Echinochrome A Treatment Alleviates Atopic Dermatitis-like Skin Lesions in NC/Nga Mice via IL-4 and IL-13 Suppression     

Hyeong Rok Yun  Sang Woo Ahn  Bomin Seol  Elena A. Vasileva  Natalia P. Mishchenko  Sergey A. Fedoreyev  Valentin A. Stonik  Jin Han  Kyung Soo Ko  Byoung Doo Rhee  Jung Eun Seol  Hyoung Kyu Kim 《Marine drugs》2021,19(11)

Atopic dermatitis (AD) is a chronic inflammatory skin disease in which skin barrier dysfunction leads to dryness, pruritus, and erythematous lesions. AD is triggered by immune imbalance and oxidative stress. Echinochrome A (Ech A), a natural pigment isolated from sea urchins, exerts antioxidant and beneficial effects in various inflammatory disease models. In the present study, we tested whether Ech A treatment alleviated AD-like skin lesions. We examined the anti-inflammatory effect of Ech A on 2,4-dinitrochlorobenzene (DNCB)-induced AD-like lesions in an NC/Nga mouse model. AD-like skin symptoms were induced by treatment with 1% DNCB for 1 week and 0.4% DNCB for 5 weeks in NC/Nga mice. The results showed that Ech A alleviated AD clinical symptoms, such as edema, erythema, and dryness. Treatment with Ech A induced the recovery of epidermis skin lesions as observed histologically. Tewameter^® and Corneometer^® measurements indicated that Ech A treatment reduced transepidermal water loss and improved stratum corneum hydration, respectively. Ech A treatment also inhibited inflammatory-response-induced mast cell infiltration in AD-like skin lesions and suppressed the expression of proinflammatory cytokines, such as interferon-γ, interleukin-4, and interleukin-13. Collectively, these results suggest that Ech A may be beneficial for treating AD owing to its anti-inflammatory effects.  相似文献   

Protein Profiling from Hormone-Induced Tetraploid Roots in Platycodon grandiflorum     

Kwon  Soo-Jeong  Roy  Swapan Kumar  Yu  Jang-Hwan  Cho  Seong-Woo  Kim  Hag-Hyun  Boo  Hee-Ock  Woo  Sun-Hee 《Journal of Crop Science and Biotechnology》2019,22(5):465-474

Journal of Crop Science and Biotechnology - The root of Platycodon grandiflorum is used as traditional oriental medicine in Asian countries since ancient times to treat bronchitis, tonsillitis,...  相似文献   

Effects of Nitrogen,Phosphorus and Potassium Fertilizers on Growth Characteristics of Two Species of Bellflower (Platycodon grandiflorum)     

Kwon  Soo-Jeong  Kim  Hye-Rim  Roy  Swapan Kumar  Kim  Hyun-Jung  Boo  Hee-Ock  Woo  Sun-Hee  Kim  Hag-Hyun 《Journal of Crop Science and Biotechnology》2019,22(5):481-487

Journal of Crop Science and Biotechnology - Fertilization plays a vital role to enhance productivity in several medicinal plants, including Bellflower. A pot experiment was conducted in 2018 to...  相似文献   

Complete genome sequence and pathogenic analysis of a new betanodavirus isolated from shellfish     

Young Chul Kim  Woo Ju Kwon  Joon Gyu Min  Kwang Il Kim  Hyun Do Jeong 《Journal of fish diseases》2019,42(4):519-531

We determined the complete genomic RNA sequence of a new type of betanodavirus Korea shellfish nervous necrosis virus (KSNNV) isolated from shellfish. Compared with other isolates representing four genotypes of betanodaviruses, the identity of the whole nucleotide sequence of the virus was in the range of 76%–83% with the presence of specific genetic motifs and formed a separate new branch in the phylogenetic analysis. In pathogenic analysis by immersion method, KSNNV‐KOR1 shows 100% cumulative mortality like SFRG10/2012BGGa1 (RGNNV) in newly hatched sevenband grouper and mandarin fish, which is clearly different from those found in negative control groups. There were no significant differences in increasing rates of mortality and viral intra‐tissue concentration of larval fishes infected with KSNNV‐KOR1 at both 20 and 25°C water temperature. Histopathological examination of each fish species in the moribund stage revealed the presence of clear vacuoles in both brain and retinal tissues similar to typical histopathology features of RGNNV. In the present study, we first report a new betanodavirus from shellfish as the aetiological agent of viral nervous necrosis disease in fish with complete genomic nucleotide sequence and pathogenic analysis.  相似文献   

Anaesthetic efficacy and physiological responses to clove oil-anaesthetized kelp grouper Epinephelus bruneus     

Min Ouk Park  Woo June Hur  Soo-Yeon Im  Dong-Won Seol  Jinhwan Lee  & In-Seok Park 《Aquaculture Research》2008,39(8):877-884

The efficacy of clove oil as an anaesthetic and at producing a physiological response (plasma cortisol and glucose) was evaluated in the kelp grouper, Epinephelus bruneus . To acquire complete anaesthesia in less than 3 min and recovery in <10 min, three doses of clove oil were tested at 18, 22 and 26 °C. Although higher anaesthetic doses resulted in shorter induction times and longer recovery times, and a lower temperature resulted in longer anaesthesia induction and slower recovery, we found the optimal dose and administering temperature of clove oil to be 250–300 mg L⁻¹ at water temperature of 18 °C, 150–200 mg L⁻¹ at water temperature of 22 °C and 50–100 mg L⁻¹ at water temperature of 26 °C respectively. Following the administration of 150 mg L⁻¹ of clove oil at 22 °C, the plasma cortisol level was highest (4.24 ± 1.571 μg dL⁻¹) after 12 h and the plasma glucose was highest (92.7 ± 9.61 mg dL⁻¹) after 2 h. These results should be useful to the aquaculture industry, where anaesthesia is necessary for a range of activities.  相似文献   

Effects of nutrient solution electrical conductivity and sulfur, magnesium, and phosphorus concentration on sesquiterpene lactones in hydroponically grown lettuce (Lactuca sativa L.)     

Myeong Whoon Seo  Dong Sik Yang  Stanley J. Kays  Jun-Hong Kim  Jin Ho Woo  Kuen Woo Park   《Scientia Horticulturae》2009,122(3):369-374

The effect of nutrient solution electrical conductivity (EC) and sulfur (S), magnesium (Mg), and phosphorus (P) levels on the content of the primary sesquiterpene lactones (SLs), lactucin, 8-deoxylactucin, and lactucopicrin, in hydroponically grown lettuce was assessed. Lettuce grown at 4 EC levels (0.5, 1.0, 2.0, and 3.0 dS m⁻¹) displayed significant differences in leaf area index, number of leaves, plant height, fresh weight per plant, and chlorophyll content that were highest at EC 2.0 dS m⁻¹. Lactucin (5.5 μg g⁻¹ dry weight), 8-deoxylactucin (7.5), lactucopicrin (35.8), and total SLs (48.7) concentraions were highest at EC 0.5 dS m⁻¹. Four S (8, 16, 48, and 80 mg L⁻¹) and Mg (6, 12, 36, and 60 mg L⁻¹) levels and 3 P (8, 16, and 48 mg L⁻¹) levels were assessed for their effect on individual and total SLs. S and P had the greatest effect on SL levels. Plants in the lowest S level had significantly higher lactucin, lactucopicrin and total SLs. Each of the SLs was higher in the highest P level while Mg influenced only the lactucopicrin level in a quadratic manner. The results indicate that solution culture conditions can strongly influence the SL concentration and therefore bitterness and acceptability of lettuce.  相似文献   

Triblock copolymer syntheses of mesoporous silica with periodic 50 to 300 angstrom pores   总被引：32，自引：0，他引：32  

D Zhao  J Feng  Q Huo  N Melosh  GH Fredrickson  BF Chmelka  GD Stucky 《Science (New York, N.Y.)》1998,279(5350):548-552

Use of amphiphilic triblock copolymers to direct the organization of polymerizing silica species has resulted in the preparation of well-ordered hexagonal mesoporous silica structures (SBA-15) with uniform pore sizes up to approximately 300 angstroms. The SBA-15 materials are synthesized in acidic media to produce highly ordered, two-dimensional hexagonal (space group p6mm) silica-block copolymer mesophases. Calcination at 500 degrees C gives porous structures with unusually large interlattice d spacings of 74.5 to 320 angstroms between the (100) planes, pore sizes from 46 to 300 angstroms, pore volume fractions up to 0.85, and silica wall thicknesses of 31 to 64 angstroms. SBA-15 can be readily prepared over a wide range of uniform pore sizes and pore wall thicknesses at low temperature (35 degrees to 80 degrees C), using a variety of poly(alkylene oxide) triblock copolymers and by the addition of cosolvent organic molecules. The block copolymer species can be recovered for reuse by solvent extraction with ethanol or removed by heating at 140 degrees C for 3 hours, in both cases, yielding a product that is thermally stable in boiling water.  相似文献   

中国水稻品种对光照长度反应特性的研究——Ⅱ 品种在短光照下的生育期及在不同长度光照下产量构成因素的变化     

吴光南 《作物学报》1963,2(2):147-160

用800个中国水稻品种试验的结果指出:不同地区原产的品种不但对光照长度的反应特性不同,而且在短日照下的生育期也不同。这种特性称为短日生育性。北方的品种短日生育性较小;南方的品种从小到大都有。品种成熟期的早晚是其光照长度反应特性和短日生育性在一定环境条件下的具体表现,改变环境条件时,早晚熟的顺序随之改变。对光照长度反应弱的品种一般产量变化小,适应力大。试验结果得出各地区品种的光长反应特性和短日生育性。  相似文献   

Invitro haemolysis of piscine erythrocytes by purified metallo‐protease from the pathogenic haemoflagellate,Cryptobia salmositica Katz     

X Zuo  P T K Woo 《Journal of fish diseases》2000,23(3):227-230

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Cloning of first abc transporter encoding gene from Trichoderma spp. and its expression during stress and mycoparasitism          下载免费PDF全文

Lanzuise S　 Ruocco M　 Scala V　 Catapano L　 Woo S　 Ciliento R　 Ferraioli S　 Soriente I　 Vinale F　 Scala F　 Del Sorbo G 《浙江大学学报(农业与生命科学版)》2004,30(4):450-450

Trichoderma in its natural environment competes for nutrient uptake and is required to protect itself from adverse natural toxic compounds, such as those produced by plants and other microbes in the soil community, or synthetic toxic compounds released human activity. One of the most important metabolic pathways for drug resistance and substrate uptake, both in prokaryotes and eukaryotes, is ATP dependent. The role of ABC transporter proteins in the biology of Trichoderma is still not kno…  相似文献