified. Adding the HASTE sequence increased the diagnosis of arachnoid diverticulum to 52.8%. The resulting difference, after adding the HASTE sequence, of 27.8% was statistically significant (P = 0.002). No false-positive diagnoses of arachnoid diverticulum were made with either sequence. Although sensitivity in this study was likely artificially low, the significantly increased detection rate of arachnoid diverticula when using HASTE imaging indicates that this sequence is a valuable addition to MR imaging protocols for the canine spine.  相似文献   

Bone Marrow Cytological Findings in 4 Dogs and a Cat With Hemophagocytic Syndrome   总被引：1，自引：0，他引：1  

Raquel M. Walton  Jaime F. Modiano  Mary Anna Thrall  Steven L. Wheeler 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》1996,10(1):7-14

Hemophagocytic syndrome or hemophagic histiocytosis was diagnosed in 4 dogs and 1 cat by evaluation of bone marrow aspirate smears. One of the dogs had a suspected infection with canine parvovirus and a confirmed infection with Salmonella spp, 2 dogs had presumptive diagnoses of myeloproliferative and lymphoproliferative disease, respectively, and 1 dog died without a diagnosis. The cat had hepatic lipidosis and lesions compatible with feline calicivirus infection. All animals had cytopenias involving 2 or more cell lines, and fragmented erythrocytes in the blood, along with mild to moderate increases in the number of macro-phages in the bone marrow. Numerous marrow macro-phages contained phagocytized hematopoietic cells. Other cytological features of the bone marrow were variable in each patient, but the degree of response in the blood was inadequate, even in those with bone marrow hyperplasia. The phagocytosis of hematopoietic elements did not appear to be caused by a primary immune disorder, but rather by the inappropriate activation of normal macrophages secondary to infectious, neoplastic, or metabolic diseases. These findings suggest that hemophagocytic syndrome may be an important factor in the development of cytopenias; the data also support the cytological evaluation of bone marrow aspirates as an aid in the diagnosis of hemophagocytic syndrome. J Vet Intern Med 1996;10:7–14. Copyright © 7996 by the American College of Veterinary Internal Medicine .  相似文献   

MAGNETIC RESONANCE IMAGING FEATURES OF LISSENCEPHALY IN 2 LHASA APSOS     

Miyoko  Saito  DVM  Nicholas J.H.  Sharp  BVM  PhD  Gregg D.  Kortz  DVM  Alexander  De Lahunta  DVM  PhD  Richard J.  Leventer  MD  Mikihiko  Tokuriki  DVM  PhD  Donald E.  Thrall  DVM  PhD 《Veterinary radiology & ultrasound》2002,43(4):331-337

Two Lhasa Apsos were diagnosed with lissencephaly based on MR imaging and clinical findings. Histologic confirmation of the diagnosis was obtained in one dog. The MR imaging appearance of the brain in 2 Lhasa Apsos with lissencephaly was of a smooth cerebral surface and a thick neocortex with an absence of the corona radiata. This correlated very well with the histopathologic findings in the dog. Our findings, together with the histopathologic features reported previously, are most consistent with Lhasa Apsos having the canine equivalent of human classical lissencephaly. MR is the imaging modality of choice for antemortem diagnosis of canine lissencephaly.  相似文献