Hubert George Osborne
1923 – 2007     

KL Hughes 《Australian veterinary journal》2008,86(6):218-218

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Increases in leaf artemisinin concentration in Artemisia annua in response to the application of phosphorus and boron     

M.J. DaviesC.J. Atkinson  C. BurnsR. Arroo  J. Woolley 《Industrial Crops and Products》2011,34(3):1465-1473

Malaria resurgence particularly in the third world is considerable and exacerbated by the development of multi-drug resistances to chemicals such as chloroquinone. Drug therapies, as recommended by WHO include the use of antimalarial compounds derived from Artemisia annua L., i.e. artemisinin-based therapies. This work aims to determine how A. annua plant dry matter can be enhanced while maximising artemisinin concentration from understanding the plant's mineral requirements for P and B. Experiments with differing of P, from 5 to 120 mg L⁻¹ and B from 0.1 to 0.9 mg L⁻¹ were undertaken. Mineral nutrients were supplied in irrigation water to potted plants and after a period of growth, dry matter production and leaf artemisinin concentration were determined. Increases in P application enhanced plant growth and total dry matter production. An optimal application rate, with respect to dry matter, was apparent around 30 mg P L⁻¹. Despite increases in P application having no influence on leaf artemisinin concentration, optimal yields of artemisinin, on a per plant basis, were again achieved at supply rate around 30-60 mg L⁻¹. Increasing B application rate had little influence on dry matter production despite increases in B leaf tissue concentration promoting the total amount of B per plant. Leaf artemisinin concentration significantly increased with B application rate up to 0.6 mg B L⁻¹. The higher artemisinin concentrations when multiplied by total leaf dry matter at the higher B application rates produced an increase in total artemisinin production per plant. There was however no further significant effect on leaf artemisinin concentration when B supply concentrations increased further (0.9 mg L⁻¹). Artemisinin production varied between the two experiments to a greater extent than plant dry matter production and the reasons for this are discussed in relation to growing environments and their possible impacts on artemisinin biosynthesis.  相似文献   

Direct effects of induced parturition on subsequent reproductive performance of dairy cows from commercial herds in south-western Victoria     

JM MORTON  KL BUTLER† 《Australian veterinary journal》1995,72(8):293-295

SUMMARY Reproductive performance was compared between cows whose previous parturition was induced and non-induced cows with similar calving dates, in 49 winter-calving, pasture-fed, commercial dairy herds in south-western Victoria. Parturition was induced in winter when most cows were between 27 and 35 weeks of pregnancy. Reproductive performance was assessed during the next mating period after induction which was mainly in spring of the same year. Percentages of cows in induced and untreated groups that were not pregnant after the mating period (9.0% and 7.2%, respectively) did not differ significantly. Induction tended to increase the percentage of cows of unknown pregnancy status. Mean percentages for induced and untreated groups were 11.5% and 7.9%, respectively. Induced and untreated groups calved at similar intervals after the planned start of calving in the following year, and the percentages of groups that required induction in that year did not differ significantly. The direct effects of induced parturition on reproduction were therefore concluded to be minimal. In seasonal calving herds, improvements in reproductive performance could be expected among cows whose calving dates were altered substantially by induction, due to increased intervals from calving to mating start date .  相似文献   

Reply     

VP STUDDERT  KL HUGHES 《Australian veterinary journal》1991,68(9):313-314

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Physiological and behavioural responses of the domestic hen to hypoxia     

S C Woolley  M J Gentle 《Research in veterinary science》1988,45(3):377-382

Physiological and behavioural responses of adult hens and chicks were monitored in atmospheric and increasingly hypoxic conditions to investigate whether anoxic killing was a suitable alternative method for use in the slaughter industry. All birds were placed in a perspex box for easy observation and nitrogen gas was slowly administered when subjecting birds to anoxic conditions. When subjected to decreasing oxygen concentration adult birds slowly became unconscious, without showing any signs of distress, until respiratory failure supervened. Chicks showed similar results but loss of motor control was observed while still conscious which might cause some distress. Further investigations are suggested to alleviate this problem.  相似文献   

The effects of induced parturition on the incidence of clinical disease and mortality in dairy cows from commercial herds in south-western Victoria     

JM MORTON  KL BUTLER† 《Australian veterinary journal》1995,72(1):1-4

SUMMARY The effects of induced parturition on clinical disease and mortality of cows were studied in 51 winter-calving, pasture-fed, dairy herds in south-western Victoria. Parturition was induced when most cows were between 27 and 35 weeks of pregnancy. Control groups were selected from herdmates that were not induced to calve. The incidence of retained placenta was much greater among induced cows of all ages. The proportion of cows affected by any clinical disease other than retained placenta, and the incidence of mortality were much greater after induction among cows aged over 6 years but not among cows aged 3 to 6 years.  相似文献   

WHAT IS YOUR DIAGNOSIS?     

KL BOSWARD  S RICH  JD WHITE  P MARTIN  R MALIK 《Australian veterinary journal》2006,84(3):82-82

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A populist movement for health?     

Wells J  Woolley M 《Science (New York, N.Y.)》2008,322(5898):15

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Primary ureteral leiomyosarcoma in a dog          下载免费PDF全文

FW Yap  XB Huizing  R Rasotto  KL Bowlt‐Blacklock 《Australian veterinary journal》2017,95(3):68-71

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