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11.
Zohreh Hojati Farzaneh Omidi Moein Dehbashi Bahram Mohammad Soltani 《Iranian Biomedical Journal》2021,25(1):62
Background:Among different roles of miRNAs in AD pathogenesis, hsa-miR-494-3p and hsa-miR-661 functions are poorly understood. Methods:To obtain the gene targets, gene networks, gene ontology, and enrichment analysis of the two miRNAs, some web servers were utilized. Furthermore, the expressions of these miRNAs were analyzed by qRT-PCR in 36 blood sera, including 18 Alzheimer’s patients and 18 healthy individuals. Results:The in silico analysis demonstrated the highlighted roles of metabolic and cellular response to stress pathways engaged in circulating hsa-miR-494-3p and hsa-miR-661 in AD. The qRT-PCR analysis showed that the downregulated expression level of hsa-miR-661 was statistically significant (p < 0.05). Also, the ROC curve of hsa-miR-661 displayed the significant AUC (p = 0.01). Conclusion:Based on our findings, the metabolic and cellular responses to stress pathways are closely connected to these two miRNAs functions. Besides, the qRT-PCR and Roc curve determined hsa-miR-661 could be as a biomarker for diagnosis or prognosis of AD patients. Key Words: Alzheimer’s disease, Serum, Circulating microRNAs 相似文献
12.
Nassimi Zohreh Taheri Parissa Kong Xi Dong Wubei Tarighi Saeed 《European journal of plant pathology / European Foundation for Plant Pathology》2021,160(2):469-485
European Journal of Plant Pathology - Plant antimicrobial peptides (AMPs) as a part of plant defense responses, are small soluble defense molecules which can inhibit the growth of pathogens. This... 相似文献
13.
Nikookar SH Hajheydari Z Moosa-Kazemi SH Mahmoudi M Shahmohammadi S 《Pakistan journal of biological sciences: PJBS》2012,15(2):103-107
Dermatitis caused by stimulation of beetle paederus, is a common health problem in Northern and some southern parts of Iran. Since by now, traditional medicine and some corticosteroid agents have been used for treatment of dermatitis caused by beetle paederus. Because, there are few researches about classical treatment of the disease at academic level, this study planned to compare the effectiveness of triamcinolone ointment and atorvastatin tablet with placebo in treatment ofpaederus dermatitis in Northern Iran. A randomized double-blind clinical trial was carried out on 30 patients referred to the hospital and clinics at Sari and Neka countries in Northern Iran during 6 months. Patients were randomly divided into two therapeutic equal groups. The first group was triamcinolone ointment twice a day and a placebo atorvastatin tablet daily. The second group was oral atorvastatin one tablet (20 mg) daily and a placebo triamcinolone ointment twice a day. In Seventh day of visits, therapeutic response of the patients in triamcinolone and atorvastatin group were 93.33 and 80%, respectively. No significant differences were found in therapeutic outcome between the two groups (p > 0.05). The results showed both oftriamcinolone ointment and oral atorvastatin had similar effect on paederus dermatitis. Because the paederus dermatitis is a self-limited disease use of topical therapy for treatment of the disease is recommend. 相似文献
14.
The aim of this research was to identify species suitable for plantation. We first identified species for potentially suitable for plantation based on ecological capabilities regarding soil properties. We determined the area of plantation for different species based on ecological capabilities. Then, we collected relevant data such as growth patterns of different species, labor requirements for plantation and plantation cost. A linear programming model and two integer linear programming models were used for optimization. The appropriate species based on ecological capabilities were ash, elm, maple, oak and bald cypress. A linear programming model was used based on ecological capabilities classification to determine the land area of different species for plantation. Then, two integer linear programming models were employed to select the species for plantation. We set ecological properties unequal for all of the species in the first run of the integer programming model. Two groups were classified: group one included maple and ash; group two included bald cypress, oak and elm. The second integer programming model assumed equal ecological properties for all the species. Results of linear programming showed that maple and bald cypress were appropriate for plantation at the site and their plantation areas should be 151.3 and 355.3 ha, respectively. Results of the first integer linear programming model showed that maple and bald cypress would be economically profitable for plantation. The results of the second integer linear programming model showed that only bald cypress would be appropriate for plantation. 相似文献
15.
To investigate the effect of boric acid on yield and yield components of three white bean cultivars consisted of Jules, G11867, and Shekoofa, a 2-year field split-plot experiment was carried out based on a randomized complete block design with three replications during 2013 and 2014. Boron treatments consisted of 1 – control (no boric acid), 2 and 3 – application of 2 and 4?kg ha?1 of boric acid by irrigation water, respectively, 4 and 5 – foliar spray of 0.025% and 0.05% of boric acid solutions, respectively, and 6 – combination of 2?kg ha?1 of boric acid in irrigation water?+?foliar spray by 0.025% boric acid solution. Boron application significantly increased yield and its components in respect to control. The highest grain yields of all cultivars were obtained from application of 2?kg ha?1 boric acid mixed in irrigation water?+?foliar spray by 0.025% of boric acid solution. 相似文献
16.
Efficacy and hypnotic effects of melatonin in shift-work nurses: double-blind,placebo-controlled crossover trial 总被引：1，自引：0，他引：1
Khosro Sadeghniiat-Haghighi Omid Aminian Gholamreza Pouryaghoub Zohreh Yazdi 《Journal of circadian rhythms》2008,6(1):10
Background
Night work is associated with disturbed sleep and wakefulness, particularly in relation to the night shift. Circadian rhythm sleep disorders are characterized by complaints of insomnia and excessive daytime sleepiness that are primarily due to alterations in the internal circadian timing system or a misalignment between the timing of sleep and the 24-h social and physical environment. 相似文献17.
Amiri Z Mohammad K Mahmoudi M Zeraati H Fotouhi A 《Pakistan journal of biological sciences: PJBS》2008,11(8):1076-1084
This study is designed to assess the application of neural networks in comparison to the Kaplan-Meier and Cox proportional hazards model in the survival analysis. Three hundred thirty gastric cancer patients admitted to and surgically treated were assessed and their post-surgical survival was determined. The observed baseline survival was determined with the three methods of Kaplan-Meier product limit estimator, Cox and the neural network and results were compared. Then the binary independent variables were entered into the model. Data were randomly divided into two groups of 165 each to test the models and assess the reproducibility. The Chi-square test and the multiple logistic model were used to ensure the groups were similar and the data was divided randomly. To compare subgroups, we used the log-rank test. In the next step, the probability of survival in different periods was computed based on the training group data using the Cox proportional hazards and a neural network and estimating Cox coefficient values and neural network weights (with 3 nodes in hidden layer). Results were used for predictions in the test group data and these predictions were compared using the Kaplan-Meier product limit estimator as the gold standard. Friedman and Kruskal-Wallis tests were used for comparisons as well. All statistical analyses were performed using SPSS version 11.5, Matlab version 7.2, Statistica version 6.0 and S_PLUS 2000. The significance level was considered 5% (alpha = 0.05). The three methods used showed no significance difference in base survival probabilities. Overall, there was no significant difference among the survival probabilities or the trend of changes in survival probabilities calculated with the three methods, but the 4 year (48th month) and 4.5 year (54th month) survival rates were significantly different with Cox compared to standard and estimated probabilities in the neural network (p < 0.05). Kaplan-Meier and Cox showed almost similar results for the baseline survival probabilities, but results with the neural network were different: higher probabilities up to the 4th year, then comparable with the other two methods. Estimates from Cox proportional hazards and the neural network with three nodes in hidden layer were compared with the estimate from the Kaplan-Meier estimator as the gold standard. Neither comparison showed statistically significant differences. The standard error ratio of the two estimate groups by Cox and the neural network to Kaplan-Meier were no significant differences, it indicated that the neural network was more accurate. Although we do not suggest neural network methods to estimate the baseline survival probability, it seems these models is more accurately estimated as compared with the Cox proportional hazards, especially with today's advanced computer sciences that allow complex calculations. These methods are preferable because they lack the limitations of conventional models and obviate the need for unnecessary assumptions including those related to the proportionality of hazards and linearity. 相似文献
18.
Fatemeh Saeidnia Mohammad M. Majidi Soheila Spanani Mostafa Abdollahi Bakhtiari Zohreh Karami Nia Hughes 《Plant Breeding》2020,139(5):1029-1041
The consequences of recurrent drought events compared with a single drought, and drought's interaction with deliberate selfing compared with open-pollination on postdrought recovery and persistence of smooth bromegrass, are not clear. This research was conducted to investigate the effects of recurrent drought stresses compared with a single drought on stress response, poststress recovery and persistence of full-sib and half-sib progenies of smooth bromegrass. During this study, 25 selfed (S1) and 25 open-pollinated (OP) progenies of smooth bromegrass created in 2012 were evaluated in the field under normal and recurrent drought stress during 2013–2016. After the first harvest of above-ground biomass in 2016, irrigation was withheld in both environments for 2 months; plants were subsequently re-watered and evaluated. Recurrent drought stress changed the relationships between different traits. Moreover, prolonged drought stress resulted in increased plant productivity (recovery aerial biomass; RABI) of S1 and OP populations in recurrent drought stress compared with normal environment. Mandatory selfing increased persistence of smooth bromegrass genotypes but did not affect recovery after prolonged drought stress. Results revealed that, selecting among S1 families would be more effective than OP ones. 相似文献
19.
Hernandez JM Stein A Behrmann E Riedel D Cypionka A Farsi Z Walla PJ Raunser S Jahn R 《Science (New York, N.Y.)》2012,336(6088):1581-1584
Cellular membrane fusion is thought to proceed through intermediates including docking of apposed lipid bilayers, merging of proximal leaflets to form a hemifusion diaphragm, and fusion pore opening. A membrane-bridging four-helix complex of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) mediates fusion. However, how assembly of the SNARE complex generates docking and other fusion intermediates is unknown. Using a cell-free reaction, we identified intermediates visually and then arrested the SNARE fusion machinery when fusion was about to begin. Partial and directional assembly of SNAREs tightly docked bilayers, but efficient fusion and an extended form of hemifusion required assembly beyond the core complex to the membrane-connecting linkers. We propose that straining of lipids at the edges of an extended docking zone initiates fusion. 相似文献
20.
The effects of irradiance and photoperiod on the biomass and fatty acid (FA) composition of Chlorella vulgaris were examined in the exponential growth phase. Results indicated significant differences in biomass and FA at different intensities
and photoperiods. Maximum biomass (2.05 ± 0.1 g l−1) was at 62.5 μmol photons m−2 s−1 and 16:8 h light/dark photoperiod. FA composition changed considerably in different light regimes; the maximum percentage
of total saturated (SFA) (33.38%) was recorded at 100 μmol photons m−2 s−1 and 16:8 h photoperiod, while monounsaturated (MUFA) and polyunsaturated (PUFA) fatty acids decreased with increasing irradiance
and light duration. The maximum percentage of total MUFA (15.93%) and PUFA (27.40%) was recorded at 37.5 μmol photons m−2 s−1 and 8:16 h photoperiod. 相似文献