Radiology in racetrack practice     

W E Blevins  W R Widmer 《Veterinary Clinics of North America: Equine Practice》1990,6(1):31-61

This article focuses on the principles involved in making radiographs of equine limbs; understanding radiographic anatomy, including normal variations; and principles of radiographic interpretation. The influence of pathogenesis of disease on the radiographic image is considered. Diseases associated with racing as well as the developing racehorse are discussed.  相似文献   

An unusual case of traumatic pericarditis in a cow   总被引：1，自引：0，他引：1  

J E Sojka  M R White  W R Widmer  W G VanAlstine 《Journal of veterinary diagnostic investigation》1990,2(2):139-142

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Regulation of alloreactivity in vivo by a soluble form of the interleukin-1 receptor   总被引：14，自引：0，他引：14  

W C Fanslow  J E Sims  H Sassenfeld  P J Morrissey  S Gillis  S K Dower  M B Widmer 《Science (New York, N.Y.)》1990,248(4956):739-742

In vitro studies have shown that cytokines are involved in the regulation of the immune response, but their role in vivo is less well defined. Specific cytokine antagonists enable the identification of particular cytokines involved in the response and offer a means for modifying it. Systemic administration of a soluble, extracellular portion of the receptor for interleukin-1 (sIL-1R) had profound inhibitory effects on the development of in vivo alloreactivity. Survival of heterotopic heart allografts was prolonged from 12 days in controls to 17 days in mice treated with sIL-1R. Lymph node hyperplasia in response to a localized injection of allogeneic cells was completely blocked by sIL-1R treatment. The inhibition was overcome by simultaneous administration of interleukin-1 (IL-1); thus, sIL-1R acts by neutralizing IL-1. These results implicate IL-1 as a regulator of allograft rejection and demonstrate the in vivo biological efficacy of a soluble cytokine receptor.  相似文献   

Abstracts presented at the Association of Veterinary Anaesthetists Spring meeting, 22nd–23rd March 2012, Davos,Switzerland     

R Eddie Clutton  KW Clarke 《Veterinary anaesthesia and analgesia》2013,40(1):1-28

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Characterisation of novel <Emphasis Type="Italic">Fusarium graminearum</Emphasis> microsatellite markers in different <Emphasis Type="Italic">Fusarium</Emphasis> species from various countries     

Susanne Vogelgsang  Franco Widmer  Eveline Jenny  Jürg Enkerli 《European journal of plant pathology / European Foundation for Plant Pathology》2009,123(4):477-482

Fifteen novel microsatellite markers were isolated from Fusarium graminearum. The level of polymorphism at these novel and 13 previously published microsatellite markers was analysed in 33 F. graminearum strains from Europe, North America, and Nepal. The number of alleles for each of the novel markers ranged from 4 to 20 and gene diversity from 0.417 to 0.962. In comparison with the previously published markers, the resolution for distinguishing among different strains was slightly increased. Twenty-seven markers were also detectable in three F. culmorum strains and one F. crookwellense strain. None of the markers was detected in three F. avenaceum and four F. poae strains, underlining the potential use of these microsatellite markers for species differentiation.  相似文献   

Biochemical and molecular identification of species of Taenia     

AJ LYMBERY  RCA THOMPSON  S. LACHBERG  KW YAP 《Australian veterinary journal》1989,66(7):227-227

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A PROSPECTIVE CLINICAL TRIAL COMPARING METRIZAMIDE AND IOHEXOL FOR EQUINE MYELOGRAPHY     

William R.  Widmer  DVM  MS  William E.  Blevins  DVM  MS  Samuel  Jakovljevic  DVM  MS  Michel  Levy  DVM  Robert F.  Teclaw  DVM  PhD  Connie M.  Han  RVT  Cheryl D.  Hurd  RVT 《Veterinary radiology & ultrasound》1998,39(2):106-109

A prospective clinical trial comparing adverse postmyelographic effects and myelographic quality of metrizamide and iohexol was conducted. Using a predetermined, randomized assignment, 24 horses exhibiting neurologic signs were administered either metrizamide (180 mgl/ml) or iohexol (180 mgl/ml) via cerebellomedullary puncture. Each horse was evaluated postmyelographically for adverse effects. Myelographic quality was assessed by a numerical scoring method. Adverse effects were observed more frequently with metrizamide (21) compared with iohexol (6) myelography (p < 0.05). Seizures, intensification of preexisting neurologic signs and prolonged anesthetic recovery were the most common complications after myelography. There was no difference in myelographic quality (p > 0.05). We conclude that iohexol is safer than metrizamide for equine myelography and that quality myelograms can be obtained with either contrast medium.  相似文献   

Histological Comparison of Fibrous Root Infection of Disease-Tolerant and Susceptible Citrus Hosts by Phytophthora nicotianae and P. palmivora     

Widmer TL  Graham JH  Mitchell DJ 《Phytopathology》1998,88(5):389-395

ABSTRACT Phytophthora nicotianae and P. palmivora infect and cause rot of fibrous roots of susceptible and tolerant citrus rootstocks in Florida orchards. The infection and colonization by the two Phytophthora spp. of a susceptible citrus host, sour orange (Citrus aurantium), and a tolerant host, trifoliate orange (Poncirus trifoliata), were compared using light and electron microscopy. Penetration by both Phytophthora spp. occurred within 1 h after inoculation, regardless of the host species. No differences were observed in mode of penetration of the hypodermis or the hosts' response to infection. After 24 h, P. palmivora had a significantly higher colonization of cortical cells in susceptible sour orange than in tolerant trifoliate orange. Intracellular hyphae of both Phytophthora spp. were observed in the cortex of sour orange, and cortical cells adjacent to intercellular hyphae of P. palmivora were disrupted. In contrast, the cortical cells of sour orange and trifoliate orange adjacent to P. nicotianae hyphae and the cortical cells of trifoliate orange adjacent to P. palmivora were still intact. After 48 h, the cortical cells of both hosts adjacent to either Phytophthora spp. were disrupted. After 48 and 72 h, P. palmivora hyphae colonized the cortex of sour orange more extensively than the cortex of trifoliate orange; P. palmivora also colonized both hosts more extensively than P. nicotianae. A higher rate of electrolyte leakage among host-pathogen combinations reflected the combined effects of greater cell disruption by P. palmivora than by P. nicotianae, and the higher concentration of electrolytes in healthy roots of trifoliate orange than of sour orange. Although cellular responses unique to the tolerant host were not observed, reduced hyphal colonization by both pathogens in the cortex of trifoliate orange compared with sour orange is evidence for a putative resistance factor(s) in the trifoliate orange roots that inhibits the growth of Phytophthora spp.  相似文献   

Infiltrating Foxp3+ Regulatory T cells and Histopathological Features in Canine Classical and Spermatocytic Seminomas     

JH Kim  SK Chon  KS Im  NH Kim  KW Cho  JH Sur 《Reproduction in domestic animals》2013,48(2):218-222

In humans, regulatory T (T reg) cells are known to play a critical role in both the regulation of immune homoeostasis and the progression of cancer. However, there is little information about the identification, characterization and the function of T reg cells in canine tumours. We identified T reg cells in 28 canine seminoma samples using a Forkhead box P3 (Foxp3) antibody and investigated the relationship between T reg cell infiltration and histopathological features of classical and spermatocytic seminomas (SE and SS, respectively). The Foxp3 protein showed nuclear immunostaining in infiltrating lymphocytes, and Foxp3+ cells were diffused or focally distributed in seminoma tissues. Foxp3+ cells were frequently present in the SS histotype, in seminomas that showed no evidence of tumour cell invasion into the vessels and in seminomas showing a diffuse growth pattern with three cell types. Neither the SE/SS histotype nor the histopathological features of the tumour correlated with Foxp3+ cell counts. These results indicate that Foxp3+ T reg cells may be associated with a less malignant histological phenotype or may not play a critical role in the immune response of canine seminomas. Moreover, Foxp3+ T reg cells may be associated with SS seminoma, but further studies, involving a larger number of samples, are required to better understand whether these cells play a critical role in the immune response in canine seminomas. This is the first report to demonstrate the characteristics of T reg cell infiltration in canine seminoma.  相似文献   

Comparison of the clinical efficacy of cefquinome with the combination of penicillin G and gentamicin in equine patients     

A. Widmer  M. Kummer  M. Wehrli Eser  A. Fürst 《Equine Veterinary Education》2009,21(8):430-435

This prospective, randomised, nonblinded study compared the clinical efficacy of cefquinome to that of a combination of penicillin and gentamicin. Patients (374 horses and 13 donkeys) at the equine hospital of the Vetsuisse-Faculty of Zurich, presented from February-October 2007, were divided into prophylactic and therapeutic treatment groups. Equids from these groups were randomly treated either with cefquinome or with the combination of sodium penicillin and gentamicin. There was no significant difference between the 2 treatment groups for prophylactic indications. In the therapeutic group, cefquinome showed better efficacy, as demonstrated by fewer complications of wound healing and fewer treatment failures with subsequent change to another antibiotic. Side effects were very rare in both treatment groups. Cefquinome can be used with safety and efficacy in equids. Cefquinome had greater efficacy than the combination of penicillin and gentamicin in the therapeutic group. However, there was no difference between the 2 antibiotic treatments in the prophylactic group. In order to minimise the development of resistance, cefquinome should therefore not be used for routine prophylactic treatment.  相似文献