Association of suppression of extracellular signal-regulated kinase phosphorylation by epigallocatechin gallate with the reduction of matrix metalloproteinase activities in human fibrosarcoma HT1080 cells   总被引：8，自引：0，他引：8  

Maeda-Yamamoto M  Suzuki N  Sawai Y  Miyase T  Sano M  Hashimoto-Ohta A  Isemura M 《Journal of agricultural and food chemistry》2003,51(7):1858-1863

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Fetal and lactational exposure to the no-observed-adverse-effect level (NOAEL) dose of the neonicotinoid pesticide clothianidin inhibits neurogenesis and induces different behavioral abnormalities at the developmental stages in male mice     

Mizuki MAEDA  Sayaka KITAUCHI  Tetsushi HIRANO  Yoshinori IKENAKA  Misaki NISHI  Asuka SHODA  Midori MURATA  Youhei MANTANI  Yoshiaki TABUCHI  Toshifumi YOKOYAMA  Nobuhiko HOSHI 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2021,83(3):542

Recently, it has been reported that neonicotinoid pesticides (NNs) are transferred from mother to child and are assumed to affect the next generation, but the behavioral effects of NN exposure at different developmental stages have not been investigated. We exposed mice to no-observed-adverse-effect level (NOAEL) doses of clothianidin (CLO) during the fetal and lactational period, and then evaluated the neurobehavioral effects in juvenile and adult mice. Significant increases in anxiety-like behavior and locomotor activity were observed in juveniles and adults, respectively, and neuronal activity and neurogenesis in the hippocampal dentate gyrus were affected in both stages. These results suggest that fetal and lactational exposure to CLO may inhibit neurogenesis and cause different behavioral abnormalities at different developmental stages.  相似文献   

Survey of tortoises with urolithiasis in Japan     

Yoshinori TAKAMI  Hitoshi KOIEYAMA  Nobuo SASAKI  Takumi IWAI  Youki TAKAKI  Takehiro WATANABE  Yasutsugu MIWA 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2021,83(3):435

Urolithiasis is a disease often seen in tortoises at veterinary hospitals, however there have been no comprehensive research reports of tortoises with urolithiasis in Japan. In this study, we analyzed tortoises diagnosed with urolithiasis at three domestic veterinary hospitals. Based on medical records, we assessed the diagnostic method, species, sex, body weight, dietary history, husbandry, clinical signs, clinical examination, treatment for urolithiasis, and clinical outcome. The total number of cases in the 3 facilities was 101. As for species of tortoises, the most common was the African spurred tortoise (Centrochelys sulcata) with 42 cases (41.6%), followed by the Indian star tortoise (Geochelone elegans) with 30 cases (29.7%). Six other species were confirmed to have calculi. Almost all cases (99 cases, 98%) had a single calculus, and only 2 had multiple calculi. The prevalence of urolithiasis for the total number of tortoises having visited to one institution during the same period was 5.1%. Of the 86 cases that underwent calculi removal, 64 (74.4%) were successfully removed via the vent, and the efficacy of this method was confirmed. Nineteen cases (22%) were approached via plastronotomy, among which only 2 died postoperatively. In this study, we could not clarify the relationship between calculi formation and diets or other husbandry factors.  相似文献   

3维图像处理系统在稻米品质检测中的应用研究   总被引：12，自引：7，他引：12  

侯彩云  Seiichi Oshit  Yasuhisa Seo  Yoshinori Kawagoe  Toru Torii  Kenichi Kudoh  Toshiro Higuchi  Gabsoo Do 《农业工程学报》2001,17(3):92-95

利用微切片3维图像处理系统对稻米的品质特性进行了探索性的研究。结果表明，借助于3维可视化技术，可以对稻谷的外观品质、营养品质及蒸煮品质等进行更为直观且客观的观察与测定。尤其是在营养成分分布密度的评价、心白米内部组织的分析、蒸煮过程中组织结构变化的观测等方面，取得了传统研究方法难以获得的结果。利用该系统对垩白度的定量化测定，为食品的定量形态学研究开辟了一条新的研究途径。  相似文献   

Simultaneous inhibition and redistribution of spontaneous light emission in photonic crystals     

Fujita M  Takahashi S  Tanaka Y  Asano T  Noda S 《Science (New York, N.Y.)》2005,308(5726):1296-1298

Inhibiting spontaneous light emission and redistributing the energy into useful forms are desirable objectives for advances in various fields, including photonics, illuminations, displays, solar cells, and even quantum-information systems. We demonstrate both the "inhibition" and "redistribution" of spontaneous light emission by using two-dimensional (2D) photonic crystals, in which the refractive index is changed two-dimensionally. The overall spontaneous emission rate is found to be reduced by a factor of 5 as a result of the 2D photonic bandgap effect. Simultaneously, the light energy is redistributed from the 2D plane to the direction normal to the photonic crystal.  相似文献   

Purification and characterization of a novel fibrinolytic enzyme from Bacillus sp. nov. SK006 isolated from an Asian traditional fermented shrimp paste   总被引：1，自引：0，他引：1  

Hua Y  Jiang B  Mine Y  Mu W 《Journal of agricultural and food chemistry》2008,56(4):1451-1457

Bacillus sp. nov. SK006 producing four extracellular fibrinolytic enzymes was isolated from fermented shrimp paste, a traditional and popular Asian seasoning. One fibrinolytic enzyme was purified to homogeneity with a molecular mass of 43-46 kDa by SDS-PAGE and gel filtration chromatography. The specific activity was determined to be 11.2 units/mg using plasmin as a standard. The enzyme displayed optimal activity at 30 degrees C and pH 7.2. It was stable below 40 degrees C for 4 h between pH 5.0 and pH 11.0. Zinc ion stimulated the enzyme activity whereas Cu2+, Ca2+, Fe3+, and Hg2+ caused its inhibition. The fibrinolytic activity was strongly inhibited by PMSF and moderately inhibited by EDTA as well as PCMB. The enzyme exhibited a higher affinity toward N-Succ-Ala-Ala-Pro-Phe-pNA and was able to degrade fibrin clots either by forming active plasmin from plasminogen or by direct fibrinolysis. The N-terminal amino acid sequence was found to be AQSVPYEQPHLSQ, which is different from that of other known fibrinolytic enzymes.  相似文献   

Parietal-eye phototransduction components and their potential evolutionary implications     

Su CY  Luo DG  Terakita A  Shichida Y  Liao HW  Kazmi MA  Sakmar TP  Yau KW 《Science (New York, N.Y.)》2006,311(5767):1617-1621

The parietal-eye photoreceptor is unique because it has two antagonistic light signaling pathways in the same cell-a hyperpolarizing pathway maximally sensitive to blue light and a depolarizing pathway maximally sensitive to green light. Here, we report the molecular components of these two pathways. We found two opsins in the same cell: the blue-sensitive pinopsin and a previously unidentified green-sensitive opsin, which we name parietopsin. Signaling components included gustducin-alpha and Galphao, but not rod or cone transducin-alpha. Single-cell recordings demonstrated that Go mediates the depolarizing response. Gustducin-alpha resembles transducin-alpha functionally and likely mediates the hyperpolarizing response. The parietopsin-Go signaling pair provides clues about how rod and cone phototransduction might have evolved.  相似文献   

Excision of a feline limbal melanoma and use of nictitans cartilage to repair the resulting corneoscleral defect     

Kanai K  Kanemaki N  Matsuo S  Ichikawa Y  Okujima H  Wada Y 《Veterinary ophthalmology》2006,9(4):255-258

A limbal melanoma was surgically removed from a 12-year-old castrated male black domestic shorthair (DSH) cat. The resulting full-thickness eye wall defect was repaired using the autologous third eyelid cartilage. The patient was followed for 85 days postoperatively, during which time there was no recurrence. Other than a small amount of fibrin and blood at the anterior lens capsule, no significant complications were seen. Use of the third eyelid cartilage as graft material following resection of a feline limbal melanoma can be effective for repairing large eye wall defects and preserving ocular function. The third eyelid proved to be a convenient source of graft material. In addition, autologous grafting can reduce the potential for iatrogenic spread of infectious agents such as feline herpes virus.  相似文献   

Trichomes: interaction sites of tomato leaves with biotrophic powdery mildew pathogens     

Tomoko Suzuki  Tomoe Murakami  Yoshihiro Takizumi  Hiroyuki Ishimaru  Daiki Kudo  Yoshihiro Takikawa  Yoshinori Matsuda  Koji Kakutani  Yuling Bai  Teruo Nonomura 《European journal of plant pathology / European Foundation for Plant Pathology》2018,150(1):115-125

The present study aimed to explore the possibility of using the type I trichomes of tomato (Solanum lycopersicum) to monitor the infection processes of powdery mildews by microscopy. Individual trichome cells of two tomato genotypes were inoculated with pathogenic and non-pathogenic powdery mildew species, Pseudoidium neolycopersici, Erysiphe trifoliorum and Podosphaera xanthii. On the trichome cells of the tomato cultivar Moneymaker, hyphae of the pathogenic Pseudoidium neolycopersici (isolates KTP-03 and KTP-04) grew vigorously; whereas hyphal growth of the non-pathogenic Erysiphe trifoliorum and Podosphaera xanthii ceased after appressorium formation, which was associated with papilla formation and hypersensitive cell death, respectively. Similar infection processes of the tested powdery mildews were seen in Moneymaker epidermal cells. Therefore, tomato trichomes are suitable for analysing, at individual cell level, the infection processes of different pathotypes of powdery mildews and for observing the cytological responses of plants by non-pathogenic powdery mildews. On the other hand, it was observed that both isolates KTP-03 and KTP-04 failed to produce conidiophores on the hyphae elongating on Moneymaker trichomes. Similarly, no conidiophores were produced on the hyphae elongating on trichomes of Solanum peruvianum LA2172, which is resistant to KTP-03 and susceptible to KTP-04. Interestingly, delayed cell death occurred in LA2172 epidermal cells, which were attacked by KTP-03 hyphae elongating from trichomes and conidiophores were formed on new hyphae growing from the leaf epidermal cells. Thus, leaf trichomes and epidermal cells of the wild tomato species LA2172 reacted differently to the avirulent isolate KTP-03.  相似文献   

Optimal sap flux sensor allocation for stand transpiration estimates: a non-dimensional analysis     

Hikaru Komatsu  Tomonori Kume  Yoshinori Shinohara 《Annals of Forest Science》2017,74(2):38

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