Molecular biology. MeCP2 repression goes nonglobal     

Klose R  Bird A 《Science (New York, N.Y.)》2003,302(5646):793-795

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A muscleblind knockout model for myotonic dystrophy     

Kanadia RN  Johnstone KA  Mankodi A  Lungu C  Thornton CA  Esson D  Timmers AM  Hauswirth WW  Swanson MS 《Science (New York, N.Y.)》2003,302(5652):1978-1980

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Green chemistry. Shy chemicals offer a solution     

Bradley D 《Science (New York, N.Y.)》2003,300(5628):2022-2023

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Condensed matter physics. New superconductors propel Chinese physicists to forefront     

Cho A 《Science (New York, N.Y.)》2008,320(5875):432-433

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Isolation of a cDNA from the virus responsible for enterically transmitted non-A, non-B hepatitis   总被引：59，自引：0，他引：59  

G R Reyes  M A Purdy  J P Kim  K C Luk  L M Young  K E Fry  D W Bradley 《Science (New York, N.Y.)》1990,247(4948):1335-1339

Major epidemic outbreaks of viral hepatitis in underdeveloped countries result from a type of non-A, non-B hepatitis distinct from the parenterally transmitted form. The viral agent responsible for this form of epidemic, or enterically transmitted non-A, non-B hepatitis (ET-NANBH), has been serially transmitted in cynomolgus macaques (cynos) and has resulted in typical elevation in liver enzymes and the detection of characteristic virus-like particles (VLPs) in both feces and bile. Infectious bile was used for the construction of recombinant complementary DNA libraries. One clone, ET1.1, was exogenous to uninfected human and cyno genomic liver DNA, as well as to genomic DNA from infected cyno liver. ET1.1 did however, hybridize to an approximately 7.6-kilobase RNA species present only in infected cyno liver. The translated nucleic acid sequence of a portion of ET1.1 had a consensus amino acid motif consistent with an RNA-directed RNA polymerase; this enzyme is present in all positive strand RNA viruses. Furthermore, ET1.1 specifically identified similar sequences in complementary DNA prepared from infected human fecal samples collected from five geographically distinct ET-NANBH outbreaks. Therefore, ET1.1 represents a portion of the genome of the principal viral agent, to be named hepatitis E virus, which is responsible for epidemic outbreaks of ET-NANBH.  相似文献   

Temperature, cloud structure, and dynamics of venus middle atmosphere by infrared remote sensing from pioneer orbiter     

Taylor FW  Diner DJ  Elson LS  McCleese DJ  Martonchik JV  Delderfield J  Bradley SP  Schofield JT  Gille JC  Coffey MT 《Science (New York, N.Y.)》1979,205(4401):65-67

Further results from the Venus orbiter radiometric temperature experiment (VORTEX) on the Pioneer orbiter are presented. These are used to characterize the three-dimensional temperature field, the cloud structure, and the dynamics of the 60-to 130-kilometer altitude region of the Venus atmosphere. One of the new discoveries is a "dipole" structure at high latitudes, with two hot spots rotating around the pole, surrounded by banks of cold cloud.  相似文献   

Quantitative analysis of culture using millions of digitized books   总被引：1，自引：0，他引：1  

Michel JB  Shen YK  Aiden AP  Veres A  Gray MK;Google Books Team  Pickett JP  Hoiberg D  Clancy D  Norvig P  Orwant J  Pinker S  Nowak MA  Aiden EL 《Science (New York, N.Y.)》2011,331(6014):176-182

We constructed a corpus of digitized texts containing about 4% of all books ever printed. Analysis of this corpus enables us to investigate cultural trends quantitatively. We survey the vast terrain of 'culturomics,' focusing on linguistic and cultural phenomena that were reflected in the English language between 1800 and 2000. We show how this approach can provide insights about fields as diverse as lexicography, the evolution of grammar, collective memory, the adoption of technology, the pursuit of fame, censorship, and historical epidemiology. Culturomics extends the boundaries of rigorous quantitative inquiry to a wide array of new phenomena spanning the social sciences and the humanities.  相似文献   

Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease     

Outeiro TF  Kontopoulos E  Altmann SM  Kufareva I  Strathearn KE  Amore AM  Volk CB  Maxwell MM  Rochet JC  McLean PJ  Young AB  Abagyan R  Feany MB  Hyman BT  Kazantsev AG 《Science (New York, N.Y.)》2007,317(5837):516-519

The sirtuins are members of the histone deacetylase family of proteins that participate in a variety of cellular functions and play a role in aging. We identified a potent inhibitor of sirtuin 2 (SIRT2) and found that inhibition of SIRT2 rescued alpha-synuclein toxicity and modified inclusion morphology in a cellular model of Parkinson's disease. Genetic inhibition of SIRT2 via small interfering RNA similarly rescued alpha-synuclein toxicity. Furthermore, the inhibitors protected against dopaminergic cell death both in vitro and in a Drosophila model of Parkinson's disease. The results suggest a link between neurodegeneration and aging.  相似文献   

Reversal of neurological defects in a mouse model of Rett syndrome   总被引：2，自引：0，他引：2  

Guy J  Gan J  Selfridge J  Cobb S  Bird A 《Science (New York, N.Y.)》2007,315(5815):1143-1147

Rett syndrome is an autism spectrum disorder caused by mosaic expression of mutant copies of the X-linked MECP2 gene in neurons. However, neurons do not die, which suggests that this is not a neurodegenerative disorder. An important question for future therapeutic approaches to this and related disorders concerns phenotypic reversibility. Can viable but defective neurons be repaired, or is the damage done during development without normal MeCP2 irrevocable? Using a mouse model, we demonstrate robust phenotypic reversal, as activation of MeCP2 expression leads to striking loss of advanced neurological symptoms in both immature and mature adult animals.  相似文献   

THE OCCURRENCE OF ZINC IN CERTAIN INVERTEBRATES     

Bradley HC 《Science (New York, N.Y.)》1904,19(474):196-197

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