LOW-FIELD MAGNETIC RESONANCE IMAGING OF EARLY SUBCHONDRAL CYST-LIKE LESIONS IN INDUCED CRANIAL CRUCIATE LIGAMENT DEFICIENT DOGS     

Debra K.  Baird  DVM  John T.  Hathcock  DVM  MS  Steven A.  Kincaid  DVM  MS  PhD  Paul F.  Rumph  DVM  MS  John  Kammermann  MS  William R.  Widmer  DVM  MS  Denise  Visco  PhD  Donald  Sweet  MD 《Veterinary radiology & ultrasound》1998,39(3):167-173

Six healthy adult male mongrel dogs underwent cranial cruciate ligament transection in the left stifle. Survey radiography of both stifles and low-field (0.064 T) MRI of the left stifle were performed preoperatively and at 2, 6, and 12 weeks postoperatively. Focal changes in signal intensity were seen with MRI in the subchondral bone of the medial tibial condyle at 2 and 6 weeks postoperatively. At 12 weeks postoperative, a cyst-like lesion was detected using MRI in the subchondral bone of the medial tibial condyle in 4 of 6 dogs and a less defined lesion at this site in the remaining 2 dogs. The cyst-like lesion was spherical in shape and showed typical characteristics of fluid with low signal intensity on T1-weighted images, high signal intensity on T2-weighted images and high signal intensity on inversion recovery images. The lesion was seen in the subchondral bone of the caudal medial and/or middle region of the tibial plateau slightly cranial to the insertion of the caudal cruciate ligament. No subchondral cysts were seen in the tibia on radiographs. Histopathologically, the tibia was characterized by a loose myxomatous phase of early subchondral cyst formation.  相似文献   

COMPARISON BETWEEN THE SCINTIGRAPHIC UPTAKE AND PLASMA CLEARANCE OF ^99mTc-DIETHYLENETRIAMINEPENTACETIC ACID (DTPA) FOR THE EVALUATION OF THE GLOMERULAR FILTRATION RATE IN DOGS     

Paul Y.  Barthez  DVM  William J.  Hornof  DVM  MS  Larry D.  Cowgill  DVM  PhD  Larry A.  Neal  BS  Paul  Mickel 《Veterinary radiology & ultrasound》1998,39(5):470-474

The scintigraphically measured percentage dose uptake of ^99mTc-DTPA by the kidneys and the plasma clearance of ^99mTc-DTPA have been reported to correlate well with inulin clearance. These two parameters were evaluated in seven dogs with known or suspected naturally occurring renal disease and compared to simultaneously measured renal inulin clearance. Correlation between inulin clearance and the ^99mTc-DTPA plasma clearance was better ( p =.0016) than the correlation between the percentage DTPA uptake by the kidney. It was concluded that measurement of ^99mTc-DTPA plasma clearance is a more accurate method to estimate global glomerular filtration rate (GFR) than the percentage kidney uptake.  相似文献   

Induced Meiotic Gynogenesis of Paddlefish Polyodon spathula     

Steven D.  Mims  William L.  Shelton  Otomar  Linhart  Changzheng  Wang 《Journal of the World Aquaculture Society》1997,28(4):334-343

Viable, diploid gynogenetic (gynogenotes) paddlefish Polyodon spathula were produced by activating eggs with ultraviolet-irradiated shovelnose sturgeon Scaphirhynchus platorynchus spermatozoa and heat shocking. Without irradiation treatment, sturgeon spermatozoa appeared to activate the eggs (up to gastrulation), but did not result in any viable hybrids. Experiment 1 determined that heat-shock treatment of 35 C for a 2-min duration within the interval of 2–22 min post-activation resulted in highest yield of gynogenotes (12–19%) from eggs incubated at 18 C. Experiment 2 applied the heat shock treatment at 35 C from 14.0 to 28.0 min in 2-min intervals after activation at 18 C for a larger scale of gynogenetic production. Both experiments showed that the best yields of gynogenotes were obtained when the heat shock treatment occurred at 16, 18, and 20 min after activation. When these times were expressed in terms of τ₀. units (duration of one mitotic cycle of synchronous cell division related to water temperatures), optimal activations were 0.26, 0.29, and 0.32τ₀ (τ₀@ 18 C = 63.5 min). Experiment 3 tested the utility of τ₀. at two different pre-shock incubation water temperatures of 18 C and 16 C, and determined that there was no significant interaction in percentage of viable gynogenotes between two different incubation temperatures and the mitotic intervals (0.21, 0.26, 0.31, 0.36, 0.41τ₀) tested. Best survival of gynogenotes occurred when eggs held at either pre-shock incubation water temperatures were shocked at 0.26τ₀ All gynogenotes examined were histologically confirmed to have ovarian tissue and were determined to have similar oocyte development to that of normal female (control) paddlefish.  相似文献   

Phase II Clinical Trial of Carboplatin in Canine Transitional Cell Carcinoma of the Urinary Bladder   总被引：4，自引：3，他引：1  

Ruthanne Chun  Deborah W. Knapp  William R. Widmer  Dennis B. DelNicola  Nita W. Glickman  Thomas Kuczek  Amalia Degortari  Connie M. Han 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》1997,11(5):279-283

Fourteen dogs with histologically-confirmed transitional cell carcinoma (TCC) of the urinary bladder were treated with 300 mg/m² carboplatin every 3 weeks. Response to therapy was assessed with abdominal radiography, double contrast cystography, urinary bladder ultrasonography and thoracic radiography before therapy and at 6–week intervals during therapy. Dogs were monitored for hematologic toxicity with a CBC and platelet count performed immediately before and 10 to 14 days after carboplatin treatment. Tumor responses included progressive disease in 11 dogs and stable disease in 1 dog. Two dogs were euthanized due to carboplatin toxicity before assessment of tumor response. Toxicity included thrombocytopenia with or without neutropenia in 7 dogs and gastrointestinal toxicity in 6 dogs. Carboplatin therapy was not beneficial in the treatment of TCC in the 14 dogs in this study.  相似文献   

Severe combined immunodeficiency now a solution     

William E. Jones DVM  PhD 《Journal of Equine Veterinary Science》1997,17(12):630-632

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Vaccination of Mixed and Full-Sib Families of Channel Catfish Ictalurus punctatus Against Enteric Septicemia of Catfish With a Live Attenuated Edwardsiella ictaluri Isolate (RE-33)     

David J.  Wise Phillip H.  Klesius Craig A.  Shoemaker William R.  Wolters 《Journal of the World Aquaculture Society》2000,31(2):206-212

These studies were conducted to evaluate the efficacy of a live attenuated Edwardsiella ictaluri vaccine against enteric septicemia of catfish. In one study channel catfish fingerlings (72 d of age post hatch) were immersed for 30 min in water containing E. ictaluri RE-33 at dosages of 1 × 10⁶, 1 × 10⁷ and 2 × 10⁷ CFU/ML of water. No mortalities were observed following vaccination. Following exposure to virulent Edwardsiella ictaluri the cumulative mortality of fish vaccinated with dosages of at least 1 × 10⁷ CFU/mL were significantly lower than that of non-vacccinated fish in both laboratory and field challenges. Vaccination with 1 × 10⁶ CFU RE-33mL provided some protection during the laboratory challenge but failed to protect fish under field conditions. In a second study, vaccination of 6 full-sib families of channel catfish at a vaccine dosage of 1 × 10⁷ CFU/mL resulted in a relative percent survival among families ranging from 67.1 to 100%. Significant differences in mortality were found among families and between vaccinated and unvaccinated groups, but there was no family by vaccine interaction. Families with the highest mortality after vaccination were also shown to have the highest mortality without vaccination (r = 0.82; P = 0.04).  相似文献   

Pathologic Factors Affecting Postsplenectomy Survival in Dogs     

William L. Spangler DVM  Phd  Philip H. Kass 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》1997,11(3):166-171

The apparently high prevalence of splenomegaly in dogs, along with the surgical accessibility of the spleen, results in a relatively large number of splenectomies in dogs in clinical veterinary practice. Splenic nodular lesions are widely considered to be indicative of hemangiosarcoma and thus a disease that is ultimately fatal. This study correlates the results of complete pathologic evaluation and classification of 500 spleens obtained by splenectomy with survival information for each dog. Among the spleens examined, 257 of 500 (51.4%) were classified nonneoplastic and 241 (48.2%) were neoplastic; 2 (0.4%) were unclassified. Miscellaneous non-nodular splenomegaly accounted for 46 of 257 (18%) of the nonneoplastic lesions; nodular splenomegaly accounted for 206 of 257 (79%) of nonneoplastic splenic lesions and was composed of lymphoid hyperplastic nodules and associated hematomas, hyperplastic lymphoid nodules alone, or hematomas with no apparent underlying cause. Nodular neoplastic diseases of the spleen were divided among benign tumors (11.5%) and a variety of primary sarcomas. Hemangiosarcoma made up 51% of splenic malignancies but accounted for less than 25% of the spleens evaluated. Survival of dogs with hematomas associated with nonneoplastic conditions of the spleen was markedly different from that in dogs with hemangiosarcoma-associated hematomas, even though most could not be effectively differentiated on gross inspection. Two month postoperative survival was 83% for dogs with nonneoplastic-related hematomas, whereas only 31% of dogs with hemangiosarcoma, with or without associated hematomas, were alive after 2 months. Twelve-month survival times were 64% and 7%, respectively. An overall postsplenectomy survival rate of 52% was based on the number of dogs surviving for a minimum of 6 months postoperatively.  相似文献   

Theriogenology     

Wynne A. DiGrassie DVM  William B. Ley DVM  MS 《Journal of Equine Veterinary Science》1997,17(10):528-529

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Sectional notes     

H. G. Zuckerman  C. H. Metzger  B. A. Brown  W. B. Ward  Frank W. Hussey  R. W. Donaldson  E. E. Isaac  Marx Koehnke  William H. Martin  K. H. Fernow  E. V. Hardenburg  Robert Schmidt  E. M. Gillig  E. B. Tussing  E. R. Jackman  T. E. Odland  S. P. Swenson  John Tucker 《American Journal of Potato Research》1936,13(8):223-232

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Stomatal conductance of Acer rubrum ecotypes under varying soil and atmospheric water conditions: predicting stomatal responses with an abscisic acid-based model     

Bauerle WL  Toler JE  Wang GG 《Tree physiology》2004,24(7):805-811

A multiplicative model of stomatal conductance was developed and tested in two functionally distinct ecotypes of Acer rubrum L. (red maple). The model overcomes the main limitation of the commonly used Ball-Berry model (Ball et al. 1987) by accounting for stomatal behavior under soil drying conditions. We combined the Ball-Berry model with an integrated expression of abscisic acid (ABA)-based stomatal response to ABA concentration ([ABA]) in bulk leaf tissue (gfac), which coupled physiological changes at the leaf level with those in the root. The factor gfac = exp(-beta[ABA]L) incorporated the stomatal response to [ABA] into the Ball-Berry model by down regulating stomatal conductance (gs) in response to physiological changes in the root. The down regulation of gs is pertinent under conditions where soil drying may modify the delivery of chemical signals to leaf stomata. Model testing indicated that the multiplicative model was capable of predicting gs in red maple under wide ranges of soil and atmospheric conditions. Concordance correlation coefficients were high (between 0.59 and 0.94) for the tested ecotypes under three environmental conditions (atmospheric, rhizospheric and minimal stress). The study supported the use of gfac as a gas exchange function that controls water stress effects on gs and aids in the prediction of gs responses.  相似文献