实验性流行性腹泻仔猪小肠粘膜上皮细胞及肠系膜淋巴结的超微结构     

田欣田  郑兆荣  邱震东  刘宝岩  杨盛华 《中国兽医学报》1988,(2)

给8头生后3d的哺乳仔猪经口感染猪流行性腹泻病毒(PEDV)“吉”毒株,于感染后18、30、45和96h各扑杀2头,以透射电镜和扫描电镜观察了小肠粘膜上皮细胞及肠系膜淋巴结的超微结构。结果表明,小肠上皮细胞的病变因感染时间不同而有明显差异。上皮细胞的脱落和残留上皮细胞超微结构的破坏,以感染后30h最严重,病毒在这些上皮细胞内的增殖最显著。感染后45h,见有大量新生上皮细胞修补损伤的肠绒毛。感染后96h,小肠绒毛短缩、粗大乃至发生融合。实验仔猪肠系膜淋巴结内巨噬细胞和淋巴细胞的超微结构均遭到破坏,在巨噬细胞内见有PED冠状病毒粒子。  相似文献   

Platelet activating factor as a mediator of equine cell locomotion     

J. Dawson  P. Lees  A. D. Sedgwick 《Veterinary research communications》1988,12(2-3):101-107

Equine polymorphonuclear (PMN) and mononuclear (MN) leucocytes were separated on Percoll gradients and used to study the chemoattractant properties of the polar ether-linked phospholipid, platelet activating factor (PAF). Six concentrations of PAF ranging from 1 ng/ml to 100 g/ml were studied in each of two in vitro assay systems, the agarose microdroplet and a microfilter technique. Very significant (p<0.01) increases in the movement of both PMN and MN cells were obtained with most concentrations of PAF. In two instances there was no apparent concentration-response relationship, although the action of PAF was approximately bell-shaped in two others. The possible significance of these findings for equine inflammatory conditions is discussed.  相似文献   

Escherichia coli sepsis and endotoxemia in conscious young pigs     

E. Schrauwen  E. Cox  A. Houvenaghel 《Veterinary research communications》1988,12(4-5):295-303

In conscious pigs the influence of intravenous infusion of live E. coli (7×10⁸/kg), of the equivalent amount of endotoxin (20 g/kg) or of a high dose of endotoxin (2.5 mg/kg) on the hemodynamic, clinical and pathological parameters and on survival rate was studied. E. coli and endotoxin infusion resulted in pulmonary hypertension, systemic arterial hypotension, a decrease in cardiac output and an increase in heart rate. Clinical signs were characterized by respiratory and nervous disturbances, whereas necropsy revealed hemorrhages and edema in several organs. Although these findings were similar in the three groups, a marked difference in lethality was observed. Infusion of E. coli or of the high dose of endotoxin resulted in a significant mortality, whereas all pigs survived the infusion of the low dose of endotoxin. This suggests that the lethal pathophysiological mechanisms may only become activated when a sufficient amount of endotoxin is released into the circulation.  相似文献   

Bovine and canine acute phase proteins   总被引：1，自引：0，他引：1  

P. D. Eckersall  J. G. Conner 《Veterinary research communications》1988,12(2-3):169-178

Acute phase proteins are serum proteins which increase in concentration during the acute phase response to inflammation or infection. The response occurs in all animals, but in different species the response of individual proteins can be significantly different. Of the numerous acute phase proteins which have been identified in humans, a number have been examined in cattle and dogs but usually on an individual basis with little reference to their part in the acute phase response. Biochemical, physiological and clinical investigations into haptoglobin, fibrinogen, ₁-proteinase inhibitor, ceruloplasmin, seromucoid and C-reactive protein of cattle and dogs have therefore been reviewed with the emphasis on their role in this response to tissue damage.  相似文献   

Some Other Books of Interest: The Earth's Fragile Systems     

W DF 《Science (New York, N.Y.)》1988,241(4872):1519

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Pay Cap for Grantees Has Up Side for NSF     

W J 《Science (New York, N.Y.)》1988,241(4870):1159

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Volcanic rocks: mantle xenoliths     

Shervais JW 《Science (New York, N.Y.)》1988,241(4863):366-367

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Science and technology awards     

Trivelpiece AW 《Science (New York, N.Y.)》1988,241(4869):1025

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Effects of Acid rain on freshwater ecosystems   总被引：1，自引：0，他引：1  

Schindler DW 《Science (New York, N.Y.)》1988,239(4836):149-157

Acid-vulnerable areas are more numerous and widespread than believed 7 years ago. Lakes and streams in acid-vulnerable areas of northeastern North America have suffered substantial declines in acid-neutralizing capacity, the worst cases resulting in biological damage. Many invertebrates are very sensitive to acidification, with some disappearing at pH values as high as 6.0. However, the recent rate of acidification of lakes is slower than once predicted, in part the result of decreases in sulfur oxide emissions. A discussion of some of the processes that have contributed to the acidification of lakes as well as those that have protected acid-sensitive freshwaters is presented. The author is in the Department of Fisheries and Oceans, Freshwater Institute, 501 University Crescent, Winnipeg, Manitoba R3T 2N6, Canada.  相似文献   

NSF Appoints Two Assistant Directors     

W J 《Science (New York, N.Y.)》1988,240(4855):980

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