Experimental transmission of jaagsiekte (ovine pulmonary adenomatosis) to goats   总被引：1，自引：0，他引：1  

R C Tustin  A L Williamson  D F York  D W Verwoerd 《The Onderstepoort journal of veterinary research》1988,55(1):27-32

Jaagsiekte was successfully transmitted to at least 2 out of 6 goats inoculated intratracheally with partially purified jaagsiekte retrovirus. Multiple, small, well circumscribed nodules found in the lungs consisted of typical papilliform proliferations of neoplastic Type II epithelial cells. Histological evidence of a mild interstitial pneumonia in 4 of the experimental animals can probably be attributed to a contaminating lentivirus in the jaagsiekte retrovirus preparation, as suggested by the seroconversion of the animals.  相似文献   

RADIOGRAPHIC VISUALIZATION OF THE RUMINANT UPPER URINARY TRACT BY A DOUBLE CONTRAST TECHNIQUE     

A. P. Singh  MVSc  PhD  Jit  Singh  MVSc  PhD  H. D. Williamson  MA  BA  DCR  P. K. Peshin  MVSc  J. M. Nigam  MVSc  PhD  FRVAC 《Veterinary radiology & ultrasound》1983,24(3):106-111

The ruminant urinary tract is normally obscured by abdominal viscera, which hampers rediographic investigation by conventional urographic methods. A double contrast technique that uses pneumoperitoneum in conjunction with excretory urography is described. Bolus and infusion urographic techniques were used in sheep and calves. Only the infusion technique was used in cows. The radiographic anatomy of the upper urinary tract in these animals is described. Visualization of the nephrogram and collecting system varied, depending on the method of excretory urography used.  相似文献   

PREGNANCY RATES AND NON-RETURN RATES FOLLOWING ARTIFICIAL AND NATURAL BREEDING IN DAIRY HERDS     

N. B. Williamson  R. S. Morris  † G. A. Anderson 《Australian veterinary journal》1978,54(3):111-114

SUMMARY Information routinely supplied during the conduct of a dairy herd health program was analysed to evaluate the performance of artificial breeding in Victoria. A comparison was made between 60 to 90-day non-return rates (supplied by artificial breeding centres) and pregnancy rates (determined by manual pregnancy diagnosis) for first artificial inseminations in 108 herd years in which both items were available in the 1973 and 1974 breeding seasons. The values were 69.3% and 58.2% respectively (P <0.001). Non-return rates and conception rates were found to decline as herd size increased. Pregnancy rates to first artificial and natural services did not differ significantly from each other but pregnancy rates were significantly more variable to natural than artificial service (P < 0.001). The mean pregnancy rate to artificial insemination for all herd years studied was 57.5% and the pregnancy rate to natural service was 58.0%.  相似文献   

A Functional Analysis of Ankle Extension in the Ricochetal Rodent (Dipodomys merriami)     

R. G. Williamson  jr E. C. Frederick 《Anatomia, histologia, embryologia》1977,6(2):157-166

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A study of oestrous behaviour and oestrus detection methods in a large commercial dairy herd. II. Oestrous signs and behaviour patterns     

N B Williamson  R S Morris  D C Blood  C M Cannon  P J Wright 《The Veterinary record》1972,91(3):58-62

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Upregulation of c-Myc may contribute to the pathogenesis of canine pemphigus vulgaris     

Williamson L  Suter MM  Olivry T  Wyder M  Müller EJ 《Veterinary dermatology》2007,18(1):12-17

The pathomechanism in human pemphigus vulgaris (PV) has recently been described to rely on generalized c-Myc upregulation in skin and oral mucosa followed by hyperproliferation. Here we assessed whether dogs suffering from PV present the same pathological changes as described for human patients with PV. Using immunofluorescence analysis on patients' biopsy samples, we observed marked nuclear c-Myc accumulation in all layers of the epidermis and oral mucosa in all (3/3) dogs analysed. In addition, c-Myc upregulation was accompanied by an increased number of proliferating Ki67-positive cells. These molecular changes were further paralleled by deregulated expression of wound healing and terminal differentiation markers as observed in human PV. Together these findings suggest a common pathomechanism for both species which is of particular relevance in the light of the recently discussed novel therapeutic strategies aiming at targeting PV antibody-induced signalling cascades.  相似文献   

Retinal photoreceptor damage produced in guinea pigs by tunicamycin     

BG Spencer  PC Blumbergs  J Manavis  JW Finnie 《Australian veterinary journal》2020,98(9):424-428

Corynetoxins, members of the tunicamycin group of antibiotics, produce a severe and frequently fatal neurological disorder in ruminant livestock, and guinea pigs are a useful model to study the pathology and pathogenesis of this disease. The aim of this study was to determine whether tunicamycin produced ocular damage in this species, which could have pharmacotherapeutic and diagnostic value. Four 8-week-old guinea pigs were treated with tunicamycin, and two control animals were given the drug vehicle only. Guinea pigs were injected subcutaneously with 400 μg/kg of tunicamycin, in dimethyl sulphoxide, and killed 48 h post-injection. The eyes were then examined by light microscopy. Immunohistochemistry for rhodopsin was also performed. The principal pathological finding was marked retinal photoreceptor damage, which was characterised by disruption and disorganisation of rods, sometimes progressing to necrosis and separation of the outer segment. The cytoplasm of some rods was focally distended by accumulated, proteinaceous material. Rhodopsin immunopositivity in injured rods was markedly diminished and associated with shrinkage and shortening of the injured rod's outer segment. Ocular pathology, in the form of reproducible and extensive retinal photoreceptor damage, was found in guinea pigs given tunicamycin, extending the range of species found to be susceptible to this toxic injury. The guinea pig could prove to be a good animal model to test potential therapeutic interventions, and as brain lesions are often minimal and liver pathology non-specific in intoxicated ruminants, any spontaneously arising ophthalmic injury found in these species could be diagnostically useful.  相似文献   

Number,causes and destinations of horses leaving the Australian Thoroughbred and Standardbred racing industries     

PC Thomson  AR Hayek  B Jones  DL Evans  PD McGreevy 《Australian veterinary journal》2014,92(8):303-311

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Production and description of interspecific hybrids between Poa pratensis and P. Longifolia     

Cynthia J. Williamson  Patricia J. Watson 《Euphytica》1980,29(3):715-725

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Needs-based decision-making for cotton problems in Africa: A response to Hillocks     

Stephanie Williamson  Simon Ferrigno  Simplice Davo Vodouhe 《国际虫害防治杂志》2013,59(4):219-224

Abstract

This Forum contribution forms a response to the thoughtful article on the role of Bt cotton for African smallholders by Rory Hillocks in International Journal of Pest Management 51(2):131–141. We urge a more nuanced approach to consideration of pesticide-related and other technical issues in the conventional cotton sector, including recent estimates of external costs to health from current patterns of pesticide use, even at the low application levels in volume/area terms reported from Africa. We examine economic and institutional aspects of cotton production and the debates centred upon the potential of Bt cotton for resource-poor farmers in developing countries. Based on research and project experience over the last decade, we discuss the role of organic cotton and the benefits it provides for African men and women smallholders, and conclude with a summary of the potential for expansion and policy, research and development needs.  相似文献