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51.
Overconstraints exist widely in planar closed chain mechanisms and mechanical systems result in a series of detrimental influences on behavior of machines, and attention is given to them by machine designer. Some analysis methods of overconstraints in planar closed chain mechanisms are presented, and more study due to the faultiness of these methods. In accordance with faultiness of two common kind of methods, formulas method and loop analysis method of degrees of freedom, and by combining these two methods, an useful mechanism overconstraints analysis method which is convenient for computer aided overconstraints analysis is gained via research on the two methods thoroughly and systematically, and some new views about mechanism overconstraints analysis are presented. 相似文献
52.
高度对色斑法测量雨滴粒径影响的试验研究 总被引:2,自引:0,他引:2
以前的色斑法雨滴率定只考虑色斑直径与雨滴真实粒径的关系,忽略了高度对率定的影响。在大量试验的基础上,通过回归分析,得到了以色斑直径和高度为变量的率定公式。研究表明,水滴下落高度小于5m时需考虑高度的影响;高度大于5m时,高度的影响可以忽略。通过相关性分析,公式的拟合性较好,对以后的色宽法测量雨滴粒径有指导意义。 相似文献
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国外水泵研究现状概述 总被引:7,自引:3,他引:7
以丰富的材料为基础,概括性地评价了西方近年中在水泵技术各研究领域,如流场计算、汽蚀机理、振动、无泄漏密封等方面的研究现状及成果,这些资料将为国内水泵技术人员的产品开发、科研活动提供有益的启发和借鉴。 相似文献
57.
张家口地区马铃薯种植面积广,畜力犁收获时效率低,漏收和破损较为严重,外购的马铃薯收获机不适合当地农民的种植方式.为此,设计了马铃薯收获机.该机可实现马铃薯挖掘、薯土分离和薯秧分离.同时,对该机部分关键零件进行了设计,对样机在玉米茬地和马铃薯地的工作性能进行了试验研究.试验结果满足当地农民的使用要求,试验数据对设计多行马铃薯收获机具有参考和借鉴作用. 相似文献
58.
对4102非道路柴油机的主要零部件进行了精确的建模,确定了主要的载荷工况,分别对曲轴及连杆在增压前后两种情况下进行了有限元分析以及强度计算,并对计算结果进行了分析比较,找出了增压后零部件的薄弱部位,提出了适当的改进措施。 相似文献
59.
AIM To observe the effect of Fuzilizhong decoction on the inflammatory damage of non-alcoholic fatty liver disease (NAFLD) rats and to explore its mechanism. METHODS SPF male SD rats were randomly divided into 6 groups: control group, model group, high dose (20 mg·kg-1·d-1), middle dose (10 mg·kg-1·d-1), low dose (5 mg·kg-1·d-1) Fuzilizhong decoction group and Yishanfu (30 mg·kg-1·d-1)group, 8 rats in each group. A NAFLD rat modelwas established by intragastric administration of fat emulsion for 4 weeks. Then the drug was given for 4 weeks in each treatment group. HE staining was performed to observe the histopathological changes of the rat liver.The serum levels of interleukin-2(IL-2), IL-6 and tumor necrosis factor-α(TNF-α) were measured by ELISA. The expression of toll like receptor 4(TLR4) and NF-κB p65 in liver tissues at mRNA and protein levels was determined by RT-qPCR and Western bolt,respectively. RESULTS Compared with control group, the inflammatory damage of liver tissue was more serious, the serum levels of IL-2, IL-6 and TNF-α, the mRNA expression TLR4 and NF-κB p65 in liver tissues were significantly increased in model group(P <0.05). However, compared with model group, the liver pathological changes in each treatment group were significantly relieved, the serum levels of IL-2, IL-6 and TNF-α, the mRNA expression of TLR4 and NF-κB p65 in liver tissues were significantly reduced(P <0.05).In addition, the changes of TLR4 and p-NF-κB p65 protein levels in liver tissue were consistent with the changes of TLR4 and NF-κB p65 mRNA. CONCLUSION Fuzilizhong decoction attenuates the inflammatory damages of NAFLD in rats by inhibiting TLR4/NF-κB p65 signaling pathway. 相似文献
60.
XU Jia-qi AN Mei-ling YUAN Yue HAO Yi-fan WANG Xiu-wen ZHANG Min WEI Xiao-wei LI Hua WANG Ren-jun 《园艺学报》2021,36(12):2148-2158
AIM To investigate whether microRNA-9-5p (miR-9-5p) mediates sympathetic overactivity by targeting KCNN3 (potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3) gene,which encoded small-conductance calcium-activated potassium channel 3 (SK3) protein, in paraventricular nucleus (PVN) of rats with type 2 diabetes mellitus (T2D). METHODS A rat model of T2D was established by high-fat diet combined with intraperitoneal injection of 30 mg/kg streptozotocin. The levels of miR-9-5p and KCNN3 mRNA in PVN were detected by real-time PCR. The relationship between KCNN3 and miR-9-5p was predicted by TargetScan. Recombinant adeno-associated virus (rAAV)-miR-9-5p or KCNN3 were bilaterally microinjected into the PVN to observe the changes in plasma glucose levels and sympathetic drive indicators. The number of FosB and SK3 positive cells was measured by immunofluorescence staining. The protein expression of SK3 was determined by Western blot. The relationship between KCNN3 and miR-9-5p were confirmed by cell transfection and dual-luciferase reporter assay. RESULTS Compared with the rats in diabetes control (DC) group, the blood glucose, sympathetic drive indexes and the level of miR-9-5p in PVN were significantly increased, while the SK3 expression in PVN was obviously reduced in the diabetes mellitus (DM) rats. After microinjecion of rAAV-miR-9-5p in PVN, the sympathetic drive indexes, blood glucose, and the number of FosB-positive cells were increased significantly, but the SK3 protein expression was significantly reduced (P <0.05). However, up-regulation of KCNN3 in PVN had the opposite effect. These responses were obviously enhanced in DM rats compared with DC rats. The results of cell transfection and dual-luciferase reporter assay demonstrated that miR-9-5p bound to the 3’-UTR of KCNN3 and inhibit its expression. CONCLUSION miR-9-5p was up-regulated in PVN of the rats with T2D, and it may mediate sympathoexcitation by targeting KCNN3 . 相似文献