Bacterial Enteritis in Dogs and Cats: Diagnosis, Therapy, and Zoonotic Potential     

J. Scott Weese 《Veterinary Clinics of North America: Small Animal Practice》2011,41(2):287-309

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The World Small Animal Veterinary Association (WSAVA)     

P. V. Steagall  L. Pelligand  S. W. Page  M. Bourgeois  S. Weese  G. Manigot  D. Dublin  J. P. Ferreira  L. Guardabassi  Members of the WSAVA Therapeutic Guidelines Group 《The Journal of small animal practice》2020,61(9):E162-E176

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Contributing factors to surgical site infection after tibial plateau leveling osteotomy: A follow-up retrospective study     

Chris R. M. Hagen BSc  DVM  Ameet Singh DVM  DVSc  DAVCS  J. Scott Weese DVM  DVSc  DACVIM  Quinn Marshall BSc  Alex zur Linden DVM  DACVR  Thomas W. G. Gibson DVM  DVSc  DACVS  DACVSMR 《Veterinary surgery : VS》2020,49(5):930-939

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Diagnostic and public health investigation of Mycobacterium tuberculosis infection in a dog in Ontario,Canada     

Luke A. J. Haydock  Anthony C. G. Abrams-Ogg  J. Scott Weese  Michael R. Goldstein  Amy B. Clifford  Adrian Sebastian  Elizabeth H. Rea  Frances B. Jamieson  Carla Duncan  Olga Andrievskaia  Mirjana Savic  Durda Slavic  Robert A. Foster  Christopher J. Greenwood  Tamara L. MacDonald  Jacqueline E. Scott  Andrea Sanchez 《Journal of veterinary diagnostic investigation》2022,34(2):292

A 4-y-old, female mixed-breed dog was presented to the Ontario Veterinary College for further evaluation of multiple pulmonary and hepatic masses, intrathoracic lymphadenitis, and recent development of a pyogranulomatous pleural effusion. Along with other comprehensive tests, a thoracic lymph node biopsy was performed, and Mycobacterium tuberculosis complex infection was confirmed by real-time PCR. The dog’s condition declined post-operatively, and euthanasia was elected. Postmortem examination confirmed severe granulomatous pneumonia, hepatitis, intrathoracic and intraabdominal lymphadenitis, omentitis, and nephritis. Line-probe assays performed on samples collected postmortem confirmed the species as M. tuberculosis. 24-loci MIRU-VNTR genotyping, spoligotyping, and whole-genome sequencing revealed relations to known human isolates, but no epidemiologic link to these cases was investigated. Given the concern for potential human exposure during this animal’s disease course, a public health investigation was initiated; 45 individuals were tested for M. tuberculosis exposure, and no subsequent human infections related to this animal were identified. Our case highlights the need for more readily available, minimally invasive testing for the diagnosis of canine mycobacteriosis, and highlights the ability of canid species to act as potential contributors to the epidemiology of M. tuberculosis infections.  相似文献   

Echocardiographic evaluation of the effects of medetomidine and xylazine in dogs   总被引：1，自引：0，他引：1  

JS RAND  WT REYNOLDS  J. PRIEST† 《Australian veterinary journal》1996,73(2):41-44

The echocardiographic effects of medetomidine and xylazine were evaluated in 6 healthy dogs. Values for echocardiographic variables were significantly different from pre-treatment values after administration of both drugs. The effects of medetomidine were similar to that of xylazine. Because of their cardiac depressant effects, both drugs should be used with care in sick dogs.  相似文献   

Performance and microbiological safety testing after multiple use cycles and hydrogen peroxide sterilization of a 5‐mm vessel‐sealing device     

D. Valenzano  G. Hayes  D. Gludish  S. Weese 《Veterinary surgery : VS》2019,48(5):885-889

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Characterization of the otic bacterial microbiota in dogs with otitis externa compared to healthy individuals     

Juraj Korbelik  Ameet Singh  Joyce Rousseau  J. Scott Weese 《Veterinary dermatology》2019,30(3):228-e70

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Analysis of the otic mycobiota in dogs with otitis externa compared to healthy individuals          下载免费PDF全文

Juraj Korbelik  Ameet Singh  Joyce Rousseau  J. Scott Weese 《Veterinary dermatology》2018,29(5):417-e138

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In vitro antimicrobial activity of miconazole and polymyxin B against canine meticillin-resistant Staphylococcus aureus and meticillin-resistant Staphylococcus pseudintermedius isolates     

Boyen F  Verstappen KM  De Bock M  Duim B  Weese JS  Schwarz S  Haesebrouck F  Wagenaar JA 《Veterinary dermatology》2012,23(4):381-5, e70

Background – Meticillin‐resistant Staphylococcus aureus (MRSA) and meticillin‐resistant Staphylococcus pseudintermedius (MRSP) infections are increasingly reported in dogs, and these bacteria may be isolated from ear infections. Hypothesis/Objectives – The main aim of the present study was to investigate the in vitro antimicrobial activity of miconazole, polymyxin B and a combination of both against 24 canine MRSA and 50 canine MRSP isolates. The minimal inhibitory concentration (MIC) values of 12 other antimicrobial agents were also determined. Methods – All MIC values were determined according to a broth microdilution assay. Results – Acquired resistance was found to all tested agents, except for linezolid, miconazole and polymyxin B. The MIC values for miconazole and polymyxin B against MRSA were in the range of 4–8 and 8–64 μg/mL, respectively, while the MIC values for miconazole and polymyxin B against MRSP were in the range of 1–2 and 0.25–4 μg/mL, respectively. Using a combination of miconazole and polymyxin B, there was no evidence for enhanced in vitro activity of the combination (i.e. synergy) of both products. Nevertheless, MIC₉₀ values of the combination of these antimicrobial agents and of a commercial product containing both agents were at least 1000 times lower than the concentration present in the commercial product. Conclusions and clinical importance – These results indicate that the topical use of a combination of miconazole and polymyxin B in a 43.5:1 ratio may have potential for the treatment of MRSA‐mediated and MRSP‐associated otitis externa in dogs.  相似文献   

Detection and characterization of Clostridium perfringens in the feces of healthy and diarrheic dogs     

Michael R. Goldstein  Stephen A. Kruth  Alexa M.E. Bersenas  Marie K. Holowaychuk  J. Scott Weese 《Canadian journal of veterinary research》2012,76(3):161-165

Clostridium perfringens has been implicated as a cause of diarrhea in dogs. The objectives of this study were to compare 2 culture methods and to evaluate a multiplex polymerase chain reaction (PCR) assay to detect C. perfringens toxin genes alpha (α), beta (β ), beta 2 (β2), epsilon (ɛ), iota (ι), and C. perfringens enterotoxin (cpe) from canine isolates. Fecal samples were collected from clinically normal non-diarrheic (ND) dogs, (n = 105) and diarrheic dogs (DD, n = 54). Clostridium perfringens was isolated by directly inoculating stool onto 5% sheep blood agar (SBA) and enrichment in brain-heart infusion (BHI) broth, followed by inoculation onto SBA. Isolates were tested by multiplex PCR for the presence of α, β, β2, ɛ, ι, and cpe genes. C. perfringens was isolated from 84% of ND samples using direct culture and from 87.6% with enrichment (P = 0.79). In the DD group, corresponding isolation rates were 90.7% and 93.8% (P = 0.65). All isolates possessed the α toxin gene. Beta (β), β2, ɛ, ι, and cpe toxin genes were identified in 4.5%, 1.1%, 3.4%, 1.1%, and 14.8% of ND isolates, respectively. In the DD group, β and β2 were identified in 5%, ɛ and ι were not identified, and the cpe gene was identified in 16.9% of isolates. Enrichment with BHI broth did not significantly increase the yield of C. perfringens, but it did increase the time and cost of the procedure. C. perfringens toxin genes were present in equal proportions in both the ND and DD groups (P ≤ 0.15 to 0.6). Within the parameters of this study, culture of C. perfringens and PCR for toxin genes is of limited diagnostic usefulness due to its high prevalence in normal dogs and the lack of apparent difference in the distribution of toxin genes between normal and diarrheic dogs.  相似文献